Article
Oncology
Swati Misri, Kirti Kaul, Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Martin P. Barr, Dinesh K. Ahirwar, Ramesh K. Ganju
Summary: This study demonstrates that cannabidiol (CBD) inhibits the growth and metastasis of drug-resistant non-small cell lung cancer cells (NSCLC) and induces apoptosis of cisplatin-resistant cells. It acts through the TRPV2 receptor and modulates oxidative stress pathways. CBD could be a promising therapeutic strategy for cisplatin-resistant NSCLC.
Article
Biochemistry & Molecular Biology
Yun Chen, Hongying Zhou, Sifu Yang, Dan Su
Summary: Long-term use of platinum-based drugs can lead to strong drug resistance in NSCLC. Increasing drug dosage is not effective and may cause complications. High levels of drug resistance in tumors are usually mediated by multidrug resistance-related genes. In this study, ABCC2 was found to be upregulated in cisplatin-resistant NSCLC cells and knockdown of ABCC2 reversed cisplatin resistance, suggesting it could be a potential therapeutic strategy for overcoming drug resistance in NSCLC patients.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Cell Biology
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou
Summary: This study reveals that G protein-coupled receptor neurokinin-1 (NK1R) is significantly upregulated in lung cancer samples and is associated with advanced clinical stages and poor prognosis. NK1R co-expresses with epidermal growth factor receptor (EGFR) and interacts with it in tumor cells. Activation of NK1R promotes lung cancer cell proliferation and migration through EGFR signaling pathways. Inhibition of NK1R suppresses cell proliferation and migration, and knockdown of NK1R slows down tumor growth. The presence of a selective NK1R antagonist enhances the sensitivity of lung cancer cells to specific drugs.
CELL DEATH & DISEASE
(2022)
Article
Respiratory System
Shaojia Wang, Chao Liu, Qing Lei, Zhengwei Wu, Xiangshuai Miao, Debing Zhu, Xu Yang, Na Li, Mingwei Tang, Yan Chen, Weiwei Wang
Summary: PCAT-1 is highly expressed in gefitinib-resistant NSCLC tissues and cells, and its knockdown can enhance gefitinib sensitivity and induce apoptosis. The mechanism involves inhibiting AKT and GSK3 phosphorylation. Hence, PCAT-1 may serve as a potential therapeutic target for improving gefitinib efficacy.
RESPIRATORY RESEARCH
(2021)
Article
Oncology
Si-Liang Wei, Jing-Jing Ye, Li Sun, Lei Hu, Yuan-Yuan Wei, Da-Wei Zhang, Meng-Meng Xu, Guang-He Fei
Summary: This study identified a novel mechanism involving circKIF20B/miR-615-3p/MEF2A signaling axis in the progression of gefitinib resistance in NSCLC. Downregulation of circKIF20B promotes resistance to gefitinib, while upregulation restores sensitivity. Exosomal circKIF20B may serve as a potential therapeutic target and liquid biopsy candidate in gefitinib-resistant NSCLC.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Chaojie Li, Nannan Yang, Zhijin Chen, Ning Xia, Qungang Shan, Ziyin Wang, Jian Lu, Mingyi Shang, Zhongmin Wang
Summary: Our study revealed that Tie1 is upregulated in a hypoxic environment in non-small cell lung carcinoma (NSCLC) cells, promoting stemness and resistance to cisplatin. Silencing Tie1 reduced stemness properties and increased sensitivity to cisplatin, suggesting its role in tumorigenesis and drug resistance in NSCLC. Additionally, Tie1 expression was induced by hypoxia in an HIF-1 alpha-dependent manner, further supporting its involvement in promoting stemness and drug resistance in NSCLC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Wei Yu, Xiao Zhang, Wei Zhang, Minggang Xiong, Yuhan Lin, Ming Chang, Lin Xu, Yi Lu, Yun Liu, Jian Zhang
Summary: The study found that 19-HB inhibits the proliferation, migration, and invasion, and promotes the apoptosis of NSCLC cells through the Wnt/beta-catenin pathway. Additionally, 19-HB inhibited the growth of xenograft tumors in nude mice with limited toxicity to the liver and kidney.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Ruijie Zhang, Xiaozhi Yang, Dana M. Roque, Chenglong Li, Jiayuh Lin
Summary: LLL12B is a novel small molecule that inhibits the STAT3 pathway in ovarian cancer cells, reducing cell viability and proliferation, and enhancing inhibitory effects when used in combination with frontline chemotherapeutic drugs.
Article
Genetics & Heredity
Shulei Gong, Shiyang Wang, Mingrui Shao
Summary: Methyltransferase-like 14 (METTL14) mediates N-6-methyladenosine (m(6)A) modification to facilitate non-small cell lung cancer (NSCLC) cell resistance to cisplatin (DDP) via the miR-19a-5p/RBM24/AXIN1 axis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Engineering, Multidisciplinary
Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang
Summary: Tan IIA, an active ingredient of Salvia miltiorrhiza, inhibits lung cancer growth by inducing autophagic apoptosis.
Article
Cell Biology
Xiao-Zhong Liao, Ying Gao, Hong-Wei Zhao, Mi Zhou, Dan-Lei Chen, Lan-Ting Tao, Wei Guo, Ling-Ling Sun, Chu-Ying Gu, Han-Rui Chen, Zhi-Wei Xiao, Jia-Xing Zhang, Mei-Fang He, Li-Zhu Lin
Summary: The study demonstrates that the combination of cordycepin (Cor) and cisplatin (DDP) has a synergistic effect on inhibiting proliferation and promoting apoptosis of non-small cell lung cancer (NSCLC) cells. The synergistic actions are associated with the activation of AMPK and inhibition of the AKT pathway. This combination therapy may offer a new therapeutic option for DDP-resistant NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Sravani Ramisetty, Prakash Kulkarni, Supriyo Bhattacharya, Arin Nam, Sharad S. Singhal, Linlin Guo, Tamara Mirzapoiazova, Bolot Mambetsariev, Sandeep Mittan, Jyoti Malhotra, Evan Pisick, Shanmuga Subbiah, Swapnil Rajurkar, Erminia Massarelli, Ravi Salgia, Atish Mohanty
Summary: Translational research in medicine involves collaboration between scientists from different disciplines to apply knowledge from basic sciences to clinical practice. This approach, known as 'Team Medicine', focuses on addressing specific medical goals through partnership between basic science researchers and clinicians. Using cisplatin resistance in non-small cell lung cancer (NSCLC) as an example, this study demonstrates how a 'Team Science' approach was used to identify a previously approved compound that can alleviate cisplatin resistance in NSCLC. It also highlights the potential of a 'Team Medicine' approach in understanding resistance mechanisms and developing strategies to overcome drug resistance in NSCLC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Verena Klingseisen, Julia Slanovc, Manuel Regouc, Andelko Hrzenjak
Summary: This study analyzed the influence of bisdemethoxycurcumin (BDMC) on non-small cell lung carcinoma (NSCLC) cells and found that BDMC had significant cytotoxic effects, especially on cisplatin-resistant cells. BDMC induced apoptosis and autophagy, inhibited cell cycle progression, and suppressed the growth and motility of cisplatin-resistant cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)