Review
Cell Biology
Tanya J. Lupancu, Mahtab Eivazitork, John A. Hamilton, Adrian A. Achuthan, Kevin M-C Lee
Summary: CCL17 is a chemokine that is upregulated in autoimmune and inflammatory diseases, as well as cancer. It acts as a chemoattractant for T cells through its interaction with CCR4, and may also play a role in other cell types. This review summarizes the biology of CCL17, its regulation, and its potential involvement in disease pathogenesis.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Microbiology
Aparna Jorapur, Lisa A. Marshall, Scott Jacobson, Mengshu Xu, Sachie Marubayashi, Mikhail Zibinsky, Dennis X. Hu, Omar Robles, Jeffrey J. Jackson, Valentin Baloche, Pierre Busson, David Wustrow, Dirk G. Brockstedt, Oezcan Talay, Paul D. Kassner, Gene Cutler
Summary: The Epstein-Barr Virus (EBV) is involved in the development of various types of cancers. EBV+ tumors can recruit immunosuppressive regulatory T cells and express high levels of chemokines CCL17 and CCL22. The expression of these chemokines can come from both tumor cells and infiltrating immune cells. A recently discovered small molecule antagonist of CCR4 can effectively block T-reg migration, which may provide a potential treatment for EBV+ tumors.
Article
Cardiac & Cardiovascular Systems
Guoshuai Feng, Geetika Bajpai, Pan Ma, Andrew Koenig, Andrea Bredemeyer, Inessa Lokshina, Lulu Lai, Irmgard Foerster, Florian Leuschner, Daniel Kreisel, Kory J. Lavine
Summary: This study identified CCL17 as a proinflammatory mediator in CCR2(+) macrophages and dendritic cells, and suggested that inhibiting CCL17 could promote Treg recruitment and suppress myocardial inflammation.
Article
Biochemistry & Molecular Biology
Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Baerbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M. Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jaeck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff
Summary: This study finds that Irf4(-/-) mice are prone to developing BCP-ALL, and further investigates the impaired differentiation but enhanced proliferation of Irf4(-/-) preB-I cells, possibly due to Jak3 mutations.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Immunology
Qiaoyun Wu, Yujun Zheng, Jiaying Yu, Xinwang Ying, Xiaoxue Gu, Qianqian Tan, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li, Songhe Jiang
Summary: Neuropathic pain, a common clinical disease, is difficult to be cured with drugs. The response of spinal microglia, including the regulation of PD-L1, plays a critical role in the occurrence and progression of pain. Electroacupuncture has a significant analgesic effect, but its specific mechanism remains to be explored. This study verified the role of PD-L1 in electroacupuncture analgesia and the underlying molecular mechanism through rat models and BV2 microglial cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Hematology
Leonie Frauenfeld, Natalia Castrejon-de-Anta, Joan Enric Ramis-Zaldivar, Sebastian Streich, Julia Salmeron-Villalobos, Franziska Otto, Annika Katharina Mayer, Julia Steinhilber, Magda Pinyol, Barbara Mankel, Colleen Ramsower, Irina Bonzheim, Falko Fend, Lisa M. Rimsza, Itziar Salaverria, Elias Campo, Olga Balague, Leticia Quintanilla-Martinez
Summary: Genetic characterization of DLBCL-AE revealed its heterogeneity and enrichment in cases with IRF4 alterations. DLBCL-IRF4 in adults showed similarities to the pediatric counterpart.
