Review
Cell Biology
Desh Deepak Singh, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ihn Han, Eun-Ha Choi, Dharmendra K. Yadav
Summary: There are common molecular mechanisms and underlying pathology, such as insulin resistance and impaired synaptic plasticity, between type 2 diabetes mellitus and dementia. Analyzing risk factors is crucial for disease development and clinical management.
Article
Neurosciences
S. Sri Sabari, Kiruthika Balasubramani, Mahalaxmi Iyer, Harysh Winster Sureshbabu, Dhivya Venkatesan, Abilash Valsala Gopalakrishnan, Arul Narayanaswamy, Nachimuthu Senthil Kumar, Balachandar Vellingiri
Summary: Growing evidence suggests a connection between insulin dysregulation in the brain and Parkinson's disease (PD), although the link between PD and type 2 diabetes mellitus (T2DM) is still debated. Insulin plays a crucial role in brain function, and changes in insulin metabolism and signaling can lead to various brain disorders. T2DM is linked to PD and other neurodegenerative diseases, sharing pathophysiological factors such as insulin dysregulation, oxidative stress, microglial activation, and inflammation. Further research should focus on understanding the role of insulin in order to develop effective therapies for T2DM-associated PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francisco Jose Sanz, Cristina Solana-Manrique, Joaquin Lilao-Garzon, Yeray Brito-Casillas, Silvia Munoz-Descalzo, Nuria Paricio
Summary: Recent studies have found a potential link between diabetes and Parkinson's disease. Using fruit fly and mouse models, as well as human neuron-like cells, researchers discovered that high glucose levels may contribute to the development of Parkinson's disease, and the anti-diabetic drug metformin could potentially be used as a treatment for the disease.
Review
Cell Biology
Carmen M. Labandeira, Arturo Fraga-Bau, David Arias Ron, Elena Alvarez-Rodriguez, Pablo Vicente-Alba, Javier Lago-Garma, Ana I. Rodriguez-Perez
Summary: The relationship between Parkinson's disease and diabetes has gained attention, as diabetes increases the risk and affects the prognosis and progression of Parkinson's disease. The use of insulin and antidiabetic medications in Parkinson's disease treatment may open new possibilities.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Neurosciences
Marco Greco, Anas Munir, Debora Musaro, Chiara Coppola, Michele Maffia
Summary: Parkinson's disease is a pathological condition characterized by protein aggregation, and type 2 diabetes may be one of its etiological factors as it alters biological processes such as autophagy and mitochondrial homeostasis.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
A. G. Unnikrishnan, R. K. Sahay, Uday Phadke, S. K. Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S. K. Wangnoo, Santosh Singhal, Mathew John, Ajay Kumar, Mala Dharmalingam, Subodh Jain, Shehla Shaikh, Willem J. Verberk
Summary: Through studying newly diagnosed T2DM patients in India, it is found that they have high cardiovascular disease risk. This indicates the need for further extension of ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases.
Article
Endocrinology & Metabolism
Fiona Bragg, Christiana Kartsonaki, Yu Guo, Michael Holmes, Huaidong Du, Canqing Yu, Pei Pei, Ling Yang, Donghui Jin, Yiping Chen, Dan Schmidt, Daniel Avery, Jun Lv, Junshi Chen, Robert Clarke, Michael Hill, Liming Li, Iona Millwood, Zhengming Chen
Summary: Metabolites across diverse pathways were independently associated with the risk of T2D in Chinese adults, providing valuable etiological insights and potential to improve T2D risk prediction.
Article
Endocrinology & Metabolism
Fiona Bragg, Christiana Kartsonaki, Yu Guo, Michael Holmes, Huaidong Du, Canqing Yu, Pei Pei, Ling Yang, Donghui Jin, Yiping Chen, Dan Schmidt, Daniel Avery, Jun Lv, Junshi Chen, Robert Clarke, Michael Hill, Liming Li, Iona Millwood, Zhengming Chen
Summary: A study conducted on Chinese adults found that circulating metabolites are independently associated with the risk of type 2 diabetes (T2D), providing valuable insights into the etiology of the disease and potential for improving T2D risk prediction.
Review
Clinical Neurology
Kaitlyn M. L. Cramb, Dayne Beccano-Kelly, Stephanie J. Cragg, Richard Wade-Martins
Summary: Cramb et al. provide a review of evidence suggesting dopamine release deficits occur prior to neurodegeneration in Parkinson's disease. They also highlight the need for further investigation in understanding the mechanisms behind these deficits.
Review
Neurosciences
Klara Komici, Grazia Daniela Femminella, Leonardo Bencivenga, Giuseppe Rengo, Gennaro Pagano
Summary: Studies show that while the prevalence of DM in PD patients is similar to the general population, individuals with DM have a higher risk of developing PD. Furthermore, the presence of DM is associated with greater severity and faster progression of PD symptoms compared to PD patients without DM.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Endocrinology & Metabolism
Kalie L. Tommerdahl, Karl Baumgartner, Michal Schafer, Petter Bjornstad, Isabella Melena, Shannon Hegemann, Amy D. Baumgartner, Laura Pyle, Melanie Cree-Green, Uyen Truong, Lorna Browne, Judith G. Regensteiner, Jane E. B. Reusch, Kristen J. Nadeau
Summary: The study evaluated the impact of BMI on cardiovascular and kidney outcomes in youth with T1D and T2D, finding that obese adolescents with T1D have a higher cardiovascular and kidney disease risk profile, similar to youth with T2D.
Review
Immunology
Shen Lu, Yanrong Li, Zhaojun Qian, Tiesuo Zhao, Zhiwei Feng, Xiaogang Weng, Lili Yu
Summary: This article reviews the role and research progress of the inflammasome in insulin resistance (IR) and type 2 diabetes mellitus (T2DM), emphasizing on the structure, activation, and regulation of several main inflammasomes. The therapeutic options associated with inflammasome for the treatment of T2DM, particularly NLRP3-related agents, are also discussed. In summary, this review provides insights into the involvement of the inflammasome in IR and T2DM and highlights its potential as a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Julienne Haas, Daniela Berg, Anja Bosy-Westphal, Eva Schaeffer
Summary: Studies show that patients with Parkinson's disease have a strong craving for sweets and consume more high-sugar food. This high-sugar intake may increase insulin concentration, which can positively affect dopamine concentration in the brain and act as self-medication to compensate for dopamine deficiency. However, it may also lead to insulin resistance and diabetes, which are discussed as causes for progressive neurodegeneration in Parkinson's disease.
Review
Food Science & Technology
Mengjiao Wang, Min Chen, Rui Guo, Yangyang Ding, Haihui Zhang, Yuanqing He
Summary: This review summarizes the role of sulforaphane in improving T2DM and its potential mechanisms, especially in insulin resistance, glucose metabolism, lipid metabolism, oxidative stress, and inflammatory factors. It also emphasizes the effects of sulforaphane on T2DM complications and provides evidence for further research and development as a hypoglycemic drug.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Psychology, Developmental
Marco Pozzi, Roberta Ida Ferrentino, Giulia Scrinzi, Cristina Scavone, Annalisa Capuano, Sonia Radice, Maria Nobile, Pietro Formisano, Emilio Clementi, Carmela Bravaccio, Carla Carnovale, Simone Pisano
Summary: Antipsychotics increase weight, BMI, and waist size in pediatric patients. Olanzapine and clozapine have the highest risk, followed by risperidone, quetiapine, and aripiprazole. The risk magnitude is specific to each drug and not influenced by the duration of clinical observations.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Giuseppe Gabriele Iorio, Alessandro Conforti, Roberta Vallone, Luigi Carbone, Margherita Matarazzo, Anna De Rosa, Pasquale De Rosa, Silvia Picarelli, Flora Fedele, Giuseppe Perruolo, Pietro Formisano, Raffaele Iorio, Carlo Alviggi, Fabiola Di Dato
Summary: Research showed that WD patients with hepatic onset, diagnosed early and well-treated, do not show impaired fertility potential. However, males may have reduced sperm motility and females lower LH values. Only patients with poor disease control exhibit some evidence of impaired fertility.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Endocrinology & Metabolism
Vittoria D'Esposito, Maria Rosaria Ambrosio, Domenico Liguoro, Giuseppe Perruolo, Manuela Lecce, Serena Cabaro, Marianna Aprile, Ada Marino, Vincenzo Pilone, Pietro Forestieri, Claudia Miele, Dario Bruzzese, Daniela Terracciano, Francesco Beguinot, Pietro Formisano
Summary: In individuals with severe obesity, inflammatory cytokines derived from adipose tissue contribute to the development of type 2 diabetes. Specifically, TNF alpha levels are elevated in adipose tissue and differentiated adipocytes from individuals with impaired glucose tolerance and type 2 diabetes, compared to those with normal glucose tolerance. The anti-inflammatory flavonoid quercetin may help attenuate this inflammatory response and potentially prevent the progression to type 2 diabetes in severe obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Multidisciplinary Sciences
Marco Milone, Antonella Desiderio, Nunzio Velotti, Michele Manigrasso, Sara Vertaldi, Umberto Bracale, Michele D'Ambra, Giuseppe Servillo, Giuseppe De Simone, Fatima Domenica Elisa De Palma, Giuseppe Perruolo, Gregory Alexander Raciti, Claudia Miele, Francesco Beguinot, Giovanni Domenico De Palma
Summary: The study found that compared to extracorporeal anastomosis, intracorporeal anastomosis significantly reduced levels of proinflammatory mediators such as IL-6, CRP, TNF, and IL-1 beta, while also increasing levels of anti-inflammatory cytokines IL-10 and IL-13. In terms of hormonal response, cortisol levels were increased in the extracorporeal anastomosis group, while insulin levels were reduced.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Pellegrino Cerino, Alfonso Gallo, Biancamaria Pierri, Carlo Buonerba, Denise Di Concilio, Maria Concetta Cuomo, Lucia Vassallo, Gabriella Lo Conte, Annachiara Coppola, Antonio Pizzolante, Giovanni Boccia, Veronica Ferrucci, Luigi Atripaldi, Maria Triassi, Daniela Pacella, Michele Cennamo, Paolo Romano, Teresa Maria Sorbo, Alessandro Furno, Oriana Catapano, Aldo Contina, Giuseppe Perruolo, Maurizio D'Amora, Daniela Terracciano, Giuseppe Portella
Summary: The study compared four chemiluminescence immunoassays and one immunochromatography test for the evaluation of SARS-CoV-2 infection spread in Salerno Province. A total of 3,185 specimens from citizens were tested for anti-SARS-CoV-2 antibodies as part of a screening program.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Neurosciences
Marianna Liparoti, Emahnuel Troisi Lopez, Laura Sarno, Rosaria Rucco, Roberta Minino, Matteo Pesoli, Giuseppe Perruolo, Pietro Formisano, Fabio Lucidi, Giuseppe Sorrentino, Pierpaolo Sorrentino
Summary: This study investigated the effects of sex hormones on the organization of the brain network and their potential relationship with psychological states throughout the menstrual cycle. Results showed that variations in sex hormones during different menstrual cycle phases were correlated with changes in brain network topology and psychological well-being.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Vittoria D'Esposito, Jose Camilla Sammartino, Pietro Formisano, Alessia Parascandolo, Domenico Liguoro, Daniela Adamo, Gilberto Sammartino, Gaetano Marenzi
Summary: This study evaluated the effects of different titanium implant surfaces on BFP-MSCs viability and secretion of cytokines, with results showing that the surfaces did not impair cell viability and preserved their secretion abilities. Further research is needed to define implant surface parameters for optimal release of chemokines.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Francesca Chiara Pignalosa, Antonella Desiderio, Paola Mirra, Cecilia Nigro, Giuseppe Perruolo, Luca Ulianich, Pietro Formisano, Francesco Beguinot, Claudia Miele, Raffaele Napoli, Francesca Fiory
Summary: Diabetes mellitus can lead to cognitive dysfunction, with alterations in the dopaminergic system playing a role. Research suggests that advanced glycation end products may be associated with cognitive impairment and changes in the dopaminergic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Roberto Buonaiuto, Fabiana Napolitano, Sara Parola, Pietro De Placido, Valeria Forestieri, Giovanna Pecoraro, Alberto Servetto, Luigi Formisano, Pietro Formisano, Mario Giuliano, Grazia Arpino, Sabino De Placido, Carmine De Angelis
Summary: Leptin, a hormone involved in appetite control and energy balance, can contribute to chronic inflammation and cancer development when adipose tissue expands. Leptin activates multiple cancer pathways and affects cancer immune response. High levels of leptin associated with obesity are related to breast cancer risk.
