Review
Cell Biology
Faith M. Joseph, Nicolas L. Young
Summary: Post-translational modifications (PTMs) of histones play a key role in DNA-based processes and contribute to cell differentiation and gene function by adding an extra layer of regulation. Variations in histone sequences within each family of histones expand the chromatin repertoire and provide further mechanisms for regulation and signaling. However, much remains unknown about variant-specific PTMs and their role in regulating chromatin due to limited technologies and appropriate reagents.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Food Science & Technology
Aurelie Etier, Fabien Dumetz, Sylvain Chereau, Nadia Ponts
Summary: Studies have shown that histone post-translational modifications play a crucial role in biological processes of fungi, particularly in regulating primary and secondary metabolisms of filamentous fungi.
Review
Biochemistry & Molecular Biology
Ivana Samarzija
Summary: The specific functional form of a protein is mostly achieved through dynamic interactions of many enzymes in post-translational modifications, which cells widely use to respond to stimuli, regulate transcription, and maintain proteostasis. Post-translational modifications play important roles in driving prostate cancer, particularly in regulating protein activity at the level of post-translational modifications.
Review
Biochemistry & Molecular Biology
Nikita Shepelev, Olga Dontsova, Maria Rubtsova
Summary: Telomere length is associated with cell proliferative potential and is maintained by telomerase. Telomerase is activated during cellular division and plays a crucial role in processes like regeneration, immune response, embryonic development, and cancer progression. Understanding the regulatory mechanisms of telomerase biogenesis and activity is important for manipulating telomerase and influencing these processes. This review focuses on the molecular mechanisms involved in telomerase regulation and the role of post-transcriptional and post-translational modifications in telomerase biogenesis and function in yeast and vertebrates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Vincenzo Cavalieri
Summary: The emergence of a nucleosome-based chromatin structure during the evolutionary transition from prokaryotes to eukaryotes plays a crucial role in adaptive responses to environmental influence through epigenetic mechanisms involving histones. The overwhelming number of post-translational modifications at multiple residues of histones and their implications in nucleosome dynamics and chromatin processes are discussed in this review.
Review
Biochemistry & Molecular Biology
Dongha Kim, Hye Jin Nam, Sung Hee Baek
Summary: Lysine-specific demethylase 1 (LSD1) plays a crucial role in regulating gene expression through its catalytic activity and interactions with various protein partners. The function of LSD1 is tightly regulated by diverse post-translational modifications (PTMs). This review provides a comprehensive understanding of the regulation and function of LSD1 following various PTMs and discusses the therapeutic implications of targeting these modifications for human diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Review
Immunology
Yingying Lin, Ting Qiu, Guifeng Wei, Yueyue Que, Wenxin Wang, Yichao Kong, Tian Xie, Xiabin Chen
Summary: Inflammation is a defensive reaction to external stimuli in the human body and is associated with various diseases. Histone modifications play a significant role in the regulation of inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose-Luis Garcia-Gimenez, Concepcion Garces, Carlos Roma-Mateo, Federico Pallardo
Summary: Epigenetic regulation of gene expression plays a crucial role in cellular response to environmental changes, but cellular imbalance can lead to pathological conditions. Oxidative stress and free radicals can influence histone modifications, affecting gene expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Microbiology
Yiman Li, Zhihui Song, Ente Wang, Liming Dong, Jie Bai, Dong Wang, Jinyan Zhu, Chao Zhang
Summary: Invasive aspergillosis is a significant cause of death in patients with hematological malignancies and transplant recipients. Antifungal drug resistance has become a concern in managing infections, and understanding histone posttranslational modifications may provide insights for developing new antifungal drugs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Sony Shrestha, Amuza Byaruhanga Lucky, Awtum Marie Brashear, Xiaolian Li, Liwang Cui, Jun Miao
Summary: This study profiled the histone post-translational modifications (PTMs) in the development of Plasmodium falciparum gametocytes, revealing novel PTM sites and distinct patterns from asexual stages. The results suggest that these PTMs play critical roles in gametocyte development and provide insights into the epigenetic regulation in the life cycle of the malaria parasite.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Multidisciplinary Sciences
Rafael Fogaca de Almeida, Matheus Fernandes, Lyris Martins Franco de Godoy
Summary: Histone post-translational modifications (hPTMs) are abundant and varied in Trypanosoma cruzi, indicating potential conserved epigenetic functions. The comprehensive map of hPTMs provided by this study can serve as a basis for further research on epigenetic mechanisms and the development of epigenetic drugs against trypanosomatids.
Review
Oncology
Chiara Mazziotta, Carmen Lanzillotti, Roberta Gafa, Antoine Touze, Marie-Alice Durand, Fernanda Martini, John Charles Rotondo
Summary: This article reviews the recent progress in understanding the etiology and treatment of Merkel Cell Carcinoma (MCC), focusing on the role of histone post-translational modifications (PTMs) and their potential as diagnostic and therapeutic markers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bethany C. Taylor, Nicolas L. Young
Summary: Histone post-translational modifications (PTMs) play a crucial role in regulating the genome by storing and transmitting complex signals about the genome state. Different PTM sites on the same histone molecule or nucleosome work in concert, supported by 'readers' structures, to transduce signals in specific cellular contexts.
