Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma

Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

(2019) Xiaolan Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Presence of Circulating miR-145, miR-155, and miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors

(2019) Vianey Gonzalez-Villasana et al.   DISEASE MARKERS

Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application

(2018) Takuma Yamashita et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Exosomes in cancer development and clinical applications

(2018) Yu-Ling Tai et al.   CANCER SCIENCE

MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway

(2018) Chang Chai et al.   CNS Neuroscience & Therapeutics

Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model

(2018) Meenakshi Malhotra et al.   Oncotarget

Effect of pH, temperature and freezing-thawing on quantity changes and cellular uptake of exosomes

(2018) Yirui Cheng et al.   Protein & Cell

Exosome Drug Delivery through the Blood–Brain Barrier: Experimental Approaches and Potential Applications

(2018) T. A. Druzhkova et al.   Neurochemical Journal

Exosomal miR-21-5p derived from gastric cancer promotes peritoneal metastasis via mesothelial-to-mesenchymal transition

(2018) Qiang Li et al.   Cell Death & Disease

Synthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation

(2018) Xi Liu et al.   Molecular Therapy-Nucleic Acids

Effect of exosomal miRNA on cancer biology and clinical applications

(2018) Zhenqiang Sun et al.   Molecular Cancer

Interplay between miRNAs and human diseases

(2017) Prosenjit Paul et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer

(2017) Mitsuo Tsukamoto et al.   ONCOLOGY

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

(2017) Lin Cheng et al.   Stem Cells International

Efficient production and enhanced tumor delivery of engineered extracellular vesicles

(2016) Dionysios C. Watson et al.   BIOMATERIALS

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Regulatory mechanisms of microRNA expression

(2016) Lyudmila F. Gulyaeva et al.   Journal of Translational Medicine

Inhibition of miR-21 in glioma cells using catalytic nucleic acids

(2016) Agnieszka Belter et al.   Scientific Reports

A novel serum microRNA signature to screen esophageal squamous cell carcinoma

(2016) Zebo Huang et al.   Cancer Medicine

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Polymer Nanoparticles Mediated Codelivery of AntimiR-10b and AntimiR-21 for Achieving Triple Negative Breast Cancer Therapy

(2015) Rammohan Devulapally et al.   ACS Nano

Macrophage-secreted Exosomes Delivering miRNA-21 Inhibitor can Regulate BGC-823 Cell Proliferation

(2015) Jian-Jun Wang et al.   Asian Pacific Journal of Cancer Prevention

Role of MicroRNA 21 in Mesenchymal Stem Cell (MSC) Differentiation: A Powerful Biomarker in MSCs Derived Cells

(2015) Durairaj Sekar et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Tracking miRNAs' footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy

(2015) Nazila Nouraee et al.   GENES CHROMOSOMES & CANCER

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth

(2015) Matteo Setti et al.   Oncotarget

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

MicroRNA-21 Promotes Glioblastoma Tumorigenesis by Down-regulating Insulin-like Growth Factor-binding Protein-3 (IGFBP3)

(2014) Chuan He Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Exosomal microRNAs as Biomarkers of Colon Cancer

(2014) Hiroko Ogata-Kawata et al.   PLoS One

Ionizing Radiation and Glioblastoma Exosomes: Implications in Tumor Biology and Cell Migration

(2014) W. Tris Arscott et al.   Translational Oncology

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

Targeting miR-21 for the Therapy of Pancreatic Cancer

(2013) Flavie Sicard et al.   MOLECULAR THERAPY

Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors

(2013) Rasmus O Bak et al.   MOLECULAR THERAPY

Functional Profiling of Precursor MicroRNAs Identifies MicroRNAs Essential for Glioma Proliferation

(2013) Saija Haapa-Paananen et al.   PLoS One

Expression, Tissue Distribution and Function of miR-21 in Esophageal Squamous Cell Carcinoma

(2013) Nazila Nouraee et al.   PLoS One

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles in physiological and pathological conditions

(2012) Yuana Yuana et al.   BLOOD REVIEWS

Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma

(2012) Youhei Tanaka et al.   CANCER

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

(2012) J. Huan et al.   CANCER RESEARCH

MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma

(2012) Pedro M. Costa et al.   HUMAN MOLECULAR GENETICS

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

(2012) Gavriel Mullokandov et al.   NATURE METHODS

Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo

(2011) A. B. Gaur et al.   NEURO-ONCOLOGY

Recurrent Glioblastoma: A Fresh Look at Current Therapies and Emerging Novel Approaches

(2011) Mark R. Gilbert   SEMINARS IN ONCOLOGY

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma

(2010) E. G. Van Meir et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs

(2010) Federica Collino et al.   PLoS One

MicroRNA sponges: Progress and possibilities

(2010) M. S. Ebert et al.   RNA

Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas

(2009) Rolf F. Barth et al.   JOURNAL OF NEURO-ONCOLOGY

Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells

(2009) Takeshi Haraguchi et al.   NUCLEIC ACIDS RESEARCH

Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles

(2009) Alex Yuan et al.   PLoS One

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

(2008) T. Papagiannakopoulos et al.   CANCER RESEARCH

MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

(2008) G. Gabriely et al.   MOLECULAR AND CELLULAR BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

(2008) Z Lu et al.   ONCOGENE