Article
Immunology
Odalys Blanco, Wendy Ramirez, Yuliannis Lugones, Elaine Diaz, Alain Morejon, Valentin S. Rodriguez, Wilma Alfonso, Alexis Labrada
Summary: Surfacen® exhibited favorable bronchodilation and anti-inflammatory, anti-allergic effects in a murine allergen-induced acute asthma model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
William P. Pederson, Jaime M. Cyphert-Daly, Robert M. Tighe, Loretta G. Que, Julie G. Ledford
Summary: The study suggests that expression of a glutamine (Q) at position 223 in SP-A2 is more protective than lysine (K) in acute exposures to ozone. SP-A2 223Q variant mice showed lower levels of inflammation markers post-O3 exposure, indicating a reduced impact on respiratory diseases.
Article
Immunology
Miao-Hsi Hsieh, Pei-Chi Chen, Han-Yin Hsu, Jui-Chang Liu, Yu-Sheng Ho, Yuh Jyh Lin, Chin-Wei Kuo, Wen-Shuo Kuo, Hui-Fang Kao, Shulhn-Der Wang, Zhi-Gang Liu, Lawrence Shih-Hsin Wu, Jiu-Yao Wang
Summary: Increased levels of SP-D and FMs are found in oxidative stress conditions and/or COPD patients. Our study reveals the crucial roles of SP-D in airway inflammation and emphysematous changes, and shows that rfhSP-D can reverse these changes.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Benjamin Hoffmann-Petersen, Raymond Suffolk, Jens J. H. Petersen, Thomas H. Petersen, Charlotte Brasch-Andersen, Arne Host, Susanne Halken, Grith L. Sorensen, Lone Agertoft
Summary: This study found no association between serum surfactant protein D levels, common SP-D gene variants, and asthma in Danish adolescents and young adults with mild to moderate asthma. Serum surfactant protein D did not show value as a clinical biomarker for asthma.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Letter
Medicine, General & Internal
Brian J. Lipworth, Rory Chan, Kirsten E. Stewart
Summary: In the MANDALA trial, Papi et al. showed that high-dose budesonide-albuterol is superior to albuterol as reliever therapy for reducing exacerbations in patients with uncontrolled moderate-to-severe asthma.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Critical Care Medicine
Paul M. O'Byrne, J. Mark FitzGerald, Eric D. Bateman, Peter J. Barnes, Jinping Zheng, Per Gustafson, Rosa Lamarca, Margareta Puu, Christina Keen, Vijay K. T. Alagappan, Helen K. Reddel
Summary: In patients with mild asthma, as-needed budesonide-formoterol reduces the short-term risk of severe exacerbations after a single day of higher use. The use of an anti-inflammatory reliever may reduce the risk of short-term severe exacerbations by providing increased doses of inhaled corticosteroids and formoterol when symptoms occur.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Paul E. Pfeffer, Ian S. Mudway, Jonathan Grigg
Summary: There is global concern about the harmful impact of polluted air on respiratory health of asthma patients. Despite multiple epidemiologic studies showing ongoing associations, inconsistent findings suggest a need for experimental studies to clarify the mechanistic basis of the effects of ambient pollution on the lungs.
Article
Immunology
Qiqi Wang, Qiong Wang, Ziyue Zhao, Jingbo Fan, Linghan Qin, David B. Alexander, Hiroyuki Tsuda, Dahai Zhao, Jiegou Xu
Summary: Alveolar macrophages are responsible for clearing airborne dust and pathogens. The study found that surfactant proteins can enhance phagocytosis of various nanomaterials by alveolar macrophages, and increase cytokine production. Surfactant proteins opsonize nanomaterials through the CD14 receptor, serving as a common pathway for their phagocytosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Fanny Edit Maria Goth, Birgitte Johanne Schmidt, Klaus Juul, Per Albertsen, Lone Agertoft, Inger Merete Jorgensen
Summary: The purpose of this cohort study is to investigate the relationship between the risk of developing asthma-like symptoms and asthma in childhood and genetics, environmental exposures, prenatal and early postnatal events. The cohort includes 1,500 women and their babies born at Nordsjaellands Hospital in Denmark from 2013 to 2014. Published data from the cohort has found an association between respiratory symptoms and neonatal FeNO, as well as different risk factors for preterm and term born infants. Future plans include ongoing examinations and data collection until the age of 18.
