Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy
出版年份 2019 全文链接
标题
Therapeutic efficacy of a novel humanized antibody-drug conjugate recognizing plexin-semaphorin-integrin domain in the RON receptor for targeted cancer therapy
作者
关键词
RON receptor tyrosine kinase, PSI domain, Monoclonal antibody, Humanization, Antibody-drug conjugates, Receptor internalization, Epithelial cancer, cancer stem cells, Tumor xenograft model, Therapeutic efficacy
出版物
Journal for ImmunoTherapy of Cancer
Volume 7, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-09-13
DOI
10.1186/s40425-019-0732-8
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy
- (2019) Hang-Ping Yao et al. Journal for ImmunoTherapy of Cancer
- Antibody–Drug Conjugates for Cancer Treatment
- (2018) John M. Lambert et al. Annual Review of Medicine
- Mechanistic Modeling of Antibody–Drug Conjugate Internalization at the Cellular Level Reveals Inefficient Processing Steps
- (2018) Kenneth R. Durbin et al. MOLECULAR CANCER THERAPEUTICS
- Preclinical Efficacy of Anti-RON Antibody–Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase
- (2018) Hang-Ping Yao et al. MOLECULAR PHARMACEUTICS
- RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE
- (2018) Sreedhar Reddy Suthe et al. MOLECULAR CANCER THERAPEUTICS
- Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain
- (2017) Hyunkyu Park et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design
- (2016) Katie F. Maass et al. AAPS Journal
- Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer
- (2016) Liang Feng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Efficient Payload Delivery by a Bispecific Antibody-Drug Conjugate Targeting HER2 and CD63
- (2016) B. E. C. G. de Goeij et al. MOLECULAR CANCER THERAPEUTICS
- Antibody-conjugated drug assay for protease-cleavable antibody–drug conjugates
- (2016) Russell J Sanderson et al. Bioanalysis
- Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors
- (2015) Mauricio Rodriguez-Torres et al. CLINICAL & EXPERIMENTAL METASTASIS
- A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells
- (2015) J Chakedis et al. ONCOGENE
- Efficacy of Anti-RON Antibody Zt/g4-Drug Maytansinoid Conjugation (Anti-RON ADC) as a Novel Therapeutics for Targeted Colorectal Cancer Therapy
- (2014) L. Feng et al. CLINICAL CANCER RESEARCH
- Structural Basis for the Binding Specificity of Human Recepteur d'Origine Nantais (RON) Receptor Tyrosine Kinase to Macrophage-stimulating Protein
- (2014) Kinlin L. Chao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oncogenic Variant RON160 Expression in Breast Cancer and its Potential as a Therapeutic Target by Small Molecule Tyrosine Kinase Inhibitor
- (2013) Hang-Ping Yao et al. CURRENT CANCER DRUG TARGETS
- Antibody-Drug Conjugates in Cancer Therapy
- (2012) Eric L. Sievers et al. Annual Review of Medicine
- Differential expression of RON in small and non-small cell lung cancers
- (2012) Rajani Kanteti et al. GENES CHROMOSOMES & CANCER
- The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome
- (2012) Peter T. Yu et al. INTERNATIONAL JOURNAL OF CANCER
- Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase
- (2012) Kinlin L. Chao et al. PLoS One
- Ribosomal Protein S6 Kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein
- (2011) Qi Ma et al. Molecular Cancer
- The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells
- (2011) Hang-Ping Yao et al. Molecular Cancer
- Sustained Expression of the RON Receptor Tyrosine Kinase by Pancreatic Cancer Stem Cells as a Potential Targeting Moiety for Antibody-Directed Chemotherapeutics
- (2011) Snehal S. Padhye et al. MOLECULAR PHARMACEUTICS
- Silencing of RON Receptor Signaling Promotes Apoptosis and Gemcitabine Sensitivity in Pancreatic Cancers
- (2010) J. Logan-Collins et al. CANCER RESEARCH
- Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
- (2010) M. W. Pedersen et al. CANCER RESEARCH
- RON Receptor Tyrosine Kinase as a Target for Delivery of Chemodrugs by Antibody Directed Pathway for Cancer Cell Cytotoxicity
- (2009) Sunny Guin et al. MOLECULAR PHARMACEUTICS
- Engineering therapeutic monoclonal antibodies
- (2008) Xiao-yun Liu et al. IMMUNOLOGICAL REVIEWS
- Smad4-dependent TGF-β Signaling Suppresses RON Receptor Tyrosine Kinase-dependent Motility and Invasion of Pancreatic Cancer Cells
- (2008) Shujie Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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