Article
Multidisciplinary Sciences
Yali Hu, Zi-You Tian, Wei Xiong, Dedao Wang, Ruichi Zhao, Yan Xie, Yu-Qin Song, Jun Zhu, Hua Lu
Summary: This study presents a water-assisted controlled ring-opening polymerization method for ProNCA, which enables the rapid synthesis of well-defined PLP in a short time. The use of water facilitates proton shift and lowers the energy barrier, leading to fast and efficient reactions. The protein-mediated ROP of ProNCA offers a convenient approach for the synthesis of various protein-PLP conjugates with enhanced properties.
NATIONAL SCIENCE REVIEW
(2022)
Article
Polymer Science
Mahammad Anas, Tarun K. Mandal
Summary: The appropriate functionalization of synthetic polypeptides is crucial for generating self-assembled nanostructures, and this study presents a method to functionalize poly(L-glutamate)s with long chain alkyl groups. The resulting polypeptides possess weak crystallinity and display good thermoresponsive properties, forming vesicular nanoaggregates that can encapsulate organic dyes.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Junliang Zhu, Yunjie He, Chenglong Ge, Wenting Si, Ziyuan Song, Lichen Yin
Summary: In this study, a rapid and efficient method for preparing polypeptide-based inorganic/organic nano-hybrids was reported. The accelerated ring-opening polymerization of N-carboxyanhydrides (NCAs) was achieved using amine-modified mesoporous silica nanoparticles (MSN-NH2) as nano-initiators in a dichloromethane/water biphasic system. The resulting nano-hybrids exhibited spherical morphology and uniform size distribution. Moreover, this strategy can be applied to various types of NCAs and inorganic nano-initiators. The research provides a convenient approach for the synthesis of inorganic/organic nano-hybrids and promotes their potential applications in the biomedical field.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Xu Wang, Zihao Zhao, Tianrui Xue, Zhengzhong Tan, Ziyuan Song, Shiqi Wei, Yang Bo, Ying Wang, Jianjun Cheng
Summary: Ring-opening polymerization of TPE-modified NCAs was used to incorporate AIE-active segments into polypeptides, forming micelles in aqueous solution with AIE properties. The amphiphilic polypeptides show potential for formulation of doxorubicin-containing micelles for real-time drug distribution monitoring.
PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
(2021)
Article
Polymer Science
Honggang Mei, Bingjie Zhao, Huaming Wang, Sixun Zheng
Summary: The preparation of crosslinked PDCPD nanoparticles via ROMP-induced self-assembly approach was reported in this communication. The morphology of the obtained nanoparticles varied from spherical, cylindrical to planar depending on the molecular weights of Macro-CTAs, the concentrations of DCPD and the natures of solvents. The ROMPISA method provides a new and efficient approach to prepare crosslinked polymer nanoparticles.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Sofia L. Goodrich, Megan R. Hill, Rebecca A. Olson, Brent S. Sumerlin
Summary: The use of NPPOC as a photoprotecting group for primary amine initiators in NCAs polymerizations showed better polymerization control than previous methods. The addition of a small equivalence of base enhanced the control and resulted in polymers with lower dispersities. This method advances photo-controlled polypeptide synthesis by demonstrating high chain-end fidelity, efficient chain extension, and the ability to synthesize block copolymers.
Article
Polymer Science
Zhunxuan Li, Rui Chen, Ying Wang, Linlin Zhu, Wenyi Luo, Zhen Zhang, Nikos Hadjichristidis
Summary: An efficient synthetic methodology was developed for the modification of hyperbranched polyethyleneimines (PEI) using N-sulfonyl aziridines, resulting in materials with unique fluorescence properties and the ability to remove hazardous metals.
Article
Chemistry, Multidisciplinary
Qianqian Shi, Yibing Chen, Junjiao Yang, Jing Yang
Summary: This study presents the first report on polyester-based nanocarriers fabricated via ring-opening polymerization-induced self-assembly (ROPISA) of salicylic acid o-carboxyanhydride (SAOCA). The ROPISA process results in well-defined diblock copolymers that exhibit an original cylindrical morphology.
CHEMICAL COMMUNICATIONS
(2021)
Article
Polymer Science
Narumi Miyasako, Shin-ichi Matsuoka, Masato Suzuki
Summary: New ester-functionalized bicyclic aliphatic polymers were successfully synthesized through ring-opening metathesis polymerization (ROMP) of various norbornene lactones and their analogues, followed by hydrogenation. The comparison and discussion of polymerizability and thermal properties between different monomers before and after hydrogenation were conducted. The obtained polymers showed excellent thermal stability and processing deformation suitable for transparent resin materials.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yongliang Xia, Pengjun Yuan, Yanping Zhang, Yangyang Sun, Miao Hong
Summary: This study reports the efficient conversion of gamma-valerolactone and its derivatives into sustainable and degradable polythioesters through the establishment of the first isomerization-driven ring-opening polymerizations (IROPs) of corresponding thionolactone intermediates. The development of a new cationic initiator [Et3O](+)[B(C6F5)(4)](-) with high activity, exclusive selectivity, living nature, and broad scope of thionolactones is the key to this success. The study also reveals the complete inversion of configuration during IROP of enantiopure gamma-thionovalerolactone and the formation of a highly crystalline supramolecular stereocomplex.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Phuong T. T. Do, Berwyck L. J. Poad, Hendrik Frisch
Summary: This study presents a strategy to program photodegradability into vinylic polymers by utilizing the wavelength selectivity of photocycloadditions for radical ring-opening polymerization (rROP). Coumarin terminated allylic sulfides were irradiated with UVA light to initiate intramolecular [2+2] photocycloaddition, generating cyclic macromonomers. Copolymers with photoreactivity inherited from the cyclic parent monomer were synthesized through subsequent RAFT-mediated rROP with methyl acrylate. Efficient photocycloreversion of the coumarin dimers upon UVB irradiation led to polymer degradation within minutes under UVB light or days under sunlight. This synthetic strategy enables the incorporation of photolabile linkages into vinylic polymers, tuning degradation for specific wavelengths.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Taeyang An, Hanseul Ryu, Tae-Lim Choi
Summary: This study presents a versatile approach to improve the alternation and degradability of 2,3-dihydrofuran (DHF) copolymers by carefully controlling the reactivity of both the Ru initiators and the monomers. The DHF copolymers showed outstanding A, B-alternation and could be broken down to a single repeat unit level under acidic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Watcharee Funfuenha, Winita Punyodom, Puttinan Meepowpan, Wanich Limwanich
Summary: Microwave irradiation was successfully used to improve the solvent-free ring-opening polymerization of ε-caprolactone with different n-butyltin(IV) chloride initiators. The performance of these initiators was compared to the conventional tin(II) 2-ethylhexanoate. The presence of chlorine atom in the n-butyltin(IV) chloride initiators played a significant role in controlling the molecular weight of the polymer.
Article
Chemistry, Applied
Nicolas Zivic, Thomas Brossier, Floriane Crestey, Sylvain Catrouillet, Abraham Chemtob, Valerie Heroguez, Patrick Lacroix-Desmazes, Christine Joly-Duhamel, Sebastien Blanquer, Julien Pinaud
Summary: Patterned coatings based on biodegradable crosslinked poly(ester/carbonate) were prepared using photoinitiated ring-opening polymerization. The gel time was evaluated using photorheometry, and the formulation and experimental conditions were optimized for stereolithography to produce patterned coatings.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Polymer Science
Ilya Nifant'ev, Andrey Shlyakhtin, Vladimir Bagrov, Evgeny Shaputkin, Alexander Tavtorkin, Pavel Ivchenko
Summary: The study found that the acyl chlorides derived from NHS and MI can efficiently terminate the living ring-opening polymerization of aliphatic polyesters, producing NHS- and MI-functionalized polymers with high yields. These polymers exhibit high reactivity towards amine- and thiol-containing model substrates in both organic and aqueous media.
Article
Polymer Science
Zehua Li, Amanda K. Pearce, Jianzhong Du, Andrew P. Dove, Rachel K. O'Reilly
Summary: Crystallization-driven self-assembly technique was used to prepare monodisperse cationic cylindrical nanoparticles with controllable sizes, which showed promising antibacterial activity and enhanced mechanical properties in nanocomposite hydrogels.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Guomin Wang, Kaiwei Tang, Wenjuan Jiang, Qing Liao, Yong Li, Pei Liu, Yuzheng Wu, Mengting Liu, Huaiyu Wang, Bin Li, Jianzhong Du, Paul K. Chu
Summary: Adjustable electro-mechanical forces can effectively kill bacteria and adding electrical charges can enhance the antibacterial efficacy.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Danqing Liu, Yuejing Xi, Shunzhi Yu, Kexin Yang, Fan Zhang, Yuying Yang, Tianlong Wang, Shisheng He, Yunqing Zhu, Zhen Fan, Jianzhong Du
Summary: Aging population has increased the demand for orthopedic implants. However, biofilm formation on implants due to antibiotic insensitivity and antimicrobial resistance has been a major challenge. In this study, an antibacterial polypeptide coating was developed to prevent biofilm formation and acquired antibiotic resistance. The coating demonstrated excellent in vivo adhesive capacity and strong antibacterial activity. It also inhibited the expression of genes associated with antimicrobial resistance. In vivo experiments confirmed the effectiveness of the coating in preventing biofilm formation and infections. Overall, this study provides a simple method for preparing antibacterial orthopedic implants without inducing antimicrobial resistance.
