Review
Immunology
Yiwen Liu, Yan Gong, Gaosi Xu
Summary: Although the multiple hits theory is widely accepted in IgA nephropathy, increasing evidence suggests that the mononuclear/macrophage system plays important roles in disease progression, but the exact mechanism is unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Chloe M. Doyle, Erica E. Vine, Kirstie M. Bertram, Heeva Baharlou, Jake W. Rhodes, Suat Dervish, Martijn P. Gosselink, Angelina Di Re, Geoffrey P. Collins, Faizur Reza, James W. T. Toh, Nimalan Pathma-Nathan, Golo Ahlenstiel, Grahame Ctercteko, Anthony L. Cunningham, Andrew N. Harman, Scott N. Byrne
Summary: This study discusses the importance of isolating and analyzing mononuclear phagocytes from fresh human tissue to understand their role in the immune system and diseases. The challenges of freeing these cells from tissue, including susceptibility to enzymatic cleavage and cell death, as well as immunological activation/maturation during the extraction process, are highlighted. The methods for anatomical separation of mucosa and submucosa, enzyme digestion optimization, and antibody clone selection for flow cytometry analysis are described, along with the ability to sort functional, immature intestinal dendritic cells for further functional assays.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Enrique Olguin-Martinez, Blanca E. Ruiz-Medina, Paula Licona-Limon
Summary: Innate lymphoid cells (ILCs) are a newly described subgroup of lymphoid cells, showing heterogeneity similar to different groups of T cells. Different types of ILCs have distinct functions in different tissues and express different markers. Among them, ILC2s respond to stimuli like parasites and regulate immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Duan-Rui Qiao, Guan-Yue Shan, Shuai Wang, Jun-Ya Cheng, Wei-Qun Yan, Hai-Jun Li
Summary: This article outlines the impact of hepatocellular carcinoma (HCC) on the mononuclear phagocyte system (MPS). It elaborates on how HCC reshapes MPS cell phenotype and the production of associated cytokines, as well as characterizes the function and impairment of the MPS in HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Dorothee Brech, Anna S. Herbstritt, Sarah Diederich, Tobias Straub, Evangelos Kokolakis, Martin Irmler, Johannes Beckers, Florian A. Buettner, Elke Schaeffeler, Stefan Winter, Matthias Schwab, Peter J. Nelson, Elfriede Noessner
Summary: Phagocytes play important roles in tissue repair and immune activation, but they may also have immunosuppressive effects in the tumor microenvironment. A specific cell type in colon cancer, with a polarization state reflecting tissue signals and patient prognosis, has been identified and could serve as a therapeutic target for immunotherapy.
Article
Cell Biology
Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
Summary: This study reveals that aging enhances atherosclerosis through the increased inflammation of visceral fat. The transplantation of aged fat onto the carotid artery of mice resulted in larger atherosclerotic plaques with increased macrophage numbers. Inflammatory factors secreted by adipose tissue macrophages, including TNF alpha, CXCL2, and CCL2, were found to contribute to the enhancement of atherosclerosis in aging fat transplants.
