Review
Biotechnology & Applied Microbiology
Yanqi Zhang, Jianing Liu, Shiyu Liu, Lu Yu, Siying Liu, Meng Li, Fang Jin
Summary: Oral squamous cell carcinoma (OSCC), the most aggressive oral and maxillofacial malignancy, has a high incidence and low survival rate. Currently, tissue biopsy is the main method for diagnosing OSCC, but it is traumatic and time-consuming. Invasive and unpredictable treatments are the majority options for OSCC, making it difficult to achieve early diagnosis and noninvasive treatment simultaneously. Extracellular vesicles (EVs) have been studied for their role in intercellular communication and their potential as less invasive diagnostic tools for OSCC. This article explores the involvement of EVs in the diagnosis, development, and treatment of OSCC, providing new insights for the treatment of OSCC using EVs. Different mechanisms, such as inhibiting EV internalization by OSCC cells and constructing engineered vesicles, will be discussed for their potential applications in treating OSCC in this review article.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Simona Fontana, Rodolfo Mauceri, Maria Eugenia Novara, Riccardo Alessandro, Giuseppina Campisi
Summary: This pilot study utilized proteomic and bioinformatic strategies to analyze saliva small extracellular vesicles (S/SEVs) from oral squamous cell carcinoma (OSCC) patients, identifying 365 proteins that could potentially serve as novel biomarkers for early OSCC diagnosis. The analysis also revealed specific cluster of enriched functional network terms associated with each group of S/SEVs, indicating their potential value in predicting OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medical Laboratory Technology
Meng Yang, Jieying Ding, Qingqiong Luo, Xu Chen, Fuxiang Chen
Summary: By using saponin to disrupt the membranes of serum EVs, the diagnostic efficacy of SCCA for oral squamous cell carcinoma can be improved. This provides a simple and rapid method with great potential for clinical application.
CLINICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Jian Wang, Qingqing Liu, Yuanxin Zhao, Jiaying Fu, Jing Su
Summary: Cisplatin is a first-line clinical agent used for treating solid tumors by damaging the DNA of tumor cells and inducing high levels of reactive oxygen species. Tumor cells have evolved ways to tolerate this damage. Extracellular vesicles (EVs) are an important mode of information transfer in tumor cells, and under cisplatin treatment, they can be activated and mediate different responses based on their cargoes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Yanhui Lu, Zhichao Zheng, Yunyi Yuan, Janak L. Pathak, Xuechao Yang, Lijing Wang, Zhitong Ye, William C. Cho, Mingtao Zeng, Lihong Wu
Summary: Oral cancer, primarily oral squamous cell carcinoma, remains a challenge to treat with high rates of metastasis. Exosomes play a crucial role in the tumorigenesis and progression of oral squamous cell carcinoma, and show potential for clinical application in treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Omprakash Shriwas, Rakesh Arya, Sibasish Mohanty, Pallavi Mohapatra, Sugandh Kumar, Rachna Rath, Sandeep Rai Kaushik, Falak Pahwa, Krushna Chandra Murmu, Saroj Kumar Das Majumdar, Dillip Kumar Muduly, Anshuman Dixit, Punit Prasad, Ranjan K. Nanda, Rupesh Dash
Summary: The study identified RRBP1 as a major driver of cisplatin-resistance in oral squamous cell carcinoma, regulating YAP1 expression to mediate chemoresistance, and demonstrated that targeting RRBP1 could reverse cisplatin-induced chemoresistance.
BRITISH JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Zhu-Jun Law, Xin Hui Khoo, Pei Tee Lim, Bey Hing Goh, Long Chiau Ming, Wai-Leng Lee, Hui Poh Goh
Summary: Oral Squamous Cell Carcinoma (OSCC) is a cancer with poor prognosis and high recurrence rate, with tumor drug resistance being a persistent issue. Extracellular vesicles (EVs) play a crucial role in facilitating tumor progression and chemoresistance, particularly exosomes and microvesicles.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Xueying Wang, Junnan Guo, Pingyang Yu, Lunhua Guo, Xionghui Mao, Junrong Wang, Susheng Miao, Ji Sun
Summary: Head and neck squamous cell carcinoma (HNSCC) is a major malignant tumor that affects human health due to delayed diagnosis and high invasiveness. Extracellular vesicles (EVs) carry various bioactive molecules and play a role in reshaping the microenvironment and influencing cellular behavior, contributing to a deeper understanding of HNSCC biology.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemical Research Methods
Kaiyuan Xu, Liu Liu, Kaihui Wu, Miaomiao Zhang, Ruiqi Xie, Ruowei Li, Maomao Zhao, Hui Yang, Ning Duan, Xiang Wang, Wenmei Wang
Summary: This study analyzed the plasma EV proteome of rats with 4NQO-induced OSCC or MD using mass spectrometry, identifying potential biomarkers and pathological changes in early OSCC, as well as the presence of oral-derived EVs in plasma. The results highlight the need for pan-EV markers for further research.
