Coronary Artery Microcalcification: Imaging and Clinical Implications

18 F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images

(2019) Michael D. Creager et al.   Circulation-Cardiovascular Imaging

Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study

(2019) Francesco Prati et al.   EUROPEAN HEART JOURNAL

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

(2019) Juhani Knuuti et al.   EUROPEAN HEART JOURNAL

New methods to image unstable atherosclerotic plaques

(2018) Jack P.M. Andrews et al.   ATHEROSCLEROSIS

Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study

(2018) Sebastian Reith et al.   Clinical Research in Cardiology

Plaque erosion: a new in vivo diagnosis and a potential major shift in the management of patients with acute coronary syndromes

(2018) Ramon A Partida et al.   EUROPEAN HEART JOURNAL

In vivo tissue characterization of human atherosclerotic plaques by optical coherence tomography: A directional coronary atherectomy study with histopathologic confirmation

(2018) Maoto Habara et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Plaque Calcification During Atherosclerosis Progression and Regression

(2018) Atsushi Shioi et al.   Journal of Atherosclerosis and Thrombosis

Critical roles of inflammation in atherosclerosis

(2018) Junji Moriya   Journal of Cardiology

Coronary Artery Calcification and its Progression

(2018) Hiroyoshi Mori et al.   JACC-Cardiovascular Imaging

Effects of Statins on Coronary Atherosclerotic Plaques

(2018) Sang-Eun Lee et al.   JACC-Cardiovascular Imaging

Plaque Morphology as Predictor of Late Plaque Events in Patients With Asymptomatic Type 2 Diabetes

(2018) David A. Halon et al.   JACC-Cardiovascular Imaging

Optical coherence tomography-verified morphological correlates of high-intensity coronary plaques on non-contrast T1-weighted magnetic resonance imaging in patients with stable coronary artery disease

(2018) Tomoaki Kanaya et al.   European Heart Journal-Cardiovascular Imaging

Sodium-fluoride PET-CT for the non-invasive evaluation of coronary plaques in symptomatic patients with coronary artery disease: a cross-correlation study with intravascular ultrasound

(2018) Li Li et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Co-localization of plaque macrophages with calcification is associated with a more vulnerable plaque phenotype and a greater calcification burden in coronary target segments as determined by OCT

(2018) Mathias Burgmaier et al.   PLoS One

Molecular imaging of coronary inflammation

(2018) Matthieu Pelletier-Galarneau et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Non-invasive imaging of the coronary arteries

(2018) Philip D Adamson et al.   EUROPEAN HEART JOURNAL

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery

(2018) Maximillian A. Rogers et al.   Nature Reviews Cardiology

Arterial calcification: A new perspective?

(2017) R Nicoll et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Extracellular vesicles in coronary artery disease

(2017) Chantal M. Boulanger et al.   Nature Reviews Cardiology

Coronary Artery Calcification

(2017) Chris Reutelingsperger et al.   JACC-Cardiovascular Imaging

Coronary Atherosclerosis T 1 -Weighed Characterization With Integrated Anatomical Reference

(2017) Yibin Xie et al.   JACC-Cardiovascular Imaging

Coronary Artery Calcification

(2017) Takehiro Nakahara et al.   JACC-Cardiovascular Imaging

Coronary Artery Calcium Volume and Density

(2017) Michael H. Criqui et al.   JACC-Cardiovascular Imaging

Coronary Artery PET/MR Imaging

(2017) Philip M. Robson et al.   JACC-Cardiovascular Imaging

Clinical indications for coronary artery calcium scoring in asymptomatic patients: Expert consensus statement from the Society of Cardiovascular Computed Tomography

(2017) Harvey Hecht et al.   Journal of Cardiovascular Computed Tomography

CT calcium scoring. History, current status and outlook

(2017) V. Sandfort et al.   Diagnostic and Interventional Imaging

Contrast-enhanced magnetic resonance imaging for the detection of ruptured coronary plaques in patients with acute myocardial infarction

(2017) Christian H. P. Jansen et al.   PLoS One

Noninvasive Molecular Imaging of Disease Activity in Atherosclerosis

(2016) Marc R. Dweck et al.   CIRCULATION RESEARCH

PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology

(2016) Nicholas R. Evans et al.   Current Atherosclerosis Reports

2016 European Guidelines on cardiovascular disease prevention in clinical practice

(2016) Massimo F. Piepoli et al.   EUROPEAN HEART JOURNAL

The coronary calcium score is a more accurate predictor of significant coronary stenosis than conventional risk factors in symptomatic patients: Euro-CCAD study

(2016) R. Nicoll et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Zooming in on the genesis of atherosclerotic plaque microcalcifications

(2016) Jessica L. Ruiz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Statin Medication Enhances Progression of Coronary Artery Calcification