Article
Chemistry, Multidisciplinary
Ping Wei, Shuai Chen, Junqiu Shi, Jianzhong Du
Summary: An oxygen-generating polymer vesicle was developed to enhance sonodynamic therapy by overcoming the limitations of insoluble sonosensitizers and unfavorable hypoxia tumor microenvironment. These vesicles could efficiently generate reactive oxygen species upon ultrasound activation, leading to almost complete eradication of subcutaneous tumors without obvious systemic toxicity. Moreover, they showed effective behavior in reducing the expression levels of crucial tumor progression-related factors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Tao Wang, Erik Jan Cornel, Chang Li, Jianzhong Du
Summary: Biofilms have become a subject of increasing attention due to their association with bacterial infections. Traditional antibiofilm approaches based on antibiotics are often ineffective in eradicating biofilms due to limited antibiotic diffusion and inactivation. Smart drug delivery systems that target the biofilm interior show promise in overcoming this challenge. This review focuses on methods to improve drug delivery efficiency for enhanced chemotherapy of biofilms, including chemical and physical approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Polymer Science
Jinlong Qin, Min Sun, Wei Hu, Jiajing Cheng, Zhen Fan, Jianzhong Du
Summary: Immunotherapy plays an important role in cancer treatment, but there are challenges in delivering immunotherapeutic agents and activating them effectively at tumor sites. Hydrogels, combined with immunotherapies, offer a chance to enhance the immune response against tumors with reduced side effects. Stimuli-responsiveness is also applied to optimize pharmacokinetics and improve therapeutic outcomes. This review discusses the opportunities of combining immunotherapy with stimuli-responsive hydrogels, such as light, temperature, ultrasound, and magnetically responsive hydrogels, for effective cancer treatment. It also explores the potential of stimuli-responsive hydrogels as vaccine implants against cancer and Covid-19.
Article
Chemistry, Multidisciplinary
Runxin Teng, Yuying Yang, Zhuo Zhang, Kexin Yang, Min Sun, Chang Li, Zhen Fan, Jianzhong Du
Summary: A new type of antimicrobial peptides with inherent stability, antibacterial activity, and reactive oxygen species (ROS) scavenging has been developed to effectively heal infected wounds. The peptides are oxidized and assembled into nanoparticles in situ at the wound site, providing enhanced stability and significantly increased antibacterial efficiency. The nanoparticles demonstrate efficient antioxidant properties and effectively reduce ROS in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Wangmeng Hou, Xiuzhe Yin, Yao Chen, Jianzhong Du, Yongming Chen, Yi Shi
Summary: A novel aqueous ring-opening metathesis polymerization method named ME-ROMP is proposed. It involves injecting a small amount of a CH2Cl2 solution of the Grubbs' third-generation catalyst into the aqueous solution of water-soluble monomers, allowing high efficiency and controlled polymerization without deoxygenation. This method enables the synthesis of well-defined water-soluble polynorbornenes with various compositions and architectures.
Article
Materials Science, Biomaterials
Kexin Yang, Danqing Liu, Runxin Teng, Chang Li, Zhen Fan, Jianzhong Du
Summary: Delayed implant-associated infection is a significant challenge due to the risk involved in implant replacement. Mussel-inspired antimicrobial coatings can be used to coat various implants easily, but the adhesive DOPA group is prone to oxidation. Therefore, a polypeptide copolymer poly(Phe7-stat-Lys10)-b-polyTyr3 was designed to prepare an implant coating that prevents implant-associated infections through tyrosinase-induced enzymatic polymerization. This coating has excellent antibacterial effect and desirable biofilm inhibition activity, making it promising for a wide range of biomedical materials to combat delayed infections.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Qingmei Sun, Junqiu Shi, Hui Sun, Yunqing Zhu, Jianzhong Du
Summary: This review summarizes the design principles and preparation methods of membrane-compartmentalized and lumen-compartmentalized polymersomes, and discusses the recent advances of MCPs as nanoreactors and cell mimics. The future research directions of MCPs are also prospected.
Article
Chemistry, Physical
Qingmei Sun, Kai Hong, Liujie Fan, Xinyue Zhang, Tong Wu, Jianzhong Du, Yunqing Zhu
Summary: This paper introduces a novel type of PAA hydrogel that combines dual-amide and zwitterionic moieties to achieve excellent protein repulsion and cell adhesion simultaneously. The results show that the hydrogel has good cell adhesion and degradation properties, as well as excellent biocompatibility, making it suitable for tissue engineering applications.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qianxi Gu, Haolan Li, Erik Jan Cornel, Jianzhong Du
Summary: Polymerization-induced self-assembly (PISA) is a powerful method for preparing dispersed block copolymer nanoparticles with various morphologies. This Perspective provides a comprehensive introduction to PISA and discusses emerging methods that utilize polymer insolubility or polymer-polymer interactions for self-assembly. The current state and limitations of PISA are also addressed, along with insights on overcoming these limitations to meet higher nanoparticle demands.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Chemistry, Physical
Junhao Liang, Xingsen Yang, Chang Li, Beibei Zhang, Danqing Liu, Yu Fan, Yong Hu, Jianzhong Du
Summary: This study proposes a novel injectable supersoft DNA hydrogel dressing with antibacterial, antioxidant, anti-inflammatory, and angiogenic functions, which can effectively promote the healing of infected diabetic wounds.
CHEMISTRY OF MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yaning Gao, Chenchen Gao, Yirong Fan, Hui Sun, Jianzhong Du
Summary: This Review highlights the recent advances in the design principles, synthetic strategies, and biomedical applications of multicompartment polymersomes (MCPs). Different compartmentalization types and synthesis methods are discussed. Moreover, the diverse applications of MCPs in various fields are emphasized. Future perspectives for controlled synthesis and applications of MCPs are proposed.