标题
Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
作者
关键词
-
出版物
Frontiers in Neuroscience
Volume 13, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-08-23
DOI
10.3389/fnins.2019.00837
参考文献
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- (2019) Lindsey Friend et al. MOLECULES
- The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers
- (2018) Viktoria Moschetti et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span
- (2018) Neema S. Patel et al. NEUROBIOLOGY OF AGING
- A phase I, randomized, proof-of-clinical-mechanism study assessing the pharmacokinetics and pharmacodynamics of the oral PDE9A inhibitor BI 409306 in healthy male volunteers
- (2017) Katja Boland et al. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
- Endocannabinoid modulation of dopamine neurotransmission
- (2017) Dan P. Covey et al. NEUROPHARMACOLOGY
- Different phosphodiesterases (PDEs) regulate distinct phosphoproteomes during cAMP signaling
- (2017) Paul M. Epstein PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STUDY DESIGN AND CHARACTERISTICS OF TWO PHASE II PROOF-OF-CONCEPT CLINICAL TRIALS OF THE PDE9 INHIBITOR BI 409306 IN EARLY ALZHEIMER'S DISEASE
- (2016) Glen Wunderlich et al. Alzheimers & Dementia
- Natriuretic peptides in the central nervous system: Novel targets for cognitive impairment
- (2016) Simin Mahinrad et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease
- (2016) Tao Su et al. Scientific Reports
- Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
- (2016) M S Alexander et al. Translational Psychiatry
- Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor
- (2015) Dávid Nagy et al. EXPERIMENTAL NEUROLOGY
- Facilitation of Corticostriatal Transmission following Pharmacological Inhibition of Striatal Phosphodiesterase 10A: Role of Nitric Oxide-Soluble Guanylyl Cyclase-cGMP Signaling Pathways
- (2015) F. E. Padovan-Neto et al. JOURNAL OF NEUROSCIENCE
- Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease
- (2015) Dong I. Lee et al. NATURE
- A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease
- (2014) Elias Schwam et al. Current Alzheimer Research
- PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition
- (2014) Katja S. Kroker et al. NEUROBIOLOGY OF AGING
- A systematic review of the effects of NMDA receptor antagonists on oscillatory activity recorded in vivo
- (2013) Mark J Hunt et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders
- (2012) Patrick R. Verhoest et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP
- (2012) Katja S. Kroker et al. NEUROPHARMACOLOGY
- The Selective Phosphodiesterase 9 (PDE9) Inhibitor PF-04447943 Attenuates a Scopolamine-Induced Deficit in a Novel Rodent Attention Task
- (2011) Joshua D. Vardigan et al. JOURNAL OF NEUROGENETICS
- The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
- (2011) P.H. Hutson et al. NEUROPHARMACOLOGY
- Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
- (2010) Viktor Lakics et al. NEUROPHARMACOLOGY
- PDE9A-mediated regulation of cGMP: Developing a biomarker for a novel therapy for Alzheimer's disease
- (2009) Christopher J. Schmidt et al. Alzheimers & Dementia
- Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
- (2009) Patrick R. Verhoest et al. JOURNAL OF MEDICINAL CHEMISTRY
- Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
- (2009) Miles D. Houslay TRENDS IN BIOCHEMICAL SCIENCES
- Concepts of neural nitric oxide-mediated transmission
- (2008) John Garthwaite EUROPEAN JOURNAL OF NEUROSCIENCE
- Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia
- (2008) C. J. Schmidt et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents
- (2008) F. Josef van der Staay et al. NEUROPHARMACOLOGY
- Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background
- (2007) Judith A. Siuciak et al. NEUROPHARMACOLOGY
- Natriuretic peptides and their receptors in the central nervous system
- (2007) Li-Hui Cao et al. PROGRESS IN NEUROBIOLOGY
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