Review
Nutrition & Dietetics
Vincenzo Garofalo, Rosita A. Condorelli, Rossella Cannarella, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This systematic review and meta-analysis examines the relationship between iron deficiency and thyroid function. The analysis reveals that patients with iron deficiency have lower thyroid hormone levels, especially in pregnant women. It also shows that iron deficiency increases the prevalence of thyroid autoantibodies.
Review
Endocrinology & Metabolism
Vicente A. Benites-Zapata, Felipe L. Ignacio-Cconchoy, Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Percy Herrera-Anazco
Summary: This study reviewed existing studies to assess differences in serum vitamin B12 levels among patients with and without thyroid disorders (TD), frequency of vitamin B12 deficiency, and presence of anti-parietal cell antibodies in TD patients. Results showed that patients with hypothyroidism had lower vitamin B12 levels compared to healthy participants, while no significant differences were observed in patients with hyperthyroidism, autoimmune thyroid disease (AITD), or subclinical hypothyroidism (SH). The frequencies of vitamin B12 deficiency were 27%, 6%, 27%, and 18% for hypothyroidism, hyperthyroidism, SH, and AITD respectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Lin Zhou, Kang Song, Wei Luo
Summary: This study aimed to evaluate the association between resistin levels and thyroid dysfunction and explore the variations in resistin levels before and after treatment. The results confirmed that resistin levels were significantly higher in patients with thyroid dysfunction compared to euthyroid controls. After treatment, resistin levels decreased significantly in patients with thyroid dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yi-jing Liu, Hai-bing Miao, Shu Lin, Zhen Chen
Summary: Patients with rheumatoid arthritis (RA) have an increased risk of thyroid dysfunction, especially hypothyroidism. Routine examination of thyroid function in RA patients should be strengthened, and larger prospective studies are needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Nipith Charoenngam, Thanitsara Rittiphairoj, Ben Ponvilawan, Klaorat Prasongdee
Summary: This systematic review and meta-analysis found a significant association between both hypothyroidism and hyperthyroidism and an increased risk of Parkinson's disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Freddy J. K. Toloza, Arash Derakhshan, Tuija Mannisto, Sofie Bliddal, Polina Popova, David M. Carty, Liangmiao Chen, Peter Taylor, Lorena Mosso, Emily Oken, Eila Suvanto, Sachiko Itoh, Reiko Kishi, Judit Bassols, Juha Auvinen, Abel Lopez-Bermejo, Suzanne J. Brown, Laura Boucai, Aya Hisada, Jun Yoshinaga, Ekaterina Shilova, Elena N. Grineva, Tanja G. M. Vrijkotte, Jordi Sunyer, Ana Jimenez-Zabala, Isolina Riano-Galan, Maria-Jose Lopez-Espinosa, Larry J. Prokop, Naykky Singh Ospina, Juan P. Brito, Rene Rodriguez-Gutierrez, Erik K. Alexander, Layal Chaker, Elizabeth N. Pearce, Robin P. Peeters, Ulla Feldt-Rasmussen, Monica Guxens, Leda Chatzi, Christian Delles, Jeanine E. Roeters van Lennep, Victor J. M. Pop, Xuemian Lu, John P. Walsh, Scott M. Nelson, Tim I. M. Korevaar, Spyridoula Maraka
Summary: This study examined the association between abnormalities in thyroid function tests and the risk of gestational hypertension and pre-eclampsia. The results showed that subclinical hypothyroidism was associated with a higher risk of pre-eclampsia, and there was a U-shaped association between thyroid-stimulating hormone (TSH) and pre-eclampsia. Other thyroid function test abnormalities were not significantly associated with gestational hypertension or pre-eclampsia.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Yunmeng Wang, Chaowei Ding, Chang Guo, Jingru Wang, Suyun Liu
Summary: This study comprehensively investigated the association between thyroid dysfunction and venous thromboembolism (VTE), and found that patients with thyroid dysfunction are at an increased risk of VTE.
