Article
Chemistry, Analytical
Wanting Chen, Qian Li, Ranran Hou, Huaguo Liang, Yongli Zhang, Yongxia Yang
Summary: This study found that taurine has inhibitory effects on the growth and lung metastasis of breast cancer, and improves the pathological structure and metabolic disorders of tumor and lung tissue. Taurine also reverses the changes in various metabolites caused by breast cancer progression. The results suggest that taurine exerts anti-breast cancer effects through the regulation of metabolic pathways.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Francesca Di Cesare, Matteo Calgaro, Veronica Ghini, Diletta Francesca Squarzanti, Annachiara De Prisco, Annalisa Visciglia, Paola Zanetta, Roberta Rolla, Paola Savoia, Angela Amoruso, Barbara Azzimonti, Nicola Vitulo, Leonardo Tenori, Claudio Luchinat, Marco Pane
Summary: This study investigated the effects of probiotic treatment on the metabolic profiles of human urine and serum using NMR-based metabonomic approach. The results showed significant impacts of probiotics on urinary and serum metabolomes, without altering their phenotypes. The study demonstrated the variations of metabolite levels resulting from different probiotic posologies.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Energy & Fuels
Joseph A. Oyebanji, Sunday O. Oyedepo, Olawumi T. Oyebanji, Alaba O. Araoyinbo, Oluwaseun Kilanko, Joseph O. Dirisu, Bahaa Saleh
Summary: Agro-waste disposal is a serious environmental problem in developing countries like Nigeria, but it is possible to produce sustainable energy from these biomass wastes. This study aimed to determine the higher heating value (HHV) of indigenous fuelwood sawdust and analyze the chemical composition of the pyrolysis yield products. The results showed that the selected fuelwoods have HHVs ranging from 19.80 to 21.02 MJ kg-1.
Article
Biochemistry & Molecular Biology
Yu Zhou, Xi Liu, Caihua Huang, Donghai Lin
Summary: Lactate, a compound fuel in metabolism, remains unclear whether it plays an important role in muscle cell metabolism. This study assessed the effects of lactate on myoblasts and clarified the underlying metabolic mechanisms. The results showed that lactate treatment promoted the proliferation and differentiation of myoblasts, and regulated metabolisms by promoting lactate intake and utilization, activating the TCA cycle, and increasing energy production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qian Li, Wanting Chen, Wenbin Huang, Ranran Hou, Xinping Huang, Man Xu, Limei Que, Lijing Wang, Yongxia Yang
Summary: This study investigated the changes in serum metabolism in ApoE(-/-);SAP(-/-) mice compared to ApoE(-/-) mice during the progression of atherosclerosis using H-1-NMR metabonomics. The results showed that SAP deficiency regulated the levels of acetate, pyruvate, choline, and VLDL + LDL, which are metabolic markers, and this regulation occurred prior to the appearance of atherosclerotic plaques.
Article
Multidisciplinary Sciences
Emeka Godwin Anaduaka, Nene Orizu Uchendu, Dionysius Obinna Osuji, Lorreta Nwakaego Ene, Ogechukwu Peace Amoke
Summary: Insects such as Oryctes rhinoceros larva and Zonocerus variegatus are rich in nutrients and can be potential sources of food with high nutritional value. Oryctes rhinoceros larvae have higher levels of crude protein and carbohydrates, while Zonocerus variegatus have higher levels of crude lipids. Both insects contain rich mineral components and their anti-nutrient values are within tolerable levels, making them good sources of macro and micronutrients. Oryctes rhinoceros may be a better source of nutrients due to its valuable macromolecule contents.
Article
Chemistry, Organic
Shu-Qin Qin, Wei Xu, Qi-Qi Wang, Run-Yi Chen, De-Zhi Yang, Yang Lu, Wen-Cai Ye, Ren-Wang Jiang
Summary: A novel tetracationic macrocycle was synthesized and used as a cation for recognizing specific anions, leading to the formation of a unique supramolecular assembly. The binding affinity between the cation and anions was characterized, and the assembly showed selectivity towards cytosine. This study provides a new method for efficient recognition of cytosine and separation of antifungal drugs.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Yasemin Yesiltepe, Niranjan Govind, Thomas O. Metz, Ryan S. Renslow
Summary: The majority of primary and secondary metabolites in nature have yet to be identified, posing a major challenge for metabolomics studies. Complete chemical characterization of metabolomes is currently infeasible due to technical and economic limitations. Computationally predicted data can be a viable solution to expand metabolite reference libraries, but accuracy is crucial. A study using simulated experimental and theoretical NMR chemical shift databases found that a certain level of accuracy is required for confident identification of metabolites in different samples.
