Article
Nutrition & Dietetics
Liana L. Guarneiri, Meredith L. Wilcox, Kevin C. Maki
Summary: This study aimed to evaluate the bioavailability of EPA+DHA in a phospholipid-enhanced fish oil product and a krill oil product. Results showed similar absorption of EPA+DHA from both products, but with different absorption profiles, with the phospholipid-enhanced fish oil product having a higher and earlier peak concentration.
Article
Agriculture, Multidisciplinary
Xina Yu, Qingcheng Wang, Weibo Lu, Min Zhang, Kang Chen, Jing Xue, Qiaoling Zhao, Pingya Wang, Pei Luo, Qing Shen
Summary: An PreIS-HILIC-MS method was established to specifically and selectively screen PLEPA/DHA in different fish oil samples, including saury, grass carp, hairtail, and yellow croaker. The method demonstrated high sensitivity, good linearity, and suitability for quantitative analysis of PLEPA/DHA in fish oil samples, with the ability to identify and quantify 24 different compounds. The performance of this method was compared with traditional full-scan mode and showed unique superiority in targeted screening of PLEPA/DHA in fish oils.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Robbe Demets, Lore Gheysen, Ann Van Loey, Imogen Foubert
Summary: This research investigates the role of carotenoids in the oxidative stability of mixtures of fish oil and lipid extracts of two different microalgae. It finds that the initial amount of carotenoids relative to n-3 LC-PUFA is a good indicator to differentiate between oxidatively stable and unstable mixtures. The degradation of fucoxanthin, diatoxanthin, and beta-carotene during storage illustrates their antioxidative role.
Review
Food Science & Technology
Huali Ye, Yunyi Liu, Zhike Xu, Xin Wei
Summary: Glaucoma, a leading cause of irreversible vision loss worldwide, is influenced by various risk factors such as age, increased intraocular pressure, inflammation, oxidative stress, and ocular blood flow deficits. While lowering intraocular pressure is the current effective method for controlling glaucoma progression, it may not always provide satisfactory results due to inadequate response and ongoing retinal neural degeneration. Fish oil, a dietary supplement rich in omega-3 fatty acids, has been reported to benefit glaucoma patients; however, its efficiency and underlying mechanisms are still unclear. This review summarizes the roles of active ingredients in fish oil, including lowering intraocular pressure, regulating blood supply, alleviating inflammation, and reducing oxidative stress, in delaying the development of glaucoma and promoting clinical management.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Ann-Dorit Moltke SOrensen, Adane Tilahun Getachew, Charlotte Jacobsen
Summary: The study found that starfish could be a potential source of marine oil containing omega-3 fatty acids and phospholipids, however, the extraction method still needs further optimization.
Article
Chemistry, Applied
Tahere Ghorbanzade, Sahar Akhavan-Mahdavi, Mohammad Saeed Kharazmi, Salam A. Ibrahim, Seid Mahdi Jafari
Summary: Encapsulation of fish oil with beta-cyclodextrin reduced acidity and improved beneficial fatty acid content in yogurt. Yogurt fortified with encapsulated fish oil had similar sensory qualities to the control sample.
Article
Fisheries
M. B. Betancor, A. MacEwan, M. Sprague, X. Gong, D. Montero, L. Han, J. A. Napier, F. Norambuena, M. Izquierdo, D. R. Tocher
Summary: The study showed that a genetically modified Camelina oil can replace fish oil without detrimental effects on the growth or feed efficiency of European seabass, while also improving the nutritional quality of the fish fillet.
