期刊
BIOCHEMISTRY-MOSCOW
卷 81, 期 5, 页码 453-464出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297916050035
关键词
micronucleus; replication; transcription; repair; elimination
资金
- Russian Science Foundation [14-50-00029]
- Russian Science Foundation [14-50-00029] Funding Source: Russian Science Foundation
The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by the chromosomal material localized inside these cell structures.
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