期刊
CELLS
卷 8, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells8091107
关键词
lncRNA; myogenesis; muscle disease; meat production
类别
资金
- Natural Science Foundation of Hubei Province [2018CFA015]
- Fundamental Research Funds for the Central Universities [2662018PY037, 2662018PY045]
- National Key Project for Transgenic Grant [2016ZX08006-002, 2018ZX08010-12B]
- Agricultural Innovation Fund of Hubei Province [2016-620-000-001-043]
- China Postdoctoral Science Foundation [590319103]
Myogenesis is a complex biological process, and understanding the regulatory network of skeletal myogenesis will contribute to the treatment of human muscle related diseases and improvement of agricultural animal meat production. Long noncoding RNAs (lncRNAs) serve as regulators in gene expression networks, and participate in various biological processes. Recent studies have identified functional lncRNAs involved in skeletal muscle development and disease. These lncRNAs regulate the proliferation, differentiation, and fusion of myoblasts through multiple mechanisms, such as chromatin modification, transcription regulation, and microRNA sponge activity. In this review, we presented the latest advances regarding the functions and regulatory activities of lncRNAs involved in muscle development, muscle disease, and meat production. Moreover, challenges and future perspectives related to the identification of functional lncRNAs were also discussed.
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