JOURNAL OF CHEMINFORMATICS
(2022)
Article
Medicine, General & Internal
Ljubica Tasic, Natasa Avramovic, Melissa Quintero, Danijela Stanisic, Lucas G. Martins, Tassia Brena Barroso Carneiro da Costa, Milka Jadranin, Maria Theresa de Souza Accioly, Paulo Faria, Beatriz de Camargo, Bruna M. de Sa Pereira, Mariana Maschietto
Summary: Pediatric cancer NMR-metabonomics offers a powerful tool for studying tumor development and improving cancer diagnosis and treatment. This study used HR-MAS NMR to analyze Wilms tumor and normal kidney samples, revealing significant differences in metabolites between the tumor and normal tissues. These findings provide insight into the altered metabolic pathways in Wilms tumor.
Article
Integrative & Complementary Medicine
Miaosen Huang, Yiwei Peng, Qida He, Linyu Lian, Yichen Wang, Longbin Zhang, Yuan Zhang, Jiacheng Shen, Zongbao Yang
Summary: This study explored the central metabolic change mechanism of electro-acupuncture in treating GML using NMR metabonomics. The results showed that 4 days of electro-acupuncture treatment significantly improved gastric mucosal injury, with the effect stabilizing by day 7. The pathogenesis of GML and the efficacy of electro-acupuncture involve metabolic pathways such as energy, neurotransmitters, cells, and antioxidation, with treatment acting by regulating the central nervous system.
Article
Multidisciplinary Sciences
O. S. Sojinu, N. T. Biliaminu, A. M. Mosaku, K. O. Makinde, T. H. Adeniji, B. M. Adeboye
Summary: This study examined the proximate and mineral composition of plantains commonly consumed in Nigeria, finding that plantains ripened with ripening agents had higher potassium levels and lower iron levels compared to naturally ripened plantains. Additionally, plantains were shown to be a good source of minerals such as calcium, potassium, and iron.
Article
Plant Sciences
Zhi-Chao Liu, Qian Wng, Qi Zheng, Wen-Li Zhao, Cheng Chen, Ling-Yu Ruan, Han Xu, Hui-Hui Meng, Wen-Long Zhao, Wen-Ya Liu, Jia-Ge Zhong, Bu-zha-xi Luo, Kelsang Norbu, Feng Zhou, Jun-Song Wang, Xin Feng
Summary: The study investigated the potential acute toxicity and function of the traditional Tibetan medicine, 25 flavors of the turquoise pill, and its key mineral component, turquoise, on the liver and kidney of rats. Results showed that the pill could scavenge free oxygen radicals and improve aerobic respiration in the liver without causing oxidative stress in the kidney. By modulating branched-chain amino acids, it also enhanced glucose utilization and promoted aerobic respiration in the kidney. Overall, the administration of the pill and turquoise was deemed safe for liver and kidney function under the experimental conditions.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Astronomy & Astrophysics
V. Wakelam, P. Gratier, M. Ruaud, R. Le Gal, L. Majumdar, J. -C. Loison, K. M. Hickson
Summary: This paper presents the chemical composition of five cold clumps identified by the Planck mission, with radiative transfer analysis and chemical models used to constrain physical conditions and molecular column densities. The study reveals significant chemical differences among the sources, with poorer composition compared to TMC-1 CP. The chemical model successfully reproduces observational abundances for most species, indicating that the sources may be less evolved than TMC-1.
ASTRONOMY & ASTROPHYSICS
(2021)
Article
Fisheries
Ardavan Farhadi, Zhi Huang, Huaqiang Tan, Bixun Qiu, Shaobin Fang, Mhd Ikhwanuddin, Hongyu Ma
Summary: Understanding the effects of different natural diets on the growth performance and nutritional quality of mud crab Scylla paramamosain is important. This study found that feeding the crabs with Potamocorbula rubromuscula can enhance amino acid and carotenoid contents, and the post-mating period is critical for nutritional deposition.