Review
Endocrinology & Metabolism
Nydia Burgos, Freddy J. K. Toloza, Naykky M. Singh Ospina, Juan P. Brito, Ramzi G. Salloum, Leslie C. Hassett, Spyridoula Maraka
Summary: Low-quality evidence suggests that up to a third of patients remained euthyroid after thyroid hormone discontinuation, with a higher proportion of patients with an initial diagnosis of SCH remaining euthyroid than patients with an initial diagnosis of OH. A deprescribing framework focusing on adequate selection of patients for deprescribing LT4 and a systematic process is warranted to guide clinicians in re-evaluating the need for LT4 in their patients.
Review
Obstetrics & Gynecology
Yuko Hasegawa, Yoshikazu Kitahara, Satoko Osuka, Yumiko Tsukui, Mio Kobayashi, Akira Iwase
Summary: This meta-analysis investigates the impact of hypothyroidism and thyroid autoimmunity (TAI) on ovarian reserve. The findings suggest that TAI and hypothyroidism may affect ovarian reserve, with opposite effects on the anti-Mullerian hormone (AMH) levels depending on age.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Review
Psychiatry
Henry Bode, Beatrice Ivens, Tom Bschor, Guido Schwarzer, Jonathan Henssler, Christopher Baethge
Summary: Recent systematic review and meta-analysis found a modest association between hypothyroidism and clinical depression, possibly limited to overt hypothyroidism and female individuals.
Review
Geriatrics & Gerontology
Li-Yun Ma, Bing Zhao, Ya-Nan Ou, Dan-Dan Zhang, Qiong-Yao Li, Lan Tan
Summary: This study conducted a meta-analysis of 15 studies and found that hyperthyroidism and subclinical hyperthyroidism might be associated with an increased risk of dementia, while hypothyroidism and subclinical hypothyroidism did not affect the risk.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Clinical Neurology
A. Salehipour, M. Dolatshahi, M. Haghshomar, Jay Amin
Summary: Imbalances in thyroid hormones have been associated with Alzheimer's disease, but the exact role of thyroid dysfunction in the disease is still unclear. Through a systematic review and meta-analysis, this study found a higher prevalence of hypothyroidism in Alzheimer's disease. Further longitudinal analysis is needed to determine whether hypothyroidism is a risk factor or consequence of Alzheimer's disease.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Review
Surgery
Carmil Azran, Nirvana Hanhan-Shamshoum, Tujan Irshied, Tomer Ben-Shushan, Dror Dicker, Arik Dahan, Ilan Matok
Summary: Bariatric surgery is associated with decreased TSH levels and levothyroxine dose, as well as the resolution of subclinical hypothyroidism.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Review
Endocrinology & Metabolism
Carol Chiung-Hui Peng, Huei-Kai Huang, Brian Bo-Chang Wu, Rachel Huai-En Chang, Yu-Kang Tu, Kashif M. Munir
Summary: The impact of thyroid hormone therapy on mortality in adults with subclinical hypothyroidism is inconclusive, with no significant association overall but potential benefits in younger adults.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Immunology
Yu-tian Cao, Kai-yu Zhang, Jing Sun, Yan Lou, Tian-su Lv, Xinyi Yang, Wen-hui Zhang, Jiang-yi Yu, Qi-biao Wu, Xi-qiao Zhou
Summary: Platelet index abnormalities are present in patients with autoimmune thyroid disease (AITD), with increased platelet count (PLT) and mean platelet volume (MPV) in AITD patients compared to healthy controls. However, no significant difference was found in platelet distribution width (PDW). The differences in PLT were mainly observed in Hashimoto's thyroiditis (HT) and hypothyroid groups, while the differences in MPV were mainly observed in Graves' disease (GD) and hyperthyroid groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Bin Wang, Xi Jia, Qiuming Yao, Qian Li, Weiwei He, Ling Li, Ronghua Jing, Jing Zhang, Jin-an Zhang
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Qiuming Yao, Xiaofei An, Jing Zhang, Kaida Mu, Ling Li, Ronghua Song, Peilong Sun, Jin-an Zhang