Article
Engineering, Environmental
Yunxian Liu, Bing Wang, Dan Zhao, Wenhui Jin, Feng Xu, Yujia Gao, Wen Shi, Hongyang Ren
Summary: This study investigates the effect of surfactants on the behavior of ozone bubbles in water and their impact on ozone mass transfer efficiency. It was found that the addition of surfactants influenced the size, shape, and trajectory of ozone bubbles. Different surfactants had varying effects on ozone mass transfer, with nonionic and anionic surfactants inhibiting ozone mass transfer, while low concentrations of a cationic surfactant enhanced it. The study also observed changes in gas-liquid interface area and liquid phase mass transfer coefficient due to the addition of surfactants.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Immunology
Dave Francisco, Ying Wang, Craig Marshall, Michelle Conway, Kenneth J. Addison, Dean Billheimer, Hiroki Kimura, Mari Numata, Hong W. Chu, Dennis R. Voelker, Monica Kraft, Julie G. Ledford
Summary: Surfactant Protein-A (SP-A) is an innate immune modulator that regulates various pulmonary host defense functions. Dysfunctional SP-A is found in asthma, which may be linked to genetic heterogeneity. SP-A 223Q offers better protection against inflammation and mucin production compared to SP-A 223K, and individuals with two copies of the major 223Q allele experience improved lung function and asthma control. Short peptides of SP-A2 retain anti-inflammatory properties similar to the endogenous protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xue-feng Shi, Xiang He, Ze-rui Sun, Jian-xiang Wang, Yu-hai Gu, You-bang Xie, Jie Duo
Summary: This study identifies distinct miRNA signatures in Tibetan COPD patients that could be used as diagnostic biomarkers or describe differential molecular mechanisms. Functional analysis of the target genes of differentially expressed miRNAs showed their influence on cell morphogenesis and signaling pathways. Age, plasma miRNA, and SP-D mRNA expression were found to be correlated with COPD risk factors.
SCIENTIFIC REPORTS
(2022)
Review
Environmental Sciences
Shilu Tong, Yong Yin, Yixiao Bao
Summary: Asthma, affecting over 300 million people globally, is a significant burden, leading to premature death and reduced quality of life. Environmental changes are believed to be the main cause of the rising trend of asthma and other allergic diseases. Therefore, environmental modification plays a crucial role in the treatment and management of asthma, and further research and efforts are needed in this emerging field.
ENVIRONMENTAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Hanna Sikorska-Szaflik, Joanna Polomska, Barbara Sozanska
Summary: This article discusses the increasing prevalence of asthma and obesity in the pediatric population, and highlights the worse symptoms and treatment response in obese children with asthma. The shared genetic and immunologic origin of asthma and obesity is suggested. Diet plays a crucial role in controlling both diseases.
Article
Medical Laboratory Technology
Lucia Salvioni, Filippo Testa, Adela Sulejmani, Francesca Pepe, Pietro Giorgio Lovaglio, Paolo Berta, Roberto Dominici, Valerio Leoni, Davide Prosperi, Giorgio Vittadini, Miriam Colombo, Luisa Fiandra
Summary: SP-D can serve as a predictive biomarker for COVID-19 disease and its outcome. Elevated plasma levels of SP-D are associated with disease severity and mortality. Monitoring SP-D levels in hospitalized patients can guide therapeutic interventions.
CLINICA CHIMICA ACTA
(2022)