(2016) Iryna Dykun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

(2016) Joshua D. Hutcheson et al.   NATURE MATERIALS

MR Imaging of Coronary Arteries and Plaques

(2016) Marc R. Dweck et al.   JACC-Cardiovascular Imaging

Coronary Plaque Characterization Using CT

(2015) Farhood Saremi et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study

(2015) Fumiyuki Otsuka et al.   ATHEROSCLEROSIS

Coronary high-intensity plaque onT1-weighted magnetic resonance imaging and its association with myocardial injury after percutaneous coronary intervention

(2015) Tomoya Hoshi et al.   EUROPEAN HEART JOURNAL

Requiem for the ‘vulnerable plaque’

(2015) Peter Libby et al.   EUROPEAN HEART JOURNAL

High dose and long-term statin therapy accelerate coronary artery calcification

(2015) Michael Henein et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

Effect of Statin Therapy on Fibrous Cap Thickness in Coronary Plaques Using Optical Coherence Tomography: A Systematic Review and Meta-Analysis

(2015) Guian Zheng et al.   JOURNAL OF INTERVENTIONAL CARDIOLOGY

18F-NaF Uptake by Atherosclerotic Plaque on PET/CT Imaging: Inverse Correlation Between Calcification Density and Mineral Metabolic Activity

(2015) F. Fiz et al.   JOURNAL OF NUCLEAR MEDICINE

10-Year Coronary Heart Disease Risk Prediction Using Coronary Artery Calcium and Traditional Risk Factors

(2015) Robyn L. McClelland et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Myth of the “Vulnerable Plaque”

(2015) Armin Arbab-Zadeh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plaque Characterization by Coronary Computed Tomography Angiography and the Likelihood of Acute Coronary Events in Mid-Term Follow-Up

(2015) Sadako Motoyama et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Statins on Serial Coronary Calcification During Atheroma Progression and Regression

(2015) Rishi Puri et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA

(2015) Kenichi Fujii et al.   JACC-Cardiovascular Imaging

OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome

(2015) Hannah Sinclair et al.   JACC-Cardiovascular Imaging

Localization of Coronary High-Intensity Signals on T1-Weighted MR Imaging

(2015) Kenji Matsumoto et al.   JACC-Cardiovascular Imaging

Intravascular Imaging of Coronary Calcification and Its Clinical Implications

(2015) Gary S. Mintz   JACC-Cardiovascular Imaging

Identifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography

(2015) Agnese Irkle et al.   Nature Communications

Characteristics of high-risk coronary plaques identified by computed tomographic angiography and associated prognosis: a systematic review and meta-analysis

(2015) Camilla Thomsen et al.   European Heart Journal-Cardiovascular Imaging

Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis

(2015) Martijn L. L. Chatrou et al.   PLoS One

Has Our Understanding of Calcification in Human Coronary Atherosclerosis Progressed?

(2014) Fumiyuki Otsuka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms of Plaque Formation and Rupture

(2014) Jacob Fog Bentzon et al.   CIRCULATION RESEARCH

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

(2014) Peter Libby et al.   CIRCULATION RESEARCH

Small entities with large impact

(2014) Joshua D. Hutcheson et al.   CURRENT OPINION IN LIPIDOLOGY

Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models

(2014) Luis Cardoso et al.   JOURNAL OF BIOMECHANICS

Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis

(2014) Jinwei Tian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Insights Into Echo-Attenuated Plaques, Echolucent Plaques, and Plaques With Spotty Calcification

(2014) Jun Pu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comprehensive plaque assessment by coronary CT angiography

(2014) Pál Maurovich-Horvat et al.   Nature Reviews Cardiology

Changing Views of the Biomechanics of Vulnerable Plaque Rupture: A Review

(2013) Luis Cardoso et al.   ANNALS OF BIOMEDICAL ENGINEERING

Do vulnerable and ruptured plaques hide in heavily calcified arteries?

(2013) Fumiyuki Otsuka et al.   ATHEROSCLEROSIS

Vascular Calcification: An Update on Mechanisms and Challenges in Treatment

(2013) Meiting Wu et al.   CALCIFIED TISSUE INTERNATIONAL

Coronary calcium in patients with and without diabetes: first manifestation of acute or chronic coronary events is characterized by different calcification patterns

(2013) Joseph Shemesh et al.   Cardiovascular Diabetology

Detection of High-Risk Atherosclerotic Plaques by Magnetic Resonance Imaging

(2013) Teruo Noguchi et al.   CIRCULATION JOURNAL

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Atherosclerotic Plaque Composition and Classification Identified by Coronary Computed Tomography

(2013) Daniel R. Obaid et al.   Circulation-Cardiovascular Imaging

Focal Arterial Inflammation Precedes Subsequent Calcification in the Same Location

(2013) Amr Abdelbaky et al.   Circulation-Cardiovascular Imaging

Pathophysiology of Atherosclerosis Plaque Progression

(2013) Kenichi Sakakura et al.   Heart Lung and Circulation

Calcium Density of Coronary Artery Plaque and Risk of Incident Cardiovascular Events

(2013) Michael H. Criqui et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

(2013) Neil J. Stone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial

(2013) Nikhil V Joshi et al.   LANCET

Does microcalcification increase the risk of rupture?

