Article
Endocrinology & Metabolism
Tibor V. Varga, Tianwei Xu, Mika Kivimaki, Amar J. Mehta, Reiner Rugulies, Naja H. Rod
Summary: The study found that individuals with high organizational justice had more favorable long-term cardiometabolic biomarker patterns compared to those with low organizational justice. This suggests that organizational justice may contribute to the lower risk of chronic diseases by influencing metabolic trajectories over time.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Geriatrics & Gerontology
Archana Singh-Manoux, Amina Oumarou-Ibrahim, Marcos D. Machado-Fragua, Julien Dumurgier, Erics J. Brunner, Mika Kivimaki, Aurore Fayosse, Severine Sabia
Summary: Poor and declining kidney function in older adults is associated with a higher risk of dementia that is not attributable to stroke and persists after accounting for major cardiometabolic conditions.
Article
Clinical Neurology
Celine Ben Hassen, Marcos D. Machado-Fragua, Benjamin Landre, Aurore Fayosse, Julien Dumurgier, Mika Kivimaki, Severine Sabia, Archana Singh-Manoux
Summary: This study found that abnormal lipid levels in midlife are associated with a higher risk of dementia in women, but only for events occurring after the first 20 years of follow-up. No associations were observed in men.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Marcos D. Machado-Fragua, Benjamin Landre, Mathilde Chen, Aurore Fayosse, Aline Dugravot, Mika Kivimaki, Severine Sabia, Archana Singh-Manoux
Summary: This study utilized machine learning to investigate the role of midlife serum metabolites in predicting dementia, with results showing that while glucose played a significant role in dementia, metabolites measured in midlife only had a modest contribution to dementia prediction once age was taken into account.
Article
Psychiatry
Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Cheng-Chieh Lin
Summary: This study aimed to investigate the association between obesity marker trajectory patterns and cognitive impairment and decline in older adults. The results showed that maintaining high levels of fat mass and abdominal fat, as well as having a U-shaped trajectory of waist-to-hip ratio, were associated with a lower risk of cognitive impairment. Additionally, a low but slowly increasing trend in waist-to-hip ratio was associated with a decreased risk of cognitive decline.
Article
Clinical Neurology
Siiri Laari, Katri Turunen, Tatu Kauranen, Satu Mustanoja, Marius Lahti-Pulkkinen, Turgut Tatlisumak, Erja Poutiainen
Summary: In this study, we found that young stroke survivors may be at risk of memory decline over a decade after stroke, while other cognitive abilities show no significant changes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Abramova, Yana Zorkina, Valeriya Ushakova, Dmitry Gryadunov, Anna Ikonnikova, Elena Fedoseeva, Marina Emelyanova, Aleksandra Ochneva, Irina Morozova, Konstantin Pavlov, Timur Syunyakov, Alisa Andryushchenko, Victor Savilov, Marat Kurmishev, Denis Andreuyk, Svetlana Shport, Olga Gurina, Vladimir Chekhonin, Georgy Kostyuk, Anna Morozova
Summary: This study aimed to identify immune blood biomarkers associated with changes in cognitive function in patients with mild cognitive impairment (MCI). The results showed that concentrations of EGF, Eotaxin, GRO, IL-8, MCP-1, and MDC increased after cognitive training in MCI patients, and these biomarkers exhibited weak correlations with other immune parameters. Additionally, differences in concentrations of IP-10, FGF-2, TGFa, and VEGF in MCI patients were associated with APOE genotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Alessandra Mangia, Annarita Valeria Piazzolla, Maria Maddalena Squillante, Giovanna Cocomazzi, Vanna Maria Valori, Massimiliano Copetti, Paola Parente, Vito Attino, Maria Guido
Summary: Non-alcoholic fatty liver disease (NAFLD) can progress to severe liver fibrosis and cirrhosis. The presence of portal inflammation, high triglycerides levels, advanced fibrosis at baseline, and the duration of follow-up are predictors of disease progression in NAFLD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Maja R. Radojcic, Romain S. Perera, Lingxiao Chen, Tim D. Spector, Deborah J. Hart, Manuela L. Ferreira, Nigel K. Arden
Summary: The study on 19-year BMI patterns found that trajectories of increase overweight-to-obese were bidirectionally related to knee and multi-site pain, while women with BMI above 40 had an increased mortality risk.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Celine Ben Hassen, Aurore Fayosse, Benjamin Landre, Martina Raggi, Mikaela Bloomberg, Severine Sabia, Archana Singh-Manoux
Summary: This study found a significant association between midlife and late-life multimorbidity, including severity of multimorbidity, and the risk of subsequent dementia. Multimorbidity in midlife had a stronger association with dementia compared to late-life multimorbidity. The severity of multimorbidity also increased the risk of dementia.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Clinical Neurology
Maria Gaughan, Ruth Monaghan, Karen O'Connell, Nonnie McNicholas, Siew Mei Yap, Niall Tubridy, Fiadhnait O'Keeffe, Christopher McGuigan
Summary: This study aims to evaluate the prevalence of cognitive impairment over a five-year interval in participants of the original BICAMS validation study, as well as assess the changes in BICAMS subtests over time. The results showed overall stability in the prevalence of cognitive impairment as assessed by the BICAMS, with improvements seen in some specific cognitive tests.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Geriatrics & Gerontology
Yue Zeng, Terry Yat Sang Lum, Yu-Chih Chen
Summary: This study examines the intersectionality across age, socioeconomic status (SES), and race on cognitive trajectories. The results show that cognitive function declines with age and is associated with SES and race. Positive SES in both childhood and adulthood contributes to positive cognition. Accumulated SES disadvantages are linked to lower cognition. Different life course models have different effects on cognitive decline trajectories, particularly among older black respondents. Overall, those with socioeconomic advantages have a slower decline in cognition, while those with accrued disadvantages experience a faster decline. Policies that address SES inequality and promote healthy cognitive performance can help reduce racial cognitive disparities later in life.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Sunniva Brurok Myklebost, Tine Nordgreen, Oda Stakkestad Klakegg, Asa Hammar
Summary: This study examined the long-term effects of an internet-delivered intervention on residual cognitive deficits, rumination, and symptoms of major depressive disorder (MDD). The results showed a reduction in cognitive deficits and rumination, but an increase in symptoms of MDD. Additionally, participants who experienced a new episode of MDD showed different outcomes compared to those who did not.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Benjamin Landre, Aurore Fayosse, Celine Ben Hassen, Marcos D. Machado-Fragua, Julien Dumurgier, Mika Kivimaki, Severine Sabia, Archana Singh-Manoux
Summary: The study found a strong association between motor function in early old age and mortality, with evidence of terminal decline emerging early in overall motor function measures (timed chair rises and physical component summary score) and later in basic/instrumental ADL limitations.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Sharon A. Savage, John Baker, Fraser Milton, Christopher Butler, Adam Zeman
Summary: This study aimed to investigate the long-term prognosis of transient epileptic amnesia (TEA) and found that TEA patients have a similar life expectancy to the general population. Seizures are typically well controlled through medication, although adjustments may be needed. Cardiovascular disorders and other comorbidities are common in TEA patients, with hypertension being the most frequent. The incidence of dementia is relatively low compared to the persisting memory problems. Ongoing medical monitoring and attention to mood are recommended, as well as the development of effective memory interventions for TEA patients.