Article
Biochemistry & Molecular Biology
Pei-Lin Shao, Jiunn-Der Liao, Shun-Cheng Wu, Yu-Hsing Chen, Tak-Wah Wong
Summary: This study found that nonthermal microplasma (MP) treatment can promote the healing of skin wounds in diabetic mice, showing comparable or better efficacy than conventional negative pressure wound therapy (NPWT). The results suggest that MP treatment may be a promising approach for clinically treating diabetic wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Mengfan Wu, Dany Y. Matar, Zhen Yu, Ziyu Chen, Samuel Knoedler, Brian Ng, Oliver Darwish, Valentin Haug, Leigh Friedman, Dennis P. Orgill, Adriana C. Panayi
Summary: This study investigates the effect of mechanical force application on lymphangiogenesis in wound healing using a murine incisional wound model. The results show that negative pressure wound therapy can promote lymphatic vessel growth and drainage, leading to improved wound healing.
ADVANCES IN WOUND CARE
(2023)
Article
Dermatology
Jianming Mo, Yuanjing Huang, Qiu Wang, Hua Zhong, Zhenwei Zhai, Yuechou Nong, Xiaodong Yan, Xiulu Huang, Jianhao Huang, Suping Yang, Jingxia Sun, Jiaxia Han, Xing Zhou, Wensheng Lu
Summary: This study explored the efficacy of autologous full-thickness skin graft combined with negative pressure wound therapy in treating refractory diabetic lower extremity ulcers. The results showed that the graft group had a larger ulcer area, but a shorter time to complete wound re-epithelialization and faster healing speed. Additionally, the total treatment cost in the graft group was lower.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Emergency Medicine
Shizhao Ji, Xiaobin Liu, Jie Huang, Junmin Bao, Zhaohong Chen, Chunmao Han, Daifeng Hao, Jingsong Hong, Dahai Hu, Yufeng Jiang, Shang Ju, Hongye Li, Zongyu Li, Guangping Liang, Yan Liu, Gaoxing Luo, Guozhong Lv, Xingwu Ran, Zhongmin Shi, Juyu Tang, Aiping Wang, Guangyi Wang, Jiangning Wang, Xin Wang, Bing Wen, Jun Wu, Hailin Xu, Maojin Xu, Xiaofei Ye, Liangxi Yuan, Yi Zhang, Shichu Xiao, Zhaofan Xia
Summary: As China becomes an aging society, the incidence of diabetes and diabetic foot is increasing, making it a major health concern. Negative pressure wound therapy (NPWT) has shown great progress in the treatment of diabetic foot wounds, but irregular application can lead to complications. The consensus aims to provide clinicians with standardized treatment schemes for diabetic foot cases based on evidence-based practice.
Article
Dermatology
Aref Rashed, Marton Csiszar, Agnes Beledi, Karoly Gombocz
Summary: Incisional negative pressure wound therapy (INPWT) has been shown to reduce wound infections, with a greater impact on scar formation during the proliferation phase rather than the inflammatory phase. The study did not find significant differences in inflammatory biomarkers between the INPWT group and the control group.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Teng Ma, Ye Zhao, Guozheng Shen, Bangda Chai, Wei Wang, Xiaoting Li, Zhiwei Zhang, Qingyou Meng
Summary: Diabetic foot ulcer (DFU) is a severe complication in diabetes patients, and finding a successful therapeutic strategy remains challenging. This article investigates a novel bilayer cell patch for diabetic wound healing, and demonstrates its effectiveness through various experiments. The study identifies specific microRNAs in diabetes mellitus exosomes that inhibit wound healing, and shows that angiogenic-modified adipose stem cells can enhance angiogenesis in human umbilical vein endothelial cells. The findings suggest that the bilayer cell patch, combining epidermal stem cells and angiogenic-modified adipose stem cells, has great potential in promoting diabetic wound healing.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Muhammad Faisal, Peter D. Berend, Rudolf Seemann, Stefan Janik, Stefan Grasl, Andrea Ritzengruber, Herbert Mendel, Arif Jamshed, Raza Hussain, Boban M. Erovic
Summary: NPWT is effective in treating complex wounds in head and neck cancer patients, with neck involvement being common. The study found that previous irradiation and diabetes mellitus have detrimental effects on wound healing after NPWT.
