Article
Biochemistry & Molecular Biology
A. M. U. B. Mahfuz, Muhammad Nasir Iqbal, Felipe Stambuk Opazo, A. M. Zubair-Bin-Mahfuj
Summary: Antibiotic resistance is a global concern, with Elizabethkingia species like E. anophelis and E. meningoseptica being resistant to multiple antibiotics. Researchers are exploring new antibiotics that target unconventional sites, such as bacterial ribonucleotide reductases. This study evaluates the binding affinities of compounds inhibiting Pseudomonas aeruginosa growth by targeting its ribonucleotide reductase with enzymes from E. anophelis and E. meningoseptica to combat infections in the future.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Infectious Diseases
Pavel A. Andriyanov, Pavel A. Zhurilov, Daria D. Kashina, Anastasia Tutrina, Elena A. Liskova, Irina Razheva, Denis Kolbasov, Svetlana A. Ermolaeva
Summary: This study reports the first isolation of E. anophelis strain in Russia and its isolation from raw cow's milk. The strain displayed resistance to multiple antimicrobials and carried various antibiotic resistance determinants and virulence factors.
Article
Immunology
Shaohua Hu, Yan Lv, Hao Xu, Beiwen Zheng, Yonghong Xiao
Summary: This study investigated the association between antimicrobial resistance and biofilm formation ability in Elizabethkingia anophelis isolated from hospitalized patients in China. The results showed high resistance to current antibiotics among clinical E. anophelis isolates, with all strains being multidrug-resistant and 20 being extensively drug-resistant. The isolates also exhibited the ability to form biofilm, with a positive correlation between biofilm formation and antibiotic resistance. The study highlights the importance of understanding the resistance mechanisms and biofilm formation in E. anophelis infections for improving therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Yu-Lin Lee, Kuan-Ming Liu, Hui-Lan Chang, Yi-Ci Liao, Jen-Shiou Lin, Fang-Yen Kung, Cheng-Mao Ho, Kai-Hsiang Lin, Ying-Tsong Chen
Summary: The incidence of Elizabethkingia anophelis bacteremia has increased significantly in Changhua Christian Hospital since 2013. A specific lineage of E. anophelis strains with unique genomic features has emerged and shown resistance to antibiotics. This finding has important implications for further research and developing effective treatment strategies.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Liangcai Xu, Bo Peng, Yuxiang He, Yujun Cui, Qinghua Hu, Yarong Wu, Hongbiao Chen, Xiaofeng Zhou, Lili Chen, Min Jiang, Le Zuo, Qiongcheng Chen, Shuang Wu, Yang Liu, Yanming Qin, Xiaolu Shi
Summary: During the COVID-19 pandemic, three fever epidemic clusters unrelated to COVID-19 occurred in Shenzhen, China. This study investigated and characterized the Elizabethkingia anophelis contaminant isolated from throat and anal swab samples of patients. The study found that the patients' samples and blank samples were positive for E. anophelis, but the patients were not infected with this bacterium, and the causative agent for the fevers remains unidentified.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Ho Yin Pekkle Lam, Shih-Yi Peng, Prajna Paramita, Wen-Jui Wu, Li-Kuang Chen, Huei-Jen Chao, Meng-Jiun Lai, Kai-Chih Chang
Summary: In this study, two new phages, TCUEAP2 and TCUEAP3, infecting E. anophelis were isolated from wastewater. The results showed that both TCUEAP2 and TCUEAP3 belong to the Siphoviridae family and have an icosahedral head with a non-contractile tail. TCUEAP3 has a longer latent period and higher burst size compared to TCUEAP2, and both phages have a narrow host range.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Shaoxing Zhang, Yuxin Zhang, Ruijie Liu, Shuying Yuan, Yanwen Chen, Wenjie Li, Xinrong Lu, Yongliang Tong, Linlin Hou, Li Chen, Guiqin Sun
Summary: The purpose of this study was to analyze the genotype-phenotype relationship of the ant(6) gene in clinical EM isolates and provide evidence for precision medicine. The biochemical function of ANT(6) FMS-007 was verified, and important sites related to ant(6) genotypes and phenotypes in EM clinical isolates were identified. This study has significant implications for the verification of known or unknown functional resistant genes.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Infectious Diseases
Siyuan Ma, Yali Gong, Xiaoqiang Luo, Yuan Peng, Cheng Zhang, Xiaorong Zhang, Xiaohong Hu, Peng Tang, Zhiqiang Yuan, Gaoxing Luo, Haisheng Li
