期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1859, 期 11, 页码 1440-1448出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2016.09.005
关键词
Regulation of gene expression; Influenza A virus; Innate immunity; Antiviral responses; Viral counter-responses
资金
- University of Helsinki [465/51/2014]
- Jane and Aatos Erkko foundation
- Sigrid Juselius foundation
- Finnish Cultural foundation
- Academy of Finland [252252, 256159, 255780, 135628, 255842]
- European Molecular Biology Organization
- Helsinki Biomedical Graduate School scholarship
- Academy of Finland (AKA) [255780, 252252, 255842, 255780, 252252, 255842] Funding Source: Academy of Finland (AKA)
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.
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