JOURNAL OF PROTEOMICS
(2022)
Article
Microbiology
Rafaela F. Amatuzzi, Daniel Zamith-Miranda, Isadora F. Munhoz da Rocha, Aline C. R. Lucena, Sharon de Toledo Martins, Rodrigo Streit, Charley C. Staats, Gabriel Trentin, Fausto Almeida, Marcio L. Rodrigues, Joshua D. Nosanchuk, Lysangela R. Alves
Summary: Antifungal resistance is increasing, with Candida auris being highly resistant to antifungal drugs. This study found that treatment with caspofungin led to increased production of extracellular vesicles (EVs) in C. auris and altered the content of RNA and proteins enclosed in the EVs. The ability of C. auris to change the composition of EVs may contribute to its ability to evade antifungal treatment.
Article
Oncology
Leanne L. Leung, Muhammad Kashif Riaz, Xinyu Qu, Jason Chan, Katie Meehan
Summary: Oral cancers occurring in different subsites may have distinct etiologies, with squamous cell carcinomas in the oral tongue and oropharynx showing an increasing incidence. Human papilloma virus (HPV) is an important risk factor for oropharyngeal cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Meng Yang, Qingqiong Luo, Xu Chen, Fuxiang Chen
Summary: Bitter melon-derived extracellular vesicles (BMEVs) demonstrated significant therapeutic efficacy against oral squamous cell carcinoma (OSCC) and reduced drug resistance. The study provides evidence for the development of PDEVs-enhanced therapy for cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Karolina Dzaman, Katarzyna Czerwaty
Summary: It estimated that there are over 890,000 new cases of head and neck squamous cell carcinoma (HNSCC) worldwide each year, accounting for approximately 5% of all cancer cases. The use of extracellular vesicles (EVs) in HNSCC treatment shows promise in drug delivery, immune modulation, diagnostics, gene therapy, and tumor microenvironment modulation. However, there are challenges in EV isolation, purification, and standardization of EV-based therapies in HNSCC.
Article
Biotechnology & Applied Microbiology
Tao Liu, Fei Jiang, Li-Yuan Yu, You-Yang Wu
Summary: This study elucidated the inhibitory effects of lidocaine on cell proliferation and cisplatin resistance in A431 human cutaneous squamous cell carcinoma cells through the miR-30c/SIRT1 pathway. The findings suggest that lidocaine has promising potential as a treatment strategy for cSCC.
Review
Dentistry, Oral Surgery & Medicine
Yingchun Qie, Xia Sun, Yongqiang Yang, Tao Yan
Summary: Oral squamous cell carcinoma, accounting for 80% of all oral cancers, has a high recurrence rate and poor prognosis with a 5-year survival rate less than 50%. Researchers have been exploring therapeutic strategies and diagnostic methods for oral squamous cell carcinoma by investigating the role of exosomes, which have shown great potential in tumorigenesis, progression, and metastasis. This study aims to summarize the latest research on exosomes in oral squamous cell carcinoma and explore their biological functions and applications for therapeutic strategies.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Food Science & Technology
Ting Yi Heung, Jessica Yue Shuen Huong, Wan Yeng Chen, Yi Wen Loh, Kooi Yeong Khaw, Bey-Hing Goh, Yong Sze Ong
Summary: Papaya extracts or their bioactive compounds may serve as a potential broad-spectrum therapy for cancer by targeting multiple characteristics of cancer development.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Tak Loon Khong, Xin-Hui Khoo, Ida Hilmi
Summary: The study found that interventions such as medical education, specialist nurse coordinators, continuous quality improvement, and clinical decision support systems are effective in improving clinicians' compliance to PPS guidelines, leading to a reduction in over- and underutilization of colonoscopy surveillance resources.
DIGESTIVE DISEASES
(2022)
Review
Pharmacology & Pharmacy
Hooi Leong Loo, Bey Hing Goh, Learn-Han Lee, Lay Hong Chuah
Summary: With the increasing prevalence of impaired wound healing, there has been a growing interest in the development of novel wound dressings with enhanced healing functions. Nanoparticle-based delivery systems, particularly chitosan-based nanoparticles, have emerged as promising candidates due to their non-toxicity, biocompatibility, and bioactivity. This review focuses on the application of chitosan-based nanoparticle systems in wound treatment, discussing their properties, mechanisms, and potential for improving wound healing. The results show that chitosan-based nanoparticles exhibit superior wound healing effects, either alone or as drug delivery vehicles. Overall, there are great opportunities and potentials for the use of chitosan nanoparticles in wound healing.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Camille Keisha Mahendra, Khang Wen Goh, Long Chiau Ming, Gokhan Zengin, Liang Ee Low, Hooi-Leng Ser, Bey Hing Goh
Summary: Cosmetics play an immeasurable role in our lives, from personal hygiene to skincare. Given the rise in demand for natural products, cosmetic companies are constantly searching for innovative ingredients and formulations. Swietenia macrophylla seeds have been found to possess potential cosmetic properties, such as skin whitening and protection against environmental damage, making them important in the pursuit of ageless beauty.
