Article
Biology
L. Coudert, A. Osseni, Y. G. Gangloff, L. Schaeffer, P. Leblanc
Summary: This study reveals that Hrs/Hgs is a key regulator that modulates myogenesis at various levels through controlling intracellular trafficking, signaling, and degradation pathways. The depletion of Hrs impairs myoblast differentiation by altering MRF expression, activating MEK/ERK pathway, inhibiting Akt2 signaling, and activating myogenic repressors. Restoring the impaired differentiation in Hrs-depleted cells can be achieved by inhibiting MEK/ERK pathway or GSK3 beta. Additionally, functional autophagy required for myogenesis is strongly inhibited in the absence of Hrs.
Article
Immunology
Min Zhou, Bingshu Li, Cheng Liu, Ming Hu, Jianming Tang, Jie Min, Jianhong Cheng, Li Hong
Summary: The study reveals that M2 macrophages promote myoblast differentiation and muscle regeneration through exosomal miR-501, suggesting a potential therapeutic approach for muscle injuries, including SUI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cynthia M. McKee, Douglas J. Chapski, Michelle Wehling-Henricks, Manuel Rosa-Garrido, Makoto Kuro-O, Thomas M. Vondriska, James G. Tidball
Summary: This study reveals that modulation of muscle stem cell numbers during early postnatal development has long-term effects on muscle growth. The anti-aging protein Klotho influences myogenesis by increasing satellite cell numbers and influencing the epigenetic regulation of genes involved in myogenesis. Klotho reduces the expression of Jmjd3, leading to decreased expression of Wnt genes and inhibition of canonical Wnt signaling, which delays muscle differentiation.
Review
Biochemistry & Molecular Biology
Karolina Archacka, Maria A. Ciemerych, Anita Florkowska, Karolina Romanczuk
Summary: miRNAs and lncRNAs play crucial roles in gene expression regulation, especially in myogenic differentiation. Manipulating the levels of specific miRNAs and lncRNAs can improve myogenic differentiation of stem and progenitor cells, while physical activity can affect the expression of miRNAs and lncRNAs, ultimately impacting muscle health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Leonardo Martins, Weslley Wallace Amorim, Marcos Fernandes Gregnani, Ronaldo de Carvalho Araujo, Fatimunnisa Qadri, Michael Bader, Joao Bosco Pesquero
Summary: This study found that the absence of the B1 receptor promotes better muscle healing and reduces fibrosis after traumatic skeletal muscle injury. In contrast, the absence of the B2 receptor leads to more severe tissue destruction and excessive fibrosis.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shanshan Wang, Baohua Tan, Liyao Xiao, Jiekang Zeng, Xinming Zhao, Linjun Hong, Zicong Li, Gengyuan Cai, Enqin Zheng, Ting Gu, Zhenfang Wu
Summary: In this study, the researchers identified the lncRNA Gm10561 as an important regulator in skeletal myogenesis. It was found that Gm10561 facilitated the proliferation and differentiation of myoblasts by acting as a sponge of miR-432 to modulate MEF2C and E2F3 expression. These findings suggest that the lncRNA-Gm10561-miR-432-MEF2C/E2F3 axis plays a crucial role in myogenesis.
Article
Surgery
Hananiah Tardivo Quintana, Vivianne Izabelle de Araujo Baptista, Mariana Cruz Lazzarin, Hanna Karen Moreira Antunes, Luciana Le Sueur-Maluf, Camila Aparecida Machado de Oliveira, Flavia de Oliveira
Summary: Using short-term and long-term intensive insulin therapies can improve muscle regeneration and decrease muscle atrophy in young rats with extensive skin burns. Insulin benefits myogenic parameters during regeneration and modulates MuRF1, an important mediator of muscle atrophy.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Eun Ju Lee, Sibhghatulla Shaikh, Mohammad Hassan Baig, So-Young Park, Jeong Ho Lim, Syed Sayeed Ahmad, Shahid Ali, Khurshid Ahmad, Inho Choi
Summary: This study reports the potential of novel peptides MIF1 and MIF2 derived from MSTN in enhancing myogenesis and reducing adipogenesis. Modified MIF1 and MIF2 showed better cell proliferation and differentiation compared to non-modified peptides. Pretreatment of mice with (Ac)-MIF1 or (Ac)-MIF2-(NH2) promoted muscle regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Jianjun Jin, Mengmeng Du, Jian Wang, Yubo Guo, Jiali Zhang, Hao Zuo, Yunqing Hou, Shanshan Wang, Wei Lv, Wei Bai, Jin Wang, Xizhen Zhan, Yaxin Peng, Qian Tong, Jin Chai, Zaiyan Xu, Bo Zuo
Summary: The study identified SYISL as a conserved lncRNA that modulates myogenesis in mice, pigs, and humans, and also demonstrated its previously unknown ability to promote muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Biochemistry & Molecular Biology
HoTae Lim, In Young Choi, Sang-Hwan Hyun, Hyesoo Kim, Gabsang Lee
Summary: Using hPSCs to generate skeletal muscle tissues in vitro provides a valuable model for understanding molecular functions and gene regulatory networks involved in muscle differentiation and disease pathology. The combination of established myogenesis protocols and molecular profiling techniques offers insights into normal and disease skeletal muscle development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Orthopedics
Farina Mohamad Yusoff, Ayumu Nakashima, Masato Kajikawa, Shinji Kishimoto, Tatsuya Maruhashi, Yukihito Higashi
Summary: The effects of LIPUS on myogenic regulatory factors and related myogenesis elements were studied. It was found that LIPUS promoted muscle regeneration by increasing the expression of specific factors.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cell Biology
Nicole L. L. Jacobsen, Aaron B. B. Morton, Steven S. S. Segal
Summary: In acute skeletal muscle injury, myofibers and capillaries are damaged, affecting contractile function and local perfusion. The regeneration of myofibers and microvessels from satellite cells and surviving fragments, respectively, restores the integrity of muscle tissue. This study investigates whether the spatiotemporal coupling between myofiber and microvascular regeneration persists when muscle tissue is completely removed and local guidance cues are lost.
Article
Geriatrics & Gerontology
Na Liang, Jia He, Jiaqi Yan, Xueying Han, Xiaoqian Zhang, Yamei Niu, Wuga Sha, Jun Li
Summary: DBC1 knockdown in skeletal muscle leads to muscle atrophy and impairs muscle regeneration through the regulation of FOXO3. This research highlights the importance of DBC1 for healthy skeletal muscle function and its connection to muscular atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Oncology
Larissa Kotelevets, Eric Chastre
Summary: Extracellular vesicles, such as exosomes, ectosomes, and apoptotic bodies, play a critical role in intercellular communication and can be used for noninvasive diagnosis of cancer. They can also be engineered for efficient delivery of therapeutic agents for tumor treatment. This review highlights the importance of extracellular vesicles in colorectal cancer progression, diagnosis, and potential therapeutic approaches.
Review
Biochemistry & Molecular Biology
Jiju Li, Yangli Pei, Rong Zhou, Zhonglin Tang, Yalan Yang
Summary: N-6-methyladenosine (m(6)A) modification is a widely conserved chemical modification in cellular RNAs that plays a critical role in skeletal muscle development. Exploration of the functions and mechanisms of m(6)A modification and its regulators provides a deeper understanding of the regulatory mechanisms underlying skeletal muscle development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
A. Reghan Foley, Yaqun Zou, James E. Dunford, Jachinta Rooney, Goutam Chandra, Hui Xiong, Volker Straub, Thomas Voit, Norma Romero, Sandra Donkervoort, Ying Hu, Thomas Markello, Adam Horn, Leila Qebibo, Jahannaz Dastgir, Katherine G. Meilleur, Richard S. Finkel, Yanbin Fan, Kamel Mamchaoui, Stephanie Duguez, Isabelle Nelson, Jocelyn Laporte, Mariarita Santi, Edoardo Malfatti, Thierry Maisonobe, Philippe Touraine, Michio Hirano, Imelda Hughes, Kate Bushby, Udo Oppermann, Johann Bohm, Jyoti K. Jaiswal, Tanya Stojkovic, Carsten G. Bonnemann