Article
Microbiology
Jose J. Rivera Rivas, Charles J. Czuprynski
Summary: Histophilus somni is a Gram-negative coccobacillus that causes diffuse vasculitis and intravascular thrombosis in cattle. Our study demonstrates that exposure to H. somni cells causes monocyte-derived macrophages to release microparticles with pro-coagulant activity, potentially amplifying thrombus formation.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Kipyo Kim, Yun-Gyeong Kim, Su Woong Jung, Yang Gyun Kim, Sang-Ho Lee, Seung-Hae Kwon, Ju-Young Moon
Summary: This study utilized optical tissue clearing combined with multiphoton microscopy and light sheet fluorescence microscopy to evaluate and visualize the morphological and functional alterations of renal mononuclear phagocytes (MNPs) in acute kidney injury (AKI). The findings showed that CD11c+ cells increased in number and underwent morphological changes in AKI, accompanied by increased expression of MHC class II and CD86 on CD11c-YFP+ cells. The NLRP3 inhibitor MCC950 attenuated the activation of CD11c+ cells and improved renal function in AKI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Steven P. Cass, Olivia Mekhael, Danya Thayaparan, Joshua J. C. McGrath, Spencer D. Revill, Matthew F. Fantauzzi, Peiyao Wang, Amir Reihani, Aaron Hayat, Christopher S. Stevenson, Anna Dvorkin-Gheva, Fernando M. Botelho, Martin R. Stampfli, Kjetil Ask
Summary: Cigarette smoke exposure altered the composition of pulmonary macrophages by expanding CD11b(+) subpopulations. These compositional changes were associated with attenuated fibrogenesis, as well as predominant M1 polarization and decreased fibrotic activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hillard M. Lazarus, Katherine Pitts, Tisha Wang, Elinor Lee, Elizabeth Buchbinder, Michael Dougan, David G. Armstrong, Robert Paine, Carolyn E. Ragsdale, Timothy Boyd, Edwin P. Rock, Robert Peter Gale
Summary: Endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) supports the differentiation and metabolism of mononuclear phagocytes. Recombinant human GM-CSF has immune modulating properties and can restore the normal function of dysfunctional mononuclear phagocytes caused by deficient endogenous GM-CSF.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Matthew Stephens, Shan Liao, Pierre-Yves von der Weid
Summary: The location of TLR4 and the type of bacterial-derived LPS play a key role in the activation of macrophages. Different bacterial species signal to macrophages through different pathways, allowing the cells to distinguish between bacteria and initiate specialized immune responses using TLR4.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Kandasamy Rajamanickam, Venkatasubramanian Leela, Gopalakrishnan Suganya, Sabiha Hayath Basha, Manoharan Parthiban, Pasuvalingam Visha, Ayyasamy Elango
Summary: This study aimed to investigate the molecular and functional responses of bovine monocyte-derived macrophages to thermal and lipopolysaccharide-induced stress. The results showed that the combined stimulation of heat and lipopolysaccharide led to increased apoptosis, reduced mitochondrial membrane potential and cell viability, decreased oxidative and phagocytosis ability, as well as dysregulation of gene expressions related to heat shock, cell signaling, and inflammation.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lauren B. Rodda, Jason Netland, Laila Shehata, Kurt B. Pruner, Peter A. Morawski, Christopher D. Thouvenel, Kennidy K. Takehara, Julie Eggenberger, Emily A. Hemann, Hayley R. Waterman, Mitchell L. Fahning, Yu Chen, Malika Hale, Jennifer Rathe, Caleb Stokes, Samuel Wrenn, Brooke Fiala, Lauren Carter, Jessica A. Hamerman, Neil P. King, Michael Gale, Daniel J. Campbell, David J. Rawlings, Marion Pepper
Summary: The study found that individuals recovered from mild COVID-19 develop sustained SARS-CoV-2-specific immunological memory for at least 3 months, including immunoglobulin antibodies, neutralizing plasma, and memory B and T cells. These memory lymphocytes exhibit potent antiviral function, aiding in immune defense.
