Article
Oncology
Baocheng Zhu, Hengguan Cui, Weiqiang Xu
Summary: Hydrogen gas treatment significantly inhibits proliferation and migration of gastric cancer cells, while affecting the expression of related genes, showing potential therapeutic effects. In addition, the lncRNA MALAT1/miR-124-3p/EZH2 axis may serve as an important target for intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Jin Hu, Haohao Huang, Zihan Xi, Shenghui Ma, Jie Ming, Fang Dong, Hui Guo, Huiqiong Zhang, Ende Zhao, Guojie Yao, Liu Yang, Feng Zhang, Wuping Zheng, Hengyu Chen, Tao Huang, Lei Li
Summary: In this study, the researchers investigated the functional role of a novel long noncoding RNA SEAS1 in breast cancer progression. They found that SEAS1 was downregulated in TNBC tissues and its knockdown increased the proliferation, migration, and invasion of TNBC cell lines. They also discovered that SEAS1 acted as a sponge for miR-3940-3p, preventing the degradation of its target gene KLLN, which acts as a tumor inhibitor. Additionally, they demonstrated that SMAD3 directly interacted with the promoter of SEAS1 and suppressed its transcription, thereby promoting TNBC progression. Their findings suggest that SEAS1 may serve as a potential biomarker and therapeutic target for TNBC.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Qin Li, Shuo Li, Jin Ding, Bo Pang, Ranran Li, Hui Cao, Li Ling
Summary: A study found that the proliferation of trophoblasts in early-onset preeclampsia (ePE) is regulated by lncRNA MALAT1. The level of MALAT1 was decreased in placental tissue samples from ePE patients, and it was positively correlated with neonate birth-weight. Knockdown of MALAT1 inhibited trophoblast cell growth and migration, and promoted cell apoptosis. Moreover, MALAT1 reduction affected cell proliferation and growth through the regulation of miR-101-3p and VEGFA.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yingzhi Gu, Yuxing Bai
Summary: This study aimed to determine whether lncRNA MALAT1 promotes the osteogenic differentiation of human PDLSCs in vitro. The results showed that MALAT1 regulates human PDLSC differentiation by regulating the miR-93-5p/SMAD5 axis.
Article
Cell Biology
Chunchun Ma, Hongliang Wang, Gang Zong, Jie He, Yuyang Wang, Fan Yang, Zhihao Yang, Erbao Bian, Bing Zhao
Summary: In this study, the upregulation of HNF1A-AS1 in GBM was associated with poor patient survival, revealing its precise mechanism in promoting GBM malignancy, including regulating ENO1 expression by interacting with miR-22-3p. Knockdown of HNF1A-AS1 significantly inhibited the malignant phenotypes of GBM cells, indicating its potential as a therapeutic target.
CELL DEATH DISCOVERY
(2021)
Article
Endocrinology & Metabolism
Yuan Zhou, Zhuo Xu, Yuanyi Wang, Qiang Song, Ruofeng Yin
Summary: This study investigates the role of MALAT1 in osteogenic differentiation and cell apoptosis in osteoporosis. MALAT1 upregulates the expression of Bmp4, Col1a1, and Spp1, enhances ALP activity, and inhibits apoptosis. MALAT1 promotes osteogenic differentiation and inhibits cell apoptosis through the miR-485-5p/WNT7B axis, suggesting its potential as a target for alleviating osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoming Liu, Dandan Peng, Yixin Cao, Yuanzhe Zhu, Jianjun Yin, Guangxing Zhang, Xiaodong Peng, Yanqiu Meng
Summary: Recent studies have highlighted the crucial role of aberrant regulatory interactions in driving malignant phenotypes of hepatocellular carcinoma (HCC) cells. Specifically, the long noncoding RNA DLX6-AS1 was shown to promote HCC progression by modulating the miR-513c/Cul4A/ANXA10 axis, affecting cell viability, migration, invasion, and apoptosis. Silencing DLX6-AS1 could inhibit HCC development and provide potential therapeutic targets for HCC treatment.
CANCER GENE THERAPY
(2021)
Article
Medicine, Research & Experimental
Zhi-Hui Wu, Juan Zhou, Guo-Hong Hu, Jie Liu, Wen-Can Li, Xi-Hua Lai, Min Liu
Summary: The study revealed that CASC2 regulates cell proliferation and apoptosis in LUAD by modulating the expression of miR-21 and p53. P53 was identified as an upstream transcription factor of CASC2, activating its transcription. These findings offer a new insight into the pathological mechanisms of LUAD.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Lin Yang, Wan-li Deng, Bao-guo Zhao, Yao Xu, Xiao-wen Wang, Yu Fang, Hai-juan Xiao
Summary: LOC554202 is upregulated in HCC patients and can promote HCC progression by competitively binding to miR-485-5p. This suggests that targeting the FOXO3/LOC554202/miR-485-5p/BSG axis may be beneficial for HCC treatment.
CANCER GENE THERAPY
(2022)
Article
Multidisciplinary Sciences
Weiping Xia, Xiang Chen, Zewu Zhu, Hequn Chen, Bingsheng Li, Kangning Wang, Li Huang, Zhi Liu, Zhi Chen
Summary: The study found that lncRNA MALAT1 promotes the process of renal interstitial fibrosis through the miR-124-3p/ITGB1 signaling pathway, suggesting its potential as a therapeutic target for RIF.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Yifei Yun, Yutong Zhang, Qiqi Xu, Yao Ou, Xifa Zhou, Zhonghua Lu
Summary: The study found that SOX17 reduces the radioresistance of ESCC cells by suppressing MALAT1 transcription. Additionally, MALAT1 acts as a sponge for miR-199a, increasing the expression of HIF1α. SOX17 also reduces the radioresistance of ESCC cells by decreasing HIF1α expression and inhibits tumor formation in a nude mouse model.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Renbo Guo, Benkui Zou, Yiran Liang, Jiasheng Bian, Jian Xu, Qian Zhou, Chao Zhang, Tao Chen, Mingshan Yang, Huansheng Wang, Fajun Pei, Zhonghua Xu
Summary: This study identified an uncharacterized and upregulated lncRNA RCAT1 in renal cell carcinoma, which played a key role in cell proliferation and metastasis by modulating the miR-214-5p/E2F2 axis, suggesting that lncRNA RCAT1 might be a new prognostic biomarker and potential therapeutic target for renal cell carcinoma.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Haozi Huang, Guowei Zhang, Zhenying Ge
Summary: The overexpression of MALAT1 in diabetic rats and HG-treated cells may exacerbate renal fibrosis and cell damage via the miR-2355-3p/IL6ST axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Chen Zhong, Qian Yu, Yucong Peng, Shengjun Zhou, Zhendong Liu, Yong Deng, Leiguang Guo, Shiguang Zhao, Gao Chen
Summary: This study identified OXCT1-AS1 as a potential therapeutic target for glioma treatment, as high expression was associated with poor prognosis in GBM. OXCT1-AS1 inhibits glioma progression by acting as a ceRNA of miR-195 to enhance CDC25A expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chuan-jian Shi, Yan-biao Zheng, Fei-fei Pan, Feng-wei Zhang, Peng Zhuang, Wei-ming Fu
Summary: Gallic acid (GA) exerts anti-tumor effects on hepatocellular carcinoma (HCC) by suppressing the MALAT1-Wnt/beta-catenin signaling axis, suggesting its potential as a chemo-prevention and chemotherapy agent for HCC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Yingying Lin, Keman Liao, Yifeng Miao, Zhongrun Qian, Zhaoyuan Fang, Xi Yang, Quanmin Nie, Gan Jiang, Jianhua Liu, Yiyi Yu, Jieqing Wan, Xiaohua Zhang, Yaomin Hu, Jiyao Jiang, Yongming Qiu
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Oncology
Jing Cui, Herui Wang, Rogelio Medina, Qi Zhang, Chen Xu, Iris H. Indig, Jingcheng Zhou, Qi Song, Pauline Dmitriev, Mitchell Y. Sun, Liemei Guo, Yang Wang, Jared S. Rosenblum, John S. Kovach, Mark R. Gilbert, Zhengping Zhuang
Article
Cell Biology
Jiong Yu, Xiaowei Shi, Chunzhang Yang, Petra Bullova, Christopher S. Hong, Cody L. Nesvick, Pauline Dmitriev, Karel Pacak, Zhengping Zhuang, Hongcui Cao, Lanjuan Li
Article
Oncology
Keman Liao, Zhongrun Qian, Shuai Zhang, Binghong Chen, Zhiqiang Li, Renhua Huang, Lilin Cheng, Tianwei Wang, Renhao Yang, Jin Lan, Xiaojie Lu, Lin Kong, Xiwen Song, Yongming Qiu, Yingying Lin
Article
Oncology
Jun-Jun Qiu, Shu-Gen Sun, Xiao-Yan Tang, Ying-Ying Lin, Ke-Qin Hua
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Medicine, Research & Experimental
Jared S. Rosenblum, Herui Wang, Pauline M. Dmitriev, Anthony J. Cappadona, Panagiotis Mastorakos, Chen Xu, Abhishek Jha, Nancy Edwards, Danielle R. Donahue, Jeeva Munasinghe, Matthew A. Nazari, Russell H. Knutsen, Bruce R. Rosenblum, James G. Smirniotopoulos, Alberto Pappo, Robert F. Spetzler, Alexander Vortmeyer, Mark R. Gilbert, Dorian B. McGavern, Emily Chew, Beth A. Kozel, John D. Heiss, Zhengping Zhuang, Karel Pacak
Summary: Mutations in the EPAS1 gene can lead to a new clinical feature - vascular malformations, which are present in both syndrome patients and mutant mice. The variant allele frequency in patient vessels is higher than in normal tissues, and veins in the murine retina and intracranial dura fail to regress as expected at the developmental time points.