ANNALS OF NEUROLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Jyoti Jaiswal, Sreetama SenChandra, Daniel Bittel, Adam Horn
Article
Cell Biology
Adam Horn, Shreya Raavicharla, Sonna Shah, Dan Cox, Jyoti K. Jaiswal
JOURNAL OF CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Prech Uapinyoying, Jeremy Goecks, Susan M. Knoblach, Karuna Panchapakesan, Carsten G. Bonnemann, Terence A. Partridge, Jyoti K. Jaiswal, Eric P. Hoffman
Article
Biochemistry & Molecular Biology
Adam J. Bittel, Sen Chandra Sreetama, Daniel C. Bittel, Adam Horn, James S. Novak, Toshifumi Yokota, Aiping Zhang, Rika Maruyama, Kenji Rowel Q. Lim, Jyoti K. Jaiswal, Yi-Wen Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Adam Horn, Jyoti K. Jaiswal
BIOCHEMICAL SOCIETY TRANSACTIONS
(2020)
Article
Cell Biology
Daniel C. Bittel, Goutam Chandra, Laxmi M. S. Tirunagri, Arun B. Deora, Sushma Medikayala, Luana Scheffer, Aurelia Defour, Jyoti K. Jaiswal
Article
Physiology
Nantaporn Haskins, Shivaprasad Bhuvanendran, Claudio Anselmi, Anna Gams, Tomas Kanholm, Kristen M. Kocher, Jonathan LoTempio, Kylie I. Krohmaly, Danielle Sohai, Nathaniel Stearrett, Erin Bonner, Mendel Tuchman, Hiroki Morizono, Jyoti K. Jaiswal, Ljubica Caldovic
Summary: The mitochondrial enzymes involved in energy transformation are organized into multiprotein complexes for efficient ATP production. Three of the mammalian urea cycle enzymes are located in the mitochondria, playing a crucial role in converting ammonia into urea to protect the brain from ammonia toxicity. The urea cycle intermediates are tightly channeled in and out of mitochondria, suggesting coordinated interaction between enzymes is necessary for efficient activity.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Vanessa E. Jahnke, Jennifer M. Peterson, Jack H. Van der Meulen, Jessica Boehler, Kitipong Uaesoontrachoon, Helen K. Johnston, Aurelia Defour, Aditi Phadke, Qing Yu, Jyoti K. Jaiswal, Kanneboyina Nagaraju
Letter
Biochemistry & Molecular Biology
Kyle Salka, Karima Abutaleb, Elizabeth Chorvinsky, Girija Thiruvengadam, Maria Arroyo, Jose L. Gomez, Maria J. Gutierrez, Dinesh K. Pillai, Jyoti K. Jaiswal, Gustavo Nino
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Goutam Chandra, Sen Chandra Sreetama, Davi A. G. Mazala, Karine Charton, Jack H. VanderMeulen, Isabelle Richard, Jyoti K. Jaiswal
Summary: This passage discusses the important role of the endoplasmic reticulum in maintaining physiological calcium balance and cell membrane repair, highlighting the crucial functions of SERCA and ANO5 in regulating intracellular calcium levels.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xavier Suarez-Calvet, Esther Fernandez-Simon, Patricia Pinol-Jurado, Jorge Alonso-Perez, Ana Carrasco-Rozas, Cinta Lleixa, Susana Lopez-Fernandez, Gemma Pons, Laura Soria, Anne Bigot, Vincent Mouly, Isabel Illa, Eduard Gallardo, Jyoti K. Jaiswal, Jordi Diaz-Manera
Summary: The study presented a method to isolate and grow SCs and FAPs from frozen human skeletal muscle biopsies, demonstrating their multipotency and interactions.
Editorial Material
Biochemistry & Molecular Biology
Marshall W. Hogarth, Prech Uapinyoying, Davi A. G. Mazala, Jyoti K. Jaiswal
Summary: In addition to myofibers, there are many mononucleated cells in skeletal muscle, including fibro-adipogenic progenitors (FAPs), which support muscle development and regeneration in adults. Recent evidence suggests that defects in FAP function contribute to chronic muscle diseases, making targeting FAPs a potential avenue for treating these diseases.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Daniel C. Bittel, Sen Chandra Sreetama, Goutam Chandra, Robin Ziegler, Kanneboyina Nagaraju, Jack H. Van der Meulen, Jyoti K. Jaiswal
Summary: Efficient sarcolemmal repair is crucial for muscle cell survival. This study presents a novel gene therapy approach for limb girdle muscular dystrophy 2B (LGMD2B) targeting reduced secretion of acid sphingomyelinase (ASM). Treatment with liver-specific adeno-associated virus (AAV) vector expressing human ASM (hASM) restored membrane repair capacity and improved muscle strength in patient cells and a mouse model. This non-muscle-targeted gene therapy could attenuate muscle degeneration and provide a potential treatment for LGMD2B.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Goutam Chandra, Davi A. G. Mazala, Jyoti K. Jaiswal
Summary: Cells utilize ER-driven Cl- uptake to sequester injury-induced cytosolic Ca2+ overload, which is crucial for maintaining cellular function and repair response. Lack of ER-resident Anoctamin 5 (ANO5) contributes to difficulties in coping with Ca2+ overload, leading to muscular dystrophy.