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Ni Yan, Kaida Mu, Xiao-fei An, Ling Li, Qiu Qin, Rong-hua Song, Qiu-ming Yao, Xiao-qing Shao, Jin-an Zhang
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Rong-Hua Song, Bin Wang, Qiu-Ming Yao, Qian Li, Xi Jia, Jin-An Zhang
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Endocrinology & Metabolism
Bin Wang, Weiwei He, Qian Li, Xi Jia, Qiuming Yao, Ronghua Song, Qiu Qin, Jin-an Zhang
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Jian Xu, Bin Wang, Qian Li, Qiuming Yao, Xi Jia, Ronghua Song, Jin-an Zhang
HORMONE AND METABOLIC RESEARCH
(2019)
Review
Immunology
Rong-hua Song, Qiu-ming Yao, Bin Wang, Qian Li, Xi Jia, Jin-an Zhang
AUTOIMMUNITY REVIEWS
(2019)
Article
Immunology
Yanfei Jiang, Xudong Mao, Ronghua Song, Kaida Mu, Yanping Yang, Jin-An Zhang
Summary: The study found that the SNP rs3778638 in the PSORS1C1 gene is associated with susceptibility to Graves' disease, but not with Hashimoto's thyroiditis. Additionally, no linkage disequilibrium was observed for the other three SNPs in PSORS1C1 among patients with AITD and controls.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Immunology
Qiu Qin, Ronghua Song, Peng Du, Chaoqun Gao, Qiuming Yao, Jin-An Zhang
Summary: The study identified exosomal candidate proteins in the pathogenesis of Rheumatoid Arthritis (RA) among which 32 were upregulated and 5 were downregulated. These proteins interacted with each other and were mainly involved in inflammatory-related pathways, suggesting their role in mediating the onset of RA.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Cell Biology
Xi Jia, Tian-Yu Zhai, Bing Wang, Jin-An Zhang, Rong-Hua Song
Summary: The TCR repertoire in patients with autoimmune thyroid diseases (AITDs) is expanded and has many upregulated TRBV genes. The differences in TCR profiles become more pronounced in patients with refractory Graves' disease (RGD) as the disease progresses.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Immunology
Wen Wang, Zheng-yao Yu, Rong-hua Song, Shuang-tao He, Liang-feng Shi, Jin-an Zhang
Summary: This study explores the association between ATG5 gene polymorphisms and AITDs, specifically HT and GD. The research finds that allele A frequency of rs6568431 and allele G frequency of rs6937876 are significantly higher in AITDs patients, while the G allele frequency of rs6937876 is significantly higher in GD patients with ophthalmopathy. This study reveals the association between ATG5 gene and AITDs for the first time.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Rong-Hua Song, Jing Zhao, Chao-Qun Gao, Qiu Qin, Jin-An Zhang
Summary: This study investigated the association between ALKBH5 gene polymorphisms and autoimmune thyroid disease (AITD), focusing on the variants rs9913266 and rs12936694 which showed significant differences in AITD and Graves' disease. Moreover, the minor allele of rs9913266 was found to be associated with the risk of female AITD and Hashimoto's thyroiditis development. Additionally, haplotypes CGACA and CAGCG were significantly correlated with susceptibility to AITD and Graves' disease.
ADVANCES IN MEDICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Rong-hua Song, Xue-rong Liu, Chao-qun Gao, Peng Du, Jin-an Zhang
Summary: The study did not find a significant correlation between METTL3 genotypes at seven SNPs and AITD development among both GD and HT patients, except for a borderline association between rs3752411 and GD under certain conditions. Subgroup analysis showed that certain SNPs had higher minor allele frequencies in male AITD patients compared to healthy volunteers, while the genotype distribution of another SNP was significantly different between the groups. Multivariate logistic regression analyses revealed a significant correlation between specific allele frequencies and GD in male patients, indicating a potential role of METTL3 as a candidate gene for AITD treatment.
Article
Immunology
Weiwei He, Bin Wang, Qian Li, Qiuming Yao, Xi Jia, Ronghua Song, Sheli Li, Jin-an Zhang
FRONTIERS IN IMMUNOLOGY
(2019)