Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes

(2018) Chen Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apelin-13 attenuates ER stress-mediated neuronal apoptosis by activating Gα i /Gα q -CK2 signaling in ischemic stroke

(2018) Fei Wu et al.   EXPERIMENTAL NEUROLOGY

Mitophagy Contributes to the Pathogenesis of Inflammatory Diseases

(2018) Yan Zhao et al.   INFLAMMATION

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway

(2017) Hyo Jeong Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats

(2017) Chang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

(2017) Qi He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Salvianolic Acids for Injection (SAFI) suppresses inflammatory responses in activated microglia to attenuate brain damage in focal cerebral ischemia

(2017) Pengwei Zhuang et al.   JOURNAL OF ETHNOPHARMACOLOGY

NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

(2017) Honglei Guo et al.   MEDIATORS OF INFLAMMATION

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat

(2017) Wijitra Chumboatong et al.   NEUROCHEMISTRY INTERNATIONAL

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

(2016) Min-Ji Kim et al.   Autophagy

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

(2016) Jing Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In Brief: Mitophagy: mechanisms and role in human disease

(2016) Maya Z Springer et al.   JOURNAL OF PATHOLOGY

Mending a broken heart: the role of mitophagy in cardioprotection

(2015) Alexandra G. Moyzis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

(2014) Wenjie Guo et al.   Autophagy

Salubrinal protects against rotenone-induced SH-SY5Y cell death via ATF4-parkin pathway

(2014) Liang Wu et al.   BRAIN RESEARCH

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy

(2014) Peng Wang et al.   NEUROCHEMICAL RESEARCH

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

(2014) Sijun Yang et al.   Redox Biology

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Molecular signaling toward mitophagy and its physiological significance

(2013) Du Feng et al.   EXPERIMENTAL CELL RESEARCH

ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin

(2013) X. Sun et al.   JOURNAL OF NEUROSCIENCE

Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis

(2013) Cai-xia Wu et al.   NEUROSCIENCE LETTERS

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

(2010) L Bouman et al.   CELL DEATH AND DIFFERENTIATION

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging

(2010) Yakup Batlevi et al.   NEUROBIOLOGY OF DISEASE

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM