Article
Acoustics
Seyede Farnaz Sadeghian, Marjan Majdinasab, Maryam Nejadmansouri, Seyed Mohammad Hashem Hosseini
Summary: The effects of high-energy fabrication methods, HPH and US, on the physicochemical properties of flaxseed oil-in-water nanoemulsions containing clove essential oil and/or pomegranate peel extract were investigated. Nanoemulsions with similar droplet size were prepared by HPH and/or US. Droplet size increased over time. Lower storage temperature and US fabrication accelerated Ostwald ripening rate. Higher storage temperature and US fabrication decreased centrifugal stability of nanoemulsions. CEO exhibited better antioxidant properties than PPE. The absence of antioxidants, US fabrication, and higher storage temperature decreased the oxidative stability of nanoemulsions. The results of this study are important for controlling oxidative stability during long-term storage and for the design of functional foods and beverages.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Asmaa O. Manaa, Hoda H. Bagjdadi, Nefertiti A. El-Nikhely, Lamia A. Heikal, Lobna S. El-Hosseiny
Summary: This study successfully developed a stable nanoemulsion of oregano essential oil (ONE) and evaluated its antibacterial and anticancer effects, finding that the nanoemulsion exhibited improved activity. Furthermore, the nanoemulsion significantly inhibited cell proliferation and induced apoptosis, as evidenced by upregulation of apoptotic markers and downregulation of proliferation markers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ting Liu, Zhipeng Gao, Weiming Zhong, Fuhua Fu, Gaoyang Li, Jiajing Guo, Yang Shan
Summary: LEO was successfully nanoemulsified using a nanoemulsion technique to improve its water solubility and stability. The optimized preparation procedure resulted in LEO-NEs with small droplet size and good antioxidant activity. These findings provide a theoretical basis for the industrial application of lemon essential oil.
Article
Plant Sciences
Keerthiraj Manjesh, Aditi Kundu, Anirban Dutta, Supradip Saha, Bhagyasree Sira Neelakanthaiah
Summary: The present study developed nanoemulsions of essential oil and lipid-soluble extract of Pogostemon cablin leaves using biosurfactant and investigated their physico-chemical properties and insecticidal efficacy.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Physical
Raj Kumar, Shivani Uppal, Kumari Mansi, Joydeep Das, Satish Kumar Pandey, Khushwinder Kaur, S. K. Mehta
Summary: This study reports the fabrication of TPGS assisted clove oil in water nanoemulsion for the delivery of polyphenolic nutraceuticals curcumin and resveratrol and analyzes their synergetic healing potential. The nanoemulsion exhibited antimicrobial activity and showed enhanced effectiveness against different bacterial strains when combined with curcumin and resveratrol. The formulated system also demonstrated anti-tumor activity on breast cancer cell lines MDA MB 231 and Hep G2, expanding the biological applications of the system.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Food Science & Technology
Xiaoli Liu, Liuqing Chen, Yanan Kang, Dong He, Bingxin Yang, Kegang Wu
Summary: Nanoemulsion formulations of essential oils can enhance their water solubilities and antimicrobial activities. The study on cinnamon essential oil nanoemulsions showed that they inhibited the growth of various foodborne pathogens, with Gram-negative bacteria being more sensitive to the nanoemulsions than Gram-positive bacteria.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Wantida Chaiyana, Sudarat Jiamphun, Suchanan Bezuidenhout, Kankanit Yeerong, Nutnicha Krueathanasing, Pattiya Thammasorn, Pipat Jittasai, Suphachai Tanakitvanicharoen, Singkome Tima, Songyot Anuchapreeda
Summary: This study aimed to extract oil from Gryllus bimaculatus de Geer, evaluate its potential for cosmeceutical applications, and develop nanoemulsions to enhance its cosmeceutical properties. The results showed that G. bimaculatus oil had antioxidant, anti-tyrosinase, and anti-skin aging activities. The oil was safe and could be successfully developed into nanoemulsions, which significantly enhanced its cosmeceutical effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Acoustics
Rania A. Hashad, Ritu Singla, Sukhvir Kaur Bhangu, Edwina Jap, Haiyan Zhu, Anton Y. Peleg, Luke Blakeway, Christoph E. Hagemeyer, Francesca Cavalieri, Muthupandian Ashokkumar, Karen Alt
Summary: In this study, a novel nanocarrier system was developed using the natural food preservative peptide Nisin. The system, called nisin-shelled nanoemulsions (NSNE), exhibited stable and uniform nanoemulsion structure with high bactericidal activity and drug loading capacity. Moreover, the nisin shell was used for the specific attachment of a cancer targeting ligand, leading to the successful assembly of targeted NSNE loaded with the chemotherapeutic drug Doxorubicin. The targeted NSNE demonstrated cancer-specific binding and enhanced cytotoxicity to HER2 expressing tumor cells.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tahir Mehmood, Anwaar Ahmed, Zulfiqar Ahmad, Muhammad Sameem Javed, Hafiz Rizwan Sharif, Faiz-ul-Hassan Shah, Muhammad Imran, Mohamed A. Abdelgawad, Shamas Murtaza
Summary: This study developed a nanoemulsion-based colloidal system for the incorporation of L-ascorbic acid into food products. The encapsulated L-ascorbic acid in nanoemulsions remained stable under various processing conditions. The retention of L-ascorbic acid was significantly affected by temperature and storage intervals.
Article
Food Science & Technology
Qiao He, Lianjiao Zhang, Zhehao Yang, Tian Ding, Xingqian Ye, Donghong Liu, Mingming Guo
Summary: The antibacterial activities of thyme essential oil nanoemulsions prepared by ultrasonication and high-pressure homogenization were evaluated, with superior bacteriostatic and bactericidal effects observed for the ultrasonicated samples. The underlying antibacterial mechanisms targeting cell membranes of both Gram-negative and Gram-positive bacteria were investigated, revealing membrane disintegrations and dysfunctions associated with fatty acid composition modifications upon exposure to the nanoemulsions. These results provide insights into the mode of action of the nanoemulsions, laying a critical theoretical basis for their future application in food matrix.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Chemistry, Applied
Camila A. Palla, Aixa Aguilera-Garrido, Maria Elena Carrin, Francisco Galisteo-Gonzalez, Maria Jose Galvez-Ruiz
Summary: This study successfully loaded curcumin into monoglyceride (MG) oleogels and produced stable gelled-oil nanoemulsions. The effects of ultrasonication processing parameters and formulation on particle size and stability were evaluated, and a surfactant mixture of Pluronic F-68 and Tween 80 with a low oleogel/aqueous phase ratio produced the most stable nanoemulsions. The results also showed that structuring oil particles with MG crystals can enhance the encapsulation efficiency of curcumin and slow down its release.
Article
Chemistry, Multidisciplinary
Afzal Hussain, Syed Sarim Imam, Mohammad A. Altamimi, Mudassar Shahid, Osamah Abdulrahman Alnemer
Summary: This study aimed to develop green nanoemulsions using capryol-C90, lecithin, Tween 80, and N-methyl-2-pyrrolidone. The HSPiP software and experimental data were utilized to explore suitable excipients, and the nanoemulsions were evaluated for their in vitro characterization parameters. The results showed that the optimized nanoemulsions exhibited good hydrophobicity and stability under various stress conditions.
Article
Food Science & Technology
Diqiong Wang, Mingming Zhong, Yufan Sun, Lin Fang, Yuanda Sun, Baokun Qi, Yang Li
Summary: This study investigated the stability, rheological properties, and encapsulation efficiency of LP nanoemulsions under different pH conditions. Results indicated superior performance in neutral and alkaline environments, providing valuable theoretical reference for further applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Yucheng Peng, Brian Via
Summary: Pre-treatments such as homogenization or ultrasonication can significantly decrease the viscosity of CNC suspensions and affect the degree of crystallinity of the films formed. The viscosity of the suspension changed with time after treatment and settling in room conditions led to an increase in viscosity. UV and visible light interferences varied for films generated from differently treated suspensions.
Article
Polymer Science
Paramee Noonim, Bharathipriya Rajasekaran, Karthikeyan Venkatachalam
Summary: The effect of ultrasonication on the properties and stability of palm oil-based oleogels prepared with different concentrations of carnauba wax was investigated. The study found that ultrasonication, especially with higher carnauba wax concentration, improved the physical, thermal, and structural properties, as well as the storage stability of the oleogels.