(2013) Myriam Cilla et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries

(2013) A. Kelly-Arnold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are the Culprit Lesions Severely Stenotic?

(2013) Giampaolo Niccoli et al.   JACC-Cardiovascular Imaging

Relation Between Angiographic Lesion Severity, Vulnerable Plaque Morphology and Future Adverse Cardiac Events (from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree Study)

(2012) Kyeong Ho Yun et al.   AMERICAN JOURNAL OF CARDIOLOGY

A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture

(2012) Natalia Maldonado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Macrophages play a unique role in the plaque calcification by enhancing the osteogenic signals exerted by vascular smooth muscle cells

(2012) Koji Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute Coronary Events

(2012) Armin Arbab-Zadeh et al.   CIRCULATION

Coronary Computed Tomographic Angiography and Risk of All-Cause Mortality and Nonfatal Myocardial Infarction in Subjects Without Chest Pain Syndrome From the CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry)

(2012) Iksung Cho et al.   CIRCULATION

Update on acute coronary syndromes: the pathologists' view

(2012) Erling Falk et al.   EUROPEAN HEART JOURNAL

Significance of intraplaque neovascularisation for vulnerability: optical coherence tomography study

(2012) Jinwei Tian et al.   HEART

Arterial calcification: Friend or foe?

(2012) Rachel Nicoll et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding

(2012) Natalia Maldonado et al.   JOURNAL OF BIOMECHANICS

Obstructive Coronary Atherosclerosis and Ischemic Heart Disease: An Elusive Link!

(2012) Mario Marzilli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Spotty Calcification as a Marker of Accelerated Progression of Coronary Atherosclerosis

(2012) Yu Kataoka et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Coronary Arterial 18F-Sodium Fluoride Uptake

(2012) Marc R. Dweck et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies

(2012) Guillermo J. Tearney et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS

(2012) Kousuke Hattori et al.   JACC-Cardiovascular Imaging

Detection of High-Risk Atherosclerotic Plaque

(2012) Jerome L. Fleg et al.   JACC-Cardiovascular Imaging

Coronary Calcium: New Insights, Recent Data, and Clinical Role

(2012) George Youssef et al.   Current Cardiology Reports

Positive Remodeling on Coronary Computed Tomography as a Marker for Plaque Vulnerability on Virtual Histology Intravascular Ultrasound

(2011) Eleanore S.J. Kröner et al.   AMERICAN JOURNAL OF CARDIOLOGY

Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries

(2011) Ruben B. Roijers et al.   AMERICAN JOURNAL OF PATHOLOGY

Cardiovascular Calcification

(2011) Sophie E. P. New et al.   CIRCULATION JOURNAL

In vivo critical fibrous cap thickness for rupture-prone coronary plaques assessed by optical coherence tomography

(2011) T. Yonetsu et al.   EUROPEAN HEART JOURNAL

Comprehensive assessment of spotty calcifications on computed tomography angiography: Comparison to plaque characteristics on intravascular ultrasound with radiofrequency backscatter analysis

(2011) Joëlla E. van Velzen et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Correlation of Inflammation Assessed by 18F-FDG PET, Active Mineral Deposition Assessed by 18F-Fluoride PET, and Vascular Calcification in Atherosclerotic Plaque: A Dual-Tracer PET/CT Study

(2011) T. Derlin et al.   JOURNAL OF NUCLEAR MEDICINE

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

A Prospective Natural-History Study of Coronary Atherosclerosis

(2011) Gregg W. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stabilisation of atherosclerotic plaques

(2011) Jacob Fog Bentzon et al.   THROMBOSIS AND HAEMOSTASIS

Association Between IVUS Findings and Adverse Outcomes in Patients With Coronary Artery Disease

(2011) Patrick A. Calvert et al.   JACC-Cardiovascular Imaging

Concept of Vulnerable/Unstable Plaque

(2010) Aloke V. Finn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extensive Coronary Calcification: A Clinically Unrecognised Condition

(2010) Rachel Nicoll et al.   Current Vascular Pharmacology

The Dynamic Nature of Coronary Artery Lesion Morphology Assessed by Serial Virtual Histology Intravascular Ultrasound Tissue Characterization

(2010) Takashi Kubo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Regulatory mechanisms in vascular calcification

(2010) Andrew P. Sage et al.   Nature Reviews Cardiology

Relationship between coronary remodeling and plaque characterization in patients without clinical evidence of coronary artery disease

(2007) Teruyoshi Kume et al.   ATHEROSCLEROSIS