Kinetic Transition in Amyloid Assembly as a Screening Assay for Oligomer-Selective Dyes

A long-lived Aβ oligomer resistant to fibrillization

(2018) Mimi Nick et al.   BIOPOLYMERS

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

(2018) Filip Hasecke et al.   Chemical Science

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic Acid)

(2015) Nadine D. Younan et al.   BIOCHEMISTRY

Mechanism of Nucleated Conformational Conversion of Aβ42

(2015) Ziao Fu et al.   BIOCHEMISTRY

Effect of acidic and basic pH on Thioflavin T absorbance and fluorescence

(2015) Ellen V. Hackl et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Stable, Metastable, and Kinetically Trapped Amyloid Aggregate Phases

(2014) Tatiana Miti et al.   BIOMACROMOLECULES

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systemic Amyloidoses

(2013) Luis M. Blancas-Mejía et al.   Annual Review of Biochemistry

Structural fingerprints and their evolution during oligomeric vs. oligomer-free amyloid fibril growth

(2013) Joseph Foley et al.   JOURNAL OF CHEMICAL PHYSICS

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The case for soluble Aβ oligomers as a drug target in Alzheimer's disease

(2013) Franz Hefti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

Protein aggregation: Mechanisms and functional consequences

(2012) Gaetano Invernizzi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

In Situ Monitoring Alzheimer's Disease β-Amyloid Aggregation and Screening of Aβ Inhibitors Using a Perylene Probe

(2012) Meng Li et al.   Small

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Spatial Extent of Charge Repulsion Regulates Assembly Pathways for Lysozyme Amyloid Fibrils

(2011) Shannon E. Hill et al.   PLoS One

Observation of spatial propagation of amyloid assembly from single nuclei

(2011) T. P. J. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Fluorescent Pentameric Thiophene Derivative Detects in Vitro-Formed Prefibrillar Protein Aggregates

(2010) Per Hammarström et al.   BIOCHEMISTRY

Interactions between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors

(2010) Alexander K. Buell et al.   BIOPHYSICAL JOURNAL

Dynamics of protofibril elongation and association involved in Aβ42 peptide aggregation in Alzheimer’s disease

(2010) Preetam Ghosh et al.   BMC BIOINFORMATICS

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

Amyloid Protofibrils of Lysozyme Nucleate and Grow Via Oligomer Fusion

(2009) Shannon E. Hill et al.   BIOPHYSICAL JOURNAL

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioflavin T Hydroxylation at Basic pH and Its Effect on Amyloid Fibril Detection

(2008) Vito Foderà et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Folding versus aggregation: Polypeptide conformations on competing pathways

(2007) Thomas R. Jahn et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE