Article
Oncology
Yaoyao Xiong, Xiongbing Zu, Long Wang, Yuan Li, Minfeng Chen, Wei He, Lin Qi
Summary: The study identified lncRNA VIM-AS1 as highly expressed in bladder cancer, especially in metastatic tissues and high-metastatic cell lines. VIM-AS1 acted as a ceRNA for miR-655, competing with ZEB1 for miR-655 binding, promoting EMT in both high- and low-metastatic bladder cancer cells, and enhancing cancer cell metastasis.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Tuan Luu
Summary: Pancreatic cancer, known for its high mortality and insensitivity to existing therapies, has attracted increasing scholarly attention for its progression mechanisms, particularly the role of epithelial-mesenchymal transition (EMT) in cancer genesis and metastasis. Recent discoveries on EMT-regulating factors in pancreatic cancer have shed light on the relationship between EMT and this cancer type, marking a key advancement in research on EMT in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Tianying Zheng, Wenfei Han, Aijun Wang, Yonggang Wang
Summary: This study reveals that miR-128-3p inhibits epithelial-mesenchymal transition, invasion, and migration of pancreatic cancer cells by targeting ZEB1.
Article
Biochemistry & Molecular Biology
Chao Li, Juanjuan Cai, Weifeng Liu, Zhenzhen Gao, Guogang Li
Summary: circ-STK39 expression is upregulated in pancreatic cancer tissues and cells, indicating its potential role in pancreatic cancer progression. Downregulation of circ-STK39 inhibits proliferation and migration of pancreatic cancer. Furthermore, TRAM2 and miR-140-3p are identified as downstream targets of circ-STK39, and TRAM2 overexpression reverses the effects of miR-140-3p on migration, proliferation, and epithelial-mesenchymal transition (EMT) in pancreatic cancer.
Article
Biochemistry & Molecular Biology
Sergey E. Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev, Alexey G. Mittenberg
Summary: P53 plays a critical role in protecting the genome and preventing tumor formation, including metastases. The interaction between p53 and the transcription factor Zeb1 is important in carcinogenesis, particularly in the process of epithelial to mesenchymal transition (EMT). Additionally, the composition of Zeb1 interactome is affected by the presence of cancer stem cells and the level of Oct4/Sox2 expression, indicating that stemness influences the specificity of Zeb1 interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kai Zhang, Huifang Zhao, Yaru Sheng, Xinyu Chen, Penghui Xu, Jinming Wang, Zhongzhong Ji, Yuman He, Wei-Qiang Gao, Helen He Zhu
Summary: The study reveals the important role of Zeb1 in regulating hematopoietic stem cell (HSC) stemness. Zeb1 acts as a transcriptional suppressor on mitochondrial fusion protein Mfn2, leading to fragmented mitochondrial morphology and low metabolic status. Zeb1(+)LSKs represent a subset of functional long-term HSCs.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Xin Zhao, Xiaoshi Zhang, Xinxue Zhang, Tao Jiang, Jialei Zhai, Huaguang Wang, Mengxiu Huang, Ren Lang, Qiang He
Summary: This study revealed that miR-374b-5p is downregulated in pancreatic cancer (PC) and its overexpression can inhibit the proliferation, migration, and invasion of PC cells by suppressing the expression of KDM5B, thereby reducing epithelial-mesenchymal transition (EMT) in PC. The findings suggest that miR-374b-5p could potentially serve as a prognostic biomarker and therapeutic target for EMT induced by KDM5B in PC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lili Liang, Andreas M. Kaufmann
Summary: Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic and solid tumors. They possess unique properties, including slow proliferation, self-renewal, differentiation, and the ability to undergo epithelial-mesenchymal transition (EMT) and its reverse process. CSCs play a crucial role in tumor growth, therapy resistance, and cancer metastasis. Strategies targeting CSCs are being developed for novel anti-metastasis treatments, aiming to improve therapeutic efficiency and prognosis with fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Dandan Wang, Liangyi Cui, Qing Yang, Jiao Wang
Summary: The up-regulated circZFPM2 in ectopic endometrial tissues can induce EMT through the miR-205-5p /ZEB1 signaling pathway, promoting cell proliferation, migration, and invasion. This may serve as a promising biomarker in the diagnosis and treatment of endometriosis.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Rahul Bhome, Muhammad Emaduddin, Victoria James, Louise M. House, Stephen M. Thirdborough, Massimiliano Mellone, Joeri Tulkens, John N. Primrose, Gareth J. Thomas, Olivier De Wever, Alex H. Mirnezami, A. Emre Sayan
Summary: This study reveals a new mechanism of cell communication in CRC through the EV-mediated transfer of miRNAs, explaining why CRC tumors with greater metastatic potential are rich in CAFs.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Review
Biochemistry & Molecular Biology
Joanna Kozak, Alicja Forma, Marcin Czeczelewski, Pawel Kozyra, Elzbieta Sitarz, Elzbieta Radzikowska-Buchner, Monika Sitarz, Jacek Baj
Summary: Epithelial-mesenchymal transition (EMT) is a key process in the development of gastric cancer, affecting patient outcomes. There is an urgent need for research on pharmacological agents targeting EMT to prevent progression and potential metastasis of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jinguo Zhang, Wencai Guan, Xiaolin Xu, Fanchen Wang, Xin Li, Guoxiong Xu
Summary: The study reveals that Sorcin plays a key role in chemoresistance of ovarian cancer, potentially driving PTX resistance through miR-142-5p and ZEB1. Targeting the SRI/Smad4/ZEB1/miR-142-5p loop may reverse chemoresistance.