Review
Food Science & Technology
Omar Belmehdia, Naoual El Menyiy, Abdelhakim Bouyahya, Aicha El Baaboua, Nasreddine El Omari, Monica Gallo, Domenico Montesano, Daniele Naviglio, Gokhan Zengin, Nadia Skali Senhaji, Bey Hing Goh, Jamal Abrini
Summary: This review discusses the recent advances in the chemical composition and biological activities of propolis. It highlights the various important bioactive properties of propolis, including antibacterial, antioxidant, and anticancer effects. Data shows that propolis has low toxicity even at high doses, making it a promising source of bioactive compounds for drug development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Ling Sze Yap, Wai Leng Lee, Adeline Su Yien Ting
Summary: This study demonstrated the novelty of upstream and downstream bioprocessing of L-asparaginase from a fungal endophyte, Colletotrichum gloeosporioides, and evaluated its cytotoxicity. The purified fungal L-asparaginase showed high purity and significant anticancer effect, indicating its potential as an alternative chemotherapy drug.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ida Normiha Hilmi, Nik Arsyad Nik Muhamad Affendi, Shahreedhan Shahrani, Abdul Malik Thalha, Alex Hwong-Ruey Leow, Xin-Hui Khoo
Summary: The aim of this study was to determine the accuracy of a standardized protocol in the initial diagnosis of Crohn's disease (CD) versus intestinal tuberculosis (ITB). The results showed that the protocol had a high accuracy in differentiating CD from ITB.
DIGESTIVE DISEASES
(2023)
Article
Pathology
Kar-Yan Su, Jie-Yi Koh Kok, Yie-Wei Chua, Shearn-Dior Ong, Hooi Leng Ser, Priyia Pusparajah, Pui San Saw, Bey Hing Goh, Wai-Leng Lee
Summary: Extracellular vesicles (EVs) are membrane-derived lipid bilayers released by cells. Bacterial EVs (BEVs) have attracted interest as potential diagnostic markers due to their differential bacterial composition in biofluids between patients and healthy controls. This review outlines the commonly used approach for investigating BEVs in biofluids, including 16S ribosomal RNA gene sequencing, and discusses the potential of BEVs as biomarkers for various diseases.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Medicine, General & Internal
Le-Wei Wong, Siow-Hui Mak, Bey-Hing Goh, Wai-Leng Lee
Summary: In conjunction with imaging analysis, pathology-based assessments of biopsied tissue are the gold standard for diagnosing solid tumors. However, the disadvantages of tissue biopsies have led to the development of liquid biopsy, which involves sampling and clinical assessment of bodily fluids for cancer diagnosis. Extracellular vesicles (EVs), carrying molecular profiles of their cell or tissue origins, have emerged as one of the most promising biomarkers for cancer, allowing for non-invasive and rapid diagnosis with the help of Fourier-transform infrared spectroscopy (FTIR).
Article
Dentistry, Oral Surgery & Medicine
Halah Ahmed, Ian Paterson, Sadat A. A. Aziz, Ottavio Cremona, Max Robinson, Marco Carrozzo, Ruth A. Valentine
Summary: In this study, the role of Epsin3 and Notch1 in oral carcinogenesis was investigated, aiming to explore their potential as biomarkers. The results showed that Epsin3 was upregulated in oral epithelial dysplasia and oral squamous cell carcinoma, suggesting its potential as a biomarker for oral epithelial dysplasia. Notch signaling was downregulated in oral squamous cell carcinoma, possibly through an Epsin3-induced de-activation pathway.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Shahdadi, Maliheh Faryabi, Haroon Khan, Ali Salehi Sardoei, Bahman Fazeli-Nasab, Bey Hing Goh, Khang Wen Goh, Ching Siang Tan
Summary: This study examined the antibacterial effects of Mentha longifolia essential oil and pulegone in edible coatings on the growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli in cheese. The results showed that the addition of these compounds significantly reduced bacterial growth during storage. Increasing the concentration of chitosan, M. longifolia, and pulegone in the coatings further decreased the bacterial population, with pulegone exhibiting a stronger effect. Overall, the findings suggest that M. longifolia essential oil and pulegone, combined with alginate and chitosan coatings, have antibacterial effects against S. aureus, L. monocytogenes, and E. coli in cheese.
Article
Medicine, General & Internal
Najwa Hazwani Muhammad Haskani, Long Chiau Ming, Jagjit Singh Dhaliwal, Daniel Vui Teck Wee, Bey Hing Goh, Majid Ali, Shazwani Shaharuddin, Khang Wen Goh, Hui Poh Goh
Summary: This study aimed to identify and review research related to the practice of patients with DM in Brunei Darussalam in order to identify associated factors influencing diabetic medication knowledge and adherence. The results revealed relatively poor medication knowledge and inappropriate diabetes-related practices in studies conducted in Brunei Darussalam. However, no study has directly measured both medication awareness and compliance among Brunei Darussalam T2DM patients. Future studies can focus on the relation between these two factors in different geographical locations characterized by different diabetes-related practices and culture.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Biochemistry & Molecular Biology
Wei Hsum Yap, Bey Hing Goh
