Article
Biotechnology & Applied Microbiology
Marta Miola, Cristina Multari, Nina Kostevsek, Roberto Gerbaldo, Francesco Laviano, Enrica Verne
Summary: The aim of this study was to design new hybrid nanoplatforms through the eco-friendly use of tannic acid for biomedical applications. The results demonstrate that the synthesized nanoparticles possess both magnetic and plasmonic properties and are non-toxic.
Article
Chemistry, Multidisciplinary
E. A. K. Nivethaa, S. Dhanavel, V Narayanan, S. Narayana Kalkura, J. Sivasankari, N. Sivanandham, A. Stephen
Summary: The study successfully synthesized a CS/Au/MWCNT nanocomposite using the chemical reduction method for the effective delivery of the anticancer drug 5-Fluorouracil, achieving higher encapsulation efficiency and sustained release. Compared to the binary system, the ternary nanocomposite exhibited improved cytotoxicity and significant inhibition of breast cancer cells.
Article
Chemistry, Physical
Jaya R. Lakkakula, Rui Werner Macedo Krause, Deepika Divakaran, Sagar Barage, Rohit Srivastava
Summary: The circulation time and solubility of 5-Fluorouracil have been prolonged and increased by complexing it with cyclodextrin and conjugating it onto gold nanoparticles to form 5Fu ICAu. The 5Fu-ICAu system showed higher cell inhibition rate on breast cancer cell lines due to the enhanced EPR effect allowing selective accumulation of nanoparticles at tumor sites.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
Maryam Amirishoar, Shokoofeh Noori, Javad Mohammadnejad, Masoumeh Rajabi Bazl, Asghar Narmani
Summary: In this study, folic acid-functionalized PLGA nanocomposites were developed and showed potential for photothermal therapy (PTT) and photodynamic therapy (PDT) of breast cancer cells MCF-7 using near-infrared irradiation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biophysics
Gautier Laurent, Chahrazad Benbalit, Claire Chretien, Constantin Dupuis, Yann Pellequer, Rana Bazzi, Vivek Sudam Thakare, Franck Denat, Stephane Roux, Arnaud Beduneau
Summary: Encapsulation of gold nanoparticles in polymeric nanoparticles can avoid rapid renal clearance, prolong vascular residence time, and promote passive uptake in cancer cells. This encapsulation method does not alter the contrast agent properties of the gold nanoparticles, paving the way for innovative imaging-guided anticancer therapies in personalized medicine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Bahram Yavari, Seyyed Shamsadin Athari, Yadollah Omidi, Akram Jalali, Rezvan Najafi
Summary: EpCAM aptamer-activated nanoparticles were synthesized to enhance treatment efficiency in colorectal cancer. The nanoparticles showed superior cytotoxicity in vitro and effectively inhibited tumor growth in vivo without causing significant side effects.
JOURNAL OF DRUG TARGETING
(2023)
Article
Nanoscience & Nanotechnology
Agnieszka Pasciak, Aleksandra Pilch-Wrobel, Lukasz Marciniak, P. James Schuck, Artur Bednarkiewicz
Summary: Localized photothermal therapy is a promising method for combating cancer and enhancing other treatment modalities, but there is currently no consensus on how to accurately compare the light-to-heat conversion efficiency of different nanomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Susana Barbosa Ribeiro, Aurigena Antunes de Araujo, Maisie Mitchele Barbosa Oliveira, Alaine Maria dos Santos Silva, Arnobio Antonio da Silva-Junior, Gerlane Coelho Bernardo Guerra, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao, Raimundo Fernandes de Araujo Junior, Vinicius Barreto Garcia, Roseane Carvalho Vasconcelos, Caroline Addison Carvalho Xavier de Medeiros
Summary: Oral mucositis, characterized by severe ulcers in the oral region from chemotherapy, lacks effective therapy. Dexamethasone-loaded nanoparticles showed therapeutic effects in a hamster model, reducing inflammation, oxidative stress, and modulating gene expression.
