Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction

(2018) Xiangling Chen et al.   CANCER LETTERS

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction

(2017) Lei Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

(2017) Stephen T. Hallett et al.   Cell Reports

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90

(2016) Fen Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

A Dynamic View of ATP-coupled Functioning Cycle of Hsp90 N-terminal Domain

(2015) Huaqun Zhang et al.   Scientific Reports

FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation

(2014) Wei Huang et al.   Molecular Cancer

A global view of Hsp90 functions

(2013) Gabriela Chiosis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression and purification of recombinant NRL-Hsp90α and Cdc37-CRL proteins for in vitro Hsp90/Cdc37 inhibitors screening

(2013) Jing He et al.   PROTEIN EXPRESSION AND PURIFICATION

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions

(2012) David S. Hong et al.   CANCER TREATMENT REVIEWS

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SplitRenillaLuciferase Protein Fragment-assisted Complementation (SRL-PFAC) to Characterize Hsp90-Cdc37 Complex and Identify Critical Residues in Protein/Protein Interactions

(2010) Yiqun Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting HSP90 for cancer therapy

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction

(2009) Tao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Cdc37·Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy

(2008) Sridhar Sreeramulu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

(2008) T. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

(2008) J R Smith et al.   ONCOGENE