Article
Biochemistry & Molecular Biology
Na Zhang, Jiafei Ji, Dandan Zhou, Xuan Liu, Xinglin Zhang, Yingqi Liu, Weifang Xiang, Meida Wang, Lian Zhang, Guannan Wang, Baiqu Huang, Jun Lu, Yu Zhang
Summary: The study revealed that in direct co-culture model, breast cancer cells undergo epithelial-mesenchymal transition (EMT) and exhibit stronger migration and invasion abilities by activating Notch signaling. Additionally, non-senescent breast cancer cells facilitate senescent breast cancer cells to re-enter the cell cycle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yves Boucher, Ashwin S. Kumar, Jessica M. Posada, Evisa Gjini, Kathleen Pfaff, Mikel Lipschitz, Ana Lako, Dan G. Duda, Scott J. Rodig, F. Stephen Hodi, Rakesh K. Jain
Summary: The study showed that a single dose of bevacizumab can reduce the density of angiopoietin-2-positive vessels and increase the infiltration of immune cells in patients with primary triple-negative breast cancer, suggesting a potential rationale for combining bevacizumab with immune checkpoint blockers in neoadjuvant treatment to improve efficacy.
NPJ PRECISION ONCOLOGY
(2021)
Article
Biology
Yinan Jiang, Yichen Guo, Jinjin Hao, Rachael Guenter, Justin Lathia, Adam W. Beck, Reagan Hattaway, Douglas Hurst, Qiming Jane Wang, Yehe Liu, Qi Cao, Helen Krontiras, Herbert Chen, Roy Silverstein, Bin Ren
Summary: The study explores the arteriolar niche within the tumor microenvironment for breast cancer stem cell regulation, finding that BCSCs interact with arteriolar endothelial cells through LPA/PKD-1 signaling. This interaction promotes EC differentiation and BCSC self-renewal, highlighting the potential therapeutic impact of targeting the LPA/PKD-1-CD36 pathway to disrupt the arteriolar niche and eliminate CSCs.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Arushi Jaiswal, Kiichi Murakami, Andrew Elia, Yukiko Shibahara, Susan J. Done, Stephen A. Wood, Nicholas J. Donato, Pamela S. Ohashi, Michael Reedijk
Summary: The study suggests that inhibition of USP9x can treat TNBC by reducing Notch activity, decreasing tumor inflammation, enhancing antitumor immune response, and suppressing tumor growth. Pharmacological inhibition of USP9x can remodel the tumor immune landscape, reduce tumor growth without toxicity, and target Notch in metabolically vulnerable tissues like TNBC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Sheng Xia, Heather L. Menden, Sherry M. Mabry, Venkatesh Sampath
Summary: HDAC6 regulates VEGF-induced angiogenesis through acetylation and repression of NICD and SNW1 transcriptional regulators.
Article
Biochemistry & Molecular Biology
Polash Kumar Biswas, Sang Rok Park, Jongyub An, Kyung Min Lim, Ahmed Abdal Dayem, Kwonwoo Song, Hye Yeon Choi, Yujin Choi, Kyoung Sik Park, Hyun Jin Shin, Aram Kim, Minchan Gil, Subbroto Kumar Saha, Ssang-Goo Cho
Summary: In this study, the expression of GPR50 in CSLC and breast cancer cell lines was evaluated, and its role in CSLC progression was investigated. Knockdown of GPR50 in CSLC resulted in decreased cancer properties and stemness. GPR50 was found to regulate NF-kB and NOTCH signaling pathways, as well as ADAM-17 activity, in CSLC. Overall, this study provided novel insights into GPR50-mediated regulation of the NF-kappa B-Notch signaling pathway in CSLC and its implications for treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuxi Ma, Yongyou Zhu, Li Shang, Yan Qiu, Na Shen, Jonathan Wang, Tiffany Adam, Wei Wei, Qingxuan Song, Jun Li, Max S. Wicha, Ming Luo
Summary: This study reveals that XIST plays a crucial role in regulating breast cancer stem cells by activating IL-6 proinflammatory signaling pathway. This finding is significant for understanding the mechanism of breast cancer development.
Article
Oncology
Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf, Sadegh Babashah
Summary: Breast cancer is a complex disease with different molecular subtypes. Notch signaling pathway plays a crucial role in breast cancer progression by regulating the differentiation of breast epithelial cells. Through analysis of large-scale databases, we found that Notch regulators have different roles and functions in different subtypes. Modulating the expression levels of Notch receptors and effectors may be a potential therapeutic approach for breast cancer.
