Article
Polymer Science
Banafsheh Safari, Marziyeh Aghazadeh, Leila Roshangar, Ayuob Aghanejad, Soodabeh Davaran
Summary: This study reports the fabrication and evaluation of a bioactive hybrid scaffold collagen/P-PCL for bone tissue engineering. The scaffold showed biocompatibility, osteoconductivity, and osteoinductivity, supporting the proliferation and differentiation of AD-MSCs.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Quanying Liu, Manyu Chen, Peiyang Gu, Lei Tong, Peilei Wang, Jiayi Zhu, Yang Xu, Gonggong Lu, En Luo, Jie Liang, Yujiang Fan, Xingdong Zhang, Yong Sun
Summary: Integrating a biomimetic extracellular matrix into 3D printing scaffolds improves the microenvironment for bone substitute design. A soft-hard bone implant (BM-g-DPCL) was constructed, consisting of a bioactive matrix integrated chemically on a polydopamine-coated porous gradient scaffold. The implant promoted bone tissue integration and induced bone matrix deposition.
Article
Materials Science, Biomaterials
Xiongcheng Xu, Long Xiao, Yanmei Xu, Jin Zhuo, Xue Yang, Li Li, Nianqi Xiao, Jing Tao, Quan Zhong, Yanfen Li, Yuling Chen, Zhibin Du, Kai Luo
Summary: The study developed a PCL/LAP scaffold with excellent bioactivity using 3D printing technology, promoting osteogenic differentiation and angiogenesis of bone marrow mesenchymal stem cells, resulting in significant enhancement of vascularized bone formation in a calvarial defect model.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Banafsheh Safari, Marziyeh Aghazadeh, Ayuob Aghanejad
Summary: Recent trends in bone tissue engineering have focused on developing biomimetic constructs with appropriate mechanical and physiochemical properties. In this study, a new biomaterial scaffold based on a bisphosphonate-containing synthetic polymer combined with gelatin was fabricated. The scaffold showed aligned pores, high porosity, and good biodegradability. It exhibited good cytocompatibility with human Adipose-Derived Mesenchymal Stem Cells (hADMSCs) and promoted mineralization and ALP activity. The scaffold also demonstrated high expression of osteogenic genes, suggesting its potential for bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hatice Genc, Alessandro Cianciosi, Raphael Lohse, Philipp Stahlhut, Jurgen Groll, Christoph Alexiou, Iwona Cicha, Tomasz Juengst
Summary: This study aimed to develop a suitable hydrogel-based 3D platform for long-term culture of primary endothelial cells (ECs) and fibroblasts. Two hydrogel systems, G1MM and G2LH, were cross-linked using thiol-ene click reaction. The G2LH hydrogel showed better cell- cell interactions, F-actin organization, and collagen and fibronectin production, supporting long-term culture and matrix remodeling.
Article
Materials Science, Multidisciplinary
Fereshteh Mahmoodiyan Najafabadi, Saeed Karbasi, Soheila Zamanlui Benisi, Shahrokh Shojaei, S. Ali Poursamar, Reyhaneh Nasr Azadani
Summary: This study synthesized magnetic mesoporous bioactive glass using the sol-gel method and incorporated alumina nanowires. The synthesized glass exhibited a mesoporous structure and paramagnetic properties. The 3D printed scaffold showed homogeneous structures with interconnected pores. The addition of alumina nanowires improved the mechanical strength, contact angle, degradation, and bioactivity of the scaffold.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Hairui Suo, Yu Chen, Jiali Liu, Ling Wang, Mingen Xu
Summary: A novel biphasic scaffold was designed and fabricated using HAp and PCL through a multi-nozzle 3D printing technique, showing mechanical properties between pure HAp and PCL scaffolds. Finite element simulation demonstrated a biomimetic strengthened structure of the biphasic scaffold under compression, suitable for osteochondral tissue engineering applications.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Materials Science, Ceramics
Chenglong Wang, Chunyang Meng, Zhuo Zhang, Qingsan Zhu
Summary: This study used bioactive glass to improve the bone repair scaffold material made of polycaprolactone (PCL) and found that increasing the content of bioactive glass can enhance the hydrophilicity of the scaffold, improve cell adhesion and proliferation, and promote bone repair. The results of the study suggest that PCL scaffolds containing 20% bioactive glass have great potential for clinical bone repair.
