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Biochemistry & Molecular Biology
Man Liu, Shan-Shan Zhang, Dong-Ni Liu, Ying-Lin Yang, Yue-Hua Wang, Guan-Hua Du
Summary: Chrysomycin A has anti-neuroinflammatory effects possibly through regulating cytokine responses and immune system processes. KEGG enrichment analysis suggests its mechanisms may involve TNF signaling pathway, cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, IL-17 signaling pathway and NOD-like receptor signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jae Kwang Kim, Hye Jin Yang, Younghoon Go
Summary: Quercus acuta Thunb. extract shows significant anti-neuroinflammatory effects by inhibiting NF-kappa B and MAPK activation, and activating Nrf2/HO-1 signaling pathways, suggesting its potential in preventing microglia-mediated neuroinflammation.
Article
Biochemistry & Molecular Biology
Jung Lo, Hsin-En Wu, Ching-Chih Liu, Kun-Che Chang, Po-Yen Lee, Po-Len Liu, Shu-Pin Huang, Pei-Chang Wu, Tzu-Chieh Lin, Yu-Hung Lai, Yo-Chen Chang, Yuan-Ru Chen, Sheng- Lee, Yu-Kai Huang, Shu-Chi Wang, Chia-Yang Li
Summary: In this study, the researchers investigated the effect of nordalbergin, a compound derived from Dalbergia sissoo wood bark, on inflammation in microglial cells. They found that nordalbergin could suppress the production of inflammatory molecules and reduce oxidative stress through inhibiting specific signaling pathways. These findings suggest that nordalbergin has the potential to inhibit the progression of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
You-Chang Oh, Wei Li, Jang-Gi Choi
Summary: The activation of microglial cells and their neuroinflammatory reactions play a role in degenerative brain diseases, making regulation of their activation an important research focus for therapeutic agents. Saussureae Radix (SR) has shown potential in inhibiting neuroinflammation by reducing inflammatory mediators and promoting antioxidative pathways. Isolation and analysis identified key compounds in SR that could be beneficial in treating inflammation-related degenerative brain diseases.
MEDIATORS OF INFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Molu Ban, Hua Su, Xianbiao Zeng, Chunxia Chen, Shuguang Zhou, Xiaoyu Chen, Zhihuan Nong
Summary: This study investigated the anti-neuroinflammatory effects and molecular mechanisms of an active fraction from Spatholobus suberectus Dunn (ASSD) on mouse microglia BV2 cells. The results showed that ASSD suppressed microglia-mediated inflammatory responses by modulating microglia activation, inducing a shift from M1 to M2 polarization, and inhibiting the TLR4/MyD88/NF-kappa B signaling pathway.
Article
Biochemistry & Molecular Biology
Meng Liy Pan, Nur Nabilah Ahmad Puzi, Yin Yin Ooi, Rajesh Ramasamy, Sharmili Vidyadaran
Summary: The latest research shows that microglia phenotype is not limited to the binary states of "resting" and "activated", but exhibits wide diversity. Testing different stimulation protocols for BV2 microglia, we found differences in the response of the cells in terms of intracellular ROS, nitric oxide, CD40 expression, and migratory capacity.