Review
Pharmacology & Pharmacy
Dilip K. Patel, Roohi Kesharwani, Amita Verma, Fahad A. Al-Abbasi, Firoz Anwar, Vikas Kumar
Summary: Malignant breast cancers are a major cause of increased deaths among women worldwide. Recent research has shown that the Wnt signaling pathway plays a crucial role in this disease, regulating the growth and proliferation of cancer cells, sustaining stemness, therapy resistance, and aggregate formation. The three highly conserved Wnt signaling pathways, Wnt-planar cell polarity (PCP), Wnt/β-catenin signaling, and Wnt-Ca2+ signaling, have distinct roles in the maintenance and improvement of breast cancer. In this review, we examine ongoing studies on Wnt signaling pathways, discuss how dysregulation of these pathways promotes breast cancers, and explore how Wnt dysregulation could be utilized for new treatments for malignant breast cancers.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Yanzhu Shi, Deyu Zhang, Jingyi Chen, Qiwei Jiang, Songze Song, Yue Mi, Tao Wang, Qinong Ye
Summary: This study identified six key genes related to breast cancer metastasis, with BEND5 being the most significant one. Low expression of BEND5 is associated with advanced stage and shorter overall survival in breast cancer patients. Functional experiments showed that BEND5 can suppress the growth and metastasis of breast cancer. Mechanistically, BEND5 inhibits the Notch signaling pathway through interacting with the transcription factor RBPJ/CSL.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Pratibha Pandey, Fahad Khan, Min Choi, Sujeet Kumar Singh, Han Na Kang, Moon Nyeo Park, Seong-Gyu Ko, Sanjeev Kumar Sahu, Rupa Mazumder, Bonglee Kim
Summary: Natural products have been an unmatched source of anticancer medications in the current drug development period. They modify the cancer microenvironment and various signaling pathways, playing a significant role in cancer treatment. These substances are effective against multiple signaling pathways, particularly in cell death and embryonic developmental pathways. More research is needed to fully understand their function in cancer treatments and their potential as therapeutic agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Tianshu Zhang, Huimin Zhou, Kexin Wang, Xiaowei Wang, Mengyan Wang, Wenxia Zhao, Xiaoming Xi, Yang Li, Meilian Cai, Wuli Zhao, Yanni Xu, Rongguang Shao
Summary: Breast cancer is one of the most common malignant tumors in women and its occurrence has become the biggest threat. Understanding the characteristics and molecular mechanisms of breast cancer stem cells is crucial for developing targeted drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Frederick Allen, Ivan Maillard
Summary: The Notch signaling pathway has been investigated as a therapeutic target for cancers and immune/inflammatory disorders, orchestrating cell fate decisions and regulating immune responses through cell-to-cell contacts. It has shown potential in inhibiting tumor growth and preventing/reversing inflammatory disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed, Mona S. Abdellateif
Summary: This study characterized breast cancer stem cells (BCSCs) through genetic profiling, revealing specific molecular profiles that differ according to their phenotypes. These profiles could potentially impact patients' prognosis and outcome.
CANCER CELL INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Yan Li, Jianhua Wang, Chengzhen Gao, Qiyan Hu, Xiaogang Mao
Summary: ITM2A is downregulated in cervical tumor tissues and associated with poor survival; Overexpression of ITM2A increases the sensitivity of cervical cancer cells to cisplatin; ITM2A may mediate cisplatin-resistant cervical cancer through the Notch signaling pathway.
Article
Cell Biology
Rui Zhao, Xianji Liu, Zenghua Qi, Xiaoqiang Yao, Suk Ying Tsang
Summary: The study found that TRPV1 channels regulate the electrophysiological characteristics of ESC-CMs by controlling calcium release from the sarcoplasmic reticulum (SR) and stimulating Na+/Ca2(+) exchanger (NCX) activity. These novel findings reveal an important interplay between TRPV1 and NCX in regulating the physiological functions of ESC-CMs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Xianji Liu, Rui Zhao, Qianqian Ding, Xiaoqiang Yao, Suk Ying Tsang
Summary: TRPC7 regulates the automaticity of mESC-CMs through two mechanisms: by positively regulating the intracellular Ca2+ clock through the regulation of activities of RyR2 and SERCA, and by positively regulating the membrane clock via its influence on NCX activity. The expression level of TRPC7 affects the frequency of Ca2+ transients, local Ca2+ releases, and action potentials.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Chang-Bo Zheng, Wen-Cong Gao, Mingxu Xie, Zhichao Li, Xin Ma, Wencong Song, Dan Luo, Yongxiang Huang, Jichen Yang, Peng Zhang, Yu Huang, Weimin Yang, Xiaoqiang Yao
Summary: This study demonstrates that Ang II promotes excessive cardiomyocyte autophagy through SOCE/Orai1, which are major contributing factors in cardiac hypertrophy. Inhibition of SOCE or silencing of Orai1 attenuated Ang II-induced cardiomyocyte autophagy and pathological cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Sun, Zijun Zhang, Hang Zhao, Miaoyun Qiu, Ying Wen, Xiaoqiang Yao, Wai Ho Tang
Summary: TRPM2 is highly expressed in various cancers and is associated with adverse prognosis and immune infiltration in kidney renal clear cell carcinoma (KIRC). It may play a role in T-cell activation and can serve as a marker to predict prognosis and immune infiltration in KIRC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Meeting Abstract
Genetics & Heredity
Shen Gu, Chen Wang, Wai Lan Yeung, Xiao Qiang Yao, Yuet Ping Liz Yuen
GENETICS IN MEDICINE
(2022)
Review
Physiology
Jun Zhang, Huikai Yuan, Xiaoqiang Yao, Shuo Chen
Summary: Mammalian expression systems, particularly HEK-293 cells, combined with electrophysiological studies, have greatly improved our understanding of ion channels. It was previously assumed that endogenous ion channels in HEK-293 cells were negligible, but recent studies have shown their presence should be considered. This article summarizes the different endogenously expressed ion channels in HEK-293 cells and highlights the variability in expression patterns and channel profiles. A better understanding of endogenous ion channels can help minimize potential issues in characterizing heterologously expressed ion channels. It is recommended to examine the functional profile of HEK-293 cells before transfection, especially when endogenous ion channels are not overwhelmed by exogenous ion channels.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Cell Biology
Yunting Zhang, Fan Ying, Xiaoyu Tian, Zhenchuan Lei, Xiao Li, Chun-Yin Lo, Jingxuan Li, Liwen Jiang, Xiaoqiang Yao
Summary: TRPM2 plays a promoting role in the progression of hypercholesterolemia-induced atherosclerosis by linking ROS to Ca2+ and inflammation.
