Review
Medicine, Research & Experimental
Saurabh Shah, Paras Famta, Deepkumar Bagasariya, Kondasingh Charankumar, Anupama Sikder, Rama Kashikar, Arun K. Kotha, Mahavir Bhupal Chougule, Dharmendra Kumar Khatri, Amit Asthana, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava
Summary: This review highlights the importance of mesoporous silica nanoparticles (MSN) as delivery vehicles in cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters affecting MSN synthesis, drug loading characteristics, and targeting cancer cells specifically are explained. The applications and potential of MSN in nanotheranostics and imaging are illustrated. The review also discusses the hurdles encountered during the translation process and potential solutions.
MOLECULAR PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Maria Vallet-Regi
Summary: This article reports our contributions to mesoporous silica materials in biomedicine, demonstrating their potential in drug delivery with high loading capacity and stimuli-responsive features. The research findings suggest that mesoporous silica nanoparticles have promising applications in drug delivery.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Pharmacology & Pharmacy
Simona Ionita, Daniel Lincu, Raul-Augustin Mitran, Laila Ziko, Nada K. Sedky, Mihaela Deaconu, Ana-Maria Brezoiu, Cristian Matei, Daniela Berger
Summary: Resveratrol, a naturally occurring polyphenol with antioxidant, cardioprotective and anticancer potential, has low aqueous solubility that limits its application. Encapsulation in mesoporous silica matrices and functional modification can increase its dissolution rate. The functionalized mesoporous carriers showed high anticancer activity, highlighting their potential use in cancer treatment.
Article
Pharmacology & Pharmacy
Jie Zhuang, Yiming Yu, Rui Lu
Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Parya Kazemzadeh, Khalil Sayadi, Ali Toolabi, Jalil Sayadi, Malihe Zeraati, Narendra Pal Singh Chauhan, Ghasem Sargazi
Summary: Mesoporous silica nanoparticles (MSNs) are widely used in drug delivery applications due to their favorable biocompatibility and controlled drug release properties. However, more research, such as in vivo biocompatibility studies and toxicity studies, is needed to advance this field.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Applied
Hamed Tabasi, Mohammad Taqi Hamed Mosavian, Majid Darroudi, Majid Khazaei, Alireza Hashemzadeh, Zahra Sabouri
Summary: In this study, magnetic nanoparticles with high surface area and small diameter were successfully synthesized as potential nanocarriers for drug delivery. The nanoparticles showed good dispersity and optimal magnetization in biological conditions, overcoming obstacles in drug delivery.
JOURNAL OF POROUS MATERIALS
(2022)
Article
Chemistry, Analytical
Albert Yu, Xiaoyong Dai, Zixian Wang, Huaqing Chen, Bing Guo, Laiqiang Huang
Summary: Immunotherapy is a promising treatment modality for cancer, using the body's immune response to fight against cancer. Mesoporous silica, as a nanomaterial, can facilitate the advancement of immunotherapy with its high porosity and biocompatibility.
Article
Pharmacology & Pharmacy
Siti Norain Harun, Haslina Ahmad, Hong Ngee Lim, Suet Lin Chia, Martin R. Gill
Summary: Ru-PIP is a potential anticancer drug that acts by inhibiting DNA replication, and its limited bioavailability can be overcome by using mesoporous silica nanoparticles (MSNs) as a drug delivery agent. Encapsulated Ru-PIP in MSNs exerted significant cytotoxicity on cancer cell lines, indicating the potential of MSNs as an ideal drug delivery agent for sustained release of Ru-PIP by diffusion.
Article
Engineering, Mechanical
Li Wan, Yi Wang, Xiaolong Tan, Yulong Sun, Jing Luo, Hongyu Zhang
Summary: This study developed biodegradable lubricating drug-loaded nanoparticles for the treatment of osteoarthritis. The nanoparticles showed enhanced lubrication and sustained drug release behavior. The results suggest that these nanoparticles may be a promising approach for osteoarthritis therapy.
Article
Chemistry, Physical
Cristina Carucci, Giulia Sechi, Marco Piludu, Maura Monduzzi, Andrea Salis
Summary: This study focuses on optimizing the loading and release processes of the flavonoid quercetin by changing the solvent composition, leading to a more sustained release and improved stability and release concentration of quercetin in a pH-sensitive antimicrobial drug delivery system based on Mesoporous silica nanoparticles (MSN) functionalized with different compounds.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Pharmacology & Pharmacy
Ahmed Abu-Dief, Mosa Alsehli, Abdullah Al-Enizi, Ayman Nafady
Summary: Nanotechnology provides the means to design and fabricate delivery vehicles capable of overcoming physiologically imposed obstacles and undesirable side effects of systemic drug delivery. Mesoporous Silica Nanoparticles (MSNPs) have sparked interest in nanomedicine research community due to their stability and versatility in drug delivery systems. This review article emphasizes the design, synthesis, and influencing factors of MSNPs, as well as their fate in the body and potential applications when combined with other functional materials.