Summary: The prevalence of E. meningoseptica infections in mainland China has been increasing, along with multidrug resistance and high mortality rates. Inappropriate antibiotic treatment and the use of central venous catheters are important risk factors that should be addressed.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Hung-Jen Tang, Yi-Tsung Lin, Chi-Chung Chen, Chih-Wei Chen, Ying-Chen Lu, Wen-Chien Ko, Hung-Jui Chen, Bo-An Su, Ping-Chin Chang, Yin-Ching Chuang, Chih-Cheng Lai
Summary: The study revealed that E. anophelis isolates were susceptible to certain antibiotics, with the combination of minocycline and cefoperazone/sulbactam showing the best synergistic effects in combating biofilm formation of clinical isolates. Additionally, novel mutations were identified, indicating antibiotic resistance mechanisms.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Dongdong Wei, Yuan Cheng, Shuangyan Xiao, Wenyu Liao, Qing Yu, Shuyu Han, Shuaishuai Huang, Jingu Shi, Zongsheng Xie, Pengfei Li
Summary: In this study, multiple pathogenic bacteria were isolated from the brains of five bullfrogs with meningitis-like disease on a South China farm in Guangxi. The NFEM01 strain was identified as E. miricola, and it was found to cause typical symptoms of meningitis-like disease when artificially infected into bullfrogs. The study provides a reference for further understanding the pathogenesis mechanism of E. miricola-induced bullfrog meningitis-like disease and its prevention and treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Shaohua Hu, Yingying Chen, Hao Xu, Jing Chen, Shaojun Hu, Xiaohua Meng, Shujun Ni, Yonghong Xiao, Beiwen Zheng
Summary: This study comprehensively analyzes the global distribution, evolutionary history, and transmission networks of E. meningoseptica. The emerging bacteria are found in Asia, Europe, and North America, and show genetic diversity. The most likely source of E. meningoseptica is the United States, and the pathogen can spread within hospitals and across borders. The observation of minor variations in resistance genotypes and virulence genes support the inherent resistance and pathogenicity of E. meningoseptica. Minocycline and doxycycline demonstrate potent antimicrobial activity against this pathogen.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Seyed Mohammad Ghafoori, Alyssa M. Robles, Angelika M. Arada, Paniz Shirmast, David M. Dranow, Stephen J. Mayclin, Donald D. Lorimer, Peter J. Myler, Thomas E. Edwards, Misty L. Kuhn, Jade K. Forwood
Summary: Elizabethkingia anophelis is an emerging multidrug resistant pathogen with antibiotic resistance genes including a chloramphenicol acetyltransferase (CAT). The high-resolution crystal structure of CAT protein from E. anophelis NUHP1 strain shows similarity to Type B (CatB) proteins from other bacteria, suggesting its role in chloramphenicol resistance. This research expands the structural and functional understanding of proteins from Flavobacteriaceae pathogens.
SCIENTIFIC REPORTS
(2021)
Article
Parasitology
Maria G. Onyango, Rachel Lange, Sean Bialosuknia, Anne Payne, Nicholas Mathias, Lili Kuo, Aurelien Vigneron, Dilip Nag, Laura D. Kramer, Alexander T. Ciota
Summary: The study identified a specific microbiota associated with ZIKV infection in Aedes albopictus midgut, and a negative correlation between this microbiota and ZIKV infection rate. Supplemental feeding of this microbiota can reduce ZIKV infection rate, potentially influencing vector-borne pathogen control strategies.
PARASITES & VECTORS
(2021)
Article
Microbiology
Ming-Hsien Chiang, Fang-Ju Chang, Dinesh Kumar Kesavan, Aparna Vasudevan, Huaxi Xu, Kuo-Lun Lan, Shu-Wei Huang, Hung-Sheng Shang, Yi-Ping Chuang, Ya-Sung Yang, Te-Li Chen
Summary: This study reveals the immunological relevance and crucial role of imipenem-induced outer membrane vesicles (OMVs) from Elizabethkingia anophelis in bacterial survival under antibiotic stress conditions, rather than being a source of antibiotic resistance. Furthermore, this is the first study to discuss the protein-protein interaction network of OMVs released by E. anophelis, particularly under antibiotic stress. These findings provide important insights into clinical antibiotic stewardship.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
I-Fan Lin, Chung-Hsu Lai, Shang-Yi Lin, Ching-Chi Lee, Nan-Yao Lee, Po-Yu Liu, Chih-Hui Yang, Yi-Han Huang, Jiun-Nong Lin
Summary: Fluoroquinolones have potential effectiveness against Elizabethkingia anophelis, but maintaining serum concentrations above the mutant prevention concentration (MPC) is challenging under current recommended doses.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)