BIOCHEMICAL JOURNAL
(2021)
Review
Immunology
You-Wei Wang, Jia-Chen Zuo, Chong Chen, Xiao-Hong Li
Summary: Post-translational modifications (PTMs) covalently attach functional groups to proteins, leading to structural and functional changes. PTMs play a significant role in regulating liver cancer development and the immune response against cancer. Immunotherapies that harness the immune system's potential have shown promise in improving cancer patient prognosis and survival. This review provides a comprehensive summary of key PTMs and their potential targets to enhance immunotherapies against liver cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yunhua Peng, Huadong Liu, Jiankang Liu, Jiangang Long
Summary: Mitochondria play a crucial role in the initiation and development of tumor cells, with metabolic proteins serving as key mediators in tumorigenesis. Understanding mitochondria-related post-translational modifications is important for the future of cancer treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Muthukrishnan Eaaswarkhanth, Ajai K. Pathak, Linda Ongaro, Francesco Montinaro, Prashantha Hebbar, Osama Alsmadi, Mait Metspalu, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Summary: Recent research has shown the diverse genetic architecture of consanguineous populations in the Arabian Peninsula, with high genetic heterogeneity observed among Kuwaiti subgroups. The analysis of genome-wide SNP data from Kuwaiti individuals reveals a varied genetic history among the populations, with distinct sources of ancestry including sub-Saharan/Western Africa and West Eurasia. This study provides insights into the fine-scale population structure and genetic heterogeneity in the region, offering clues for disease-gene discovery in Arabian Peninsula populations.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Oncology
Gary Wildey, Ashley M. Shay, Karen S. McColl, Suzy Yoon, Mohammad A. Shatat, Ahmad Perwez, Kyle B. Spainhower, Adam M. Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati
Summary: Genomic studies have found that some small cell lung cancer (SCLC) tumors do not have RB1 mutations, contrary to the canonical model. This study examined RB1 protein expression and its function in SCLC and found that 14% of SCLC tumors expressed abundant RB1 protein, which was associated with neuroendocrine gene expression and enriched in YAP1 expression. SCLC cells with RB1 protein expression were sensitive to growth inhibition by the CDK4/6 inhibitor palbociclib, and a patient with wild-type RB1 SCLC showed a significant decrease in mutant TP53 ctDNA allelic fraction and tumor mass after treatment with the CDK4/6 inhibitor abemaciclib.
MOLECULAR CANCER THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Abdulmohsen Alterki, Mohamed Abu-Farha, Eman Al Shawaf, Fahd Al-Mulla, Jehad Abubaker
Summary: Obstructive sleep apnoea (OSA) is a prevalent but underdiagnosed disorder that disrupts the circadian rhythm and is characterized by frequent interruptions in breathing during sleep, leading to systemic consequences. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases, and it is also linked to obesity. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation, and metabolic dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ashraf Al Madhoun, Shihab Kochumon, Dania Haddad, Reeby Thomas, Rasheeba Nizam, Lavina Miranda, Sardar Sindhu, Milad S. Bitar, Rasheed Ahmad, Fahd Al-Mulla
Summary: Obesity is associated with chronic low-grade inflammation. Obese individuals have higher levels of CAV1 protein in adipose tissues. This study found a positive correlation between CAV1 gene expression and TNF-a. and NF -KB gene expression in obese adipose tissues.
Article
Biochemistry & Molecular Biology
Nadeem Akhter, Ajit Wilson, Hossein Arefanian, Reeby Thomas, Shihab Kochumon, Fatema Al-Rashed, Mohamed Abu-Farha, Ashraf Al-Madhoun, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Summary: Obesity and metabolic syndrome are associated with metabolic inflammation, endotoxin, and free fatty acids. The study found that the interaction between metabolic stress and endoplasmic reticulum (ER) stress promotes inflammation and triggers TNF-alpha production through the ROS/CHOP/HIF-1 alpha and MAPK/NF-kappa B pathways. Antioxidants show therapeutic potential in inflammatory conditions involving metabolic/ER stresses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Anwar Mohammad, Eman Alshawaf, Hossein Arefanian, Sulaiman K. Marafie, Abbas Khan, Dong-Qing Wei, Fahd Al-Mulla, Jehad Abubaker
Summary: In this study, natural medicinal compounds were investigated as potential inhibitors of SARS-CoV-2-NSP3 macrodomain-I. Computational modeling and simulation tools were used to explore the structural dynamics and binding affinity of the compounds. Two significant hits were identified, with strong binding affinity and inhibitory potential. The findings provide a basis for novel drug development against SARS-CoV-2 and its variants.