CURRENT DRUG DELIVERY
(2022)
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Article
Chemistry, Physical
Md Aquib, Hang Zhang, Faisal Raza, Parikshit Banerjee, Rohit Bavi, Samuel Kesse, Kofi Oti Boakye-Yiadom, Mensura Sied Filli, Muhammad Asim Farooq, Bo Wang
Summary: Aminated mesoporous silica nanoparticles (AMPSNPs) were developed as a nanocarrier for disulfiram (DSF) delivery in cancer therapies. The optimized AMPSNPs showed excellent properties and compatibility, providing potential for effective drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Oncology
Carla Giacobino, Marta Canta, Cristina Fornaguera, Salvador Borros, Valentina Cauda
Summary: Immunotherapy has made significant progress in recent years, becoming a powerful tool to combat cancer. The use of biologically derived vesicles for cancer immunotherapy involves transporting molecules that can trigger an immune response to fight cancer cells, including using extracellular vesicles as new cancer vaccines.
Article
Chemistry, Medicinal
Roger Riera, Jana Tauler, Natalia Feiner-Gracia, Salvador Borros, Cristina Fornaguera, Lorenzo Albertazzi
Summary: The use of dSTORM technology to study the time stability and cell trafficking of OM-pBAE nanoparticles reveals that different oligopeptide combinations can affect the properties and performance of the nanoparticles. This study provides a strong basis for the future selection of specific pBAE nanoparticle compositions.
Article
Chemistry, Multidisciplinary
Robert Texido, Pol Cabanach, Richard Kaplan, Cristina Garcia-Bonillo, Dario Perez, Shuo Zhang, Salvador Borros, Abdon Pena-Francesch
Summary: This study introduces a versatile methodology for creating anti-biofouling coatings on medical devices, specifically silicone-based materials. The coatings consist of a functional anchor, a zwitterionic polymer, and a polydopamine layer, providing superhydrophilic and anti-biofouling properties. The results demonstrate significant reduction in bacterial adhesion, making it a promising strategy for preventing bacterial infections in healthcare settings.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Multidisciplinary Sciences
Cristina Garcia-Bonillo, Robert Texido, Joan Gilabert-Porres, Salvador Borros
Summary: This study provides a solution to the problem of biofilm formation on medical devices through the use of nanostructured metallic silver coatings. The silver nanostructures effectively prevent bacteria adhesion and reduce bacterial adhesion by up to six orders of magnitude.
Article
Physics, Applied
Patricia Gimenez-Barrera, Sergi Colominas, Salvador Borros
Summary: Despite numerous studies on the degradation of ductile metals in cultural heritage, there is still a lack of standardized restoration protocols. Traditional restoration methods such as chemical cleaning and electrochemical treatments often cause aggressive damage to the metal surface. In this research, a cold plasma design is proposed as a minimally invasive approach to restore ductile metals. The effectiveness of this technique was demonstrated through corrosion models created on lead samples and analyzed using various characterization techniques, including electrochemical impedance spectroscopy.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Polymer Science
Oiane Ruiz de Azua, Nuria Agullo, Jordi Arbusa, Salvador Borros
Summary: This study investigated the influence of formulation stoichiometry on the glass transition temperature (Tg) and mechanical properties of epoxy adhesives through DSC, DMA, rheometer, and tensile and shear strength testing. The results showed that an excess of epoxy resin combined with a complex curing system can undergo homopolymerization reaction at room temperature, resulting in an increase in Tg up to 70 degrees C. However, as the excess of epoxy resin is increased, the gel time becomes slower. In terms of mechanical properties, an excess of epoxy resin provides a tighter and tougher material while maintaining the flexibility of the stoichiometric formulation to enhance resistance to impact, thermal shock, and thermal cycling.
Article
Nanoscience & Nanotechnology
Robert Texido, Gloria Nieva-Esteve, Joan Gilabert-Porres, Guillermo Reyes, Salvador Borros
Summary: This article introduces a fabrication method for a strain sensor based on silver microplates. The sensor exhibits high stretchability, high conductivity, good linearity, and high sensitivity. It is capable of measuring very small deformations, even in dynamic range. Furthermore, this technology expands the potential applications of wearable electronic devices.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Maria Navalon-Lopez, Aurora Dols-Perez, Santiago Grijalvo, Cristina Fornaguera, Salvador Borros
Summary: Oligopeptide end-modified poly(beta-amino ester)s (OM-pBAEs) offer a means for effective gene therapeutics with high transfection efficacy, low toxicity, precise targeting, biocompatibility, and biodegradability. Understanding the role and conformation of each component in OM-pBAE/polynucleotide nanoparticles is crucial for the development and improvement of gene delivery vehicles.
