Review
Cell & Tissue Engineering
Mehdi Jahedi Zargar, Saeid Kaviani, Mohammad Vasei, Mina Soufi Zomorrod, Saeed Heidari Keshel, Masoud Soleimani
Summary: Exosomes are extracellular vesicles with diverse cellular functions and potential therapeutic effects. Exosomes derived from mesenchymal stem cells in particular have attracted attention for their ability to modulate the immune system and aid in tissue repair in various diseases, including respiratory conditions.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Chuncha Bao, Chengqi He
Summary: Osteoarthritis is a common chronic painful disease characterized by articular cartilage degeneration, and MSC-derived exosomes are considered as a promising alternative therapy for OA by promoting cartilage repair through delivering various bioactive molecules.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Cell & Tissue Engineering
Mojdeh Salehi Namini, Fatemeh Daneshimehr, Nima Beheshtizadeh, Vahid Mansouri, Jafar Ai, Hossein Kargar Jahromi, Somayeh Ebrahimi-Barough
Summary: Peripheral nerve injury (PNI) is a public health concern that can result in loss of sensory or motor function. Exosome-based therapies have emerged as effective strategies for promoting nerve regeneration and functional recovery. However, challenges such as cell origin, dosage, and targeted delivery still exist for the clinical translation of exosome therapeutics. This review focuses on the role of Schwann cell and mesenchymal stem cell (MSC)-derived exosomes in nerve tissue regeneration and provides insights for developing cell-free MSC therapeutic strategies for nerve injury.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Neurosciences
Xiangyun Yao, Zhiwen Yan, Xiaojing Li, Yanhao Li, Yuanming Ouyang, Cunyi Fan
Summary: Peripheral nerve injuries are common traumatic injuries worldwide, and the use of FK506-stimulated ADSCs has shown potential in promoting nerve regeneration, offering hope for the treatment of severe PNIs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Lin Lu, Aoshuang Xu, Fei Gao, Chenjun Tian, Honglin Wang, Jiayao Zhang, Yi Xie, Pengran Liu, Songxiang Liu, Cao Yang, Zhewei Ye, Xinghuo Wu
Summary: Intervertebral disc degeneration (IVDD) is a major cause of low back pain, which puts a significant burden on healthcare systems worldwide. Current treatments for IVDD are limited, but regenerative strategies involving mesenchymal stem cells (MSCs) and exosomes show promise. This review summarizes the current treatment methods for disc degenerative diseases, highlights the therapeutic role and underlying mechanism of MSC-derived exosomes in IVDD, and discusses future developments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Zeshu Zhu, Ping Zhu, Xiongwei Fan, Xiaoyang Mo, Xiushan Wu
Summary: This article summarizes that mesenchymal stem cells (MSCs) are a potent therapeutic strategy for repairing cardiac injury, but recent studies show that MSCs cannot survive in the heart for a long time. Consequently, the exosomes secreted by MSCs may play a dominant role in the repair of heart injury, promoting the restoration of cardiac cells, vascular proliferation, and immune regulation. The article also summarizes the current research on the acting mechanism, application prospects, and challenges of exosomes, including non-coding RNA, in repairing cardiac injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Neurosciences
Tianhao Yu, Yingxi Xu, Muhammad Arslan Ahmad, Rabia Javed, Haruo Hagiwara, Xiaohong Tian
Summary: Autologous nerve grafts are widely accepted as the gold standard for peripheral nerve repair, but their usability is reduced by inherent drawbacks. Exosomes, as key players in intercellular communication, have shown promising potential in treating peripheral nerve injury and enhancing the repairing capacity of nerve grafts.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Emergency Medicine
Taotao Hu, Shusen Chang, Fang Qi, Zhonghui Zhang, Jiayin Chen, Lingli Jiang, Dali Wang, Chengliang Deng, Kaiyu Nie, Guangchao Xu, Zairong Wei
Summary: This study investigated the role of exosomes derived from Schwann cell-like cells (SCLCs) in peripheral nerve regeneration. SCLCs-exo significantly enhanced motor function recovery, attenuated muscle atrophy, and facilitated axonal regrowth, myelin formation, and angiogenesis. Furthermore, SCLCs-exo efficiently promoted proliferation and migration of Schwann cells and upregulated the expression of neurotrophic factors, myelin regulators, and myelin proteins.
Review
Medicine, General & Internal
Martin Aman, Matthias Schulte, Yu Li, Benjamin Thomas, Simeon Daeschler, Maximilian Mayrhofer-Schmid, Ulrich Kneser, Leila Harhaus, Arne Boecker
Summary: Critically sized nerve defects require reconstruction for lifelong disabilities. Local application of mesenchymal stem cells (MSCs) is considered promising in enhancing peripheral nerve regeneration. A systematic review and meta-analysis were conducted to evaluate the effects of MSCs in preclinical studies. The results showed that co-transplantation of MSCs increased functional index, nerve conduction velocity recovery, muscle atrophy, and axon regeneration in rats with critically sized defects. These findings demonstrate the potential clinical benefits of MSCs in peripheral nerve reconstruction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Zheng Yang, Yang Yang, Yichi Xu, Weiqian Jiang, Yan Shao, Jiahua Xing, Youbai Chen, Yan Han
Summary: In this study, engineered exosomes were used as carriers to efficiently deliver NT-3 mRNA to recipient cells and promote nerve regeneration in a rat sciatic nerve defect model, demonstrating the potential for improving nerve regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Medicine, Research & Experimental
Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu, Heng Ma
Summary: Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative treatment aimed at increasing mitochondrial number and improving mitochondrial function, has been emerged with great therapeutic potential. Substantial evidence indicates that mitochondrial transplantation improves cardiac function and outcomes in patients with CVD. Therefore, mitochondrial transplantation has profound implications in the prevention and treatment of CVD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Qinfeng Yang, Shenghui Su, Shencai Liu, Sheng Yang, Jing Xu, Yixiu Zhong, Yusheng Yang, Liangjie Tian, Zilin Tan, Jian Wang, Zhiqiang Yu, Zhanjun Shi, Fangguo Liang
Summary: An electroconductive hydrogel loaded with bone marrow stem cell-derived exosomes was designed to treat diabetic peripheral nerve injury, resulting in functional recovery and pain relief. This system showed potential for nerve regeneration, functional restoration, and pain relief in patients with diabetic peripheral nerve injury.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Seung-Young Jeong, Hye-Lan Lee, SungWon Wee, HyeYeong Lee, GwangYong Hwang, SaeYeon Hwang, SolLip Yoon, Young-Il Yang, Inbo Han, Keung-Nyun Kim
Summary: Spinal cord injury (SCI) caused by trauma leads to permanent loss of motor, sensory, and autonomic functions. Stem cell therapy, particularly using peripheral nerve-derived stem cell (PNSC) spheroids, has shown therapeutic potential. This study investigated the combined therapy of PNSC spheroids and resolvin D1 (RvD1) for SCI treatment. In vitro analysis confirmed RvD1's anti-inflammatory activity, and in vivo studies using a rat SCI model demonstrated enhanced neuronal regeneration and anti-inflammatory effects with the combined therapy. These findings suggest a novel therapeutic approach for SCI management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Jing Wang, Junwen Wang, Xinyan Li, Kai Shu
Summary: Traumatic brain injury (TBI) is a complex and life-threatening condition with no effective treatment to date. Exosomes (Exos), particularly those derived from cells, have the potential to deliver drugs to target lesions in the brain by crossing the blood-brain barrier. Moreover, Exos-derived microRNAs show promise as biomarkers for TBI. This review examines the potential impact of cell-derived Exos and exosome-derived microRNAs on the diagnosis, therapy, and prognosis prediction of TBI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Zhixiao Liu, Hua Tong, Jian Li, Ling Wang, Xiaoyi Fan, Honghao Song, Mei Yang, Haowei Wang, Xin Jiang, Xuhui Zhou, Hongbin Yuan, Yue Wang
Summary: The stiffness of exosome-loaded hydrogels plays an important role in tissue regeneration, with soft hydrogels showing better repair of injured peripheral nerves compared to stiff hydrogels. Soft hydrogels promote nerve repair by quickly releasing exosomes to inhibit macrophage infiltration and the expression of proinflammatory factors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yumei Liu, Ruiqi Dong, Yuxiang Yang, Hui Xie, Yufeng Huang, Xiaoguang Chen, Dongmei Wang, Ziqiang Zhang
Summary: T-2 toxin, a common contaminant in food, induced kidney injury in rabbits, characterized by increased oxidative stress and inflammation. However, pretreatment with a low dose of SeMet effectively reversed these effects, suggesting a potential protective role of selenium against T-2 toxin-induced kidney damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ziqiang Zhang, Yaolu Xu, Jiajia Wang, Hui Xie, Xueyan Sun, Xuemin Zhu, Lan Wei, Yumei Liu
Summary: Selenium in the form of selenomethionine has been shown to effectively alleviate the immunotoxic effects caused by T-2 toxin, by enhancing antioxidant and anti-inflammatory capabilities.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ziqiang Zhang, Mengyu Zhang, Zhixiang Zhang, Yingying Sun, Jiajia Wang, Chenhao Chang, Xinyan Zhu, Monan Li, Yumei Liu
Summary: This study confirmed that the combination of ADSCs and Mel can promote nerve regeneration by altering the early autophagy activity of the injured nerve.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ziqiang Zhang, Jiajia Wang, Jianing Wang, Hui Xie, Zhikai Zhang, Lihui Shi, Xuemin Zhu, Qiongxia Lv, Xiaoguang Chen, Yumei Liu
Summary: The aim of this study was to investigate the protective effects of selenomethionine (SeMet) on intestinal injury induced by ochratoxin A (OTA) in rabbits. The results showed that SeMet pretreatment attenuated the changes in serum biochemical indicators and decline in production performance caused by OTA exposure. SeMet also inhibited oxidative damage and improved the anti-inflammatory response and intestinal barrier damage in rabbits through the activation of the Nrf2 pathway and inhibition of NF-kappa B activation. The most significant improvement was observed with a dose of 0.4 mg/kg SeMet.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Toxicology
Ziqiang Zhang, Yingying Sun, Haojie Wang, Yuxiang Yang, Ruiqi Dong, Yaolu Xu, Mengyu Zhang, Qiongxia Lv, Xiaoguang Chen, Yumei Liu
Summary: This study investigated the therapeutic effect of Mel-incubated Adipose-derived mesenchymal stem cells (ADSCs) on CCl4-induced hepatic fibrosis. The results showed that Mel-pretreated ADSCs significantly improved CCl4-induced liver fibrosis by inhibiting the expression of proapoptotic genes, promoting the expression of an anti-apoptotic gene, and reducing inflammatory cytokine levels.