A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice

Enhancing anti-tumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

(2019) K M Heinhuis et al.   ANNALS OF ONCOLOGY

Association of Patient Sex With Efficacy of Immune Checkpoint Inhibitors and Overall Survival in Advanced Cancers

(2019) Christopher J. D. Wallis et al.   JAMA Oncology

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

Trial watch: dietary interventions for cancer therapy

(2019) Sarah Lévesque et al.   OncoImmunology

Trial watch: dendritic cell vaccination for cancer immunotherapy

(2019) Jenny Sprooten et al.   OncoImmunology

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer

(2018) Matthew D. Hellmann et al.   CANCER CELL

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

(2018) Leanne M. Redman et al.   Cell Metabolism

Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

(2018) Shetal A. Patel et al.   IMMUNITY

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma

(2018) Alexander M.M. Eggermont et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

(2018) Leena Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

(2018) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Combining Immune Checkpoint Inhibitors With Conventional Cancer Therapy

(2018) Yiyi Yan et al.   Frontiers in Immunology

Tumor mutational burden is a determinant of immune-mediated survival in breast cancer

(2018) Alexandra Thomas et al.   OncoImmunology

Preclinical evaluation of a MAGE-A3 vaccination utilizing the oncolytic Maraba virus currently in first-in-human trials

(2018) Jonathan G. Pol et al.   OncoImmunology

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

(2018) Jonathan G. Pol et al.   OncoImmunology

Systemic autophagy in the therapeutic response to anthracycline-based chemotherapy

(2018) Francesca Castoldi et al.   OncoImmunology

Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance

(2017) Norma Bloy et al.   IMMUNOLOGICAL REVIEWS

Chemotherapy oxaliplatin sensitizes prostate cancer to immune checkpoint blockade therapies via stimulating tumor immunogenicity

(2017) Jin Zhou et al.   Molecular Medicine Reports

Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications

(2017) Mariona Cabo et al.   OncoImmunology

Trial Watch: Adoptively transferred cells for anticancer immunotherapy

(2017) Carole Fournier et al.   OncoImmunology

Trial watch: DNA-based vaccines for oncological indications

(2017) Stefano Pierini et al.   OncoImmunology

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Trial watch: Immune checkpoint blockers for cancer therapy

(2017) Claire Vanpouille-Box et al.   OncoImmunology

Pro-necrotic molecules impact local immunosurveillance in human breast cancer

(2017) Gautier Stoll et al.   OncoImmunology

PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma

(2017) Jan Budczies et al.   OncoImmunology

Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential

(2017) Priya Balasubramanian et al.   EBioMedicine

Autophagy induction for the treatment of cancer

(2016) Federico Pietrocola et al.   Autophagy

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Natural and therapy-induced immunosurveillance in breast cancer

(2015) Guido Kroemer et al.   NATURE MEDICINE

Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

(2015) Laila Noli et al.   Stem Cell Reports

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

(2015) Kirsten Ridder et al.   OncoImmunology

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

The anticancer immune response: indispensable for therapeutic success?

(2008) Laurence Zitvogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH