Review
Pharmacology & Pharmacy
Jianglei Li, Meihong Yu, Shifeng Fu, Deliang Liu, Yuyong Tan
Summary: This review summarizes the research progress and underlying mechanism of ACY-1215 in cancer and other human diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Article
Biochemistry & Molecular Biology
Hye Sun Shin, Yuri Lee, Mi Hee Shin, Soo Ick Cho, Christos C. Zouboulis, Min Kyoung Kim, Dong Hun Lee, Jin Ho Chung
Summary: Proper regulation of histone acetylation is crucial for sebocyte lipogenesis, with inhibitors of p300 histone acetyltransferase leading to decreased expression of key lipogenic genes and decreased lipid droplet formation. In contrast, inhibition of histone deacetylase promotes lipogenesis by increasing the expression of these genes. These findings suggest a potential therapeutic strategy for skin diseases related to excess sebum production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuri Lee, Mi Hee Shin, Min-Kyoung Kim, Yeon Kyung Kim, Hye Sun Shin, Dong Hun Lee, Jin Ho Chung
Summary: The study found that the expression of HDAC4 and HDAC11 is universally decreased in UV-irradiated and intrinsically aged skin, suggesting a universal role in increased histone acetylation associated with skin aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agricultural Engineering
Xuefeng Lu, Tae Kyung Hyun
Summary: Post-translational histone modifications, such as histone acetylation, play key roles in regulating gene expression in plant growth, development, and stress responses. The research found that HDAC inhibitors led to hyperacetylation of histone H3, enhancing MeJA-induced ginsenoside production in ginseng adventitious roots. Additionally, the study identified specific PgHDACs that may serve as crucial factors in controlling MeJA-induced ginsenoside production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Medicinal
Yuqi Jiang, Jie Xu, Kairui Yue, Chao Huang, Mengting Qin, Dongyu Chi, Qixin Yu, Yue Zhu, Xiaohan Hou, Tongqiang Xu, Min Li, C. James Chou, Xiaoyang Li
Summary: The study focused on modifying HDAC inhibitors to deactivate the Michael reaction in order to improve their potency. Compound 11h showed significant improvements in both HDAC inhibitory activity and cell-based antitumor assay, demonstrating potential for clinical application and efficacy against AML.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Article
Health Care Sciences & Services
Nikolaos Garmpis, Christos Damaskos, Dimitrios Dimitroulis, Gregory Kouraklis, Anna Garmpi, Panagiotis Sarantis, Evangelos Koustas, Alexandros Patsouras, Iason Psilopatis, Efstathios A. Antoniou, Michail Karamouzis, Konstantinos Kontzoglou, Afroditi Nonni
Summary: This study found a relationship between HDAC-2 expression and clinical features and survival of breast cancer. Higher expression of HDAC-2 was correlated with the aggressiveness and poor prognosis of breast cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Obstetrics & Gynecology
Marina Ilicic, Tamas Zakar, Amy Gregson, Waleed M. Hussein, Roger Smith, Jonathan W. Paul
Summary: The article summarizes the crucial role of myometrial phenotypic transformation during pregnancy to facilitate childbirth, and the involvement of protein acetylation in this process. Studies show that histone deacetylase inhibitors have significant relaxation effects on pregnant human myometrium.
REPRODUCTIVE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Meran Keshawa Ediriweera
Summary: Histone acetylation is a crucial epigenetic event and continues to be an area of great interest in biochemical research. The balance between histone acetyltransferases (HATs) and histone deacetylases (HDACs) is disrupted in various human cancers. Histone deacetylase inhibitors (HDACi) have shown promising results in restoring dysregulated histone acetylation profiles and are considered as potential anti-cancer therapeutics. Recent studies have identified odd-chain fatty acids as novel HDACi, further expanding the understanding of fatty acids in cancer therapy.
DRUG DISCOVERY TODAY
(2023)
Article
Agriculture, Multidisciplinary
Javier A. . G. Vanegas, Horacio B. Pacule, Rebeca M. Capitao, Carlos R. . D. Correia, Willian C. Terra, Vicente P. Campos, Denilson F. Oliveira
Summary: The study found that esters of cinnamic acid can replace cinnamaldehyde with good nematicidal effects against Meloidogyne incognita, including activity against nematode eggs. Additionally, these esters may act against nematodes by inhibiting histone deacetylase.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jwa-Young Kim, Hae-Yong Kweon, Dae-Won Kim, Je-Yong Choi, Seong-Gon Kim
Summary: This study revealed that 4-hexylresorcinol is a novel class I HDAC inhibitor, reducing the expression and activity of HDAC in human umbilical endothelial cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Organic
Catalina Cortes-Guajardo, Francisca Rojas-Hernandez, Romina Paillao-Bustos, Marjorie Cepeda-Plaza
Summary: This article explores the role of the divalent metal ion in the mechanism of the 8-17 DNAzyme, confirming its function as a general acid through experimental verification. The study suggests that the hydrated metal ion stabilizes the 5’-O leaving group as a general acid, in addition to activating the 2’-OH nucleophile by the general base G14 in the catalytic mechanism of the enzyme.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbala Mifsud, Cameron S. Osborne
Summary: The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using transcriptomics, epigenomics, and machine learning.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Daniela Fera, Matthew S. Lee, Kevin Wiehe, R. Ryan Meyerhoff, Alessandro Piai, Mattia Bonsignori, Baptiste Aussedat, William E. Walkowicz, Therese Ton, Jeffrey O. Zhou, Samuel Danishefsky, Barton F. Haynes, Stephen C. Harrison
NATURE COMMUNICATIONS
(2018)