Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling

Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment

(2018) Jillian M. Pattison et al.   NATURE GENETICS

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development

(2016) Katherine L. Dauber et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Telomere Length Defines the Cardiomyocyte Differentiation Potency of Mouse Induced Pluripotent Stem Cells

(2016) Tania Aguado et al.   STEM CELLS

Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations

(2016) Elisa Varela et al.   Nature Communications

A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues

(2015) Isha Sethi et al.   BMC GENOMICS

Hallmarks of pluripotency

(2015) Alejandro De Los Angeles et al.   NATURE

A qPCR ScoreCard quantifies the differentiation potential of human pluripotent stem cells

(2015) Alexander M Tsankov et al.   NATURE BIOTECHNOLOGY

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

TeratoScore: Assessing the Differentiation Potential of Human Pluripotent Stem Cells by Quantitative Expression Analysis of Teratomas

(2015) Yishai Avior et al.   Stem Cell Reports

Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing

(2014) Jiameng Dan et al.   DEVELOPMENTAL CELL

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances

(2014) Jérôme D. Robin et al.   GENES & DEVELOPMENT

Emerging interactions between skin stem cells and their niches

(2014) Ya-Chieh Hsu et al.   NATURE MEDICINE

Short Telomeres in ESCs Lead to Unstable Differentiation

(2013) Fabio Pucci et al.   Cell Stem Cell

Notch signaling represses p63 expression in the developing surface ectoderm

(2013) A. M. B. Tadeu et al.   DEVELOPMENT

Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium

(2013) Monica M. Laronda et al.   DEVELOPMENTAL BIOLOGY

Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

(2013) Evan S Bardot et al.   EMBO JOURNAL

AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning

(2012) Yunbo Qiao et al.   CELL RESEARCH

Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

(2012) Naoki Oshimori et al.   Cell Stem Cell

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk

(2012) Arie B. Brinkman et al.   GENOME RESEARCH

Association of telomere length with authentic pluripotency of ES/iPS cells

(2011) Junjiu Huang et al.   CELL RESEARCH

Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

(2011) Wen-Hui Lien et al.   Cell Stem Cell

The role of telomeres in the ageing of human skin

(2011) Erin M. Buckingham et al.   EXPERIMENTAL DERMATOLOGY

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

(2011) E. Ezhkova et al.   GENES & DEVELOPMENT

p63, a Story of Mice and Men

(2011) Hans Vanbokhoven et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in Mice

(2010) Agueda M. Tejera et al.   DEVELOPMENTAL CELL

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging

(2009) Mary Armanios et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

(2009) Elena Ezhkova et al.   CELL

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

(2009) Xiaohua Su et al.   Cell Stem Cell

Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells

(2009) G. J. Stout et al.   Disease Models & Mechanisms

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study

(2009) Hind Guenou et al.   LANCET

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3

(2008) G. L. Sen et al.   GENES & DEVELOPMENT

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT

Skin stem cells: rising to the surface

(2008) Elaine Fuchs   JOURNAL OF CELL BIOLOGY

Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair

(2008) Maria Antsiferova et al.   LABORATORY INVESTIGATION

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL