期刊
EBIOMEDICINE
卷 47, 期 -, 页码 563-577出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2019.08.073
关键词
Mesenchymal stromal (or stem) cells; MSC; Rheumatoid arthritis; Pre-clinical study; Clinical trials; Meta-analysis
资金
- NIH [1DP2CA195763]
- Baylx Inc. [BI-206512]
- National Institute of Neurological Disorders and Stroke (NINDS/NIH) [NS082174]
Background: This study aims to evaluate the quality of preclinical data, determine the effect sizes, and identify experimental measures that inform efficacy using mesenchymal stromal (or stem) cells (MSC) therapy in animal models of rheumatoid arthritis (RA). Methods: Literature searches were performed on MSC predinical studies to treat RA. MSC treatment effect sizes were determined by the most commonly used outcome measures, including paw thickness, dinical score, and histological score. Findings: A total of 48 studies and 94 treatment arms were included, among which 42 studies and 79 treatment arms reported that MSC improved outcomes. The effect sizes of RA treatments using MSC, when compared to the controls, were: paw thickness was ameliorated by 53.6% (95% confidence interval (CI): 26.7% -80A%), histological score was decreased by 44.9% (95% CI: 33.3% -56.6%), and dinical score was decreased by 29.9% (95% CI: 16.7% -43.0%). Specifically, our results indicated that human umbilical cord derived MSC led to large improvements of the dinical score (-42.1%) and histological score (-51.4%). Interpretation: To the best of our knowledge, this meta-analysis is to quantitatively answer whether MSC represent a robust RA treatment in animal models. It suggests that in preclinical studies. MSC have consistently exhibited therapeutic benefits. The findings demonstrate a need for considering variations in different animal models and treatment protocols in future studies using MSC to treat RA in humans to maximise the therapeutic gains in the era of precision medicine. (C) 2019 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据