期刊
WORLD JOURNAL OF STEM CELLS
卷 11, 期 8, 页码 452-463出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v11.i8.452
关键词
Ischemic stroke; Stroke patients; Central nervous system; Neural stem/progenitor cells; Multipotent stem cells; Stem-cell-based therapies
资金
- Japan Society for the Promotion of Science (JSPS) KAKENHI [15K06723, 18K07380]
- Grants-in-Aid for Scientific Research [15K06723, 18K07380] Funding Source: KAKEN
Ischemic stroke is a critical disease which causes serious neurological functional loss such as paresis. Hope for novel therapies is based on the increasing evidence of the presence of stem cell populations in the central nervous system (CNS) and the development of stem-cell-based therapies for stroke patients. Although mesenchymal stem cells (MSCs) represented initially a promising cell source, only a few transplanted MSCs were present near the injured areas of the CNS. Thus, regional stem cells that are present and/or induced in the CNS may be ideal when considering a treatment following ischemic stroke. In this context, we have recently showed that injury/ischemia-induced neural stem/progenitor cells (iNSPCs) and injury/ischemia-induced multipotent stem cells (iSCs) are present within post-stroke human brains and post-stroke mouse brains. This indicates that iNSPCs/iSCs could be developed for clinical applications treating patients with stroke. The present study introduces the traits of mouse and human iNSPCs, with a focus on the future perspective for CNS regenerative therapies using novel iNSPCs/iSCs.
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