CERAMICS INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Hao Pan, Li Deng, Lingwei Huang, Qi Zhang, Jing Yu, Yueyue Huang, Lei Chen, Jiang Chang
Summary: Biomaterial-based bone grafts have been shown to be effective in treating large bone defects, and this study highlights the importance of immunomodulation and immune-regulated bone regeneration in addition to the direct interaction between scaffolds and bone-related cells. The study presents a three-dimensional printed silicate bioceramic scaffold with well-defined pore structures, which has the potential to be an implantable biomaterial for bone repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Sinan Wang, Bin Luo, Baoshuai Bai, Qianyi Wang, Hongying Chen, Xiaoyan Tan, Zhengya Tang, Sisi Shen, Hengxing Zhou, Zhengwei You, Guangdong Zhou, Dong Lei
Summary: Tissue engineering is a promising approach for cartilage regeneration, and the modification and drug loading of poly(glycerol sebacate) (PGS) scaffolds pose a key challenge. In this study, a new strategy of super swelling-absorption and cross-linked networks locking was used to create a 3D printed PGS-CS/Gel scaffold based on FDA-approved PGS, gelatin, and chondroitin sulfate. The PGS-CS/Gel scaffold exhibited desirable properties and successfully repaired cartilage in a rabbit model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Jupei Zhang, Zhen Zeng, Yanxin Chen, Li Deng, Yanxin Zhang, Yumei Que, Yiren Jiao, Jiang Chang, Zhihong Dong, Chen Yang
Summary: The increasing number of mastectomies has led to the development of adipose tissue restoration techniques. However, current clinical strategies are not effective due to the need for personalized customization and timely vascularization in adipose regeneration. This study used 3D printing technology to create a composite hydrogel scaffold that promoted adipose tissue regeneration in vitro and in vivo, making it a potential candidate for adipose tissue engineering.
REGENERATIVE BIOMATERIALS
(2023)
Article
Polymer Science
Matteo Bergoglio, Ziba Najmi, Andrea Cochis, Marta Miola, Enrica Verne, Marco Sangermano
Summary: This study presents a novel approach for fabricating bioactive glass reinforced scaffolds using 3D printing technology. The composite scaffold, made from a bio-based acrylate resin derived from soybean oil and a reactive diluent called isobornyl acrylate, showed improved mechanical behavior compared to traditional mould-synthetized samples. The addition of bioactive glass particles did not significantly affect the curing process or the cytocompatibility of the scaffold, but resulted in higher metabolic activity and increased cell attachment on the scaffold surfaces.
Article
Polymer Science
Woo-Shik Jeong, Young-Chul Kim, Jae-Cheong Min, Ho-Jin Park, Eun-Ju Lee, Jin-Hyung Shim, Jong-Woo Choi
Summary: In this study, the efficacy of a 3D-printed, patient-specific polycaprolactone/beta tricalcium phosphate scaffold in the treatment of complex zygomatico-maxillary defects was evaluated. The results demonstrated satisfactory volume conformity and bone formation, indicating the potential of this technique to replace traditional implants in the future.
