Article
Clinical Neurology
Torsten Rackoll, Alexander H. Nave, Martin Ebinger, Matthias Endres, Ulrike Grittner, Agnes Floeel
Summary: The study found a higher rate of serious adverse events in patients undergoing aerobic training compared to the relaxation group within six months post-stroke. The association between aerobic training and serious adverse events was modified by the presence of diabetes mellitus and atrial fibrillation.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Sophie A. van den Berg, Simone M. Uniken Venema, Hendrik Reinink, Jeannette Hofmeijer, Wouter J. Schonewille, Irene Miedema, Puck S. S. Fransen, D. Martijn O. Pruissen, Theodora W. M. Raaijmakers, Gert W. van Dijk, Frank-Erik De Leeuw, Jorine A. van Vliet, Vincent I. H. Kwa, Henk Kerkhoff, Alex van't Net, Rene Boomars, Arjen Siegers, Tycho Lok, Klaartje Caminada, Laura M. Esteve Cuevas, Marieke C. Visser, Casper P. Zwetsloot, Jooske M. F. Boomsma, Mirjam H. Schipper, Roeland P. J. van Eijkelenburg, Olvert A. Berkhemer, Daan Nieboer, Hester F. Lingsma, Bart J. Emmer, Robert J. van Oostenbrugge, Aad van der Lugt, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, Diederik W. J. Dippel, Paul J. Nederkoorn, H. Bart van der Worp
Summary: The MR ASAP trial did not find evidence to support the benefit of transdermal glyceryl trinitrate started within 3 hours of symptom onset in patients with presumed acute stroke in the prehospital setting, and it showed potential early harm in patients with intracerebral hemorrhage.
Article
Medicine, General & Internal
Isla S. Mackenzie, Christopher J. Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D. Struthers, Alan G. Begg, Li Wei, Anthony J. Avery, Jaspal S. Taggar, Andrew Walker, Suzanne L. Duce, Rebecca J. Barr, Jennifer S. Dumbleton, Evelien D. Rooke, Jonathan N. Townend, Lewis D. Ritchie, Thomas M. MacDonald
Summary: The ALL-HEART study aimed to determine whether allopurinol therapy improves major cardiovascular outcomes in patients with ischaemic heart disease. The study found no difference in the primary outcome of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death between participants receiving allopurinol therapy and those receiving usual care.
Article
Medicine, General & Internal
Pengfei Yang, Lili Song, Yongwei Zhang, Xiaoxi Zhang, Xiaoying Chen, Yunke Li, Lingli Sun, Yingfeng Wan, Laurent Billot, Qiang Li, Xinwen Ren, Hongjian Shen, Lei Zhang, Zifu Li, Pengfei Xing, Yongxin Zhang, Ping Zhang, Weilong Hua, Fang Shen, Yihan Zhou, Bing Tian, Wenhuo Chen, Hongxing Han, Liyong Zhang, Chenghua Xu, Tong Li, Ya Peng, Xincan Yue, Shengli Chen, Changming Wen, Shu Wan, Congguo Yin, Ming Wei, Hansheng Shu, Guangxian Nan, Sheng Liu, Wenhua Liu, Yiling Cai, Yi Sui, Maohua Chen, Yu Zhou, Qiao Zuo, Dongwei Dai, Rui Zhao, Qiang Li, Qinghai Huang, Yi Xu, Bengiang Deng, Tao Wu, Panping Lu, Xia Wang, Mark W. Parsons, Ken Butcher, Bruce Campbell, Thompson G. Robinson, Mayank Goyal, Diederik Dippei, Yvo Roos, Charles Majoie, Longde Wang, Yongjun Wang, Jianmin Liu, Craig S. Anderson
Summary: Intensive blood pressure control to lower than 120 mm Hg should be avoided in patients who have received endovascular thrombectomy for acute ischaemic stroke due to intracranial large-vessel occlusion, as it may compromise functional recovery. The more intensive treatment group showed a higher likelihood of poor functional outcome, early neurological deterioration, and major disability at 90 days compared to the less intensive treatment group.
