Article
Medicine, Research & Experimental
Shuguang Han, Feng Zhu, Xiaoxia Huang, Panpan Yan, Ke Xu, Fangfang Shen, Jiawen Sun, Zeyu Yang, Guoxi Jin, Yiqun Teng
Summary: Maternal obesity increases the susceptibility of offspring to non-alcoholic fatty liver disease (NAFLD). Reduced level of autophagy and liver fibrosis play vital roles in this increased susceptibility.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Chunbin Sun, Jin Zhang, Jiong Hou, Menglin Hui, Hualong Qi, Tong Lei, Xiaoshuang Zhang, Luxi Zhao, Hongwu Du
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common lipid metabolism disorder. Autophagy plays a crucial role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active components of Pueraria lobata, have antioxidant and anti-inflammatory effects. This study demonstrates that Pueraria flavonoids can reduce intracellular lipid accumulation and inflammation levels in NAFLD by stimulating autophagy through the PI3K/Akt/mTOR signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Yamei Duan, Xiongfeng Pan, Jiayou Luo, Xiang Xiao, Jingya Li, Prince L. Bestman, Miyang Luo
Summary: This study found a significant association between inflammatory cytokines and non-alcoholic fatty liver disease (NAFLD). Increased concentrations of C-reactive protein (CRP), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and intercellular adhesion molecule-1 (ICAM-1) were significantly associated with increased risks of NAFLD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shuiliang Ruan, Chenyang Han, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Qiaobing Guan, Wenyan Li, Caiqun Zhang, Yi Yang
Summary: The study demonstrated that Antcin A could inhibit pyroptosis in Kupffer cells and alleviate the inflammatory response in liver tissue of NAFLD mice by targeting the NLRP3 inflammasome. This mechanism contributes to the protective effects of Antcin A on liver health.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Lina Jian, Huixing Wu, Haiyan Zeng, Ting Quan, Fan Xia, Shijian Xiang, Benjie Zhou
Summary: Isoliquiritigenin has therapeutic potential in relieving inflammation and lipid metabolism disorders in NAFLD. It effectively reduces lipid accumulation and suppresses inflammation factors expression, preventing weight gain and liver damage in HFD mice. It exerts its anti-NAFLD effect through the mTOR pathway and autophagy.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Endocrinology & Metabolism
Aldo Grefhorst, Ivo P. van de Peppel, Lars E. Larsen, Johan W. Jonker, Adriaan G. Holleboom
Summary: NAFLD is one of the most common liver disorders worldwide, with a complex etiology involving genetic susceptibility and unhealthy lifestyle factors. Disruption of hepatic lipid homeostasis, including the emerging role of lipophagy, is a key feature in the development and progression of NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Lidia Giubilei, Anna Caterina Procopio, Rocco Spagnuolo, Francesco Luzza, Luigi Boccuto, Emidio Scarpellini
Summary: The intestinal microbiota, the microbial community in the gastrointestinal tract, plays a crucial role in human health. Dysbiosis of the intestinal microbiota is associated with the development of various diseases.
Editorial Material
Gastroenterology & Hepatology
Satya Priya Sharma, Ki Tae Suk, Dong Joon Kim
Summary: The review highlights the crucial role of gut microbes in maintaining liver homeostasis and the impact of dysbiosis on the development of fatty liver disease. The changes in gut microbial composition in alcoholic and nonalcoholic fatty liver diseases and how they contribute to the pathophysiology of the disease are discussed. New approaches related to gut microbes for the diagnosis and treatment of fatty liver disease are also summarized.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yamei Duan, Jiayou Luo, Xiongfeng Pan, Jia Wei, Xiang Xiao, Jingya Li, Miyang Luo
Summary: This study evaluated the association between inflammatory markers and NAFLD in obese children. The findings indicated that levels of IL-1 beta, IL-6, and IL-17 were significantly associated with NAFLD, suggesting that these inflammatory cytokines may serve as non-invasive markers for the development of NAFLD.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Ying Yang, Yue Wu, Jie Zou, Yu-Hao Wang, Meng-Xia Xu, Wei Huang, Dao-Jiang Yu, Li Zhang, Yuan-Yuan Zhang, Xiao-Dong Sun
Summary: Naringenin (NAR) alleviates non-alcoholic fatty liver disease (NAFLD) by increasing energy expenditure and regulating autophagy through direct and indirect activation of AMPK signaling pathway. The direct binding of NAR and AMPK gamma 1 requires further validation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yiyuan Zheng, Dan Fang, Chaoyuan Huang, Lina Zhao, Liming Gan, Youlan Chen, Fengbin Liu
Summary: The study revealed that Gentiana scabra (GS) can regulate pro-inflammatory macrophages in the treatment of non-alcoholic fatty liver disease (NAFLD), potentially inhibiting TBK1 phosphorylation and MCP1 expression to alleviate the inflammatory cascade. This suggests GS may be an effective option for NAFLD prevention and treatment, offering new insights for improving current intervention strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fei Zhou, Mingning Ding, Yiqing Gu, Guifang Fan, Chuanyang Liu, Yijie Li, Rong Sun, Jianzhi Wu, Jianchao Li, Xiaoyong Xue, Hongjuan Li, Xiaojiaoyang Li
Summary: Aurantio-obtusin (AO) has been shown to alleviate hepatic steatosis in mice and lipid accumulation in hepatocytes by promoting autophagy flux and activating AMPK/TFEB signaling pathway. This study provides new opportunities for the pharmacological treatment of nonalcoholic fatty liver disease (NAFLD) and associated complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chien-Chih Chen, Li-Wen Hsu, Kuang-Den Chen, King-Wah Chiu, Chao-Long Chen, Kuang-Tzu Huang
Summary: The liver plays a central role in energy metabolism and dysregulated Ca2+ signaling is closely associated with non-alcoholic fatty liver disease (NAFLD). Therefore, targeting Ca2+ signaling for treatment of NAFLD is of great importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Dongqing Wu, Huaqing Zhu, Hua Wang
Summary: The liver, as the largest vital solid organ in the body, consists of multiple types of cells that communicate critically to maintain liver function homeostasis. Extracellular vesicles (EVs) play a significant role in cell-to-cell communication and are involved in the development of liver diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe G. N. Garcia, Donna D. Zhang
Summary: The mechanisms of high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) involve autophagy inhibition, NRF2 suppression, and promotion of ferroptosis. Activation of NRF2 can counteract the NRF2 suppression and ferroptotic cell death caused by HFD. The regulation of NRF2 by saturated fatty acids (SFAs) versus monounsaturated fatty acids (MUFAs) may explain their different effects.
