期刊
FRONTIERS IN NEUROLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2019.00894
关键词
LINE-1; HERV; retrotransposition; CNS; inflammation; reverse transcriptase inhibitors
资金
- National Institutes of Health [R01MH094753]
- California Institute for Regenerative Medicine (CIRM) [DISC1-08825]
- NARSAD Young Investigator grant [25400]
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-understood. Indeed, retrotransposons have evaded evolutionary attempts at repression and may contribute to somatic mosaicism. Retrotransposons are emerging as potent regulatory elements within the human genome. In the diseased state, there is mounting evidence that endogenous retroelements play a role in etiopathogenesis of inflammatory diseases, with a disposition for both autoimmune and neurological disorders. We postulate that active mobile genetic elements contribute more to human disease pathogenesis than previously thought.
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