Article
Medicine, General & Internal
Peter J. Mitchell, Bernard Yan, Leonid Churilov, Richard J. Dowling, Steven J. Bush, Andrew Bivard, Xiao Chuan Huo, Guoqing Wang, Shi Yong Zhang, Mai Duy Ton, Dennis J. Cordato, Timothy J. Kleinig, Henry Ma, Ronil Chandra, Helen Brown, Bruce C. Campbell, Andrew K. Cheung, Brendan Steinfort, Rebecca Scroop, Kendal Redmond, Ferdinand Miteff, Yan Liu, Dang Phuc Duc, Hal Rice, Mark W. Parsons, Teddy Y. Wu, Huy-Thang Nguyen, Geoffrey A. Donnan, Zhong Rong Miao, Stephen M. Davis
Summary: This study compared the clinical outcomes of acute ischemic stroke patients with large vessel occlusion who received direct endovascular thrombectomy or bridging therapy. The results showed that direct endovascular thrombectomy did not achieve non-inferiority compared to bridging therapy, suggesting that bridging therapy should be recommended as the standard treatment.
Article
Clinical Neurology
Andrew Bivard, Carlos Garcia-Esperon, Leonid Churilov, Neil Spratt, Michelle Russell, Bruce C. Campbell, Philip Choi, Timothy Kleinig, Henry Ma, Hugh Markus, Carlos Molina, Chung Hsu, Chon-Haw Tsai, Atte Meretoja, Daniel Strbian, Kenneth Butcher, Teddy Wu, Stephen Davis, Geoffrey Donnan, Christopher Levi, Mark Parsons
Summary: In this study, the efficacy and safety of tenecteplase compared to alteplase in acute stroke patients with target mismatch on perfusion imaging will be assessed. This trial aims to provide important data on the role of tenecteplase in acute ischemic stroke.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Jingjing Zhao, Fang Yuan, Changgeng Song, Rong Yin, Mingze Chang, Wei Zhang, Bei Zhang, Liping Yu, Yi Jia, Wiling Ma, Yongbin Song, Chengkai Wang, Chaohui Song, Xinfai Wang, Lei Shang, Fang Yang, Wen Jiang
Summary: In patients with severe stroke, modified full enteral nutrition or hypocaloric enteral nutrition did not significantly reduce the risk of poor outcomes compared with full enteral nutrition over a 90-day period. Hypocaloric enteral nutrition might be associated with increased mortality compared with modified full enteral nutrition. Further studies are needed to investigate the optimal strategy.
Article
Rehabilitation
Chang-Man An, Myoung-Hwan Ko, Dae-Hyun Kim, Gi-Wook Kim
Summary: The study demonstrated that whole-body tilting postural training using Spine Balance 3D may be an effective intervention for lateropulsion recovery in patients with subacute stroke, as well as for improving postural control and activities of daily living.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Medicine, General & Internal
Jingjing Zhao, Changgeng Song, Deshuai Li, Xiai Yang, Liping Yu, Kangjun Wang, Jun Wu, Xiaofeng Wang, Dongsong Li, Bo Zhang, Binyong Li, Jun Guo, Weikui Feng, Feng Fu, Xinrong Gu, Jian Qian, Jialong Li, Xiangjun Yuan, Qiuwu Liu, Jiang Chen, Xiaocheng Wang, Yi Liu, Dong Wei, Ling Wang, Lei Shang, Fang Yang, Wen Jiang
Summary: This study found no evidence that glibenclamide (1.25 mg, 3/day) significantly reduces the proportion of poor outcome at day 90 after intracerebral hemorrhage. Additionally, glibenclamide may result in a higher incidence of hypoglycemia.