Article
Agriculture, Dairy & Animal Science
Zhaoxin Yang, Xiukai Cao, Yilei Ma, Jie Cheng, Chengchuang Song, Rui Jiang, Xiaogang Wang, Yongzhen Huang, Chaogetu Buren, Xianyong Lan, Elsaeid Elnour Ibrahim, Linyong Hu, Hong Chen
Summary: This study investigated the potential associations of BAG4 copy numbers variations with growth traits in three Chinese sheep breeds, revealing significant differences in the distribution of BAG4 CNV across varieties.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jijun Xiong, Jie Quan, Chaosheng Qin, Xiaogang Wang, Qinghua Dong, Bingdong Zhang
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2020)
Review
Anesthesiology
Chaosheng Qin, Yuanming Liu, Jijun Xiong, Xiaogang Wang, Qinghua Dong, Tingshi Su, Jingchen Liu
BMC ANESTHESIOLOGY
(2020)
Article
Medicine, Research & Experimental
Guan-Zhong Qiu, Qiang Liu, Xiao-Gang Wang, Guang-Zhen Xu, Tong Zhao, Mei-Qing Lou
Article
Cell Biology
Qiang Zhu, Tao Tang, Haixiao Liu, Yinxue Sun, Xiaogang Wang, Qiang Liu, Long Yang, Zhijie Lei, Zhao Huang, Zhao Chen, Qiang Lei, Mingyang Song, Bodong Wang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Medicine, Research & Experimental
Rui Jiang, Hui Li, Jiameng Yang, Xuemei Shen, Chengchuang Song, Zhaoxin Yang, Xiaogang Wang, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Medicine, General & Internal
Fei Zhao, Hanghai Pan, XiaoGang Wang
Article
Neurosciences
Pengjiu Feng, Aimin Zhang, Ming Su, Hai Cai, Xiaogang Wang, Yan Zhang
Summary: This study revealed that dexmedetomidine protects astrocytes against apoptosis by inhibiting the JAK/STAT signal pathway and downregulating JMJD3 expression in vitro.
Article
Medicine, General & Internal
Ye Peng, Xiaolu Song, Jianping Lan, Xiaogang Wang, Manling Wang
Summary: Interaction with BMSCs and exosomes may play a vital role in the progression of MM. The study identified miR-10a and miR-16 as potential biomarkers for MM progression by regulating specific genes, suggesting their potential as therapeutic targets.
Article
Cell Biology
Yeqing Ren, Biao Yang, Geng Guo, Jianping Zhang, Yanqi Sun, Dong Liu, Shihao Guo, Yongqiang Wu, Xiaogang Wang, Shule Wang, Wenju Zhang, Xiaolong Guo, Xuepeng Li, Ren Li, Jianhang He, Zihan Zhou
Summary: GBP2 plays a critical role in glioma by regulating the EGFR signaling pathway and interacting with KIF22, which suggests its potential as a therapeutic target for glioma treatment.
CELL DEATH DISCOVERY
(2022)
Review
Clinical Neurology
Ji Jin, Geng Guo, Yeqing Ren, Biao Yang, Yongqiang Wu, Shule Wang, Yanqi Sun, Xiaogang Wang, Yuxiao Wang, Jianzhong Zheng
Summary: A meta-analysis was conducted to identify the risk factors for the recurrence of intracranial aneurysm after coil embolization. The study found that intracranial aneurysms in the middle cerebral artery and posterior circulation, as well as those larger than 7 mm, ruptured, and associated with subarachnoid hemorrhage, had a significantly higher risk of recurrence after coil embolization.
FRONTIERS IN NEUROLOGY
(2022)
Meeting Abstract
Ophthalmology
Xiaogang Wang, Jing Dong
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Pengxiao Zang, Tristan T. Hormel, Yukun Guo, Xiaogang Wang, Christina J. Flaxel, Steven Bailey, Thomas S. Hwang, Yali Jia
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Chemistry, Applied
Jiaqian Fan, Zhengfeng Xie, Xiaogang Wang, Tianzhu Shi
RUSSIAN JOURNAL OF APPLIED CHEMISTRY
(2020)
Meeting Abstract
Ophthalmology
Jie Wang, Tristan Hormel, Liqin Gao, Pengxiao Zang, Yukun Guo, Xiaogang Wang, Steven T. Bailey, Yali Jia
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)