Article
Chemistry, Multidisciplinary
Jean-Baptiste Fleury, Vladimir A. Baulin, Xavier Le Guevel
Summary: Lateral diffusion of nano-objects on lipid membranes is a crucial process in cell biology. Recent studies indicate that nanoparticle diffusion is affected by membrane proteins and deviates from Brownian motion. The presence of a protein corona on protein-coated nanoparticles leads to anomalous superdiffusion.
Review
Biotechnology & Applied Microbiology
Mengyu Guo, Chenjie Xia, Yu Wu, Nong Zhou, Zhipeng Chen, Weidong Li
Summary: Cell membrane-coated biomimetic nanoplatforms have inherent properties that enhance drug delivery efficiency. Research progress on cell membrane biomimetic technology reveals broad prospects for biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Minghai Zhang, Shanshan Cheng, Yue Jin, Nan Zhang, Yu Wang
Summary: Cell membrane camouflaging technology is an important strategy in nanomedicine, allowing for the modification of nanoparticles' membranes to enhance their properties. Various methods have been used to re-engineer nanoparticle membranes, leading to wide applications in drug delivery, imaging, detoxification, detection, and photoactivatable therapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Fatemeh Oroojalian, Mohammad Beygi, Behzad Baradaran, Ahad Mokhtarzadeh, Mohammad-Ali Shahbazi
Summary: Nanotechnology offers promising opportunities for cancer management, particularly through biomimetic approaches using immune cell membranes to coat nanoparticles for improved stability and targeting; the surface proteins from immune cells can provide various functionalities to nanoparticles, enhancing their efficacy and reducing toxicity.
Article
Pharmacology & Pharmacy
Huijie Han, Raquel Bartolo, Jiachen Li, Mohammad-Ali Shahbazi, Helder A. Santos
Summary: The development of cell membrane-modified biomimetic nanoparticles, specifically platelet membrane-coated nanoparticles, has shown great potential in the field of nanomedicine for targeted therapy. These nanoparticles can mimic the functions of primary cells and successfully deliver drugs to the targeted sites, enhancing therapeutic responses and reducing side effects. Platelet membrane-coated nanoparticles possess the characteristics of platelets, including immune system evasion and interaction with pathogens, making them an ideal drug delivery system.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Yunan Zhao, Aixue Li, Liangdi Jiang, Yongwei Gu, Jiyong Liu
Summary: The research on membrane-coated nanoparticles reveals that utilizing a combination of different cell membranes can offer more possibilities for biomedicine, providing unique biological functions such as immune evasion and targeting capability.
Article
Chemistry, Multidisciplinary
Sangrok Han, Youngki Lee, Minhyung Lee
Summary: Gene therapy using biomimetic nanoparticles coated with cell membranes showed higher transfection efficiency and lower toxicity in treating glioblastoma. In animal models, these nanoparticles induced increased gene expression and more efficient tumor size reduction compared to traditional complexes.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Li Zhu, Yuan Zhong, Shuai Wu, Meng Yan, Yu Cao, Nianlian Mou, Guixue Wang, Da Sun, Wei Wu
Summary: Nanoparticles modified by cell membranes, known as cell membrane camouflaged NPs, are capable of mimicking various biological functions and have great potential in tumor imaging. By incorporating specific receptors, antigens, and proteins from cell membranes, these CMNPs can enable precise guided imaging and treatment in cancer diagnosis.
MATERIALS TODAY BIO
(2022)
Article
Pharmacology & Pharmacy
Shengnan Huang, Chengzhi Song, Jinxin Miao, Xiali Zhu, Yongyan Jia, Yafei Liu, Dongjun Fu, Benyi Li, Mingsan Miao, Shaofeng Duan, Zhenzhong Zhang, Yurong Hu
Summary: A novel biomimetic platform RHAuNCs-miRNA for improved miRNA delivery was prepared by wrapping miRNA-loaded functionalized Au nanocages with red blood cell membrane. RHAuNCs-miRNA not only successfully loaded miRNAs but also effectively protected them from enzymatic degradation. With good stability, RHAuNCs-miRNA had the characteristics of photothermal conversion and sustained release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Atanu Naskar, Hyejin Cho, Sohee Lee, Kwang-sun Kim
Summary: Biomimetic nanoparticles fabricated with natural cellular materials are utilized in biomedical applications, utilizing the original biological functions of the cellular materials. Bacterial outer membrane vesicles are considered important molecules for coating nanoparticles and have potential applications in immune response activation, cancer therapeutics, and bacterial infection treatment with photothermal activity.