Article
Rehabilitation
Natapatchakrid Thimabut, Pattarapol Yotnuengnit, Jittima Charoenlimprasert, Thipwimon Sillapachai, Satoshi Hirano, Eiichi Saitoh, Krisna Piravej
Summary: The study found that the robot-assisted gait training device combined with physiotherapy has better effects on improving ambulatory functions in patients with subacute stroke with hemiplegia compared to physiotherapy alone. It can lead to early improvements in walking ability and Barthel Index for Activities of Daily Living.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Markus P. Schlaich, Marc Bellet, Michael A. Weber, Parisa Danaietash, George L. Bakris, John M. Flack, Roland F. Dreier, Mouna Sassi-Sayadi, Lloyd P. Haskell, Krzysztof Narkiewicz, Ji-Guang Wang
Summary: This study evaluated the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. The results showed that aprocitentan had a blood pressure lowering effect at week 4 and maintained a sustained effect at week 40. The most common adverse event was mild-to-moderate edema or fluid retention.
Article
Medicine, General & Internal
Jesse Dawson, Michele Robertson, David Alexander Dickie, Phillip Bath, Kirsten Forbes, Terence Quinn, Niall M. Broom, Krishna Dani, Alex Doney, Graeme Houston, Kennedy R. Lees, Keith W. Muir, Allan Struthers, Matthew Walters, Mark Barber, Ajay Bhalla, Alan Cameron, Alexander Dyker, Paul Guyler, Ahamad Hassan, Mark T. Kearney, Breffni Keegan, Sekaran Lakshmanan, Mary Joan Macleod, Marc Randall, Louise Shaw, Ganesh Subramanian, David Werring, Alex McConnachie
Summary: This study investigated whether allopurinol could reduce the progression of white matter hyperintensity (WMH) and blood pressure after an ischaemic stroke or transient ischaemic attack (TIA). The results showed that allopurinol had no significant effect on the progression of WMH and blood pressure.
Article
Clinical Neurology
Marjan Tabesh, Mariam Hachem, Lik-Hui Lau, Karen Borschmann, Leonid Churilov, Sarah A. L. Price, Priya Sumithran, Geoffrey Donnan, Jeffrey Zajac, Vincent Thijs, Elif Ekinci
Summary: The study demonstrated the feasibility and safety of using Metformin XR in stroke patients with pre-diabetes, with a low compliance rate. More strategies are needed to improve adherence in future trials.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Rehabilitation
Gillian Mead, David Gillespie, Mark Barber, Allan House, Steff Lewis, Hannah Ensor, Simiao Wu, Trudie Chalder
Summary: This study aimed to test the feasibility of a telephone-delivered intervention for post-stroke fatigue and evaluate its impact on fatigue and other outcomes. The results showed that the intervention did not have a significant effect on fatigue or other measured outcomes. Further trials are needed to explore the potential of interventions for post-stroke fatigue.
CLINICAL REHABILITATION
(2022)
Article
Clinical Neurology
Bernadette Kirzinger, Andrea Stroux, Torsten Rackoll, Matthias Endres, Agnes Floeel, Martin Ebinger, Alexander Heinrich Nave
Summary: Elevated levels of IL-6 and fibrinogen in early subacute stroke were associated with worse outcomes up to 6 months post-stroke. However, exposure to aerobic physical fitness training did not alter the dynamics of inflammatory markers over time.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Regina von Rennenberg, Juliane Herm, Thomas Krause, Simon Hellwig, Helena Stengl, Jan F. Scheitz, Thomas Elgeti, Sebastian N. Nagel, Matthias Endres, Karl Georg Haeusler, Christian H. Nolte
Summary: This study found that elevated cardiac biomarkers, such as high-sensitivity cardiac troponin T (hs-cTnT) and brain natriuretic peptide (BNP), in acute stroke patients are strongly associated with pathological findings on cardiac magnetic resonance imaging (CMR). The elevation of these biomarkers may help identify patients who require a more comprehensive cardiology work-up.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Allergy
Stephanie Dramburg, Serena Perna, Marco Di Fraia, Salvatore Tripodi, Stefania Arasi, Sveva Castelli, Danilo Villalta, Francesca Buzzulini, Ifigenia Sfika, Valeria Villella, Ekaterina Potapova, Maria Antonia Brighetti, Alessandro Travaglini, Simone Pelosi, Ulrike Grittner, Paolo Maria Matricardi
Article
Clinical Neurology
Jessica L. L. Rohmann, Marco Piccininni, Martin Ebinger, Matthias Wendt, Joachim E. E. Weber, Eugen Schwabauer, Frederik Geisler, Erik Freitag, Peter Harmel, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Christian H. H. Nolte, Darius G. G. Nabavi, Ingo Schmehl, Axel Ekkernkamp, Matthias Endres, Heinrich J. J. Audebert
Summary: This study used data from the B_PROUD study in Berlin to examine the effect of additional mobile stroke unit (MSU) dispatch on functional outcomes among all stroke patients. The results showed that MSU dispatch was associated with improved 3-month functional outcomes, without any significant association with the primary disability scale or 7-day mortality.