Article
Gastroenterology & Hepatology
Mingxu Xie, Joyce Wing Yan Mak, Hongyan Yu, Cherry Tsz Yan Cheng, Heyson Chi Hey Chan, Ting Ting Chan, Louis Ho Shing Lau, Marc Ting Long Wong, Wing-Hung Ko, Liwen Jiang, Xiaoqiang Yao
Summary: This study identified TM9SF4 as a novel protein associated with inflammatory bowel disease (IBD). Deficiency of TM9SF4 exacerbates intestinal inflammation, increases endoplasmic reticulum (ER) stress, and impairs the intestinal epithelial barrier. The reduced expression of TM9SF4 in inflamed colon regions of human ulcerative colitis patients further supports its importance in IBD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhaoyue Meng, Zhichao Li, Mingxu Xie, Hongyan Yu, Liwen Jiang, Xiaoqiang Yao
Summary: TM9SF4 facilitates the cofilin-induced disassembly of F-actin, promoting cancer cell motility and metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Peng Zhang, Chang-Bo Zheng, Xiao-Yu Liu, Xiaowei Zhang, Lingyan Huang, Xianhai Zeng
Summary: This study aims to explore the underlying mechanisms of COVID-19 infection in patients with type 2 diabetes mellitus (T2DM). Through single-cell sequencing, bioinformatics analysis, and basic experiments, it was found that ACE2 and TMPRSS2 are expressed in the ducts of the human pancreas, and T2DM can promote the co-expression of these genes. The study also found that increased blood glucose levels are associated with increased ACE2 expression and an increased number of lymphocytes.
Editorial Material
Cell Biology
Lin-Hua Jiang, Xiaoqiang Yao, Bilal cig
Article
Biochemistry & Molecular Biology
Eddie Chung Ting Chau, Tsz Ching Kwong, Chun Keung Pang, Lee Tung Chan, Andrew Man Lok Chan, Xiaoqiang Yao, John Siu Lun Tam, Shun Wan Chan, George Pak Heng Leung, William Chi Shing Tai, Yiu Wa Kwan
Summary: The study explores the use of genetically modified microorganisms, specifically Lactobacillus casei, as an oral vaccine candidate for delivering antigens of the SARS-CoV-2 Omicron variant. The newly developed vaccine, called OMGVac, demonstrated a strong IgG immune response against the spike protein of the Omicron variant in hamsters. The vaccine was found to be safe with no adverse effects observed, and it highlights the potential of recombinant probiotics as live delivery vectors for initiating systemic immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Juanjuan Li, Hong Ran, Xiaoxia Zeng, Dunhui Yang, Xianhai Zeng, Peng Zhang
Summary: This study evaluated the correlation between HOXB9 expression, prognosis, and immune infiltration in head and neck squamous cell carcinoma (HNSCC). HOXB9 mRNA was found to be upregulated in HNSCC tissues compared to normal tissues, and its expression was positively correlated with tumor malignancy and negatively correlated with patient prognosis. High HOXB9 expression was associated with increased infiltration of certain immune cells, while low expression was associated with an increase in other immune cell types. HOXB9 likely functions as an oncogene in HNSCC by disrupting the immune landscape.
Review
Immunology
Kang Li, Xianhai Zeng, Peng Liu, Xiaoxia Zeng, Jie Lv, Shuqi Qiu, Peng Zhang
Summary: This review discusses the important role of inflammation in the development of head and neck squamous cell carcinoma (HNSCC) through multiple mechanisms and explores the potential of targeting inflammation for the diagnosis and treatment of HNSCC, aiming to improve patient prognosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Xiao Li, Chun-Yin Lo, Chi-Wai Lau, Xiaoqiang Yao
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)