The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers

Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461

(2018) Guihong Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Poor prognosis of nucleophosmin overexpression in solid tumors: a meta-analysis

(2018) Siying Chen et al.   BMC CANCER

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

CX-5461 induces autophagy and inhibits tumor growth via mammalian target of rapamycin-related signaling pathways in osteosarcoma

(2016) Xu Li et al.   OncoTargets and Therapy

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

(2016) Jaclyn Quin et al.   Oncotarget

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape

(2015) Karl Holmberg Olausson et al.   Scientific Reports

The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription

(2015) Naohiro Katagiri et al.   Scientific Reports

Expression and Prognostic Significance of APE1/Ref-1 and NPM1 Proteins in High-Grade Ovarian Serous Cancer

(2014) Ambrogio P. Londero et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The basal transcription machinery as a target for cancer therapy

(2014) Claudia Villicaña et al.   Cancer Cell International

Enhanced levels of double-strand DNA break repair proteins protect ovarian cancer cells against genotoxic stress-induced apoptosis

(2013) Rajkumar Kalra et al.   Journal of Ovarian Research

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

The synergistic therapeutic effect of cisplatin with Human papillomavirus E6/E7 short interfering RNA on cervical cancer cell lines in vitro and in vivo

(2011) Hun Soon Jung et al.   INTERNATIONAL JOURNAL OF CANCER

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Secondary mutations of BRCA1/2 and drug resistance

(2010) Kiranjit K. Dhillon et al.   CANCER SCIENCE

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY