Article
Multidisciplinary Sciences
Ruisheng Song, Kevin Struhl
Summary: The study reveals that the calcium-dependent cytokines S100A8 and S100A9 can act as transcriptional coactivators in breast cellular transformation, enhancing oncogenic transcription and promoting the transformation phenotype.
Article
Cardiac & Cardiovascular Systems
Lifeng Feng, Guangru Li, Jiale An, Chang Liu, Xiaolong Zhu, Yang Xu, Yang Gao, Jing Li, Jie Liu, Jie Yan, Yachen Wang, Jiling Ren, Liang Yang, Zhi Qi
Summary: This study found that ET can increase MDSCs by stimulating the secretion of IL-10 from macrophages, thereby achieving the role of heart protection. This effect is mediated through the IL-10/STAT3/S100A9 signaling pathway to regulate the differentiation of MDSCs.
CIRCULATION-HEART FAILURE
(2022)
Article
Chemistry, Multidisciplinary
Antonella Russo, Hendrik Schuermann, Matthias Brandt, Katja Scholz, Anna Livia L. Matos, David Grill, Julian Revenstorff, Max Rembrink, Meike von Wulffen, Lena Fischer-Riepe, Peter J. Hanley, Hans Haecker, Monika Pruenster, Francisco Sanchez-Madrid, Sven Hermann, Luisa Klotz, Volker Gerke, Timo Betz, Thomas Vogl, Johannes Roth
Summary: It has been demonstrated that S100A8/S100A9 tetramers can weaken the inflammatory response of leukocytes in vitro and in vivo, and this is mediated by the interaction between S100A8/S100A9 tetramers and CD69, rather than the binding of S100A8/S100A9 dimers to TLR4. These findings reveal the important role of the quaternary structure of S100 proteins in regulating leukocyte inflammatory responses.
Article
Biochemistry & Molecular Biology
Marc Wolf, Robiya Joseph, Judith Austermann, Chiara Scharrnbeck-Davis, Sven Hermann, Johannes Roth, Thomas Vogl
Summary: Immune reactions involve the migration of phagocytes to sites of inflammation to prevent uncontrolled extravasation. The calcium-binding protein complex S100A8/S100A9 has both extracellular and intracellular functions, and this study reveals that it plays an important role in coordinating cytoskeleton rearrangement during cell migration. Cells lacking S100A8/S100A9 showed abnormalities in adhesion and motility, as well as dysregulated integrin-mediated adhesion and migration. The findings suggest that intracellular S100A8/S100A9 is involved in a regulatory mechanism that controls the transition between quiescent and activated states of phagocytes.
Article
Multidisciplinary Sciences
Tatsuaki Mizutani, Toshiaki Ano, Yuya Tsuruyama, Satoshi Mizuta, Keiko Takemoto, Yuki Ouchi, Daisuke Morita, Satsuki Kitano, Hitoshi Miyachi, Tatsuaki Tsuruyama, Nagatoshi Fujiwara, Masahiko Sugita
Summary: Mycobacterium infection leads to the formation of granulomas composed mainly of inflammatory M1-like macrophages, with bacteria-permissive M2 macrophages also present. In guinea pigs, S100A9-expressing neutrophils were found to border a unique M2 niche within the granulomas. Further studies in guinea pigs and mice revealed that S100A9 and COX-2 signaling play a critical role in M2 polarization, with S100A9 interacting with C/EBP beta to activate the Cox-2 promoter and promote prostaglandin E2 production.