AQUACULTURE RESEARCH
(2022)
Article
Chemistry, Analytical
Lungile Sitole, Roxanne Fortuin, Fidele Tugizimana
Summary: This study used a metabonomic approach to investigate metabolic changes in individuals with HIV receiving antiretroviral therapy. Significant differences were found in metabolites related to glutamine, glutamate, glutathione, glucose, and arginine between the treated group and the untreated group.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Review
Food Science & Technology
Sherif Shaheen, Micheal Kamal, Chao Zhao, Mohamed A. Farag
Summary: Fat replacers provide some or all of the functional properties of natural fat while providing fewer calories. Different sources of fat substitutes have different characteristics in terms of chemical synthesis, calorie reduction mechanisms, nutritional benefits, metabolism, and safety. Fat substitutes have various functions in food processing and pose fewer health risks compared to conventional fats.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Jianping Nie, Wei Liao, Zijie Zhang, Minjiao Zhang, Yuxi Wen, Esra Capanoglu, Md Moklesur Rahman Sarker, Ruiyu Zhu, Chao Zhao
Summary: This review introduces a 3D co-culture intestinal organoid system developed from stem cells, which can simulate human tissues and be used for studying glucose metabolism diseases and drug screening. The gut has been identified as an important site for studying the interactions among glucose metabolism, gut microbial metabolism, and gut microbiota. The construction methods and progress of 3D intestinal organoid systems compared to traditional 2D culture methods are also summarized in the manuscript.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Review
Food Science & Technology
Yihan Chen, Yuxi Wen, Yingying Zhu, Zhengxin Chen, Wanmeng Mu, Chao Zhao
Summary: Oligosaccharides, with various physiological activities, are being widely used in food and medical fields. Due to limited natural resources, there is a need to study un-natural oligosaccharides for their potential benefits. Different artificial strategies have been used to develop various oligosaccharides, with a focus on their effects against diabetes, obesity, aging, virus, and gut microbiota. Multi-omics approaches can be applied to study the dynamic changes of oligosaccharides and their effects on different diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Jinlin Fan, Zheng Xiao, Wanwei Qiu, Chao Zhao, Chao Yi, Dongmei Lin, Zhanxi Lin
Summary: This study used GC-QTOF-MS metabolomics and multivariate statistical analysis to investigate the dynamic changes of metabolites during the fermentation of JUNCAO wine. It identified key metabolic pathways and differential metabolites, providing a comprehensive overview of metabolite changes during fermentation.
Article
Agriculture, Multidisciplinary
Biying Luo, Yuxi Wen, Fangting Ye, Yanglin Wu, Na Li, Muhammad Salman Farid, Zhengxin Chen, Hesham R. El-Seedi, Chao Zhao
Summary: Dietary phytochemicals have various beneficial properties and are absorbed mainly in the colon, with differences in absorption and metabolism depending on the colonic microbiota. This paper focuses on the metabolism of phytochemicals in the colon and their effects on the gut microbiota. Phytochemicals can be absorbed through enzymes produced by intestinal cells and stem cells, as well as through interactions with the intestinal flora, which can help improve associated diseases.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2023)
Review
Food Science & Technology
Jingxiang Xu, Wei Liao, Yuning Liu, Yuling Guo, Shiyue Jiang, Chao Zhao
Summary: Green seaweed is a valuable marine resource, containing various nutrients and active substances that have significant biological activities and potential applications.
FOOD PRODUCTION PROCESSING AND NUTRITION
(2023)
Review
Food Science & Technology
Wenshu Ma, Na Li, Luan Lin, Jiahui Wen, Chao Zhao, Fang Wang
Summary: Hyperlipidemia constitutes a serious threat to human health, and the ability to evaluate natural active substances in regulating lipid metabolism disorders has been the focus of recent research on functional foods. Bioactive peptides stand out for their diverse sources, high nutritional content, ease of absorption and utilization by the body, and ease of sequence determination. Bioactive peptides have wide potential applications in medicine and food, and the regulation of lipid metabolism disorders by bioactive peptides from different sources provides a reference for the development and research of lipid-reducing bioactive peptides.
FOOD PRODUCTION PROCESSING AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Hesham R. El-Seedi, Mohamed F. El-Mallah, Nermeen Yosri, Muaaz Alajlani, Chao Zhao, Muhammad A. Mehmood, Ming Du, Hammad Ullah, Maria Daglia, Zhiming Guo, Shaden A. M. Khalifa, Qiyang Shou
Summary: This paper discusses the historical and existential records of marine cyanobacteria and their role in understanding their evolution. Recent advancements focus on isolating and screening bioactive compounds and their medicinal properties, highlighting compounds with potential pharmacological effects such as cytotoxicity, anticancer, and antiparasitic properties.