Article
Multidisciplinary Sciences
Ali Vaziri-Gohar, Jonathan J. Hue, Ata Abbas, Hallie J. Graor, Omid Hajihassani, Mehrdad Zarei, George Titomihelakis, John Feczko, Moeez Rathore, Sylwia Chelstowska, Alexander W. Loftus, Rui Wang, Mahsa Zarei, Maryam Goudarzi, Renliang Zhang, Belinda Willard, Li Zhang, Adam Kresak, Joseph E. Willis, Gi-Ming Wang, Curtis Tatsuoka, Joseph M. Salvino, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Jonathan R. Brody, Jordan M. Winter
Summary: The response to chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC) can be improved by hyperglycemia, which disrupts redox metabolism.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Rashed Alhammad, Mohamed Abu-Farha, Abdur Rahman, Thangavel Alphonse Thanaraj, Lemia Shaban, Reem Alsabah, Samar Hamad, Maha M. Hammad, Arshad Channanath, Fahd Al-Mulla, Jehad Abubaker
Summary: This study investigated the association between LRG1 and iron deficiency anemia markers in school-aged children. High LRG1 levels were observed in anemic children compared to non-anemic children. Significant correlations were found between LRG1 and various markers including Hb, albumin, iron, and RDW. This research provides valuable insights into the relationship between LRG1 and iron deficiency anemia in children.
Article
Cell Biology
Mohamed Abu-Farha, Dhanya Madhu, Prashantha Hebbar, Anwar Mohammad, Arshad Channanath, Sina Kavalakatt, Nada Alam-Eldin, Fatima Alterki, Ibrahim Taher, Osama Alsmadi, Mohammad Shehab, Hossein Arefanian, Rasheed Ahmad, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Jehad Abubaker
Summary: The ANGPTL8 R59W variant is associated with increased levels of TNF alpha, IL7, and NF-kappa B p65 activity. The weak transient binding of the ANGPTL8 R59W variant explains its regulatory role on the NF-kappa B pathway and inflammation.
Review
Cell Biology
Sulaiman K. Marafie, Fahd Al-Mulla
Summary: Post-translational modifications are crucial for regulating human diseases, and furin, a type of irreversible post-translational modifier, plays a role in the context of type 2 diabetes and the mTOR signaling pathway. Understanding the role of furin in diabetes and exploring its genetic variants is important for future therapeutic interventions.
Article
Biochemistry & Molecular Biology
Mohamed Abu-Farha, Shibu Joseph, Anwar Mohammad, Arshad Channanath, Ibrahim Taher, Fahd Al-Mulla, Muhammad Mujammami, Thangavel Alphonse Thanaraj, Jehad Abubaker, Anas M. Abdel Rahman
Summary: This study used metabolomics to investigate the impact of the ANGPTL8 R59W variant on metabolites in Arab individuals. The results showed significant associations between the variant and concentrations of lipid- and inflammation-related metabolites, highlighting the importance of this gene in lipid metabolism.
Article
Biochemistry & Molecular Biology
Zhi Liu, Aleksandar Krstic, Ashish Neve, Cristina Casalou, Nora Rauch, Kieran Wynne, Hilary Cassidy, Amanda McCann, Emma Kavanagh, Brendan McCann, Alfonso Blanco, Jens Rauch, Walter Kolch
Summary: KSR1 plays a critical role in mutant BRAF transformation, and its loss results in impaired cell proliferation and migration, cell cycle abnormalities, cellular senescence, and apoptosis. The study reveals that KSR1 directs ERK to phosphorylate substrates essential for cell survival, and its loss activates p38 MAPK pathway leading to cell cycle aberrations and senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Cell Biology
N. K. Aboud, L. Garcia-Gutierrez, W. Kolch, D. Matallanas
MOLECULAR BIOLOGY OF THE CELL
(2023)
Meeting Abstract
Cell Biology
N. K. Aboud, L. Garcia-Gutierrez, W. Kolch, D. Matallanas
MOLECULAR BIOLOGY OF THE CELL
(2023)
Article
Biochemistry & Molecular Biology
Hana Th. Almajed, Mohamed Abu-Farha, Eman Alshawaf, Sriraman Devarajan, Zahra Alsairafi, Ashraf Elhelaly, Preethi Cherian, Irina Al-Khairi, Hamad Ali, Rose Mol Jose, Thangavel Alphonse Thanaraj, Ebaa Al-Ozairi, Fahd Al-Mulla, Abdulnabi Al Attar, Jehad Abubaker
Summary: This study found a significant increase in circulating ANGPTL8 levels in patients with diabetic nephropathy (DN), and the levels of ANGPTL8 were positively correlated with IGFBP-4 levels. This suggests a potential role of both ANGPTL8 and IGFBP-4 in the pathophysiology of DN. These findings highlight the significance of these biomarkers and suggest them as promising diagnostic molecules for the detection of DN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)