Article
Medicine, Research & Experimental
Feng Gao, Qiaoping Xu, Zhe Tang, Nan Zhang, Yasheng Huang, Zhongyi Li, Yuliang Dai, Qiqi Yu, Jingyu Zhu
Summary: This study identified a S100A9/circMID1/miR-506-3p/MID1 axis in MDSC-Exo-regulated CRPC progression, providing new insights into the regulatory mechanisms of MDSC-Exo in CRPC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Quang Luu Quoc, Youngwoo Choi, Tra Cao Thi Bich, Eun-Mi Yang, Yoo Seob Shin, Hae-Sim Park
Summary: S100A9 is a potential serum biomarker and therapeutic target for neutrophilic asthma. Patients with neutrophilic asthma had higher levels of S100A9 protein in their blood, which could be used as a potential biomarker and therapeutic target.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Xitao Zhang, Tianlai Liu, Jinlin Huang, Jianping He
Summary: This study revealed that PICALM promotes CRC progression through the ERK/MAPK signaling pathway, highlighting its potential as a therapeutic target in clinical applications.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Panpan Liu, Cong Peng, Xiang Chen, Lisha Wu, Mingzhu Yin, Jie Li, Qunshi Qin, Yehong Kuang, Wu Zhu
Summary: The study found that increased numbers of myeloid-derived suppressor cells (MDSCs) are involved in the development of psoriasis. Acitretin, a treatment for psoriasis, was shown to reduce the number of MDSCs and promote their differentiation into macrophages and dendritic cells. This effect was mediated by acitretin's regulation of glutathione synthesis and activation of extracellular signal-regulated kinase 1/2.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Patrycja Przygodzka, Ewelina Sochacka, Kamila Soboska, Marcin Pacholczyk, Izabela Papiewska-Pajak, Tomasz Przygodzki, Przemyslaw Plocinski, Steven Ballet, An De Prins, Joanna Boncela
Summary: The study found elevated expression of NMU and NMUR2 in CRC tissue samples and variable expression in CRC cell lines. It was shown for the first time that NMUR2 activation induces signaling in CRC cells, and NMU increases motility and invasiveness in NMUR2-positive CRC cells, as well as promoting prometastatic integrin receptor subunit expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Wanying Zhang, Xiangzhi Fang, Chenggang Gao, Chaoying Song, Yajun He, Ting Zhou, Xiaobo Yang, You Shang, Jiqian Xu
Summary: Sepsis is a life-threatening condition resulting from an uncontrolled host response to infection. Myeloid-derived suppressor cells (MDSCs), which consist of pathologically activated neutrophils and monocytes, play an important role in inhibiting innate and adaptive immune responses. This review explores the characteristics and suppressive mechanisms of MDSCs, and discusses their potential applications as biomarkers and targets for clinical treatment of sepsis.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Medicine, Research & Experimental
Md Abdus Subhan, Vladimir P. Torchilin
Summary: This review elucidates the dual function of neutrophils in cancer treatment, highlighting their potential for drug delivery and targeting in pre-clinical models.
Article
Endocrinology & Metabolism
Qiuyun Guo, Qianshan Ding
Summary: This study found that glabridin (GLA) inhibits the malignant phenotypes of colorectal cancer (CRC) cells by regulating the ICAM1/p-STAT3 signaling pathway, including cell proliferation, migration, and invasion. ICAM1 was identified as a downstream target of GLA, and GLA suppressed the expression levels of ICAM1 and p-STAT3. Overexpression of ICAM1 reversed the effects of GLA on CRC cell phenotypes.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Monika Pruenster, Roland Immler, Jonas Roth, Tim Kuchler, Thomas Bromberger, Matteo Napoli, Katrin Nussbaumer, Ina Rohwedder, Lou Martha Wackerbarth, Chiara Piantoni, Konstantin Hennis, Diana Fink, Sebastian Kallabis, Tobias Schroll, Sergi Masgrau-Alsina, Agnes Budke, Wang Liu, Dietmar Vestweber, Christian Wahl-Schott, Johannes Roth, Felix Meissner, Markus Moser, Thomas Vogl, Veit Hornung, Petr Broz, Markus Sperandio
Summary: This study elucidates the mechanisms of S100A8/S100A9 release from neutrophils, revealing that E-selectin regulates the release of S100A8/S100A9 through NLRP3 and gasdermin D. This process serves as a rapid and reversible activation system that plays a crucial role in inflammation.
Review
Biochemistry & Molecular Biology
Yu Chen, Yuzhen Ouyang, Zhixin Li, Xiufang Wang, Jian Ma
Summary: S100A8 and S100A9, as Ca2+ binding proteins in the S100 family, have crucial roles in modulating inflammatory responses and inflammation-associated diseases. They participate in multiple signaling pathways in tumor cells and contribute to tumor development, growth, and metastasis. Moreover, they have shown potential as diagnostic or prognostic biomarkers in cancer and have become therapeutic targets. This review focuses on the characteristics of S100A8/A9, S100A9, and S100A8, their interactions with tumor cells and microenvironments, and their clinical applications as biomarkers and therapeutic targets.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Medicine, Research & Experimental
Jing Shi, Pu Li, Lijin Zhou, Suwen Qi, Bo Wang, Dandan Li, Liang Duan, Wei Xian Chen, Jirong Xia, Lin Zou, Shuangshuang Yang
BIOMARKERS IN MEDICINE
(2019)
Article
Oncology
He Zha, Xueru Li, Hui Sun, Liang Duan, Shimei Yuan, Huan Li, Aifang Li, Yue Gu, Jiali Zhao, Jiaqing Xie, Lan Zhou
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Article
Oncology
Yuanyuan Ye, Jun Yang, Qin Hu, Jinju Mao, Qianfan Yang, Hong Chen, Dandan Li, Pu Li, Liang Duan, Bo Wang, Juan Chen, Weixian Chen
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Shue Li, Mao Huang, Qiao Liu, Ding Wang, Rui Wu, Xiuyu Zhang, Weixian Chen, Liang Duan
Article
Immunology
Qin Hu, Feifei Zhang, Liang Duan, Bo Wang, Yuanyuan Ye, Pu Li, Dandan Li, Shengjun Yang, Lan Zhou, Weixian Chen
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Shu Chen, Qin Hu, Hong Chen, Fei-Fei Zhang, Liang Duan, Bo Wang, Dan-Dan Li, Juan Zhang, Wei-Xian Chen
Article
Medicine, Research & Experimental
Rui Wu, Yan Liu, Ruyu Yan, Xiaoyu Liu, Liang Duan
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Yingwen Liu, Jing Shi, Bo Wang, Lijing Zhou, Xiaolan Zhou, Yane Du, Dandan Li, Liang Duan, Qin Hu, Weixian Chen, Pu Li
Summary: The combination of procalcitonin (PCT) and calcitonin (CT) with other rheumatoid arthritis (RA)-related biomarkers can significantly improve the diagnostic efficiency of early RA, especially in terms of sensitivity.