Article
Engineering, Environmental
Xiaodong He, Gnanasekar Sathishkumar, Kasi Gopinath, Kai Zhang, Zhisong Lu, Changming Li, En-Tang Kang, Liqun Xu
Summary: This study developed a novel biomaterial for medical devices with excellent antibacterial and antifouling properties, providing an effective strategy to combat medical device-associated infections.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Xiaowei Yang, Qi Lai, Xinmin Yang, Banglin Xie, Bin Zhang, Xiaoyong Zhang, Yen Wei
Summary: Metformin (MET) is an oral hypoglycemic agent with wide therapeutic effects. Nanoparticulate drug delivery systems are used to overcome the limitations of MET and widely applied in the biomedical field.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Materials Science, Ceramics
Marta Miola, Cristina Multari, Doriana Debellis, Francesco Laviano, Roberto Gerbaldo, Enrica Verne
Summary: Nanomedicine has attracted significant attention in recent years, particularly focusing on the unique properties of magnetic and gold nanoparticles in theranostic applications. This study developed magneto-plasmonic heterodimers by combining MNPs and GNPs, investigating the effects of different synthesis parameters on their magnetic and optical responses. The results showed that the shape and dimensions of the nanocomposites can be tailored, making them potential candidates for cancer theranostics.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Lisa Schlichter, Florian Bosse, Bonnie J. J. Tyler, Heinrich F. F. Arlinghaus, Bart Jan Ravoo
Summary: Nanoparticles with unique properties are patterned onto unmodified silicon substrates using dip pen nanolithography. Different types of nanoparticles can be used for writing nanostructures, including hydrophilic citrate and cyclodextrin functionalized gold nanoparticles and poly(acrylic) acid decorated magnetite nanoparticles. The deposition process is fast and can be done within 0.1 s. The resulting feature sizes range from 300 to 1780 nm and the heights of the deposited structures correspond to a single or double layer of nanoparticles. Dip pen nanolithography offers a versatile method for patterning nanoparticles on silicon substrates.
Article
Physics, Multidisciplinary
Juan C. Cruz-Rodriguez, Miguel A. Camacho-Lopez, Eugenio Torres-Garcia, Liliana Aranda-Lara, Enrique Morales-Avila, Luis E. Diaz-Sanchez, Nallely P. Jimenez-Mancilla, Keila Isaac-Olive
Summary: The aim of this study was to evaluate whether irradiation of 5 nm spherical gold nanoparticles (AuNP and AuNPf) with a Nd:YAG pulsed laser at different wavelengths produces reactive oxygen species (ROS) and sufficient heat to induce cytotoxicity, and to investigate the influence of functionalization. It was confirmed that AuNP and AuNPf in solution induced ROS formation and produced a moderate increase in the temperature of the surrounding medium. Irradiation of T47D cells in the presence of AuNP significantly decreased cell viability at 532 nm, while irradiation at 1064 nm without AuNPs resulted in high cytotoxicity. Due to the solvent in the suspension, the cell toxicity caused by AuNPf could not be assessed.
Article
Multidisciplinary Sciences
Ahsan Ali, Asadullah Madni, Hassan Shah, Talha Jamshaid, Nasrullah Jan, Safiullah Khan, Muhammad Muzamil Khan, Muhammad Ahmad Mahmood
Summary: The present study aimed to prepare solid lipid-based nanoparticles (SLNs) using Precirol((R)) ATO 5 as solid lipid and Poloxamer 188 and Tween 80 as surfactant and co-surfactant respectively, and SLNs-derived gel for sustained delivery, enhanced in-vitro cytotoxicity, enhanced cellular uptake of 5-FU and enhanced permeation of 5-FU across the skin. The 5-FU-loaded SLNs had desirable particle size, encapsulation efficiency, and showed enhanced cytotoxic effect, cellular uptake, and skin permeation compared to free 5-FU drug solution and plain gel.
Review
Chemistry, Multidisciplinary
Song Shen, Jichuan Qiu, Da Huo, Younan Xia
Summary: Photothermal therapy shows great potential in killing cancer cells through hyperthermia. The efficacy is affected by various parameters, including the laser, photothermal transducers, spatial distribution of the transducers, bioeffect of the tissue (heat-sink effect, thermal conductivity), and real-time temperature monitoring.
Review
Engineering, Environmental
Huiyue Wang, Zhao Jin, Xin Hu, Qiao Jin, Songwei Tan, Ali Reza Mahdavian, Ning Zhu, Kai Guo
Summary: By combining microreactor and cation pool method or carbocation stabilization, improved living cationic polymerizations can be achieved under mild conditions. This review highlights cationic addition polymerizations of vinyl monomers and cationic ring-opening polymerizations of cyclic monomers in the context of microreactor-based flow chemistry, proposing challenges and opportunities to promote the development of cationic polymerization in both academia and industry.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Samira Sanjabi, Jaber Keyvan Rad, Ali Reza Mahdavian
Summary: Colorimetric chemical sensors using SPOH and SNO were investigated for the detection of cyanide ions, showing high selectivity and sensitivity. The sensors demonstrated a 1:1 stoichiometric ratio with CN- and detection limits lower than WHO standards.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zeinalabedin Sepehr, Hossein Nasr-Isfahani, Ali Reza Mahdavian, Behrouz Notash
Summary: The study investigates the click reactions of two spiropyran derivatives with N-alkynyl functional groups with 1-azido-4-nitrobenzene and (azidomethyl)benzene. Through synthesis and characterization, it is found that the spiro C-O bond in compound 1 is weaker than that in compound 2, attributed to the presence of the nitro group stabilizing the open-ring form.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Biomedical
Rezvan Balilvand, Azizollah Nodehi, Jaber Keyvan Rad, Mohammad Atai
Summary: The study synthesized a series of P (AA-co-IA) copolymers with different molecular weights through a water-based solution photopolymerization method. The results showed that increasing the TGA content led to a decrease in the molecular weights and polydispersity index of the synthesized copolymers. Additionally, the viscosity of copolymers decreased with increasing TGA concentration in the polymerization recipes.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Chemistry, Physical
Jaber Keyvan Rad, Zahra Balzade, Ali Reza Mahdavian
Summary: Photoswitchable spiropyran-based materials have shown tremendous progress and potential applications in various fields due to their distinctive physicochemical properties under light illumination. This review summarizes recent advancements in the development and applications of these materials, including their use as sensors, data recording devices, and in biomedical applications. The limitations and future prospects of these materials are also discussed.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS
(2022)
Article
Oncology
Parvin Sadat Mirzaghavami, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou
Summary: In this study, folic acid-conjugated PEG-PCL-PEG triblock copolymer loaded with 5-fluorouracil and magnetite nanoparticles was synthesized for targeted delivery of drugs to colon cancer cells. The nanoparticles exhibited sustained drug release and showed effective cellular uptake and antitumor activity in both in vitro and in vivo experiments.
CANCER NANOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jaber Keyvan Rad, Amir Reza Ghomi, Ali Reza Mahdavian
Summary: Photoswitchable nanofibers and nanocomposite fibers with plasmonic nanoparticles were prepared using photochemical and electrospinning techniques. The inclusion of vinylimidazole into the copolymer chains resulted in well-dispersed AuNRs. Photostudies showed a higher reflective intensity for MBVSP@F due to greater chain flexibility. Furthermore, the presence of AuNRs enhanced the photochromic properties of the nanocomposite fibers.