Review
Chemistry, Multidisciplinary
Amal A. M. Elgharbawy, Muhammad Moniruzzaman, Masahiro Goto
Summary: Researchers have successfully enhanced the technological utility of enzymes in second- and third-generation ILs in recent years, resulting in a more environmentally and economically attractive IL-assisted biocatalytic process.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2021)
Article
Engineering, Chemical
Shahidah Nusailah Rashid, Adeeb Hayyan, Maan Hayyan, Mohd Ali Hashim, Amal A. M. Elgharbawy, Fazrizatul Shakilla Sani, Wan Jefrey Basirun, Vannajan Sanghiran Lee, Yatimah Alias, Alaa Kareem Mohammed, Mohamed E. S. Mirghani, M. Y. Zulkifli, Maher Rageh
Summary: This study investigates deep eutectic solvents (DESs) as potential media for enzymatic hydrolysis, examining the physicochemical properties of ammonium and phosphonium-based DESs at different molar ratios and their eutectic points. The results show that ternary DES systems could be viable lipase activators in hydrolysis reactions, with the eutectic points highly influenced by temperature variations.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2021)
Article
Chemistry, Analytical
Sabah J. Mohammed, Mohanad Jasim M-Ridha, Khalid M. Abed, Amal A. M. Elgharbawy
Summary: This study examined the utilization of electrocoagulation (EC) for the removal of ciprofloxacin (CIP) and levofloxacin (LVX) from aqueous solutions. The results showed that the EC method achieved effective removal efficiencies of 93.47% for CIP and 88.00% for LVX under optimum conditions. The adsorption isotherm models and kinetic models were applied to determine the elimination mechanisms of CIP and LVX using the EC method. The findings suggested that the adsorption of CIP and LVX on iron hydroxide flocs followed the Sips isotherm and the removal process was controlled by chemical adsorption mechanisms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Shiva Rezaei Motlagh, Razif Harun, Dayang Radiah Awang Biak, Siti Aslina Hussain, Rozita Omar, Ramin Khezri, Amal A. Elgharbawy
Summary: The study successfully extracted lipids and EPA compounds from Nannochloropsis oceanica biomass using a combination of ionic liquids and microwave-assisted extraction. The optimized extraction parameters led to improved yields and EPA content. Results showed that the use of tetramethyl ammonium chloride as the IL performed better in extracting compounds from microalgae, suggesting potential for commercial applications.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Energy & Fuels
Shiva Rezaei Motlagh, Amal A. Elgharbawy, Ramin Khezri, Razif Harun, Rozita Omar
Summary: The study demonstrated that microwave-assisted extraction using ionic liquids, particularly choline acetate, was effective in extracting proteins from microalgae biomass. This method outperformed the conventional Soxhlet method, with higher protein yield and less environmental hazards. The innovative procedure shows promise for significant protein separation and utilization in bioproduct technologies.
BIOMASS CONVERSION AND BIOREFINERY
(2021)
Article
Business
Haruna Babatunde Jaiyeoba, Shahoriyer Hossain, Hamzah Mohd Salleh, Amal A. M. Elgharbawy
Summary: This study aims to investigate whether corporate social responsibility (CSR) can be an effective promotional tool for Malaysian halal certified companies in the era of Covid-19 pandemic. The findings indicate that commitment to halal best practices, economic responsibility, charitable donations, environmental responsibility, employee welfare, and responsible dealings with clients are the most important CSR activities that can promote halal certified companies in this era.
JOURNAL OF ISLAMIC MARKETING
(2023)
Article
Biochemistry & Molecular Biology
Chia Hau Lee, Ting Hun Lee, Pei Ying Ong, Syie Luing Wong, Norfadilah Hamdan, Amal A. M. Elgharbawy, Nurul Alia Azmi
Summary: The ultrasound-mechanical stirrer assisted extraction (UMSAE) optimized the extraction yield, total alkaloid content (TAC) and antioxidant activity from Annona muricata leaves. Compared to conventional Soxhlet extraction, satisfactory results were achieved with relatively short extraction time under the optimum conditions.
PROCESS BIOCHEMISTRY
(2021)
Review
Energy & Fuels
Shiva Rezaei Motlagh, Amal A. Elgharbawy, Ramin Khezri, Razif Harun, Dayang Radiah Awang Biak, Siti Aslina Hussain
Summary: This article reviews the potential of ILs in extracting biomolecules, lipids, and omega-3 from microalgae biomass, discussing the physicochemical properties of ILs, their advantages and limitations in lipid processing, as well as the toxicity and recyclability of ILs.
BIOMASS CONVERSION AND BIOREFINERY
(2021)
Article
Biochemistry & Molecular Biology
Nor Azrini Nadiha Azmi, Amal A. M. Elgharbawy, Hamzah Mohd Salleh, Muhammad Moniruzzaman
Summary: Fish by-product oil and lemon oil have potential applications in various industries, but their poor stability has hindered their usage. This study successfully formed an oil-in-water nanoemulsion of lemon and fish by-product oils (NE-FLO) using ultrasonication. NE-FLO showed outstanding biological properties including antioxidant, antibacterial, cell cytotoxicity, and anti-inflammatory activities.