Article
Cell Biology
Tianyu Meng, Shoupeng Fu, Dewei He, Guiqiu Hu, Xiyu Gao, Yufei Zhang, Bingxu Huang, Jian Du, Ang Zhou, Yingchun Su, Dianfeng Liu
Summary: EV effectively inhibits neuroinflammation caused by overactivated microglia by regulating the AKT/Nrf2/HO-1/NF-kappa B signaling axis. EV also suppresses LPS-induced inflammatory response and loss of dopaminergic neurons.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yinghui Wang, Zilin Wang, Ya Zhang, Zixin Zhu, Qiuju Mou, Lirong Liu, Lili Zhu
Summary: This study aimed to investigate the effect of platelet-rich plasma (PRP) on lipopolysaccharide (LPS)-mediated inflammation in BV2 microglia. The results showed that PRP can reduce apoptosis of BV2 microglia induced by LPS, inhibit the production of inflammatory cytokines, and block the activation of the NF-κB/MAPKs pathway. PRP at a concentration of 10% exhibited the optimal inhibitory effects.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Yue Jia, Dandan Zhang, Hua Yin, Haoran Li, Jing Du, Hongkun Bao
Summary: Neuroinflammation plays a critical role in neurodegenerative diseases, and microglia-mediated neuroinflammation is the main cause. Ganoderic acid A (GAA) from Ganoderma lucidum showed anti-inflammatory effects. This study found that GAA can inhibit LPS-induced neuroinflammation in BV2 microglial cells by activating the FXR receptor.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sara Standoli, Cinzia Rapino, Camilla Di Meo, Agnes Rudowski, Nicole Kaempfer-Kolb, Luisa Michelle Volk, Dominique Thomas, Sandra Trautmann, Yannick Schreiber, Dagmar Meyer zu Heringdorf, Mauro Maccarrone
Summary: Microglia, the immune cells of the central nervous system, have important roles in brain homeostasis and various neurological diseases. This study investigates the interaction between the endocannabinoid system and the sphingosine kinase/sphingosine-1-phosphate system in microglia. The results reveal that inhibiting the fatty acid amide hydrolase enzyme and activating the cannabinoid 2 receptor have anti-inflammatory effects and prevent the transcription of pro-inflammatory SphK1 and SphK2 in microglia cells challenged with lipopolysaccharide. The findings suggest the development of inhibitors for these enzymes as potential treatments for neuroinflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhao, Jiqing Fang, Yu Jia, Zi Wu, Meihui Zhang, Mingyu Xia, Jinhua Dong
Summary: A series of 1,4-heptadien-3-ones were synthesized and evaluated for their anti-neuroinflammatory effects. The compounds with methoxy groups effectively inhibited the inflammatory response induced by LPS, and the active compounds CU-19 and CU-21 significantly reduced the levels of various inflammatory mediators and regulated the expression of inflammatory proteins in cells. Mechanistically, CU-19 and CU-21 exerted their effects by inhibiting the nuclear translocation of NF-κB and phosphorylation of MAPKs.
Article
Medicine, Research & Experimental
Shan Gao, Qiao-Chu Cheng, Ya-Guang Hu, Zi-Zhu Tan, Li Chen, Si-Wei Liu, Qian-Yan Kang, Ting Wei
Summary: This study demonstrated that AK148321 alleviates neuroinflammation in LPS-stimulated BV2 microglial cells through the miR-1199-5p/HSPA5 axis, suggesting a potential therapeutic target for neurodegenerative diseases.
Article
Immunology
Xiao-Long Wang, Fei Chen, Hui Shi, Man Zhang, Lin Yan, Xiu-Ying Pei, Xiao-Dong Peng
Summary: The study revealed that OMT can regulate the polarization of microglia towards the M2 phenotype by inhibiting the TLR4/NF-Kappa B signaling pathway, effectively attenuating the LPS-induced inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiming Liu, Chi-Su Yoon, Hwan Lee, Hyeong-Kyu Lee, Dong-Sung Lee
Summary: Linderone, a compound found in Lindera erythrocarpa, has anti-inflammatory effects in BV2 cells. This study investigated the neuroprotective effects and mechanisms of linderone in BV2 and HT22 cells. Linderone suppressed the expression of inflammatory enzymes and cytokines in BV2 cells, and protected against oxidative stress in glutamate-stimulated HT22 cells. These findings provide a mechanistic explanation for the antioxidant and anti-neuroinflammatory effects of linderone. In conclusion, linderone shows therapeutic potential in neuronal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Lanqiu Zhang, Xiaolin Jiang, Jinlu Zhang, Hejun Gao, Lei Yang, Dihua Li, Qi Zhang, Botao Wang, Lihua Cui, Ximo Wang
Summary: (-)-Syringaresinol (SYR) extracted from Albiziae Cortex may exert anti-neuroinflammatory effects by inhibiting NF-κB activation, modulating microglia polarization, and interacting with ERβ. This study suggests that SYR could offer a new therapeutic avenue for brain diseases associated with inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)