Article
Chemistry, Multidisciplinary
Hang Liu, Zhaohua Miao, Zhengbao Zha
Summary: Nanoparticle-based disease diagnosis and therapy, especially using membrane coating nanotechnology, have shown great potential in enhancing disease targeting and specificity. This review summarizes the latest development of biomimetic nanoparticles for immunotherapy in treating immune-related diseases.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Neda Khosravi, Elham Pishavar, Behzad Baradaran, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: Nanomedicine research has made significant progress, but encounters obstacles such as low drug concentration and rapid drug elimination. Stem cell membranes and stem cell-derived exosomes have emerged as promising therapeutic carriers. Combining synthetic nanoparticles with stem cell membranes enhances drug delivery. Utilizing stem cell-derived exosome membranes improves the therapeutic capability of engineered drug delivery vehicles.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Minghui Li, Xinyu Cui, Feng Wei, Zhao Wang, Xiaojun Han
Summary: Cell-derived nanomaterials, such as the RBC membrane camouflaged core-shell upconversion/mesoporous silica nanoparticles, have excellent biocompatibility, immune escaping capabilities, and multicolor emission. Utilizing a synergistic chemophotodynamic therapy approach, this platform efficiently inhibits tumor growth in vivo.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Instruments & Instrumentation
Hui Liu, Yu-Yan Su, Xin-Chi Jiang, Jian-Qing Gao
Summary: Recently, the use of nanoparticle-based drug delivery systems has become widespread for disease treatment, prevention, and detection. To enhance the targeted delivery ability, a novel concept known as bionic cell membrane coating technology has been developed for nanoparticles. By leveraging the diverse biological functions of cell membrane surface proteins, nanoparticles can achieve immune escape, long circulation time, and targeted delivery. This review focuses on the synthesis, development, and application of this cell membrane coating technology, as well as the function and mechanism of monotypic/hybrid cell membrane-modified nanoparticles. It also discusses the challenges in the clinical application of bionic carriers.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Huanghe Yu, Jialong Fan, Nuzhat Shehla, Yixing Qiu, Ye Lin, Zhou Wang, Liang Cao, Bin Li, Muhammad Daniyal, Yan Qin, Caiyun Peng, Xiong Cai, Bin Liu, Wei Wang
Summary: The development of multifunctional nanoparticles utilizing nanotechnology for targeted treatment of rheumatoid arthritis has shown promising results in vivo, effectively inhibiting the progression of arthritis.
Article
Chemistry, Multidisciplinary
Ruixiang Li, Yuwei He, Ying Zhu, Lixian Jiang, Shuya Zhang, Jing Qin, Qian Wu, Wentao Dai, Shun Shen, Zhiqing Pang, Jianxin Wang
Article
Nanoscience & Nanotechnology
Boshu Ouyang, Funan Liu, Shuangrong Ruan, Huishu Guo, Zhengxu Cai, Xiangrong Yu, Zhiqing Pang, Shun Shen
ACS APPLIED MATERIALS & INTERFACES
(2019)
Review
Pharmacology & Pharmacy
Sabya Sachi Das, Saad Alkahtani, Priyanshu Bharadwaj, Mohammed Tahir Ansari, Muneera D. F. ALKahtani, Zhiqing Pang, Md Saquib Hasnain, Amit Kumar Nayak, Tejraj M. Aminabhavi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Pharmacology & Pharmacy
Yuefei Zhu, Xiangrong Yu, Soracha D. Thamphiwatana, Ying Zheng, Zhiqing Pang
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Pharmacology & Pharmacy
Honglan Wang, Huiwen Liu, Chunyan Sun, Chunying Liu, Ting Jiang, Yanxue Yin, Aoshuang Xu, Zhiqing Pang, Bo Zhang, Yu Hu
Summary: A dual-targeting drug delivery system was developed to simultaneously target CAFs and myeloma cells, showing better therapeutic effects than targeting each cell type alone. In vitro cellular uptake and cytotoxicity tests demonstrated the system's advantages, while in vivo experiments confirmed its stronger anti-tumor efficacy compared to conventional methods.
Article
Pharmacology & Pharmacy
Xinping Kuai, Yuefei Zhu, Zheng Yuan, Shengyu Wang, Lin Lin, Xiaodan Ye, Yiping Lu, Yu Luo, Zhiqing Pang, Daoying Geng, Bo Yin
Summary: This study developed an innovative platform for tumor-targeted immunotherapy using nanoemulsions and nanoparticles, which can regulate the tumor immune microenvironment to inhibit tumor growth and metastasis. This finding has significant clinical implications.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Yao Liu, Yiping Lu, Bo Ning, Xiaomin Su, Binru Yang, Haiqing Dong, Bo Yin, Zhiqing Pang, Shun Shen
Summary: In this study, an immunotherapy system based on red blood cell membrane encapsulated Listeria monacytagenes (Lmo@RBC) was developed to address the limitations of Lmo as a cancer vaccine. Lmo@RBC showed low systemic inflammatory response and enhanced accumulation in tumors, resulting in a strong and durable anti-tumor immune response with excellent therapeutic effects.