Article
Chemistry, Multidisciplinary
Huma Warsi Khan, Amal A. M. Elgharbawy, Mohamed Azmi Bustam, Masahiro Goto, Muhammad Moniruzzaman
Summary: In this study, a highly stable vegetable oil ionic liquid-based emulsion liquid membrane (VOILELM) was developed for the efficient removal of lactic acid from water. The VOILELM exhibited minimal breakage and emulsion diameter, as well as maximum stability.
Article
Chemistry, Physical
Tamrin Nuge, Adeeb Hayyan, Amal A. M. Elgharbawy, Hamzah Mohd. Salleh, Yap Jun Yong, Ainul F. Kamarudin, Hanee F. Hizaddin, Yumi Zuhanis Has-Yun Hashim, Xiaoling Liu, Jehad Saleh, Jamal Ibrahim Daoud, Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, M. Y. Zulkifli, Mohd Roslan Mohd Nor, Waleed Al Abdulmonem
Summary: In this study, the medium components and their solubility were optimized to improve recombinant phytase production in Escherichia coli DH5a. Computational works using COSMO-RS were conducted to predict the thermophysical and chemical properties of fluid mixture and support the solubility study. The interaction between medium components was studied through thermodynamic calculation, and it was found that certain components negatively affected phytase production due to the formation of insoluble complexes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Khalid M. M. Abed, Adeeb Hayyan, Amal A. M. Elgharbawy, Hanee F. F. Hizaddin, Mohd Ali Hashim, Hassimi Abu Hasan, Mahar Diana Hamid, Fathiah M. M. Zuki, Jehad Saleh, Ahmad G. H. Aldaihani
Summary: This study focuses on the role of activated carbon from palm raceme as a support material for enhancing lipase-catalyzed reactions in an aqueous solution. Deep eutectic solvent is used as a co-solvent. The effects of carbonization temperature, impregnation ratio, and carbonization time on lipase activity are studied, and the optimum conditions for AC preparation are investigated using Amano lipase and lipase from the porcine pancreas. It is found that AC has stronger interaction with lipase from the porcine pancreas and provides higher enzymatic activity. Furthermore, the combination of DES and AC enhances the activity of lipase from the porcine pancreas.
Article
Biochemistry & Molecular Biology
Huma Warsi Khan, Amal A. M. Elgharbawy, Mohamed Azmi Bustam, Masahiro Goto, Muhammad Moniruzzaman
Summary: The main objective of this study was to identify the best ionic liquid (IL) for ibuprofen extraction. A total of 152 different cation-anion combinations were screened, and quaternary ammonium (cation) and sulfate (anion) were found to have better extraction ability for ibuprofen. Based on these results, an ionic liquid-based green emulsion liquid membrane (ILGELM) was developed, and the experimental results indicated that it was highly effective for the removal and recovery of ibuprofen.
Review
Food Science & Technology
Sharifah Shahira Putra, Wan Jefrey Basirun, Amal A. M. Elgharbawy, Maan Hayyan, Waleed Al Abdulmonem, Abdullah S. M. Aljohani, Adeeb Hayyan
Summary: 3-MCPD is a common food contaminant in processed oils formed during the deodorization step of edible oil refining process. It has been detected in various food products and can cause kidney and testicular damage. This review provides an overview of its properties, occurrence, precursors, formation mechanism, toxicity, quantification methods, and mitigation strategies, highlighting the applicability, efficiency, and issues encountered during analysis. It elucidates the significance of 3-MCPDs and their food safety implications.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Engineering, Chemical
Amal A. M. Elgharbawy, Sharifah Shahira Syed Putra, Huma Warsi Khan, Nor Azrini Nadiha Azmi, Muhamad Shirwan Abdullah Sani, Nazurah Ab Llah, Adeeb Hayyan, Jegalakshimi Jewaratnam, Wan Jefrey Basirun
Summary: This research provides insights into the efficacy of a newly formed hydrophobic deep eutectic solvent (DES) based on menthol and fatty acids. The menthol:decanoic acid (1:1) combination exhibited improved thermal stability, strong catalytic activity, and reusability for up to four cycles. The hydrophobic DES showed better fatty acid conversion in ester synthesis compared to hexane. This study demonstrates promising applications of hydrophobic DESs in non-aqueous organic reactions.
