期刊
ACS INFECTIOUS DISEASES
卷 5, 期 10, 页码 1693-1697出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.9b00271
关键词
gallium nitrate; iron metabolism; Pseudomonas aeruginosa; metalloprotein; internalization pathway
资金
- National Natural Science Foundation of China [21671203, 21877131]
- Science and Technology Program of Guangzhou, China [201707010038]
- RGC of Hong Kong [17305415, 17333616]
- Ministry of Education of China [IRT-17R111]
- Fundamental Research Funds for the Central Universities
Gallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga3+ internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga3+ and Fe3+ occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga3+ internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据