ANNALS OF NEUROLOGY
(2023)
Review
Clinical Neurology
Andreas Meisel, Fulvio Baggi, Anthony Behin, Amelia Evoli, Anna Kostera-Pruszczyk, Renato Mantegazza, Raul Juntas Morales, Anna Rostedt Punga, Sabrina Sacconi, Michael Schroeter, Jan Verschuuren, Louise Crathorne, Kris Holmes, Maria-Isabel Leite
Summary: This study examined the relationship between autoantibody levels and disease activity in patients with myasthenia gravis (MG). The results indicated a potential positive correlation, which could have clinical implications in guiding treatment decisions. However, due to limited and variable evidence, routine clinical use of autoantibody level testing is not currently recommended.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Sarah Hoffmann, Werner Stenzel, Andreas Meisel
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Sarah Hoffmann, Patrick Waters, Leslie Jacobson, Markus Schuelke, Werner Stenzel, Tobias Ruck, Sophie Lehnerer, Frauke Stascheit, Corinna Preusse, Andreas Meisel
Summary: Autoantibody testing is essential for autoimmune myasthenia gravis diagnosis, but about 15% of patients still show negative results (seronegative MG). This study examined the prevalence of clustered AChR, MuSK, and LRP4 autoantibodies in a large German cohort of seronegative MG patients using a live cell-based assay. Out of 67 SNMG patients, 4.5% had clustered AChR autoantibodies, with two patients showing binding to both adult and fetal AChR. None of the patients tested positive for MuSK or LRP4 autoantibodies. Clinical characteristics were similar between patients with and without clustered AChR autoantibodies. Comparisons with a national MG registry showed broad similarities among seronegative MG patients in both cohorts.
NEUROMUSCULAR DISORDERS
(2023)
Article
Medicine, General & Internal
Sarah Dewilde, Glenn Philips, Sandra Paci, Jon Beauchamp, Silvia Chiroli, Casey Quinn, Laura Day, Mark Larkin, Jacqueline Palace, Sonia Berrih-Aknin, Kristl G. Claeys, Srikanth Muppidi, Renato Mantegazza, Francesco Sacca, Andreas Meisel, Guillaume Bassez, Hiroyuki Murai, M. F. Janssen
Summary: This study aims to explore the impact of myasthenia gravis (MG) on health-related quality of life (HRQoL) from the perspective of patients. The results showed that MG significantly affects patients' daily activities, anxiety and depression, fatigue, breathing, and vision. The impact of the disease becomes more severe with increasing disease severity.
Article
Clinical Neurology
Frauke Stascheit, Annette Aigner, Philipp Mergenthaler, Benjamin Hotter, Sarah Hoffmann, Sophie Lehnerer, Christian Meisel, Andreas Meisel
Summary: This study aimed to evaluate the association between Nfl and neuromuscular destruction and disease severity in MG patients. Serum samples from MG patients and controls were analyzed and compared. The results showed that sNfl levels were higher in MG patients compared to controls, but were not consistently associated with disease severity. Thus, sNfl is not a suitable biomarker for monitoring individual disease progression in MG patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Christiana Franke, Fabian Boesl, Yasemin Goereci, Ameli Gerhard, Finja Schweitzer, Maria Schroeder, Helle Foverskov-Rasmussen, Josephine Heine, Anneke Quitschau, Farid I. Kandil, Ann-Katrin Schild, Carsten Finke, Heinrich J. Audebert, Matthias Endres, Clemens Warnke, Harald Pruess
Summary: Autoantibodies targeting brain epitopes are common in patients with post-COVID-19 syndrome (PCS) and strongly associate with pathological cognitive screening tests, particularly when found in cerebrospinal fluid (CSF).