Article
Behavioral Sciences
Yajun Huang, Na Li, Chengfeng Yang, Yan Lin, Yuxi Wen, Lingjun Zheng, Chao Zhao
Summary: Research on the relationship between gut microbiota and animal neurophysiology and behavior has grown rapidly recently. Swarming insects, like honeybees, are suitable models for investigating the molecular mechanisms that control insect behavior. The honeybee gut bacteria model is established quickly and has a higher flux, making it useful for understanding intestinal diseases and finding molecular therapeutic targets. This review focused on the contributions of the honeybee model in learning cognition and microbiome research, particularly on the correlation between gut microbiota and brain development.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Food Science & Technology
Aijun Tong, Dengwei Wang, Xiaoyan Liu, Zhiqun Li, Runfan Zhao, Bin Liu, Chao Zhao
Summary: This study evaluated the hypoglycemic effects of low molecular weight polysaccharides fractions from Laminaria japonica (LJOO) on mice with T2DM. The results showed that LJOO decreased FBG and insulin concentrations, altered the gut microbiota composition, increased the population of beneficial bacteria, and decreased the population of harmful bacteria. Additionally, LJOO stimulated the growth of SCFA-producing bacteria, resulting in increased SCFAs levels.
Article
Food Science & Technology
Jianzhou Li, Xiaohua Chen, Ziyan Xie, Lin Liang, Anping Li, Chao Zhao, Yuxi Wen, Zaixiang Lou
Summary: This study screened lactic acid bacteria (LAB) with strong antagonistic ability against Pseudomonas aeruginosa (P. aeruginosa) and evaluated the regulatory mechanism of LAB against P. aeruginosa. The results showed that the selected LAB strains inhibited the growth, biofilm formation, and pyocyanin expression of P. aeruginosa, and promoted the expression of autoinducer-2. Lactipantibacillus plantarum (Lp. plantarum) LPyang affected the metabolic processes of P. aeruginosa by influencing metabolic substances, such as LysoPC, oxidized glutathione, betaine, etc. These findings provide new insights into the antagonistic activity of Lp. plantarum LPyang against P. aeruginosa.
Review
Food Science & Technology
Zhengxin Chen, Weihao Wu, Yuxi Wen, Lizhu Zhang, Yanglin Wu, Muhammad Salman Farid, Hesham R. El-Seedi, Esra Capanoglu, Chao Zhao
Summary: Pigment is a significant food additive that greatly impacts the sensory aspect of food. Natural sources of healthy and non-toxic edible pigments are gaining attention. Algae serves as an important natural pigment source, containing chlorophyll, phycoerythrin, carotene, and other natural pigments. Apart from coloring, pigments also have powerful physiological activities like antioxidants, anti-inflammatory, anti-obesity, and lipid-lowering properties. This review focuses on three pigments found in seaweed, presenting their main structural properties and functions, bridging the gap in pigment reviews with seaweed as the main focus. The research in this review provides a basis for the development of new health foods and offers new directions for the use of seaweed chlorophyll in the food and pharmaceutical industries.
FOOD PRODUCTION PROCESSING AND NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Minjiao Zhang, Suyue Lu, Yihan Chen, Xue Wu, Zexu Zhao, Chao Zhao
Summary: Lacto-N-fucopentaoses (LNFPs) are important components of human milk oligosaccharides (HMOs) and have various functional activities. Chemical and enzymatic synthesis are two commonly used methods to produce LNFPs, with enzymatic synthesis offering advantages such as mild reaction conditions and high yield. However, few studies have explored the use of in vivo fermentation for LNFPs production, despite its cost advantage. This paper aims to review the synthesis methods, functional activities, and emerging trends in the development of LNFPs.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ruiyu Zhu, Shuo Shan, Su Zhou, Zhen Chen, Yuanfeng Wu, Wei Liao, Chao Zhao, Qiang Chu
Summary: In this study, Saccharomyces cerevisiae KD was used to efficiently degrade patulin and alleviate the biotoxicity caused by patulin. The results showed that Saccharomyces cerevisiae KD could effectively degrade patulin, reduce oxidative stress and intestinal damage. Furthermore, Saccharomyces cerevisiae KD could regulate gene expression levels to control the ROS level and GSH content, thus decreasing intestinal damage.
Review
Chemistry, Medicinal
Heba A. S. El-Nashar, Mohamed Taleb, Mohamed EL-Shazly, Chao Zhao, Mohamed A. Farag
Summary: This review comprehensively discusses the antidiabetic effects and mechanisms of action of major soluble dietary fibers (SDF), which can aid in the development of novel natural antidiabetic drugs from SDF.
PHYTOTHERAPY RESEARCH
(2023)