Article
Oncology
Maria Rosaria Ambrosio, Giusy Mosca, Teresa Migliaccio, Domenico Liguoro, Gisella Nele, Fabrizio Schonauer, Francesco D'Andrea, Federica Liotti, Nella Prevete, Rosa Marina Melillo, Carla Reale, Concetta Ambrosino, Claudia Miele, Francesco Beguinot, Vittoria D'Esposito, Pietro Formisano
Summary: This study demonstrates that high glucose levels enhance the aggressiveness of breast cancer cells and promote a pro-tumorigenic phenotype in mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs). The findings suggest that metabolic control may be important for reducing cancer outgrowth and preserving the functions of the adipose microenvironment.
Article
Cell & Tissue Engineering
Alessia Parascandolo, Michele Francesco Di Tolla, Domenico Liguoro, Manuela Lecce, Saverio Misso, Fabiana Micieli, Maria Rosaria Ambrosio, Serena Cabaro, Francesco Beguinot, Alessandra Pelagalli, Vittoria D'Esposito, Pietro Formisano
Summary: Platelet products are commonly used in regenerative medicine for wound healing, reduction of bleeding, tissue synthesis, and revascularization. Human platelet-rich plasma (hPRP) was found to support canine mesenchymal stem cells (cMSCs) by increasing their viability and migration. This study suggests that hPRP may be a promising tool for canine tissue regeneration and repair.
STEM CELLS INTERNATIONAL
(2023)
Review
Microbiology
Antonio Santaniello, Giuseppe Perruolo, Serena Cristiano, Ayewa Lawoe Agognon, Serena Cabaro, Alessia Amato, Ludovico Dipineto, Luca Borrelli, Pietro Formisano, Alessandro Fioretti, Francesco Oriente
Summary: In March 2020, the World Health Organization declared the COVID-19 outbreak as a global pandemic due to its rapid spread worldwide. This pandemic has not only been a health emergency but also a significant general problem, leading to economic and social activities being put on hold. The review focuses on the clinical manifestations, diagnosis methods, potential transmission risks, and impact on the human-animal relationship.
Article
Biochemistry & Molecular Biology
Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano, Filomena Morisco, Silvia Savastano
Summary: Visceral obesity is associated with the progression of NASH. CK18 epitopes M30 and M65 are accurate markers for detecting NASH. This study found that CK18M30 and CK18M65 levels were significantly correlated with anthropometric and metabolic characteristics, liver stiffness, and indices of steatosis and fibrosis in subjects with visceral obesity. These levels could serve as good biomarkers for early identification of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Manuela Leri, Marzia Vasarri, Federica Carnemolla, Francesco Oriente, Serena Cabaro, Maria Stio, Donatella Degl'Innocenti, Massimo Stefani, Monica Bucciantini
Summary: In Alzheimer's disease, microglia become chronically inflammatory and neurotoxic. Genetic variants of molecules like TREM2 increase the risk of developing AD. This study explored the protective effects of extra virgin olive oil polyphenols on neuronal and microglial cells, finding that they reduce pro-inflammatory cytokines, activate the anti-inflammatory pathway, and enhance microglial activity. These findings offer important insights into the mechanisms by which olive polyphenols alleviate neuroinflammation and neuronal impairment.