Article
Medical Laboratory Technology
Yujia Fang, Dong Yan, Lixin Wang, Jie Zhang, Qingfang He
Summary: This study analyzed the differential expression of miRNAs between HCC patients and controls and found that miR-16 and miR-122 were significantly upregulated in early-stage HCC patients. Combining these miRNAs with AFP improved the diagnostic efficacy for HCC. Furthermore, miR-16 and miR-122 were found to regulate a number of potential target genes involved in cancer pathways.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Article
Gastroenterology & Hepatology
Ningning Liu, Ching Wen Chang, Clifford J. Steer, Xin Wei Wang, Guisheng Song
Summary: The study reveals that microRNA-15a/16-1 attenuates immunosuppression in hepatocellular carcinoma by disrupting CCL22-mediated communication between KCs and Tregs. MicroRNA-15a/16-1 represents a potential immunotherapy against HCC.
Review
Biochemistry & Molecular Biology
Laura Gramantieri, Francesca Fornari, Catia Giovannini, Davide Trere
Summary: miRNAs in HCC play a bidirectional role in both immune-related pathways and oncogenic pathways. Understanding their function can help identify patient subgroups and design personalized treatment strategies.
Review
Oncology
Jose D. Debes, Pablo A. Romagnoli, Jhon Prieto, Marco Arrese, Angelo Z. Mattos, Andre Boonstra
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. Late diagnosis and limited treatment options contribute to the low survival rate of patients with HCC. Currently, combining ultrasound with the biomarker AFP is a commonly used screening method, but its clinical utility and operator-dependence are controversial.
Article
Cell Biology
Jingwen Yang, Weiwei Dong, He Zhang, Huixia Zhao, Zhiyan Zeng, Fengyun Zhang, Qiuwen Li, Xiaohong Duan, Yanyan Hu, Wenhua Xiao
Summary: This study revealed that the exosomal microRNA panel has high accuracy in diagnosing HCC and has important clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: Hepatocellular carcinoma (HCC) is a common and deadly cancer, with a poor prognosis in late stages. Understanding the role of microRNAs (miRNAs) in HCC pathogenesis may lead to improved outcomes. MiRNAs have potential as valuable biomarkers and therapeutic targets in HCC diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Tingting Shi, Hisakazu Iwama, Koji Fujita, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Yasuhiro Goda, Hirohito Yoneyama, Asahiro Morishita, Joji Tani, Mari Yamada, Mai Nakahara, Kei Takuma, Tsutomu Masaki
Summary: The study evaluated the inhibitory effect of lenvatinib on sorafenib-resistant HCC cells, finding that lenvatinib suppresses cell proliferation mainly by inducing G1 cell cycle arrest through ERK signaling. The results suggest that lenvatinib may be a suitable second-line therapy for patients with sorafenib-resistant HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiehan Li, Haolin Bao, Ziyue Huang, Zixin Liang, Mei Wang, Ning Lin, Chunjie Ni, Yi Xu
Summary: Hepatocellular carcinoma (HCC) is a highly lethal and aggressive cancer with increasing incidence. Understanding the pathogenesis of HCC and identifying reliable therapeutic targets are essential for improving patient survival. MiRNAs, non-coding RNAs involved in gene regulation, have been extensively studied in HCC and are involved in various HCC-related processes. The expression status of miRNAs also plays a role in drug resistance mechanisms in HCC, with important implications for systemic treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hatem El-mezayen, Kensuke Yamamura, Toshihiko Yusa, Yosuke Nakao, Norio Uemura, Fumimasa Kitamura, Rumi Itoyama, Takanobu Yamao, Takaaki Higashi, Hiromitsu Hayashi, Katsunori Imai, Akira Chikamoto, Yo-ichi Yamashita, Hideo Baba
Summary: miR-25 is overexpressed in HCC tissue and is significantly correlated with a poorer prognosis, as well as inversely correlated with Fbxw7 expression. Inhibition of miR-25 significantly reduces the proliferation, migration, and invasion of HCC cells in vitro, suggesting its potential role as a therapeutic target in HCC treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Ting Song, Li Li, Shaobo Wu, Yan Liu, Caiping Guo, Wen Wang, Lili Dai, Tong Zhang, Hao Wu, Bin Su
Summary: Hepatocellular carcinoma (HCC) is a common and highly lethal cancer, and genetic biomarkers are increasingly playing a crucial role in early diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jung Woo Eun, Hye Ri Ahn, Geum Ok Baek, Moon Gyeong Yoon, Ju A. Son, Ji Hyang Weon, Jung Hwan Yoon, Hyung Seok Kim, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Bong-wan Kim, Hyo Jung Cho
Summary: Cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma (HCC) have downregulated expression of hsa-miR-101-3p and hsa-miR-490-3p, which target TGFBR1. The downregulation of these miRs and high TGFBR1 expression are associated with poor prognosis in HCC patients. TGFBR1 expression is also correlated with infiltration of immunosuppressive immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Shuying Chen, Zile Fu, Shuzhan Wen, Xiaoyi Yang, Chengxuan Yu, Wenhan Zhou, Yong Lin, Yuan Lv
Summary: miR-497 and miR-1246 may serve as biomarkers in HCC by regulating target genes involved in the progression of the disease. Their expression levels are significantly associated with prognosis and diagnosis of HCC.
FRONTIERS IN GENETICS
(2021)
Review
Pharmacology & Pharmacy
Yulai Zeng, Shuyu Hu, Yi Luo, Kang He
Summary: Hepatocellular carcinoma (HCC) is a common cancer with unsatisfactory early diagnosis and treatment. Exosomes, containing various components, play a crucial role in the development and prognosis of HCC. Biomarkers in exosomes show potential for novel diagnostic and prognostic tools for HCC.