Article
Engineering, Multidisciplinary
Wenzhao Wang, Jianlu Wei, Dong Lei, Suning Wang, Boqing Zhang, Shenghui Shang, Baoshuai Bai, Chenxi Zhao, Wencan Zhang, Changchun Zhou, Hengxing Zhou, Shiqing Feng
Summary: This study investigated the 3D printing of a composite scaffold made of polylactic acid (PLA), nano-hydroxyapatite (n-HA), and lithium (Li) for bone tissue repair. The scaffold's degradation and mechanical properties were evaluated, and in vitro osteogenesis and vasculogenesis were observed. The optimal doping amount of lithium ions was determined, and in vivo studies showed that the PLA/n-HA/Li composite scaffold had good printability, biocompatibility, degradability, and osteogenic inducibility, making it applicable for personalized repair of large bone defects.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Markus Laubach, Buddhi Herath, Nathalie Bock, Sinduja Suresh, Siamak Saifzadeh, Bronwin L. Dargaville, Jacqui McGovern, Marie-Luise Wille, Dietmar W. Hutmacher, Flavia Medeiros Savi
Summary: This study explores the use of Voronoi tessellation design in 3D-printed mPCL-HA composite scaffolds for scaffold-guided bone regeneration (SGBR). The results suggest that the Voronoi design allows for slow degradation and high osteogenicity, promoting tissue regeneration and bone formation without adverse reactions. The mPCL-HA Voronoi scaffolds have the potential for further preclinical animal studies before clinical trials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Behavioral Sciences
Xiaoju Wang, Peng Xia, Jiulong Song, Ting Yang, Changjun Yu, Kai Cheng, Anliang Chen, Xueping Li
Summary: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Correction
Multidisciplinary Sciences
Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayyar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yan Zhou, Xiaoteng Jia, Daxin Pang, Shan Jiang, Meihua Zhu, Geyu Lu, Yaping Tian, Caiyun Wang, Danming Chao, Gordon Wallace
Summary: The authors propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This patch eliminates the conventional interface impedance between the electrode and drug reservoir, reducing system complexity and size. The delivery dosage can be easily manipulated by tuning the viologen hydrogel and the iontophoresis stimulation mode.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Jie Liu, Junjun Ma, Weizhang Zhong, Jianrui Niu, Zaixing Li, Xiaoju Wang, Ge Shen, Chun Liu
Summary: Membrane capacitive deionization (MCDI) is an efficient desalination technology. In this study, penicillin fermentation residue biochar (PFRB) was used as an electrode in the MCDI system, showing a high-capacity desalination performance. The PFRB electrode exhibited excellent electrochemical properties and stability.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Engineering, Environmental
Ge Shen, Junjun Ma, Jianrui Niu, Ruina Zhang, Jing Zhang, Xiaoju Wang, Jie Liu, Jiarong Gu, Ruicheng Chen, Xiqing Li, Chun Liu
Summary: Capacitive deionization (CDI) is a novel electrochemical water-treatment technology that utilizes activated carbon (AC) as an electrode material. This study adopted ball milling to produce ball milled AC (BAC) with improved physical and electrochemical properties. BAC exhibited excellent pore structures and favorable surfaces for ion adsorption, leading to reduced electron transfer resistance and ion migration resistance. The average salt adsorption rates and energy-normalized removal salt were significantly enhanced in both membrane capacitive deionization (MCDI) and flow-electrode capacitive deionization (FCDI) using BAC as the electrode material.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Electrochemistry
Amruthalakshmi Vijayakumar, Yong Zhao, Kezhong Wang, Yunfeng Chao, Haiqun Chen, Caiyun Wang, Gordon G. G. Wallace
Summary: In this study, a scalable one-step glucose blowing method was used to prepare a porous N-doped carbon supported Cu nanoparticles (Cu-NC) composite catalyst for CO2 electroreduction. The Cu-NC catalyst showed efficient catalytic activity for CO2-to-C1 product (CO and formate) conversion, with a high efficiency of 69% at an overpotential of 590 mV. The excellent catalytic activity is attributed to the structure of the composite and the presence of N-species in the carbonaceous matrix.
Article
Environmental Sciences
Xiaoju Wang, Shanshan Hu, Haitao Mao, Xueyu Wei, Saraschandra Naraginti
Summary: Recently, there has been increasing attention on the development of efficient materials for degradation and detoxification of antibiotics in wastewater treatment. AgVO3, as a visible light active material, has been widely studied for environmental remediation. In this research, a novel heterojunction of AgVO3/rGO/BiVO4 was prepared through a hydrothermal method to improve its efficiency and stability. The results showed that the degradation efficiency of AgVO3/rGO/BiVO4 towards Norfloxacin (NFC) antibiotic was significantly higher compared to pure AgVO3 and BiVO4. The enhanced efficiency can be attributed to the formation of heterojunction and faster charge separation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Luyao Wang, Qingbo Wang, Emil Rosqvist, Jan-Henrik Smatt, Qiwen Yong, Lippo Lassila, Jouko Peltonen, Thomas Rosenau, Martti Toivakka, Stefan Willfoer, Patrik Eklund, Chunlin Xu, Xiaoju Wang
Summary: Fabricating bio-latex colloids with core-shell nanostructure is an effective method for obtaining films with enhanced mechanical characteristics. Nano-sized lignin is rising as a class of sustainable nanomaterials that can be incorporated into latex colloids. The correlation between surface chemistry of lignin nanoparticles (LNPs) and integration efficiency in latex colloids and from it thermally processed latex films is explored.
