Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin

Substitutions in the β subunits of sickle-cell hemoglobin improve oxidative stability and increase the delay time of sickle-cell fiber formation

(2019) Fantao Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L-glutamine for sickle cell anemia: more questions than answers

(2018) Charles T. Quinn   BLOOD

Oxidative pathways in the sickle cell and beyond

(2018) Abdu I. Alayash   BLOOD CELLS MOLECULES AND DISEASES

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells

(2018) Akito Nakagawa et al.   MOLECULAR PHARMACEUTICS

Therapeutic strategies for sickle cell disease: towards a multi-agent approach

(2018) Marilyn J. Telen et al.   NATURE REVIEWS DRUG DISCOVERY

Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway

(2018) Elie Nader et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

(2017) Ramasamy Jagadeeswaran et al.   EXPERIMENTAL HEMATOLOGY

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects

(2017) Tigist Kassa et al.   Metallomics

Sickle cell disease: Its molecular mechanism and the one drug that treats it

(2016) Frank A. Ferrone   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)

(2015) Tigist Kassa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents

(2015) A. M. Omar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

(2014) Akito Nakagawa et al.   ACS Chemical Biology

Post-translational Transformation of Methionine to Aspartate Is Catalyzed by Heme Iron and Driven by Peroxide

(2014) Michael Brad Strader et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

(2013) A. George et al.   BLOOD

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

Sickle-cell disease

(2010) David C Rees et al.   LANCET