Article
Pharmacology & Pharmacy
Chunying Liu, Shuangrong Ruan, Ying He, Xuejing Li, Yuefei Zhu, Honglan Wang, Hanwei Huang, Zhiqing Pang
Summary: Anti-virulence strategy is a promising approach to combat drug-resistant bacterial infections. In this study, erythroliposome (RM-PL), a biomimetic platform constructed by artificial and natural lipid membranes, was used to neutralize hemolytic PFTs. The detoxification ability of RM-PL was attributed to macrophages in the spleen and the liver, which absorbed and digested the toxins in lysosomes.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Xianping Liu, Yixin Chen, Daoying Geng, Haichun Li, Ting Jiang, Zimiao Luo, Jianhong Wang, Zhiqing Pang, Jun Zhang
Summary: In this study, an active targeting pH-sensitive RBC membrane-based nanoparticle drug delivery system loaded with DOX was developed for c-Met-targeted therapy of glioblastoma multiforme (GBM). The system, decorated with aptamer SL1, demonstrated excellent anti-GBM effect by facilitating DOX delivery to GBM cells.
Article
Biochemistry & Molecular Biology
Suphalak Khamruang Marshall, Pavimol Angsantikul, Zhiqing Pang, Norased Nasongkla, Rusnah Syahila Duali Hussen, Soracha D. Thamphiwatana
Summary: The development of biomimetic drug delivery systems using cell membrane as a surface coating has attracted research attention. In this study, human red blood cell (RBC) membrane-coated nanoparticles were designed as a targeted nanotheranostic against cancer. The nanoparticles showed enhanced targeting functionality and prolonged drug release. The TT-RBC-NPs platform achieved targeted drug delivery and visualization of cancer cells, with increased cellular uptake and enhanced cytotoxic efficacy.
Article
Engineering, Environmental
Qiyu Li, Zheyong Huang, Zhiqing Pang, Qiaozi Wang, Jinfeng Gao, Jing Chen, Zhengmin Wang, Haipeng Tan, Su Li, Fei Xu, Jinxiang Chen, Muyin Liu, Xueyi Weng, Hongbo Yang, Yanan Song, Juying Qian, Junbo Ge
Summary: In this study, platelet-mimetic extracellular vesicles (P-EVs) were created by decorating EVs with platelet membranes. P-EVs demonstrated targeted delivery to lesional macrophages and showed anti-inflammatory effects in atherosclerotic mice. The miRNAs delivered by P-EVs regulated macrophage function, attenuating the progression of atherosclerosis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Huiwen Liu, Honglan Wang, Qiyu Li, Yiwei Wang, Ying He, Xuejing Li, Chunyan Sun, Onder Ergonul, Fusun Can, Zhiqing Pang, Bo Zhang, Yu Hu
Summary: Chronic inflammation is critical in the onset and progression of atherosclerosis. Elevated levels of lipopolysaccharide (LPS) in the circulation system are correlated with the severity of atherosclerosis. This study focuses on using polymyxin covalently conjugated to PEGylated liposomes to adsorb LPS in the circulation system as a therapeutic target for atherosclerosis treatment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Honglan Wang, Huiwen Liu, Jia Li, Chunying Liu, Hui Chen, Junying Li, Chunyan Sun, Tao Guo, Zhiqing Pang, Bo Zhang, Yu Hu
Summary: LMNP, a novel type of macrophage membrane-coated nanoparticles, can effectively dampen HLH and alleviate related symptoms. This study provides alternative insights for the treatment of other cytokine storm-mediated pathologic conditions.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Jiaxin Zhang, Kaicheng Zhou, Jingbo Lin, Xianxian Yao, Dianwen Ju, Xian Zeng, Zhiqing Pang, Wuli Yang
Summary: This study investigated the relationship between chemotherapy resistance and ferroptosis in TNBC, and found that DOX-resistant TNBC cells had higher expression of Gpx4. Inducing ferroptosis by inhibiting Gpx4 expression can reduce TNBC resistance to DOX and enhance the therapeutic effect of chemotherapy. The combination of Fe3O4-PGA-DHA and Fe3O4-PASP-DOX demonstrated stronger cytotoxicity and increased intracellular accumulation of reactive oxygen species and lipid peroxides in TNBC cells. Furthermore, Fe3O4-PGA-DHA + Fe3O4-PASP-DOX triggered ferroptosis by inhibiting the PI3K/AKT/mTOR/GPX4 pathway. The study showed great potential for improving the therapeutic effect of TNBC.
Article
Engineering, Biomedical
Xiaomin Su, Yongbin Cao, Yao Liu, Boshu Ouyang, Bo Ning, Yang Wang, Huishu Guo, Zhiqing Pang, Shun Shen
Summary: Ferroptosis, targeting resistant tumor cells, is enhanced by localized injection of a trigger containing gambogic acid, AIPH, and Ink, along with laser irradiation to increase toxic lipid peroxides in tumor cells. This strategy disrupts intracellular redox homeostasis and boosts ferroptosis, showing promising efficacy in tumor suppression.
MATERIALS TODAY BIO
(2021)