Article
Chemistry, Applied
Pouya Kasaei, Negin Karami, Jaber Keyvan Rad, Samira Sanjabi, Ali Reza Mahdavian
Summary: In this study, a novel fluorescein mono-acrylate (Flu-Ac) was synthesized and used to produce epoxy-functionalized latex nanoparticles. The obtained fluorescent cellulose paper showed enhanced emission intensity by increasing the pH of the solution. These findings suggest the potential of these fluorescent cellulose substrates for reusable indicators with pH sensing capabilities across a range of acidity or basicity.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Samira Sanjabi, Jaber Keyvan Rad, Hamid Salehi-Mobarakeh, Ali Reza Mahdavian
Summary: The fabrication of multi-level anti-counterfeiting inks with fast reversibility and enhanced responsivity is a challenging issue. Smart capsules with nanometric size were used to prepare thermo- and photo-switchable nanocapsules. These nanocapsules showed spherical morphology and contained the desired materials in high percentages. The encapsulation of SPOH beside STC moieties enhanced the thermochromic efficiency and enabled multiple responsivities under UV-visible illumination.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Oncology
Roghayeh Sheervalilou, Samideh Khoei, Sepideh Khoee, Milad Shirvaliloo, Elaheh Sadri, Sakine Shirvalilou, Mina Goudarzi
Summary: This study introduces a magnetohyperthermia-based therapy that combines magnetic graphene oxide nanoheaters to induce magnetothermal effect and reactive oxygen species (ROS), effectively treating deep-seated tumors such as glioma. The nanoheaters showed minimal toxicity and high specific absorption rate (SAR), resulting in enhanced ROS production within tumor microenvironment. The therapy significantly inhibited tumor growth, increased survival ratio, and induced apoptotic cell death.
CANCER NANOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Adel Soleimani, Farhid Farahmandghavi, Jalil Morshedian, Jaber Keyvan Rad
Summary: Antibacterial composite polymers with ion-exchangeable zeolite were successfully developed for food packaging. The addition of hydrogen ions improved color stability and transparency. The dispersion of silver ions was improved by the presence of polyethylene-graft-maleic anhydride, while the presence of ethylene vinyl alcohol copolymer led to a droplet-matrix morphology. The composite materials exhibited remarkable antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Samira Sanjabi, Jaber Keyvan Rad, Alireza Mouraki, Narges Asadi-Aghbolaghi, Hamid Salehi-Mobarakeh, Ali Reza Mahdavian
Summary: The photochromic and solvatochromic behavior of spironaphtooxazine (SNO) and its acrylic copolymer (PCSN-3) in various solvents were investigated, and a portable probe for colorimetric detection of solvent polarity was fabricated using the results. The study provides valuable insights into the design of stimuli-responsive devices for opto-chemical sensors.
Review
Nanoscience & Nanotechnology
Sakine Shirvalilou, Zahed Tavangari, Mohammad Hossein Parsaei, Saman Sargazi, Roghayeh Sheervalilou, Milad Shirvaliloo, Habib Ghaznavi, Samideh Khoei
Summary: This review article provides a brief account of recent advances in research and application of nanoparticles in hyperthermia-based cancer therapies, including tumor-targeted therapy, thermal therapy, chemotherapy, and radiotherapy. It also highlights the challenges associated with the application of nanoparticles in cancer therapy.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Adel Soleimani, Farhid Farahmandghavi, Jalil Morshedian, Jaber Keyvan Rad
Summary: In this study, antibacterial composite polymers were prepared for food packaging to inhibit the growth of foodborne pathogens. The results showed that the composite films had reliable optical properties, good antibacterial activity, and potential for advanced antibacterial food packaging.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Environmental
Sara Ghezelsefloo, Jaber Keyvan Rad, Mahtab Hajiali, Ali Reza Mahdavian
Summary: This study focused on the preparation of fluorescent poly(methyl methacrylate-co-glycidyl methacrylate) nanoparticles bearing Rhodamine B ethylenediamine acrylate for sensing Fe2+ and Fe3+ ions. The results showed that these nanoparticles exhibited immediate color change and enhanced fluorescence emission upon the addition of Fe2+ and Fe3+, with low detection limits and a wide linear detection range. These nanoparticles could potentially be used as colorimetric and fluorescent sensors with high sensitivity and instant responsivity for Fe2+ and Fe3+ ions in future applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