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Medicine, General & Internal
Sonia Berrih-Aknin, Jacqueline Palace, Andreas Meisel, Kristl G. Claeys, Srikanth Muppidi, Francesco Sacca, Fatemeh Amini, Mark Larkin, Casey Quinn, Jon Beauchamp, Glenn Philips, Femke De Ruyck, Joyce Ramirez, Sandra Paci
Summary: This study aims to explore the impact of myasthenia gravis (MG) in the real world from a patient perspective. The study included MG patients from different countries and found that despite current treatments, patients still experience a significant burden.
Article
Medicine, Research & Experimental
Christopher Nelke, Christina B. Schroeter, Frauke Stascheit, Niklas Huntemann, Marc Pawlitzki, Alice Willison, Saskia Raeuber, Nico Melzer, Ute Distler, Stefan Tenzer, Kai Stuehler, Andreas Roos, Andreas Meisel, Sven G. Meuth, Tobias Ruck
Summary: Therapeutic strategies targeting complement have revolutionized the treatment of myasthenia gravis. A combined proteomics and metabolomics approach was used to study a cohort of MG patients treated with eculizumab or azathioprine, as well as treatment-naive patients. Eculizumab was found to modulate the serum proteometabolome, affecting pathways related to oxidative stress, MAP kinase signaling, and lipid metabolism, particularly arachidonic acid signaling.
Article
Clinical Neurology
Manuel C. Olma, Serdar Tuetuencue, Ulrike Grittner, Claudia Kunze, Muhammad Jawad-Ul-Qamar, Paulus Kirchhof, Joachim Roether, Goetz Thomalla, Roland Veltkamp, Ulrich Laufs, Darius G. Nabavi, Peter U. Heuschmann, Matthias Endres, Karl Georg Haeusler
Summary: Little is known about the extent and standardization of routine cardiac diagnostic work-up at certified stroke-units in Germany. This study analyzed the routine diagnostic work-up at different stroke centres in Germany and found that detection of atrial fibrillation (AF) varied among the centres, with lower detection rates in university-based comprehensive stroke centres compared to non-university-based and primary stroke centres. The use of echocardiography and Holter-ECG monitoring also differed among the centres.
NEUROLOGICAL RESEARCH AND PRACTICE
(2023)
Article
Neuroimaging
Laura Goeschel, Lea Kurz, Andrea Dell'Orco, Theresa Koebe, Peter Koertvelyessy, Ariane Fillmer, Semiha Aydin, Layla Tabea Riemann, Hui Wang, Bernd Ittermann, Ulrike Grittner, Agnes Floeel
Summary: This study compared the contribution of hippocampal and amygdalar volumes in the diagnosis and prediction of Alzheimer's disease (AD). The results showed that measurements of amygdalar volumes might help identify patients with subjective cognitive decline (SCD), but its association with other psychiatric disorders needs further evaluation. In patients with mild cognitive impairment (MCI), memory decline over 3 years was more strongly associated with hippocampal volumes than amygdalar volumes.
NEUROIMAGE-CLINICAL
(2023)
Article
Neuroimaging
Meltem Ivren, Ulrike Grittner, Rutvik Khakhar, Francesco Belotti, Heike Schneider, Paul Poeser, Federico D'Agata, Giannantonio Spena, Peter Vajkoczy, Thomas Picht, Tizian Rosenstock
Summary: This study compared two statistical models, one based on clinicoradiological prognostic sum score and the other based on navigated transcranial magnetic stimulation and diffusion-tensor-imaging tractography, for predicting postoperative motor outcome in glioma patients. The results showed that the model based on navigated transcranial magnetic stimulation and diffusion-tensor-imaging tractography was superior to the clinicoradiological prognostic sum score model, and a combined model combining both models was more accurate in predicting the extent of resection. Therefore, functional data from navigated transcranial magnetic stimulation combined with tractography should be used for patient counseling and surgical planning in patients with motor-associated tumors.
NEUROIMAGE-CLINICAL
(2023)