Article
Oncology
Liemei Guo, Jing Cui, Herui Wang, Rogelio Medina, Shilei Zhang, Xiaohua Zhang, Zhengping Zhuang, Yingying Lin
Summary: The study found that metformin could enhance the inhibitory effect of cisplatin on meningioma cells by activating AMPK and inhibiting the mTOR signaling pathway. Additionally, the combined treatment of metformin and cisplatin showed significant anti-cancer effects on high-grade meningiomas.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Xinjing Wang, Xiaoduan Li, Feikai Lin, Huizhen Sun, Yingying Lin, Ziliang Wang, Xipeng Wang
Summary: The study identified a novel pseudogene, lnc-CTSLP8, in ovarian cancer with significantly elevated expression in metastatic tumor tissues. Overexpression of lnc-CTSLP8 promoted ovarian cancer growth in vitro and in vivo, enhanced autophagy and EMT, and upregulated CTSL1 as a competitive endogenous RNA. Moreover, inhibition of CTSL1 and overexpression of miR-199a-5p reversed the effects of lnc-CTSLP8 overexpression, suggesting its potential as a therapeutic target for metastatic ovarian cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Cell Biology
Wenrui Zhang, Yingying Lin
Summary: Asparagine endopeptidase (AEP), also known as legumain, is a cysteine protease that specifically cleaves peptide bonds in asparaginyl residues in the mammalian genome, making it a potential therapeutic target in various carcinomas. Through intensive investigation on AEP substrates and mechanisms in tumors, researchers have identified several substrate proteins and elucidated the biochemical mechanism of AEP in carcinomas.
Article
Ophthalmology
George N. Thomas, Sieh Yean Kiew, Pali Singh, Pauline Dmitriev, Akshay S. Thomas, Sharon Fekrat
Summary: This study evaluates the effect of antiplatelet and anticoagulant agents on clinical outcomes, OCT parameters, and macular ischemia in eyes with CRVO. The results suggest that these agents do not significantly impact visual acuity, macular edema, or OCT parameters in most cases, except for ischemic CRVO eyes with poor visual acuity. The use of 81-mg aspirin is associated with foveal hemorrhage at CRVO presentation.
JOURNAL OF VITREORETINAL DISEASES
(2022)
Article
Oncology
Lu Cao, Cheng Xu, Peiqiang Yi, Huan Li, Yingying Lin, Gang Cai, Shubei Wang, Dan Ou, Min Li, Jiayi Chen
Summary: Radiation-induced heart disease (RIHD) leads to myocardial dysfunction and metabolic abnormalities in patients treated with thoracic irradiation, affecting the long-term survival benefits of radiotherapy. Asparaginyl endopeptidase (AEP) plays a key role in cellular functions and increasing its expression can enhance cellular viability and DNA repair in cardiomyocytes exposed to radiation. These findings suggest a potential regulatory pathway involving AEP, P53, and NRF2 in maintaining redox homeostasis and heart function after radiation exposure.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Guo Pin, Li Huanting, Zhu Chengzhan, Kong Xinjuan, Feng Yugong, Liu Wei, Li Shifang, Li Zhaojian, Han Kun, Yao Weicheng, Lin Yingying, Qiu Yongming, Yu Yanan
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Haiwei Wang, Xinrui Wang, Liangpu Xu, Yingying Lin, Ji Zhang, Hua Cao
Article
Neurosciences
Zhi-Han Wang, Bing-Hong Chen, Ying-Ying Lin, Jin Xing, Zi-Long Wei, Li Ren
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Hongbin Wang, Binghong Chen, Yingying Lin, Yi Zhou, Xiaobo Li
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)