NANOSCALE ADVANCES
(2023)
Article
Polymer Science
Ana Canas-Gutierrez, Lenka Toro, Cristina Fornaguera, Salvador Borros, Marlon Osorio, Cristina Castro-Herazo, David Arboleda-Toro
Summary: The aim of this study was to mimic natural bone composition, structure, and biomechanical properties by mineralizing three-dimensional microporous bacterial nanocellulose (BNC). BNC scaffolds with different pore sizes and porous interconnectivity were prepared by incorporating porogen particles during BNC fermentation and depositing calcium phosphates (CPs) in five immersion cycles. The surface crystals on the BNC scaffolds were rod-shaped, with a calcium phosphate ratio similar to immature bone and increased in size with an increasing number of cycles. The main mineral phase observed was octacalcium dihydrogen hexakis phosphate (V) pentahydrate (OCP). In vitro studies showed good cellular adhesion, proliferation, and differentiation on the scaffolds.
Article
Polymer Science
Joaquim M. Rius-Bartra, Norma Ferrer-Serrano, Nuria Agullo, Salvador Borros
Summary: Flexible capacitive sensors based on silicone rubber are important in both academic and industrial fields due to their advantages, but they require dielectric additives to enhance electrical properties, which also increase Young's modulus. Liquid silicone rubbers are commonly used in academia, but compromise mechanical integrity, while high-consistency silicone rubbers maintain mechanical integrity but have limited use in dielectrics. This paper explores the potential of vinyl-terminated HCR for developing dielectric composites with high electromechanical response while retaining mechanical and processability properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Physical
Carles Bofill-Bonet, Maria Gil-Vives, Margalida Artigues, Marta Hernandez, Salvador Borros, Cristina Fornaguera
Summary: This study focuses on controlling the biodistribution of doxorubicin in polymeric nanoparticles for targeted cancer therapy. By varying the salt concentrations in the template emulsion, the loading of doxorubicin can be controlled, and the resulting nanoparticles exhibit exceptional internalization properties.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Environmental
E. Serra, J. O. Pou, X. Berzosa, R. Gonzalez-Olmos, S. Borros
Summary: Professors Rosa Nomen and Julia Sempere from IQS, Universitat Ramon Llull, have made significant contributions to the field of chemical engineering, particularly in the areas of process safety and environmental protection. Their research has focused on understanding chemical reactions, their safety, and kinetics through thermal analysis and calorimetry. They have also worked on developing new methodologies for industrial safety and implementing flow chemistry for sustainable and safer production of specialty chemicals. Moreover, they have contributed to the advancement of adsorption-based carbon capture technologies to minimize the environmental impact of the chemical industry.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Materials Science, Biomaterials
Aparna Loecher, Michael Bruyns-Haylett, Pedro J. Ballester, Salvador Borros, Nuria Oliva
Summary: The delivery efficiency of genetic material to cells is limited by the carrier system. Poly-beta-amino esters (pBAEs) are promising polymer-based vectors that can improve cell membrane uptake and gene delivery. However, the optimal formulation for high uptake in a new cell line requires trial and error. Therefore, machine learning models, such as gradient-boosted trees and neural networks, were trained to predict cellular internalisation of pBAE polyplexes.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Cristina Fornaguera, Antoni Torres-Coll, Laura Olmo, Coral Garcia-Fernandez, Marta Guerra-Rebollo, Salvador Borros
Summary: Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide, and current standard of care has limitations in terms of efficacy and safety. Targeted therapies that modify specific subcellular routes aberrantly expressed in tumor cells, such as siRNA delivery, could provide a promising solution. This study demonstrates that oligopeptide end-modified poly(beta aminoester) (OM-pBAE) polymers can efficiently encapsulate siRNA, protecting it from degradation and allowing for targeted delivery to tumor cells. These nanoparticles are stable in the presence of serum and have shown efficacy in inhibiting lung tumor cell growth both in vitro and in vivo. The addition of anisamide functionalization further enhances the selectivity of the nanoparticles to lung tumor cells. Overall, this research represents a significant step towards developing a targeted nanotherapy for improving survival in NSCLC patients.
Meeting Abstract
Gastroenterology & Hepatology
Meritxell Perramon, Maria Navalon, Guillermo Fernandez Varo, Belen Gonzalez, Alazne Moreno-Lanceta, Cristina Fornaguera, Pedro Melgar-Lesmes, Salvador Borros, Wladimiro Jimenez
JOURNAL OF HEPATOLOGY
(2022)