Article
Food Science & Technology
Irena Jovanovic Macura, Ivana Djuricic, Tamara Major, Desanka Milanovic, Marjana Brkic, Sladjana Sobajic, Selma Kanazir, Sanja Ivkovic
Summary: High-dose fish oil supplementation has a protective effect on retinal blood vessels.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Engineering, Chemical
Zuoyi Yan, Meiqin Zheng, Daohang Ye, Tian Qi, Caijin Zhou, Huidong Zheng
Summary: This study investigated the de-oiling of concentrated phospholipids through ultrafiltration enhanced by reversed micelles using a polyethersulfone membrane. Phospholipids formed larger molecular weight reversed micellar structures in non-polar solvents, which allowed for effective membrane separation. Experimental results showed that under specific conditions, the retentate phospholipid content and yield were high, while the permeate flux was relatively low. The study also proposed a mathematical model based on the concentration polarization mechanism, indicating that the permeate flux was mainly influenced by convective transfer flow rate.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Santi Devi Upadhaya, In Ho Kim
Summary: The study showed that supplementing weaner pigs with unrefined fish oil or DHA enriched oil can significantly improve their weight gain and feed conversion rate, leading to better growth performance.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Yun-Qi Wen, Chang-Hu Xue, Hong-Wei Zhang, Li-Li Xu, Xiao-Han Wang, Shi-Jie Bi, Qian-Qian Xue, Yong Xue, Zhao-Jie Li, Joaquin Velasco, Xiao-Ming Jiang
Summary: The aim of this study was to explore the development of off-odors in fish oil from the perspective of fatty acid oxidation. It was found that oxidation of fatty acids other than DHA and EPA also contribute to the off-odors in fish oil. The off-odors of fish oil were successfully simulated by combining oxidized samples of DHA, EPA, and sunflower oil. A novel analytical approach using GC-IMS and OPLS-DA was applied to identify differences in volatile components between recombinant oil and fish oil.
Article
Agriculture, Dairy & Animal Science
Ester Santigosa, Fabio Brambilla, Luca Milanese
Summary: Microalgal oils have emerged as a sustainable alternative to fish oil and nutritionally poorer vegetable oils for aquaculture species like gilthead seabream. Incorporating microalgal oils in the diet of seabream resulted in maintained fish performance, lower contamination levels in fillets, and similar sensory quality compared to diets rich in fish oil. This offers a more resilient means for sustaining the future growth of seabream aquaculture.
Article
Biochemistry & Molecular Biology
Hyunsin (Hedy) Sung, Andrew J. Sinclair, Xiao Q. Su
Summary: This study compared the effects of krill oil (KO) and fish oil (FO) on the enrichment of molecular species of plasma phospholipids in young women after a 30-day consumption. The results showed that after 30 days of supplementation, molecular species containing EPA, DHA, and DPAn-3 had a significantly higher concentration in the KO group compared to the FO group. These findings suggest that KO, which is rich in ether phospholipids, can enrich n-3 PUFA in plasma phospholipids.
Article
Medicine, Research & Experimental
Debora S. Santos, Jose Athayde V. Morais, Isis A. C. Vanderlei, Alexandre S. Santos, Ricardo B. Azevedo, Luis A. Muehlmann, Osmindo R. P. Junior, Marcia R. Mortari, Jaqueline R. da Silva, Sebastiao W. da Silva, Joao P. F. Longo
Summary: A fish oil nanoemulsion was developed to improve oral absorption and test anti-inflammatory effects, showing low polydispersity and stable droplets. The nanoemulsion did not affect cell viability, was kinetically incorporated into cells, and exhibited significantly shorter retention in the gastrointestinal region compared to free fish oil intake. In inflammatory tests, the nanoemulsion showed less neutrophil infiltration and reduced paw edema volume, indicating significant effectiveness in modulating inflammatory disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sachiko Okue, Eimi Ishikawa, Ren Nakahara, Tsubasa Ito, Takumi Okura, Mana Sakae, Atsushi Miura, Yori Ozaki-Masuzawa, Takashi Hosono, Taiichiro Seki
Summary: Fish oil showed potent antiobesity effects in lean mice by suppressing body weight gain and inducing UCP-1 expression, while in DIO mice it improved liver steatosis without reducing body weight.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)