Article
Cell Biology
Julienne L. Carstens, Sujuan Yang, Pedro Correa de Sampaio, Xiaofeng Zheng, Souptik Barua, Kathleen M. McAndrews, Arvind Rao, Jared K. Burks, Andrew D. Rhim, Raghu Kalluri
Summary: The study indicates that partial epithelial to mesenchymal transition is associated with metastasis in pancreatic ductal adenocarcinoma (PDAC), and genetic suppression can lead to epithelial stabilization and increased liver metastasis.
Article
Biochemistry & Molecular Biology
Jenna Kitz, Cory Lefebvre, Joselia Carlos, Lori E. Lowes, Alison L. Allan
Summary: This study revealed that inducible knockdown of Zeb1 can lead to an aggressive p-EMT phenotype in prostate cancer cells, which can be mitigated by treatment with the 5-azacytidine drug. DNA methylation chip analysis also identified potential targets for identifying and targeting aggressive p-EMT prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J. A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, Jonathan M. Kurie
Summary: Cancer cells alter cancer-associated fibroblasts through specific secretory programs and repulsion processes, promoting cancer cell metastasis and sensitivity to pro-metastatic signals from fibroblasts.
Article
Cell Biology
Tingting Yu, Yong Zuo, Rong Cai, Xian Huang, Shuai Wu, Chenxi Zhang, Y. Eugene Chin, Dongdong Li, Zhenning Zhang, Nansong Xia, Qi Wang, Hao Shen, Xuebiao Yao, Zhong-Yin Zhang, Song Xue, Lei Shen, Jinke Cheng
JOURNAL OF MOLECULAR CELL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Huaize Liu, Sen Yan, Jie Ding, Ting-Ting Yu, Steven Y. Cheng
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Oncology
Ying Luo, Sihong You, Jirong Wang, Shuling Fan, Jie Shi, Ai Peng, Tingting Yu
Article
Biochemistry & Molecular Biology
Qian Li, Wenying Zhu, Bei Zhang, Yiping Wu, Sen Yan, Yufeng Yuan, Haiyan Zhang, Jie Li, Kai Sun, Hua Wang, Tingting Yu
BIOSCIENCE REPORTS
(2018)
Article
Oncology
Gorbatchev Ambroise, Ting-ting Yu, Boxi Zhang, Merve Kacal, Yuqing Hao, Andre L. Queiroz, Amanda T. Ouchida, Cecilia Lindskog, Erik Norberg, Helin Vakifahmetoglu-Norberg
BRITISH JOURNAL OF CANCER
(2020)
Article
Cell Biology
Hengqing Liao, Jing Cai, Chen Liu, Longyan Shen, Xiaohong Pu, Yixing Yao, Bo'ang Han, Tingting Yu, Steven Y. Cheng, Shen Yue
CELL DEATH & DISEASE
(2020)
Article
Oncology
Yi Zhang, Cong Chen, Tingting Yu, Tao Chen
FRONTIERS IN ONCOLOGY
(2020)
Article
Health Care Sciences & Services
Ming Xu, Liu Ouyang, Lei Han, Kai Sun, Tingting Yu, Qian Li, Hua Tian, Lida Safarnejad, Hengdong Zhang, Yue Gao, Forrest Sheng Bao, Yuanfang Chen, Patrick Robinson, Yaorong Ge, Baoli Zhu, Jie Liu, Shi Chen
Summary: By combining low-dimensional clinical and lab testing data with high-dimensional CT imaging data, this study aimed to accurately differentiate between healthy individuals, patients with COVID-19, and patients with non-COVID viral pneumonia. The use of multimodal features significantly improved classification performance, with machine learning models achieving high overall and class-specific prediction accuracy. This hybrid deep learning-machine learning framework offers a novel and effective approach for clinical applications, providing valuable insights for current COVID-19 diagnostics and other clinical applications with high-dimensional multimodal biomedical features.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ting-ting Yu, Qiu-fan Xu, Si-Yang Li, Hui-jie Huang, Sarah Dugan, Lei Shao, Jennifer A. Roggenbuck, Xiao-tong Liu, Huai-ze Liu, Betsy A. Hirsch, Shen Yue, Chen Liu, Steven Y. Cheng
