Further analyses of the safety of verubecestat in the phase 3 EPOCH trial of mild-to-moderate Alzheimer’s disease
出版年份 2019 全文链接
标题
Further analyses of the safety of verubecestat in the phase 3 EPOCH trial of mild-to-moderate Alzheimer’s disease
作者
关键词
Verubecestat, BACE inhibitor, Amyloid, Alzheimer’s disease, Clinical trial, Safety
出版物
Alzheimers Research & Therapy
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-08-07
DOI
10.1186/s13195-019-0520-1
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures
- (2019) David S. Knopman NEW ENGLAND JOURNAL OF MEDICINE
- Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease
- (2019) David Henley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease
- (2019) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interventions to Prevent Falls in Older Adults
- (2018) Janelle M. Guirguis-Blake et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Fall-Risk-Increasing Drugs: A Systematic Review and Meta-Analysis: II. Psychotropics
- (2018) Lotta J. Seppala et al. Journal of the American Medical Directors Association
- Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease
- (2018) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Complex Relationship Between Suicide, Dementia, and Amyloid: A Narrative Review
- (2018) Ismael Conejero et al. Frontiers in Neuroscience
- Risk Factors Associated with Falls in Older Adults with Dementia: A Systematic Review
- (2017) Eresha Fernando et al. Physiotherapy Canada
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease
- (2016) Jack D. Scott et al. JOURNAL OF MEDICINAL CHEMISTRY
- Alzheimer's disease
- (2016) Philip Scheltens et al. LANCET
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- The BACE1 inhibitor verubecestat (MK-8931) reduces CNS -amyloid in animal models and in Alzheimers disease patients
- (2016) M. E. Kennedy et al. Science Translational Medicine
- BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease
- (2016) Soraia Barão et al. TRENDS IN NEUROSCIENCES
- Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice
- (2016) Derya R. Shimshek et al. Scientific Reports
- The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A Pharmacodynamic Responses in Mice, Dogs, and Humans
- (2015) P. C. May et al. JOURNAL OF NEUROSCIENCE
- Alzheimer's disease
- (2015) Colin L. Masters et al. Nature Reviews Disease Primers
- Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
- (2014) Robert Vassar et al. JOURNAL OF NEUROCHEMISTRY
- Targeting the β secretase BACE1 for Alzheimer's disease therapy
- (2014) Riqiang Yan et al. LANCET NEUROLOGY
- Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
- (2014) Stephen Salloway et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
- (2014) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells
- (2013) L. Rochin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease
- (2012) Vladimir Coric et al. ARCHIVES OF NEUROLOGY
- Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis
- (2012) Reisa Sperling et al. LANCET NEUROLOGY
- The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults
- (2011) Kelly Posner et al. AMERICAN JOURNAL OF PSYCHIATRY
- Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons
- (2009) John C. Woolcott ARCHIVES OF INTERNAL MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now