Article
Microbiology
Pu Li, Jing Shi, Lijing Zhou, Bo Wang, Li Jun Zhang, Liang Duan, Qin Hu, Xiaolan Zhou, Yuan Yuan, Dandan Li, Hong Chen, Qing Zhao, Xuemei Peng, Weixian Chen
Summary: Gasdermin D (GSDMD) plays a crucial role in pyroptosis and has multiple physiological functions. This study demonstrated that GSDMD can be a highly accurate biomarker for diagnosing pleural effusion (PE) and can effectively differentiate between different types of PE, with the highest diagnostic value seen in tuberculosis cases. The combination of GSDMD with other markers can further enhance diagnostic efficiency and predict therapeutic effects, with GSDMD primarily expressed and secreted by nucleated cells in PE.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Lijun Hu, Yan Liu, Xuehua Kong, Rui Wu, Qi Peng, Yan Zhang, Lan Zhou, Liang Duan
Summary: The research found that Fusobacterium nucleatum infection is closely associated with the development of colorectal cancer, primarily by promoting the polarization of M2 macrophages to exacerbate tumor malignancy. S100A9 is a key signaling molecule that regulates the activation of M2 macrophages. Targeting the TLR4/NF-kappa B/S100A9 cascade may serve as a promising therapeutic strategy for Fusobacterium nucleatum-associated colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ding Wang, Xi Zhan, Rui Wu, Yan You, Weixian Chen, Liang Duan
Summary: Liver cirrhosis patients exhibited increased levels of circulating GSDMD, IL-1 beta and IL-18, all of which were positively correlated with disease severity. The identified circulating IL-1 beta and GSDMD exhibited potentials as novel biomarkers for liver cirrhosis patients presenting with SBP.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Xiuyu Zhang, Yan You, Qiao Liu, Xiaoyu Sun, Weixian Chen, Liang Duan
Summary: This study investigated the role of soluble receptor for advanced glycation end-products (sRAGE) in chronic hepatitis B (CHB), and found that reduced levels of serum sRAGE may be associated with increased severity of necroinflammation. The study also found that the combination of sRAGE and ALT had better predictive power for hepatic necroinflammation than either biomarker alone.
Article
Cell Biology
Yan Liu, Xuehua Kong, Yan You, Linwei Xiang, Yan Zhang, Rui Wu, Lan Zhou, Liang Duan
Summary: This study found that S100A8 mediates NLRP3 inflammasome-dependent pyroptosis in macrophages through TLR4/NF-kappa B activation and ROS production, facilitating liver fibrosis progression. Additionally, circulating GSDMD may serve as a potential biomarker for liver fibrosis evaluation.
Article
Oncology
Xi Zhan, Rui Wu, Xue-Hua Kong, Yan You, Kun He, Xiao-Yu Sun, Yong Huang, Wei-Xian Chen, Liang Duan
Summary: This study investigates the role of neutrophil extracellular traps (NETs) in HBV-related hepatocarcinogenesis and their clinical significance. The researchers found that HBV infection correlated with elevated levels of NETs in HCC patients. They also identified the mechanism by which HBV induces NETs formation through the RAGE/TLR4-ROS signaling pathway. NETs were found to facilitate the growth and metastasis of HCC, and circulating NETs showed potential as a biomarker for predicting extrahepatic metastasis in HBV-related HCC.
CANCER COMMUNICATIONS
(2023)