Summary: This study identified a patient with short stature, hypothalamic dysfunction, and mild macrocephaly carrying a maternally inherited 690 kb deletion involving a noncoding RNA gene DNM3OS. The research highlights the essential role of DNM3OS in sustaining chondrocyte proliferation independent of two microRNAs and controlling chondrocyte growth through regulation of nerve growth factor NGF.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Bo'ang Han, Zhen Sun, Tingting Yu, Yu Wang, Lun Kuang, Tianyuan Li, Jing Cai, Qing Cao, Yuan Xu, Binbin Gao, Steven Y. Cheng, Shen Yue, Chen Liu
Summary: A novel SPOP-PTEN-SUFU axis promotes ccRCC carcinogenesis by activating SHH and WNT pathways. Inhibition of SUFU leads to elevated SHH and WNT signaling, rescuing the reduced abilities of ccRCC cells caused by SPOP-knockdown. Combinatorial treatment with SHH and WNT inhibitors is more effective for suppressing ccRCC cell proliferation and aggressiveness.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Xin Yang, Nan Jin, Yu Wang, Yixing Yao, Yue Wang, Tianyuan Li, Chen Liu, Tingting Yu, Hao Yin, Ziyu Zhang, Steven Y. Cheng, Shen Yue
Summary: This study found that autophagy participates in the ubiquitination and degradation process of Ptch1, thereby regulating the transduction of the Shh signal. Blocking autophagy affects the transport of Smoothened into primary cilia, resulting in weakened Shh signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi Zhang, Zhao-bin Guo, Yu-min Nie, Guan-ping Feng, Man-jiao Deng, Yi-min Hu, Hui-jie Zhang, Yin-yi Zhao, Yi-wei Feng, Ting-ting Yu, Ke Hu
Summary: Three-dimensional tumor cell culture provides a more realistic model for cancer treatment evaluation. This study proposes a novel method for inducing the formation of multicellular spheroids (MCSs) using a hydrogel substrate. Chemotherapy and photothermal therapy based on clinical drugs and graphene device are evaluated using MCSs obtained through this method.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Oncology
Wenlong Chen, Yiwen Wang, Haitao Gu, Yi Zhang, Cong Chen, Tingting Yu, Tao Chen
Summary: This study systematically evaluated the interaction between extracellular matrix (ECM) remodeling and prognosis and the immune microenvironment in colorectal cancer (CRC) patients. It developed a prognostic model based on two ECM remodeling-related genes (MEIS2, SLC2A3) and showed their reliable predictive ability. The study also found significant differences in the tumor microenvironment and immune function between high- and low-risk CRC patients. Overall, this study has important clinical implications for immunotherapy and individualized treatment in CRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Yi Zhang, Si-yang Li, Hang-ju Zhu, Jun-Wei Lai, Shuo-shuo Sune, Yue Line, Xing-ling Li, Zhao-bin Guo, Ziheng Lv, Hongxu Meng, Ke Hu, Ming Xu, Ting-ting Yu
Summary: A novel technique that promotes protein production in mammalian cells by forming multicellular spheroids has been proposed. This finding provides a new approach for improving large-scale mammalian protein expression cell systems.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