Article
Biochemistry & Molecular Biology
Manuel Azaid Ordaz-Arias, Laura Diaz-Alvarez, Joaquin Zuniga, Mariana Esther Martinez-Sanchez, Yalbi Itzel Balderas-Martinez
Summary: This study proposes a regulatory network of cytokines, signaling pathways, and transcription factors to investigate the differentiation, heterogeneity, and plasticity of macrophages. It shows that the network structure can lead to oscillations and that the environment plays a role in macrophage differentiation and plasticity. This provides mechanistic insights into the heterogeneity and plasticity of macrophages in vivo and in vitro.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Cheoljun Choi, Abhirup Saha, Seungchan An, Yoon Keun Cho, Heeseong Kim, Minsoo Noh, Yun-Hee Lee
Summary: This study found that during obesity, increased expression of Cx43 in macrophages promotes inflammatory responses in adipose tissue. Knocking out Cx43 in macrophages can reduce inflammatory responses in adipose tissue and improve glucose tolerance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
S. Langton, J. A. Rijken, C. R. Bankhead, A. Pluddemann, C. R. Leemans
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2019)
Review
Geriatrics & Gerontology
Oghenekome A. Gbinigie, Jose M. Ordonez-Mena, Thomas Fanshawe, Annette Pluddemann, Carl J. Heneghan
Article
Public, Environmental & Occupational Health
Nav Persaud, Maggie Jiang, Roha Shaikh, Anjli Bali, Efosa Oronsaye, Hannah Woods, Gregory Drozdzal, Yathavan Rajakulasingam, Darshanand Maraj, Sapna Wadhawan, Norman Umali, Ri Wang, Marcy McCall, Jeffrey K. Aronson, Annette Pluddemann, Lorenzo Moja, Nicola Magrini, Carl Heneghan
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2019)
Review
Ophthalmology
Colm D. Andrews, Russell G. Foster, Lona Alexander, Sridhar Vasudevan, Susan M. Downes, Carl Heneghan, Annette Pluddemann
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2019)
Review
Multidisciplinary Sciences
Giorgio Cacciatore, Alessandro Ugolini, Chiarella Sforza, Oghenekome Gbinigie, Annette Pluddemann
Review
Oncology
Siamon Gordon, Annette Pluddemann, Subhankar Mukhopadhyay
JOURNAL OF PATHOLOGY
(2020)
Review
Dentistry, Oral Surgery & Medicine
S. Langton, G. C. S. Cousin, A. Pluddemann, C. R. Bankhead
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2020)
Review
Nursing
Samuel Boudreault, Junqiao Chen, Kevin Y. Wu, Annette Pluddemann, Carl Heneghan
JOURNAL OF CLINICAL NURSING
(2020)
Review
Public, Environmental & Occupational Health
Elena C. Rosca, Carl Heneghan, Elizabeth A. Spencer, Jon Brassey, Annette Pluddemann, Igho J. Onakpoya, David H. Evans, John M. Conly, Tom Jefferson
Summary: The review aimed to evaluate data on SARS-CoV-2 transmission aboard aircraft, highlighting the potential spread during air travel. Findings from 18 studies suggest the virus can be transmitted during flights, but the variation in study design and methodology hinders conclusive assessment. Standardized guidelines for future research are needed to facilitate comparison of results across studies.
JOURNAL OF TRAVEL MEDICINE
(2021)
Review
Infectious Diseases
Tom Jefferson, Elizabeth A. Spencer, Jon Brassey, Igho J. Onakpoya, Elena C. Rosca, Annette Pluddemann, David H. Evans, John M. Conly, Carl J. Heneghan
Summary: Studies have shown highly variable transmission rates, indicating the potential for SARS-CoV-2 transmission from pre-symptomatic and asymptomatic individuals.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Annette Pluddemann, Jeffrey K. Aronson, Igho Onakpoya, Carl Heneghan, Kamal R. Mahtani
BMJ EVIDENCE-BASED MEDICINE
(2018)
Article
Medicine, General & Internal
Jeffrey K. Aronson, Carl Heneghan, Kamal R. Mahtani, Annette Pluddemann
BMJ EVIDENCE-BASED MEDICINE
(2018)
Article
Medicine, General & Internal
Jack W. O'Sullivan, Amitava Banerjee, Carl Heneghan, Annette Pluddemann
BMJ EVIDENCE-BASED MEDICINE
(2018)
Article
Medicine, General & Internal
David Nunan, Jack O'Sullivan, Carl Heneghan, Annette Pluddemann, Jeffrey Aronson, Kamal Mahtani
BMJ EVIDENCE-BASED MEDICINE
(2018)