Article
Engineering, Biomedical
Qingbo Wang, Ozge Karadas, Oskar Backman, Luyao Wang, Tuomas Nareoja, Jessica M. Rosenholm, Chunlin Xu, Xiaoju Wang
Summary: In this study, a ternary-component aqueous emulsion was used to fabricate microgel assembly for 3D bioprinting. The emulsion consisted of methacrylated gelatin (GelMA) microgels, methacrylated galactoglucomannan (GGMMA), and dextran (Dex). The GGMMA and Dex provided stability to the emulsion, while GGMMA also facilitated the adhesion of GelMA microgels to form a porous hydrogel construct that supported cell growth and colonization.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Yidong Zhang, Wangfang Deng, Meiyan Wu, Mehdi Rahmaninia, Chunlin Xu, Bin Li
Summary: Nanocellulose (NC), including cellulose nanofibril (CNF) and cellulose nanocrystal (CNC), has gained attention for its unique physical and chemical properties. This review summarizes various chemical modifications, such as silanization, esterification, oxidation, and grafting, applied to NC in order to introduce new functionalities. The incorporation of NC in functional materials and the challenges in the preparation process are also discussed. Overall, NC is considered a promising green nanomaterial for large-scale applications in the future.
Article
Cell & Tissue Engineering
Reetta Sartoneva, Kaarlo Paakinaho, Markus Hannula, Kirsi Kuismanen, Heini Huhtala, Jari Hyttinen, Susanna Miettinen
Summary: This study evaluated the effect of A2P on vaginal tissue engineering for the first time and the results are highly encouraging. The scPLCL(A2P) scaffold showed potential as a scaffold for vaginal tissue engineering, promoting the viability, proliferation, and collagen production of vaginal cells.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Oncology
Rachel Kerslake, Birhanu Belay, Suzana Panfilov, Marcia Hall, Ioannis Kyrou, Harpal S. S. Randeva, Jari Hyttinen, Emmanouil Karteris, Cristina Sisu
Summary: This study evaluates the impact of growth conditions on cancer cells and compares their behavior to traditional two-dimensional models using transcriptomics, clinical, and novel experimental data. The results show that variability in growth conditions can affect key cancer genes and biological processes. It highlights the need for future studies to identify the most suitable in vitro/preclinical model for studying tumor microenvironments.
Article
Engineering, Chemical
Sara Benalia, Fiseha Tesfaye, Daniel Lindberg, Leena Hupa, Patrice Chartrand, Christian Robelin
Summary: A thermodynamic model has been developed for a mixed-phase salt system (including elements such as NaCl, Na2CO3, Na2SO4, Na2S2O7, Na2CrO4, Na2Cr2O7, Na2MoO4, Na2Mo2O7, Na2O, KCl, K2CO3, K2SO4, K2S2O7, K2CrO4, K2Cr2O7, K2MoO4, K2Mo2O7, and K2O) commonly involved in energy production. This model accurately predicts the properties and phase equilibria of solid deposits formed in steel and stainless steel installations containing alloying elements such as Ni, Cr, Mo, W, and V.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Energy & Fuels
Roland Balint, Markus Engblom, Jonne Niemi, Mikko Hupa, Leena Hupa
Summary: This study investigates the initial melting behavior of synthetic ash deposits and how it affects the final deposit morphology. The results show that the amount of melt formed during the experiment plays a crucial role in determining the deposit morphology. Two types of deposit morphologies, skeletal and molten, were identified, and their aging behaviors were found to differ. The findings provide important insights into the connection between deposit morphology and deposit aging.
Article
Chemistry, Multidisciplinary
Sara Benalia, Fiseha Tesfaye, Daniel Lindberg, David Sibarani, Leena Hupa, Patrice Chartrand, Christian Robelin
Summary: This paper evaluates crystallographic data and thermodynamic properties of various salts and provides a foundation for further research on high temperature corrosion.
JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA
(2023)