Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Stem cell-based retina models

(2018) Kevin Achberger et al.   ADVANCED DRUG DELIVERY REVIEWS

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Hydroxychloroquine retinopathy

(2017) I H Yusuf et al.   EYE

WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

(2017) Peter Loskill et al.   LAB ON A CHIP

Microfluidic co-cultures of retinal pigment epithelial cells and vascular endothelial cells to investigate choroidal angiogenesis

(2017) Li-Jiun Chen et al.   Scientific Reports

Reprogramming to pluripotency does not require transition through a primitive streak-like state

(2017) Stefanie Raab et al.   Scientific Reports

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

A model microfluidics-based system for the human and mouse retina

(2015) Shawn Mishra et al.   BIOMEDICAL MICRODEVICES

Retina-on-a-chip: a microfluidic platform for point access signaling studies

(2015) Kirsten H. Dodson et al.   BIOMEDICAL MICRODEVICES

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet–Biedl syndrome

(2015) Poppy Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxychloroquine-related retinal toxicity

(2015) Hui Jen Ding et al.   RHEUMATOLOGY

Retinal synaptic regeneration via microfluidic guiding channels

(2015) Ping-Jung Su et al.   Scientific Reports

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

(2014) Xiufeng Zhong et al.   Nature Communications

ROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium

(2014) Roxanne H. Croze et al.   Stem Cells Translational Medicine

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Ocular Toxicity of Targeted Therapies

(2012) Daniel J. Renouf et al.   JOURNAL OF CLINICAL ONCOLOGY

Isotope Coded Protein Labeling Coupled Immunoprecipitation (ICPL-IP): A Novel Approach for Quantitative Protein Complex Analysis From Native Tissue

(2012) Andreas Vogt et al.   MOLECULAR & CELLULAR PROTEOMICS

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions

(2012) Stefan Frank et al.   PLoS One

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

Rat Embryonic Fibroblasts Improve Reprogramming of Human Keratinocytes into Induced Pluripotent Stem Cells

(2011) Leonhard Linta et al.   STEM CELLS AND DEVELOPMENT

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

(2011) Patrick M Chen et al.   Cell and Bioscience

Retinal and Ocular Toxicity in Ocular Application of Drugs and Chemicals – Part II: Retinal Toxicity of Current and New Drugs

(2010) Fernando Marcondes Penha et al.   OPHTHALMIC RESEARCH

Phagocytosis of Retinal Rod and Cone Photoreceptors

(2010) Brian M. Kevany et al.   PHYSIOLOGY

Generation, Purification and Transplantation of Photoreceptors Derived from Human Induced Pluripotent Stem Cells

(2010) Deepak A. Lamba et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture

(2009) Christopher M. Puleo et al.   LAB ON A CHIP

A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells

(2009) Shozo Sonoda et al.   Nature Protocols

Review and update: Current treatment trends for patients with retinitis pigmentosa

(2009) Kelly Shintani et al.   OPTOMETRY