Review
Cell Biology
Yanlei Zhang, Quanbo Ji
Summary: Knee osteoarthritis (KOA) is a common degenerative disease in the elderly, causing chronic joint pain and physical impairment. There is currently a lack of effective interventions, making explorations of new treatments necessary. Photobiomodulation therapy (PBMT) is a drug-free, non-invasive, and safe intervention that enhances cellular activity and promotes tissue regeneration. This paper provides an overview of the effectiveness of PBMT in clinical settings, as well as the modulatory effects and potential mechanisms in addressing synovitis, cartilage degeneration, and pain resolution.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Sarah L. Cook, Evelyn P. Sievert, Roger Sciammas
Summary: The transcription factor IRF4 is essential for the selection of high-affinity GCBs, with halving Irf4 gene copy number leading to impaired generation of high-affinity cells. This study highlights the continuous role of IRF4 in later phases of the B cell response, promoting productive T follicular helper cell interactions and optimal Blimp-1 expression during GC selection and affinity maturation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
T. Hautz, S. Salcher, M. Fodor, G. Sturm, S. Ebner, A. Mair, M. Trebo, G. Untergasser, S. Sopper, B. Cardini, A. Martowicz, J. Hofmann, S. Daum, M. Kalb, T. Resch, F. Krendl, A. Weissenbacher, G. Otarashvili, P. Obrist, B. Zelger, D. Oefner, Z. Trajanoski, J. Troppmair, R. Oberhuber, A. Pircher, D. Wolf, S. Schneeberger
Summary: This study comprehensively characterized the immune cell population and their dynamic changes during liver NMP. It was found that neutrophils decreased significantly during NMP, while anti-inflammatory/tolerogenic monocytes/macrophages increased. The findings may contribute to future immune-interventional studies.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Conelius Ngwa, Abdullah Al Mamun, Yan Xu, Romana Sharmeen, Fudong Liu
Summary: The study found that IRAK4 forms a Myddosome with MyD88/IRF5/IRF4 and phosphorylates both IRFs, leading to their translocation into the nucleus. Inhibiting IRAK4 phosphorylation primarily suppresses microglial pro-inflammatory response, and improves neuronal viability and neurite lengths after ischemia.
Article
Endocrinology & Metabolism
Luisa Hueso, Patrice Marques, Brenda Morant, Herminia Gonzalez-Navarro, Joaquin Ortega, Jose T. Real, Maria J. Sanz, Laura Piqueras
Summary: This study aimed to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in morbid obesity. The circulating levels of CCL17 and CCL22 were found to be elevated in morbidly obese patients and positively correlated with BMI and HOMA-IR Index. Inhibition of CCR4 function reduced leucocyte adhesiveness and activation of the ERK1/2 pathway. These findings suggest that pharmacological modulation of the CCR4 axis could be a potential therapeutic approach for preventing adipose tissue dysfunction in obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Rebecca Metzger, Lis Winter, Nassim Bouznad, Debora Garzetti, Benedikt von Armansperg, Matjaz Rokavec, Konstantin Lutz, Yvonne Schafer, Sabrina Krebs, Elena Winheim, Verena Friedrich, Dana Matzek, Rupert Oellinger, Roland Rad, Barbel Stecher, Heiko Hermeking, Thomas Brocker, Anne B. Krug
Summary: CCL17 plays a significant role in the development of colorectal cancer by influencing the composition of the intestinal microbiome and reducing apoptosis during tumor initiation.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Damien Bertheloot, Eicke Latz, Bernardo S. Franklin
Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Xiao-Chuan Li, Shao-Jian Luo, Wu Fan, Tian-Li Zhou, Dan-Qin Tan, Rong-Xiong Tan, Qun-Ze Xian, Jian Li, Chun-Ming Huang, Mao-Sheng Wang
Summary: Macrophages play crucial roles in intervertebral disc degeneration, with different polarizations exerting diverse effects on nucleus pulposus cells, providing insights into potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jinsha Koroth, Erick O. Buko, Rebecca Abbott, Casey P. Johnson, Brenda M. Ogle, Laura S. Stone, Arin M. Ellingson, Elizabeth W. Bradley
Summary: This narrative review discusses the hallmarks of intervertebral disc degeneration, presents evidence of macrophage involvement during disc degeneration, and explores emerging research on the molecular pathways regulating macrophage functions during intervertebral disc degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)