Review
Biotechnology & Applied Microbiology
Wenqian Zhang, Lang Chen, Yuan Xiong, Adriana C. Panayi, Abudula Abududilibaier, Yiqiang Hu, Chenyan Yu, Wu Zhou, Yun Sun, Mengfei Liu, Hang Xue, Liangcong Hu, Chenchen Yan, Xuedong Xie, Ze Lin, Faqi Cao, Bobin Mi, Guohui Liu
Summary: Ulcers are a common complication of diabetes with high recurrence rates, and oxidative stress is identified as a key factor in impaired wound healing. Various antioxidant therapies have been proposed in the past 5 years to target oxidative stress and improve diabetic wound healing outcomes. These therapies include targeting Nrf2 and NF kappa B pathways, as well as utilizing vitamins, enzymes, hormones, medicinal plants, and biological materials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Dermatology
Frank W. Brennfleck, Christine Bongards
Summary: Development of subcutaneous abdominal wound healing impairment (SAWHI) can greatly affect patient care, with delayed healing, increased risk of infection, and fascial dehiscence as potential complications. Negative pressure wound therapy in the out-of-hospital setting for the management of SAWHI has been found to be cost-effective, with lower cost of care and higher closure rates.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Xinling Bi, Li Zhou, Yanfang Liu, Jun Gu, Qing-Sheng Mi
Summary: The study revealed that deficiency in miR-146a delayed skin wound healing in both normal and diabetic mice, and led to enhanced inflammatory responses, potentially associated with the NF-kappa B signaling pathway.
ADVANCES IN WOUND CARE
(2022)
Review
Dermatology
Guoqi Wang, Haiyan Xu, Gaoxiang Xu, Hao Zhang, Zhirui Li, Daohong Liu
Summary: Comparing negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy, this study found that NPWTi resulted in fewer surgeries and dressing changes, and smaller wound areas post-treatment compared to NPWT. However, no significant differences were observed in other clinical outcomes between NPWTi and NPWT. Further well-designed RCTs with larger sample sizes are needed to validate these conclusions due to heterogeneity.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Summary: Chronic wounds in poorly managed diabetics are difficult to heal due to long-term uncontrolled blood glucose levels. To prevent complications, special medical care is needed. Nanofibrous scaffolds are a promising treatment due to their flexibility, ability to load bioactive compounds, and biomimetic environment for cell proliferation.
Article
Engineering, Biomedical
Jueying Chen, Jiahui He, Yutong Yang, Lipeng Qiao, Juan Hu, Jie Zhang, Baolin Guo
Summary: The development of compressible, stretchable and self-healing hydrogel dressings with good adhesive, antibacterial and angiogenesis properties is needed to promote the regeneration of diabetic wounds in clinical applications.
ACTA BIOMATERIALIA
(2022)
Article
Cell Biology
Jacob G. Hodge, Ashley L. Pistorio, Christopher A. Neal, Hongyan Dai, Jennifer G. Nelson-Brantley, Molly E. Steed, Richard A. Korentager, David S. Zamierowski, Adam J. Mellott
Summary: This study investigated the mechanisms by which NPWT modulates wound healing in a porcine wound model, revealing enhanced plasma protein adsorption and increased cellular colonization and tissue ingrowth. Genomic analysis showed significant changes in gene expression, while histological analysis demonstrated a foreign body response and encapsulation of GranuFoam particles in NPWT wounds.
WOUND REPAIR AND REGENERATION
(2022)
Review
Pharmacology & Pharmacy
Gaofeng Wang, Zhen Lin, Yue Li, Lu Chen, Sashank K. Reddy, Zhiqi Hu, Luis Garza
Summary: With the development of society and the improvement of life quality, over 500 million people are affected by diabetes. More than 10% of diabetes patients suffer from diabetic wounds, and 80% of these wounds reoccur, highlighting the importance of developing new diabetic wound treatments. Skin microbe research has shed light on the complex relationship between microbes and diabetic wounds. Understanding the skin microbe composition in diabetic wounds can provide valuable guidance for clinical treatment and even lead to potential therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)